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Publication Open Access Aerogels in drug delivery: from design to application(Elsevier, 2021) García-González, C. A.; Sosnik, A.; Kalmar, J.; De Marco, I.; Concheiro, A.; Alvarez-Lorenzo, C.; Department of Chemical and Biological Engineering; Erkey, Can; Faculty Member; Department of Chemical and Biological Engineering; College of Engineering; 29633Aerogels are the lightest processed solid materials on Earth and with the largest empty volume fraction in their structure. Composition versatility, modularity, and feasibility of industrial scale manufacturing are behind the fast emergence of aerogels in the drug delivery field. Compared to other 3D materials, the high porosity (interconnected mesopores) and high specific surface area of aerogels may allow faster loading of small-molecule drugs, less constrained access to inner regions of the matrix, and more efficient interactions of the biological milieu with the polymer matrix. Processing in supercritical CO2 medium for both aerogel production (drying) and drug loading (impregnation) has remarkable advantages such as absence of an oxidizing environment, clean manufacture, and easiness for the scale-up under good manufacturing practices. The aerogel solid skeleton dictates the chemical affinity to the different drugs, which in turn determines the loading efficiency and the release pattern. Aerogels can be used to increase the solubility of BCS Class II and IV drugs because the drug can be deposited in amorphous state onto the large surface area of the skeleton, which facilitates a rapid contact with the body fluids, dissolution, and release. Conversely, tuning the aerogel structure by functionalization with drug-binding moieties or stimuli-responsive components, application of coatings and incorporation of drug-loaded aerogels into other matrices may enable site-specific, stimuli-responsive, or prolonged drug release. The present review deals with last decade advances in aerogels for drug delivery. An special focus is paid first on the loading efficiency of active ingredients and release kinetics under biorelevant conditions. Subsequent sections deal with aerogels intended to address specific therapeutic demands. In addition to oral delivery, the physical properties of the aerogels appear to be very advantageous for mucosal administration routes, such as pulmonary, nasal, or transdermal. A specific section devoted to recent achievements in gene therapy and theranostics is also included. In the last section, scale up strategies and life cycle assessment are comprehensively addressed.Publication Restricted Investigation of aerogel based systems for drug delivery(Koç University, 2015) Demir, Zeynep Ülker; Erkey, Can; 0000-0001-6539-7748; Koç University Graduate School of Sciences and Engineering; Chemical and Biological Engineering; 29633Publication Restricted Nanogel-incorporating ph responsive composite hydrogels for controlled drug delivery(Koç University, 2015) Cinay, Günce Ezgi; Kızılel, Seda; 0000-0001-9092-2698; Koç University Graduate School of Sciences and Engineering; Chemical and Biological Engineering; 28376Publication Metadata only Nanosensor networks for smart health care(Elsevier, 2020) Abbasi, Naveed A.; Department of Electrical and Electronics Engineering; N/A; N/A; Department of Electrical and Electronics Engineering; Akan, Özgür Barış; Khan, Tooba; Civaş, Meltem; Çetinkaya, Oktay; Faculty Member; PhD Student; PhD Student; Other; Department of Electrical and Electronics Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; 6647; N/A; N/A; N/AAdvent of nanoscale sensors has paved the way for countless applications envisioned in the concept of a Smart City. In this chapter, we are focusing on one of the most fundamental requirements of the smart city, that is, smart health care. Great advancements in personal health care are expected with the emergence of nanosensing devices; however, single nanosensor is limited in its processing power and storage; thus we need to form network of nanosensors for any health-care application. In this chapter, we first elaborate the communication paradigms for nanosensor network. Moreover, we discuss various smart health-care applications such as smart drug delivery, body area network, implantable devices to treat injuries or malfunctions, and Internet of Nano Things. In the end, we highlight the implementation challenges for the nanosensor network for biomedical applications.Publication Restricted PEG-Hydrogel coated silica aerogels A novel drug delivery system(Koç University, 2010) Giray, Seda; Erkey, Can; 0000-0001-6539-7748; Koç University Graduate School of Sciences and Engineering; Chemical and Biological Engineering; 29633Publication Restricted Visible-light-induced synthesis of novel ph responsive hybrid hydrogels for controlled drug delivery(Koç University, 2014) Çevik, Özlem; Kızılel, Seda; 0000-0001-9092-2698; Koç University Graduate School of Sciences and Engineering; Chemical and Biological Engineering; 28376