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Now showing 1 - 4 of 4
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    Application of the finite element method in the human spine biomechanics
    (Koç University, 2015) Zafarparandeh, Iman; Lazoğlu, İsmail; 0000-0002-8316-9623; Koç University Graduate School of Sciences and Engineering; Mechanical Engineering; 179391
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    Finite element model development of the human lumbar spine and dynamic stabilization device analysis
    (Koç University, 2015) Hassan, Chaudhry Raza; Erbulut, Deniz Ufuk; 0000-0002-5700-3515; Koç University Graduate School of Sciences and Engineering; Bio-Medical Sciences and Engineering; 37661
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    Tenosynovial giant cell tumor in the cervico- thoracic junction
    (Turkish Neurosurgery Society, 2012) Okutan, Özerk; Özen, Özlem; Saygılı, Barış; Beşkonaklı, Ethem; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    Tenosynovial giant cell tumor (TGT) rarely arises from the posterior coloumn of the cervical spine. Most lesions of TGT involve the tendon sheath and joint lining of the small joints of the fingers and hands, and consecutively the knee, ankles and feet, and hips. Rate of extra-articular presentation is about 5-15% in all cases. In this report, a case with paraparesis caused by TGT in the cervico-thoracic junction is presented. The clinical manifestations, diagnosis, and treatment of this unusual condition are discussed. In the treatment of TGT of the vertebral column, the main aim should be total surgical excision of the tumor. / Tenosinovyal dev hücreli tümör (TDHT) nadiren servikal omurganın arka elemanlarından nadiren köken alır. TDHT en çok el ve parmakların küçük eklemlerinin tendon kılıfı ile eklem kapsülünde ve sırasıyla diz, ayak bileği, ayak ve kalça eklemlerinde görülür. Tüm vakaların yaklaşık % 5-15’i eklem dışı yerleşimlidir. Bu raporda, parapareziye neden olan servikotorasik bileşkedeki tenosinovyal dev hücreli tümör olgusu sunulmuştur. Hastanın klinik, radyolojik ve tedavi şekli tartışılmıştır. Servikal omurgadaki tenosinovyal dev hücreli tümör tedavisinde, ana amaç tümörün total eksizyonu olmalıdır.
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    The possible effects of sodium fluoroscein to primary cell culture sampling in glioblastoma surgery
    (Elsevier, 2022) Aydın, Serdar Onur; Köse, Selin Güven; N/A; Sur, İlknur Erdem; Solaroğlu, İhsan; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 102059
    Introduction: primary glioblastoma (GBM) cell cultures have become a very important tool for future research due to the patient-specific genetic makeup of GBM cells and different treatment response variations. In sodium fluorescein-guided surgeries, regions sampled for primary cell culture are also stained with FL. However, the effects of FL on GBM cell cultures are unknown. In our study, the effect of FL on GBM cell cultures after a possible contamination was investigated. Resarch Question: does sodium fluorescein have an effect on glioblastoma cell cultures? If there is, should sodium fluorescein be used after primary cell culture sampling when performing sodium fluorescein-guided glioblastoma surgery? Methods: standard cell culture techniques were used to generate GBM cell lines, which were then split into control and FL treated groups. Cell counts, cell viability, cellular aging, and beta-galactosidase analyses were compared between these groups. Cells' microscopic pictures were also assessed. Results: our study reveals that FL-applied cultures had fewer cells overall and more s beta-galactosidase activity than control groups. The notion that FL may have an impact on the environment of GBM cell cultures is thus raised by our main findings regarding the use of FL and its effects on cell cultures. Conclusion: to prevent adverse effects on the growth of primary GBM cell cultures, neurosurgeons might think about using FL after sampling the tumor tissue during operations.