Researcher:
Loçlar, İlayda

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Undergraduate Student

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İlayda

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Loçlar

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Loçlar, İlayda

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20162

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Researcher Of Publications: search.filters.isAuthorOfPublication.024f8f0c-c780-4e03-ac45-8d1e3bfb33b6

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    PublicationMetadata only
    The clinical impact of ST131 H30-Rx subclone in urinary tract infections due to multidrug-resistant Escherichia coli
    (Elsevier, 2016) Kurt-Azap, Özlem; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Can, Füsun; İspir, Pelin; Nurtop, Elif; Şeref, Ceren; Loçlar, İlayda; Aktaş, Özge Nur; Orhan, Yelda Ceren; Ergönül, Önder; Faculty Member; Master Student; Master Student; PhD Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 103165; N/A; N/A; N/A; N/A; N/A; N/A; 110398
    In this study, risk factors for ST131 H30 and H30-Rx subclones among urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Escherichia coli were described. Urine samples were collected from consecutive outpatients registered to the outpatient clinics of Bas, kent University Hospital (Ankara, Turkey) with complaints of acute cystitis in 2011. A total of 107 MDR E. coli isolates were included in the study. of the 107 isolates studied, 26 (24.3%) were typed as ST131 clone. Extended-spectrum beta-lactamase (ESBL)-producers accounted for 59 (55.1%) of the 107 isolates. Among the 59 ESBL-positive isolates, 18 (31%) were found to belong to the ST131 clone. of the 18 ESBL-positive ST131 isolates, 17 (94%) were defined as H30 subclone, among which 16 (94%) represented the H30-Rx subclone. Among the 48 ESBL-negative isolates, 8 (17%) ST131 isolates were detected, 7 (88%) of which belonged to H30 subclone; 5 (71%) of the H30 subclone isolates were classified under H30-Rx subclone. In multivariate analysis, hospitalisation within last year was the only host risk factor associated with MDR E. coli ST131 H30-Rx subclone UTI (OR = 3.5, 95% CI 1.04-12.17; P = 0.042). CTX-M-15 production was found to be highly associated with the presence of ST131 H30-Rx subclone (OR = 4.8, 95% CI 1.54-15.32; P = 0.007). In conclusion, urinary MDR E. coli ST131 H30-Rx subclone was found to be important in the dissemination of MDR UTIs in the community. Approximately 20% of the MDR isolates were H30-Rx subclone. Infection with this subclone was found to be healthcare-associated. (C) 2015 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
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    PublicationOpen Access
    Variations in multiple syndromic deafness genes mimic non-syndromic hearing loss
    (Nature Publishing Group (NPG), 2016) Bademci, G.; Cengiz, F. B.; Foster, J., II; Duman, D.; Sennaroğlu, L.; Diaz-Horta, O.; Atik, T.; Kirazlı, T.; Olgun, L.; Alper, H.; Menendez, I.; Sennaroğlu, G.; Tokgöz-Yılmaz, S.; Guo, S.; Olgun, Y.; Mahdieh, N.; Bonyadi, M.; Bozan, N.; Ayral, A.; Özkınay, F.; Yıldırım-Baylan, M.; Blanton, S. H.; Tekin, M.; Loçlar, İlayda; School of Medicine
    The genetics of both syndromic (SHL) and non-syndromic hearing loss (NSHL) is characterized by a high degree of genetic heterogeneity. We analyzed whole exome sequencing data of 102 unrelated probands with apparently NSHL without a causative variant in known NSHL genes. We detected five causative variants in different SHL genes (SOX10, MITF, PTPN11, CHD7, and KMT2D) in five (4.9%) probands. Clinical re-evaluation of these probands shows that some of them have subtle syndromic findings, while none of them meets clinical criteria for the diagnosis of the associated syndrome (Waardenburg (SOX10 and MITF), Kallmann (CHD7 and SOX10), Noonan/LEOPARD (PTPN11), CHARGE (CHD7), or Kabuki (KMT2D). This study demonstrates that individuals who are evaluated for NSHL can have pathogenic variants in SHL genes that are not usually considered for etiologic studies.