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    PublicationOpen Access
    Kozmetik ürünler ve kadın sağlığı
    (Gülhane Military Medical Academy (GMMA) Department of Public Health, 2014) Kocaöz, Semra; Eroğlu, Kafiye; Faculty Member; School of Nursing; 6061
    Günümüzde kozmetik ürünler, çok çeşitli etkileri nedeniyle modern toplumun vazgeçilmez bir ürünü olarak karşımıza çıkmaktadır. Genellikle içeriğindeki kimyasal maddelere hiç bakılmadan kullanılan ve hedef kitlesi çoğunlukla kadınlar olan bu ürünler, bilinçsiz kullanıldığında sağlığı olumsuz etkilemektedir. Bu makalede, ilaçlar gibi yasal düzenlemeleri olması gereken kozmetik ürünlerin içeriğindeki bazı kimyasal maddelerin kadın sağlığına etkileri güncel araştırmalarla ele alınmış ve kadınlar başta olmak üzere toplumun kozmetik ürünler konusundaki farkındalığını artırmak amaçlanmıştır. / Due to their various effects, today cosmetic products are indispensable products of modern society. These products which are generally used without considering chemical material in their content and whose target group are generally women influence health negatively when they are used unconsciously. In this paper, the effect of chemical materials in the content of cosmetic products which should be used with legal arrangements on women health was analyzed through recent studies and it was aimed to analyze awareness of society, especially women, about cosmetic products.
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    PublicationOpen Access
    Therapeutic management of idiosyncratic drug-induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review
    (Springer, 2022) Niu, H.; Atallah, E.; Alvarez-Alvarez, I.; Medina-Caliz, I.; Aithal, G.P.; Andrade, R.J.; Lucena, M.I.; Arıkan, Çiğdem; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 240198
    Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. Methods: we included original articles conducted in a paediatric population (< 18 years) in which a therapeutic intervention was described to manage APAP or idiosyncratic DILI. Findings were summarized based on age groups (preterm newborn neonates, term and post-term neonates, infants, children and adolescents). Results: overall, 25 publications (fifteen case reports, six case series and four retrospective cohort studies) were included, including a total of 140 paediatric DILI cases, from preterm newborn neonates to adolescents. N-acetylcysteine was used to treat 19 APAP cases. N-acetylcysteine (n = 14), ursodeoxycholic acid (n = 3), corticosteroids (n = 31), carnitine (n = 16) and the combination of glycyrrhizin, reduced glutathione, polyene phosphatidylcholine and S-adenosylmethionine (n = 31) were the therapeutic options for treating idiosyncratic DILI. The molecular adsorbent recirculating system was used in the management of either APAP (n = 4) or idiosyncratic DILI (n = 2), while 20 paediatric ALF cases received continuous renal replacement therapy. Conclusions: this systematic review identified DILI in the paediatric population who have received specific treatment. These interventions appear to be mainly extrapolated from low-quality evidence from the adult population. Thus, there is a need for high-quality studies to test the efficacy of known and novel therapies to treat DILI specifically addressed to the paediatric population.
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    PublicationRestricted
    Work-life harmony: Conceptualization and measurement
    (Koç University, 2013) Gülseren, Duygu Biricik; Aycan, Zeynep; 0000-0003-4784-334X; Koç University Graduate School of Social Sciences and Humanities; Psychology; 5798