Research Outputs
Permanent URI for this communityhttps://hdl.handle.net/20.500.14288/2
Browse
10 results
Search Results
Publication Restricted Assessing the epigenetic modifiers of drug response in human astrocyte and glioblastoma co-cultures(Koç University, 2022) Aksu, Ali Cenk; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; Cellular and Molecular Medicine; 184359
Publication Metadata only Cancer stem cells, their microenvironment and anoikis(Begell House Inc., 2019) Ayla, Şule; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; 110772Tumors are composed of a variety of cancer cells, all of which contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) have an important role in the initiation and progression of cancer. CSCs are maintained extrinsically within the tumor microenvironment, which contains both cellular and physical factors. As a barrier to metastases, cells normally undergo apoptosis (cell death process) after they lose contact with their extracellular matrix or neighboring cells. This cell death process has been termed “anoikis.” The tumor cells that acquire malignant potential develop mechanisms to resist anoikis. The tumor microenvironment has been acknowledged to contribute to anoikis resistance of bystander cancer cells via modulation of the matrix stiffness, enhancement of oxidative stress, production of pro-survival soluble factors, trigger of epithelial-mesenchymal transition (EMT), and self-renewal ability, thus leading to metabolic deregulations of cancer cells. In this article, we review the significance of perivascular cells, extracellular matrix, tumor stiffness, and hypoxia in the regulation of CSC plasticity and anoikis resistance. With a better understanding of the CSC interaction with its niche and anoikis resistance, it is possible to identify potential therapeutic targets for the development of more effective treatments against cancer.Publication Restricted Characterizing the role and regulation of a pro-apoptotic Bcl-2 family member, harakiri (HRK) in glioblastoma multiforme(Koç University, 2015) Kaya, Ezgi; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Sciences and Engineering; Bio-Medical Sciences and Engineering; 184359Publication Restricted Design of biodegradable hydrogels for the development of in vitro models for glioblastoma multiforme(Koç University, 2017) Erkoç, Pelin; Kızılel, Seda; 0000-0001-9092-2698; Koç University Graduate School of Sciences and Engineering; Bio-Medical Sciences and Engineering; 28376Publication Restricted Epigenetic therapies to augment radiation response in glioblastoma(Koç University, 2024) Değirmenci, Nareg; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; Cellular and Molecular Medicine; 184359Publication Restricted Examining the effects of epigenetic modulation on IDH mutant GBM cells(Koç University, 2019) Kayabölen, Alişan; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; 184359Publication Restricted Identification of chromatin related genes regulating temozolomide resistance in GBM(Koç University, 2019) Şenbabaoğlu, Filiz; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; 184359Publication Restricted Identification of novel molecular players in GBM cell dispersal(Koç University, 2019) Şeker, Fidan; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; 184359Publication Restricted Interrogating the role of arginine methyltransferases in radiation response in glioma(Koç University, 2024) Köseoğlu, Beyza Nur; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Sciences and Engineering; Cellular and Molecular Medicine; 184359Publication Restricted Understanding of tumor heterogeneity in glioblastoma multiforme cell lines with differential apoptotic threshold(Koç University, 2019) Cingöz, Ahmet; Önder, Tuğba Bağcı; 0000-0003-3646-2613; Koç University Graduate School of Health Sciences; 184359