Research Outputs

Permanent URI for this communityhttps://hdl.handle.net/20.500.14288/2

Browse

Filters

20232

Advanced Search

Filter by

Settings

Indexed at: search.filters.indexed.WoSSubject: search.filters.subject.Multiple sclerosis

Search Results

Now showing 1 - 2 of 2
  • Placeholder
    PublicationMetadata only
    Correction to: the use of modified rio score for determining treatment failure in patients with multiple sclerosis: retrospective descriptive case series study
    (Springer Science and Business Media Deutschland Gmbh, 2023) Tutuncu, Mesude; Dogan, Burcu V.; Uygunoglu, Ugur; Kale Icen, Nilufer; Elmali, Ayse Deniz; Coban, Eda; Alpaslan, Bengi G.; Soysal, Aysun; Altıntaş, Ayşe; School of Medicine; Koç University Hospital
    The 6th author name and affiliation was incorrectly published in the original publication. The complete correct name and affiliation is given below. Ayse Deniz Elmali Affiliation: Istanbul University, Istanbul Faculty of Medicine, Neurology Department, Istanbul, Turkey Also, the last author name was spelled incorrectly in the original publication. The complete correct name should read as follows Aysun Soysal The original article has been corrected.
  • Placeholder
    PublicationMetadata only
    Sex, aging and immunity in multiple sclerosis and experimental autoimmune encephalomyelitis: an intriguing interaction
    (Frontiers Media S.A., 2023) Boziki, Marina; Theotokis, Paschalis; Kesidou, Evangelia; Karafoulidou, Eleni; Konstantinou, Chrystalla; Michailidou, Iliana; Bahar, Yasemin; Grigoriadis, Nikolaos; Altıntaş, Ayşe; Faculty Member; School of Medicine; 11611
    Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) with a profound neurodegenerative component early in the disease pathogenesis. Age is a factor with a well-described effect on the primary disease phenotype, namely, the relapsing-remitting vs. the primary progressive disease. Moreover, aging is a prominent factor contributing to the transition from relapsing-remitting MS (RRMS) to secondary progressive disease. However, sex also seems to, at least in part, dictate disease phenotype and evolution, as evidenced in humans and in animal models of the disease. Sex-specific gene expression profiles have recently elucidated an association with differential immunological signatures in the context of experimental disease. This review aims to summarize current knowledge stemming from experimental autoimmune encephalomyelitis (EAE) models regarding the effects of sex, either independently or as a factor combined with aging, on disease phenotype, with relevance to the immune system and the CNS. Copyright © 2023 Boziki, Theotokis, Kesidou, Karafoulidou, Konstantinou, Michailidou, Bahar, Altintas and Grigoriadis.