Research Outputs

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    Communication theoretical modeling and analysis of neuronal communication with synaptic plasticity
    (Koç University, 2022) Khan, Tooba; Akan, Özgür Barış; 0000-0003-2523-3858; Koç University Graduate School of Sciences and Engineering; Electrical and Electronics Engineering; 6647
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    Identification of the roles of cells surface proteins during cytokinesis
    (Koç University, 2021) Memiş, Ezgi; Sıcakkan, Nurhan Özlü; 0000-0002-5157-8780; Koç University Graduate School of Sciences and Engineering; Molecular Biology and Genetics; 105301
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    Image-based flow cytometry and angle-resolved light scattering to define the sickling process
    (Wiley, 2019) Sukharevsky, Ilya O.; Larkin, Sandra; Kuypers, Frans A.; Yalcin, Ozlem; Altintas, Ayhan; Yalçın, Özlem; Göktaş, Polat; Faculty Member; Researcher; School of Medicine; School of Medicine; 218440; N/A
    Red blood cells (RBCs) from sickle cell patients exposed to a low oxygen tension reveal highly heterogeneous cell morphologies due to the polymerization of sickle hemoglobin (HbS). We show that angle-resolved light scattering approach with the use of image-based flow cytometry provides reliable quantitative data to define the change in morphology of large populations of RBCs from sickle cell patients when the cells are exposed for different times to low oxygen. We characterize the RBC morphological profile by means of a set of morphological and physical parameters, which includes cell shape, size, and orientation. These parameters define the cell as discocyte, sickle, elongated, as well as irregularly or abnormal RBC shaped cells, including echinocytes, holly-leaf, and granular structures. In contrast to microscopy, quick assessment of large numbers of cells provides statistically relevant information of the dynamic process of RBC sickling in time. The use of this approach facilitates the understanding of the processes that define the propensity of sickle blood samples to change their shape, and the ensuing vaso-occlusive events in the circulation of the patients. Moreover, it assists in the evaluation of treatments that include the use of anti-sickling agents, gene therapy-based hemoglobin modifications, as well as other approaches to improve the quality of life of sickle cell patients.
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    Roles of protocadherins in mammalian cells
    (Koç University, 2018) Qureshi, Mohammad Haroon; Sıcakkan, Nurhan Özlü; 0000-0002-5157-8780; Koç University Graduate School of Sciences and Engineering; Bio-Medical Sciences and Engineering; 105301
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    The role of chromatin modifying enzymes in fibroblast-to-hepatocyte direct lineage conversion
    (Koç University, 2018) Enüstün, Eray; Önder, Tamer Tevfik; 0000-0002-2372-9158; Koç University Graduate School of Sciences and Engineering; Molecular Biology and Genetics; 42946
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    Workload management in distributed data centers : spatial and thermal awareness for energy efficiency
    (Koç University, 2016) Ali, Ahsan; Sıcakkan, Nurhan Özlü; 0000-0002-5157-8780; Koç University Graduate School of Sciences and Engineering; Computer Science and Engineering; 105301