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Publication Metadata only 18F-FDG PET/CT imaging in a patient with a rare diagnosis of sarcomatoid malignant peritoneal mesothelioina(Lippincott Williams & Wilkins, 2013) Tokmak, Handan; Demirkol, Onur M.; Kaban, Kerim; N/A; Mandel, Nil Molinas; Dilege, Şükrü; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 194197; 122573Malignant peritoneal mesothelioma is an uncommon but deadly disease arising from serosal surfaces of the peritoneum. Asbestos exposure is the most recognized risk factor. We report a case of diffuse, sarcomatoid malignant peritoneal mesothelioma who presented to the hospital with abdominal pain. The patient had an abdominal MRI scan as initial scanning which demonstrated nonspecific findings suspected of peritoneal carcinomatosis. The patient was admitted to our department for the metabolic characterization of the lesions with F-18-FDG PET/CT imaging and the diagnosis of the primary malignancy. F-18-FDG PET/CT imaging revealed diffusely increased metabolic activity throughout the peritoneum and the histopathological features were compatible with sarcomatoid malignant peritoneal mesothelioma.Publication Metadata only 32 novel pathogenic sequence variants in 253 DMD/BMD patients from Turkey(Nature Publishing Group, 2018) Toksoy, G.; Aghayev, A.; Bagirova, G.; Tekce, H. Durmus; Avci, S.; Altunolu, U.; Parman, Y.; Oflazer, P.; Yapici, Z.; N/A; Kayserili, Hülya; Faculty Member; School of Medicine; 7945N/APublication Metadata only 3D ultrasound assessment of effect of controlled ovarian stimulation on endometrioma volume(Oxford University Press (OUP), 2016) Seyhan, A.; Balaban, B.; Urman, Cumhur Bülent; Ata, Mustafa Barış; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 12147; 232576N/APublication Metadata only 423.11: Long-term compromised immune regulation after rituximab induction in blood group incompatible living-donor renal transplantation-5 year results of a prospective pilot study(Lippincott Williams & Wilkins, 2022) Weimer, Rolf; Karakizlis, Hristos; Renner, Fabrice; Dietrich, Hartmut; Daniel, Volker; Schüttler, Christian; Kämper, Daniel; Leicht, Dominik; Wörlen, Michael; Renner, Lene; Milchsack, Katrin; Padberg, Winfried; Opelz, Gerhard; Süsal, Caner; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 351800Background: An increased frequency of severe infectious diseases and BK viremia has been described after ABOi renal transplantation. As rituximab induction may alter immunoregulation in these patients, we analyzed clinically relevant immune parameters in a prospective renal transplant study up to 5 years posttransplant. Materials and Methods: Mononuclear cell subsets (peripheral blood; lymph nodes taken during transplant surgery), intracellular cytokine responses, CD4 helper function and in-vitro B cell responses were assessed pretransplant and up to 5 years posttransplant in 85 renal transplant recipients (living donation: n=25 ABO incompatible (ABOi) and n=30 ABO compatible (ABOc); deceased donation (DD): n=30, all ABO compatible). Results: Severe infectious diseases occurred more often in ABOi than ABOc recipients within 2 years posttransplant (11/24 (46%) versus 6/30 (20%), P=0.042) but not beyond. The incidence of BK viremia was significantly enhanced in rituximab versus non-rituximab treated patients (1 year: 9/29 (31%) versus 4/54 (7%), P=0.009; 5 years: 10/30 (33%) versus 7/53 (13%), P=0.029). After rituximab induction in ABOi recipients, counts of peripheral blood B cell subsets were profoundly downregulated even 3 years posttransplant and reached the level of non-ABOi recipients after 4 years (memory B cells after 5 years). T-dependent and T-independent B cell responses were significantly impaired in ABOi patients up to 2 years posttransplant (P=0.010 and P=0.053, respectively) whereas CD4 helper activity was not compromised. CD4+ T cell counts were significantly lower in ABOi compared to ABOc recipients at 3 and 6 months (P=0.025 and P=0.046, respectively), but showed no differences in the percentage of Tregs. In regional lymph nodes of ABOi patients, we found a significant downregulation of CD20+ but not CD19+ B cells (P<0.0005), of naive B cells (P=0.031) and short lived plasma cells (P<0.0005) at the time of transplantation. Conclusion: An increased frequency of severe infectious diseases and BK viremia in rituximab treated ABOi renal transplant recipients may be explained by significantly downregulated CD4+ T cell counts up to 6 months and a profoundly delayed B cell repopulation, most pronounced with regard to memory B cells, together with compromised B cell responses up to 2 years posttransplant. IL-10, as a key player in chronic BK virus infection, was not upregulated in rituximab-treated ABOi transplant recipients.Publication Metadata only 5-HT causes venodilatation to reduce blood pressure in the rat(Karger, 2016) Seitz, Bridget M.; Krieger-Burke, Theresa; Darios, Emma S.; Thompson, Janice M.; Watts, Stephanie W.; N/A; Orer, Hakan S.; Faculty Member; School of Medicine; 53477N/APublication Metadata only A 5-year analysis of demographics, cycle characteristics and reproductive outcomes of 907 egg freezing cycles in patients with diminished ovarian reserve and age-related fertility decline(Elsevier Science Inc, 2019) Çil, Aylin P.; Abalı, Remzi; Boza, Ayşen; Karakış, Lale S.; Ceyhan, Mehmet; Aksakal, Ece; Bahçeci, Mustafa; Urman, Bülent; Keleş, İpek; Öktem, Özgür; Ata, Mustafa Barış; Doctor; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; 102627; 182910Publication Metadata only A case of secondary hemophagocytic lymphohistiocytosis (HLH) following incomplete kawasaki's disease (KD). Importance of distinguishing recurrent kd from HLH(2014) Kebudi, R.; Dindar, A.; Gürakan, F.; Devecioğlu, O.; Sözmen, Banu Oflaz; Faculty Member; School of Medicine; 198711N/APublication Metadata only A case with acute baked milk protein-induced enterocolitis syndrome(Wiley, 2019) N/A; N/A; N/A; Saçkesen, Cansın; Yılmaz, Özlem; Demirkol, Demet; Faculty Member; Doctor; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 182537; 140706; 108964N/APublication Metadata only A case-control candidate gene study on base excision repair mechanism (BER) as a novel therapeutic target in bipolar disorder(Wiley, 2022) Ozerdem, Aysegul; Veldic, Marin; Singh, Balwinder; Frye, Mark; Schulze, Thomas; Biernacka, Joanna; Winham, Stacey J.; N/A; Ceylan, Deniz; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 137755N/APublication Metadata only A clinicopathological analysis of synchronously multifocal renal cell neoplasms(Springer, 2019) Gumrukcu, G.; Sayman, E.; Yuksel, O.; Aker, F.; N/A; Baydar, Dilek Ertoy; Faculty Member; School of Medicine; Koç University Hospital; 8025