Researcher: Canbaz, Ata Alpay
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Canbaz, Ata Alpay
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Publication Metadata only Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins(Nature Portfolio, 2024) Özcan, Selahattin Can; Kalkan, Batuhan Mert; Çiçek, Enes; Canbaz, Ata Alpay; Ayhan, Ceyda Açılan; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of MedicineCentrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in mammalian tissues as olfactory neuron progenitor cells. PLK4 overexpression generates centriole rosette (CR) structures which harbor more than two centrioles each. Long term PLK4 overexpression results with centrosome amplification, but the maturation of amplified centrioles in CRs and linking of PLK4 induced amplified centrosomes has not yet been investigated in detail. Here, we show evidence for generation of large clustered centrosomes which have more than 2 centriole rosettes and define these structures as centriole rosette clusters (CRCs) in cells that have high PLK4 levels for 2 consecutive cell cycles. In addition, we show that PLK4 induced CRs follow normal centrosomal maturation processes and generate CRC structures that are inter-connected with canonical centrosomal linker proteins as C-Nap1, Rootletin and Cep68 in the second cell cycle after PLK4 induction. Increased PLK4 levels in cells with C-Nap1 and Rootletin knock-out resulted with distanced CRs and CRCs in interphase, while Nek2 knock-out inhibited separation of CRCs in prometaphase, providing functional evidence for the binding of CRC structures with centrosomal linker proteins. Taken together, these results suggest a cell cycle dependent model for PLK4 induced centrosome amplification which occurs in 2 consecutive cell cycles: (i) CR state in the first cell cycle, and (ii) CRC state in the second cell cycle.Publication Metadata only Klotho in pregnancy and intrauterine development - Potential clinical implications: a review from the European Renal Association CKD-MBD Working Group(Oxford Univ Press, 2024) Tocados J.MD; Haarhaus M.; Kanbay, Mehmet; Mutlu, Ali; Bakır, Çiçek Nur; Peltek, İbrahim Batuhan; Canbaz, Ata Alpay; ; School of Medicine;Intrauterine development is crucial for life-long health; therefore, elucidation of its key regulators is of interest for their potential prognostic and therapeutic implications. Originally described as a membrane-bound anti-aging protein, Klotho has evolved as a regulator of numerous functions in different organ systems. Circulating Klotho is generated by alternative splicing or active shedding from cell membranes. Recently, Klotho was identified as a regulator of placental function, and while Klotho does not cross the placental barrier, increased levels of circulating α-Klotho have been identified in umbilical cord blood compared with maternal blood, indicating that Klotho may also play a role in intrauterine development. In this narrative review, we discuss novel insights into the specific functions of the Klotho proteins in the placenta and in intrauterine development, while summarizing up-to-date knowledge about their structures and functions. Klotho plays a role in stem cell functioning, organogenesis and haematopoiesis. Low circulating maternal and foetal levels of Klotho are associated with preeclampsia, intrauterine growth restriction, and an increased perinatal risk for newborns, indicating a potential use of Klotho as biomarker and therapeutic target. Experimental administration of Klotho protein indicates a neuro- and nephroprotective potential, suggesting a possible future role of Klotho as a therapeutic agent. However, the use of Klotho as intervention during pregnancy is as yet unproven. Here, we summarize novel evidence, suggesting Klotho as a key regulator for healthy pregnancies and intrauterine development with promising potential for clinical use. © The Author(s) 2024.Publication Metadata only Storytelling used in combination to a relaxing virtual reality experience for children with cancer: a feasibility study(Elsevier Science Inc, 2023) Konakci, Belgin; Bakır, Çiçek Nur; Canbaz, Ata Alpay; Erden, Selin Ece; Genç, Herdem Aslan; Mutluer, Tuba; School of Medicine; Koç University HospitalObjectives: Complementary treatments as a distraction in medical procedures are used in pediatric oncology patients because they are subjected to anxiety and distress. This study examined the feasibility of virtual reality (VR) and storytelling as a distraction and relaxation for children with cancer. Methods: Patients aged 6 to 17 years speaking fluent Turkish, having a diagnosis or recurrence of cancer (with no central nervous system involvement) within a year, and receiving chemotherapy for more than a month, were recruited. Baseline tests were given to children (Pediatric Quality of Life Inventory [PedsQL], Cancer Module and State-Trait Anxiety Inventory for Children) and parents (PedsQL-parent module and Child Behavior Checklist [CBCL]). Participants either received a 7-minute immersive wild dolphin VR session or VR and a 5-minute storytelling before or after the VR session for 4 sessions within a month. Visual analog scales (1-10 for nausea, fatigue, and distress) were used before and after the intervention. Results: Of 39 invited patients, 27 (70%) were interested (11.29 ± 3.55 years old; 48% female). Four patients dropped out of the study due to nausea, fatigue, and/or loss of interest. Fourteen patients were recruited to the storytelling group. Two patients were discharged from the hospital during the study. Forty-nine sessions were completed. Patients reported an average of 0.67 (±1.46), 0.43 (±1.76), and 0.24 (±0.76) points of decrease in their fatigue, distress, and nausea, respectively. Although there has not been an observed change in fatigue ( p = .32) and distress ( p = .32) between the VR-only and storytelling groups, there was a significant decrease in nausea (0.81 vs 2.41; p = .04). The majority of the participants mentioned to like (96%), recommend (92%), and be interested in repeating (80%) the intervention. Conclusions: This study demonstrated the feasibility of combining storytelling with VR as a distraction and relaxation method in decreasing distress, nausea, and fatigue in pediatric oncology patients. The results demonstrated that children adhere to the VR experience with storytelling, and likability of the intervention is high with potential benefits. Further explorations of these techniques may lead to more effective and personalized strategies to support the well-being of these patients.Publication Metadata only Resilience during the COVID-19 pandemic among people living with HIV: a cross-sectional study(Sage, 2023) N/A; Kıllı, Nesrin Ecem; Bakır, Çiçek Nur; Canbaz, Ata Alpay; Karabulut, Kardelen; Mutlu, Ali; Karataşlı, Şeyhmus; Tekin, Süda; Kayı, İlker; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 42146; 168599Background This study aims to investigate the factors shaping resilience during the COVID-19 pandemic among people living with HIV (PLWH). Methods A total of 341 participants were included in this cross-sectional study. The online survey included scales of resilience, depression & anxiety, loneliness, social support, COVID-19 fear, stress, and sociodemographic information. Results Logistic regression test results showed loneliness (OR = 2.548, 95% CI = 1.251, 5.189), social support (OR = 2.217, 95% CI = 1.148, 4.279), income (OR = 2.581, 95% CI = 1.217, 5.472), sexual orientation (OR = 2.707, 95% CI = 1.004, 7.300), age (OR = 1.044, 95% CI = 1.006, 1.083) and COVID-19 fear (OR = 0.891, 95% CI = 0.840, 0.944) were statistically significant factors associated with resilience among PLWH. Conclusion In conclusion, reducing COVID-19 fear by providing the correct information about the COVID-19 pandemic, fortifying the level of social support satisfaction, as well as minimising the level of loneliness have the potential to improve psychological resilience among PLWH.