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    A personal ethics responsibility example: the relationship between child development and drugs taken by pregnant mother
    (TÜBİTAK, 2008) Üstün, Çağatay; Department of International Relations; Özgürler, Özge; Undergraduate Student; Department of International Relations; College of Administrative Sciences and Economics; N/A
    Kişisel sorumluluk önemli bir etik kavramdır. Bu durumda hamile anne birincil derecede önem arz etmektedir. Hamile anne kendisinin ve bebeğin sağlığının korumak, bebeğin normal gelişimini temin etmek için bazı şeylere dikkat etmelidir. Bu anlamda ilaçların hamile annenin bebeği üzerindeki genel etkilerine değineceğiz. Böylece annelerin kişisel etik sorumluluğunu vurgulamayı hedefliyoruz.
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    PublicationOpen Access
    Therapeutic management of idiosyncratic drug-induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review
    (Springer, 2022) Niu, H.; Atallah, E.; Alvarez-Alvarez, I.; Medina-Caliz, I.; Aithal, G.P.; Andrade, R.J.; Lucena, M.I.; Arıkan, Çiğdem; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 240198
    Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. Methods: we included original articles conducted in a paediatric population (< 18 years) in which a therapeutic intervention was described to manage APAP or idiosyncratic DILI. Findings were summarized based on age groups (preterm newborn neonates, term and post-term neonates, infants, children and adolescents). Results: overall, 25 publications (fifteen case reports, six case series and four retrospective cohort studies) were included, including a total of 140 paediatric DILI cases, from preterm newborn neonates to adolescents. N-acetylcysteine was used to treat 19 APAP cases. N-acetylcysteine (n = 14), ursodeoxycholic acid (n = 3), corticosteroids (n = 31), carnitine (n = 16) and the combination of glycyrrhizin, reduced glutathione, polyene phosphatidylcholine and S-adenosylmethionine (n = 31) were the therapeutic options for treating idiosyncratic DILI. The molecular adsorbent recirculating system was used in the management of either APAP (n = 4) or idiosyncratic DILI (n = 2), while 20 paediatric ALF cases received continuous renal replacement therapy. Conclusions: this systematic review identified DILI in the paediatric population who have received specific treatment. These interventions appear to be mainly extrapolated from low-quality evidence from the adult population. Thus, there is a need for high-quality studies to test the efficacy of known and novel therapies to treat DILI specifically addressed to the paediatric population.