Researcher:
Erden, Nihan

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Undergraduate Student

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Nihan

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Erden

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Erden, Nihan

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2018 - 201922020 - 20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.026361b2-86da-412b-b1c1-4414d7f7e594

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    COVID-19-related oral mucosa lesions among confirmed SARS-CoV-2 patients: a systematic review
    (Wiley, 2022) Erbaş, Gizem S.; Botsali, Ayşenur; Arı, Canan; Erden, Nihan; Taşkın, Banu; Alper, Fatma Sibel; Vural, Seçil; Undergraduate Student; Doctor; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 118467; 189340
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for coronavirus disease 2019 (COVID-19), which manifests as a flu-like respiratory infection affecting multiple organ systems, including the gastrointestinal system, central nervous system, cardiovascular system, skin, and mucosa. In this review, we investigated the literature on specific manifestations of COVID-19 in the oral mucosa. An online literature search in PubMed, Scopus, Google Scholar, and Medline was conducted to retrieve relevant studies on confirmed COVID-19 patients with oral mucosa findings published between December 31, 2019, and April 07, 2021. After an independent review by two authors, 39 articles considering 59 laboratory-confirmed cases of SARS-CoV-2 infection were included in the final analysis. The most common finding, reported in 29 patients (43.9%), was Kawasaki-like syndrome. In addition, oral ulcers including aphthous, hemorrhagic, and necrotic ulcers were reported in 24 patients (36.3%). Other lesions reported included pustules, macules, bullae, maculopapular enanthema, and erythema multiforme-like lesions. Concomitant skin lesions were present in 60.6% of patients. Fever was reported in 86.2% of patients. Forty-eight patients (76.1%) were hospitalized. Loss of taste and smell was present in 30.8% of the patients. A comprehensive understanding of the dermatologic manifestations of COVID-19 can improve and facilitate patient management and referrals.
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    Annual pattern and clinical characteristics of herpes zoster in immunocompetent children in a rural area
    (Wiley-Hindawi, 2021) Gündoğdu, Mustafa; Karagün, Ebru; Acıpayam, Ayşe Şermin Filiz; Erden, Nihan; Vural, Seçil; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; N/A; 189340
    This study aims to investigate the clinical signs, symptoms, complications and seasonal distribution of herpes zoster for otherwise healthy children and to demonstrate the outcome of varicella vaccinations on the herpes zoster incidence in a pediatric population. A retrospective study was conducted by using the data of the pediatric patients who were referred to two rural cities of Turkey, clinically diagnosed as Herpes Zoster (HZ). All participants were evaluated for clinical-epidemiological factors, signs, symptoms, complications and varicella vaccination status for HZ. This study was comprised of 69 pediatric patients (29 [42%] female and 40 [58%] male) who were diagnosed with HZ. The mean age was 10.57 (6 months-17) years old. The rash of HZ mostly appeared on the thoracic dermatome as seen in 29 patients. The findings revealed that among 56 unvaccinated patients of all, 25 (44.6%) had a painful rash, in comparison among vaccinated patients none reported pain as the characterization of shingles (P = .001). Annual distribution of cases showed two peaks (March and September), whereas in August no cases were detected. of all participants, one patient had postherpetic neuralgia, who also had ophthalmic dermatomal involvement, and this was the only complication observed in this study cohort. In immunocompetent children, the most common involvement site was the thoracic dermatome. Our findings show that varicella vaccination has a protective role in the herpes zoster clinic, both by decreasing the prevalence and by making the infection course less severe.
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    Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis
    (BMJ Publishing Group, 2018) Boyle, Marie; Hardy, Timothy; Bergmann, Christina; Distler, Joerg H. W.; Adali, Gupse; Dayangac, Murat; Mann, Derek A.; Mann, Jelena; Yiğit Alpdoğan, Buket; Özler, Oğuz; Erden, Nihan; Tutucu, Faik; Zeybel, Müjdat; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 214694
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    PublicationOpen Access
    The effect of urine pH and urinary uric acid levels on the development of contrast nephropathy
    (Karger Publishers, 2019) Afşar, Barış; Sağ, Alan A.; Siriopol, Dimitrie; You, Zhiying; Garcia, Miguel L.; Covic, Adrian; Cherney, David Z. I.; Johnson, Richard J.; Aslan, Gamze; Çamkıran, Volkan; Erden, Nihan; Yılmaz, Sezen Güçlü; İncir, Said; Kanbay, Mehmet; Doctor; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 110580
    Background: hyperuricemia may cause acute kidney injury by activating inflammatory, pro-oxidative and vasoconstrictive pathways. In addition, radiocontrast causes an acute uricosuria, potentially leading to crystal formation. We therefore aimed to investigate the effect of urine acidity and urine uric acid level on the development of contrast-induced nephropathy (CIN) in patients undergoing elective coronary angiography. Methods: we enrolled 175 patients who underwent elective coronary angiography. CIN was defined as a >25% increase in the serum creatinine levels relative to basal values 48-72 h after contrast use. Prior to coronary angiography and 48-72 h later, serum uric acid, urea, creatinine, bicarbonate levels, and spot uric acid to creatinine ratio (UACR) were measured. Results: of the 175 subjects included, 29 (16.6%) developed CIN. Those who developed CIN had a higher prevalence of diabetes, higher UACR (0.60 vs. 0.44, p = 0.014), higher contrast volume, and lower serum sodium level. With univariate analysis of a logistic regression model, the risk of CIN was found to be associated with diabetes (p = 0.0016, OR = 3.8 [95% CI: 1.7-8.7]), urine UACR (p = 0.0027, OR = 9.6 [95% CI: 2.2-42.2]), serum sodium (p = 0.0079, OR = 0.8 [95% CI: 0.77-0.96]), and contrast volume (p = 0.0385, OR = 1.8 [95% CI: 1.03-3.09]). In a multiple logistic regression model with stepwise method of selection, diabetes (p = 0.0120, OR = 3.2 [95% CI: 1.3-8.1]) and UACR (p = 0.0163, OR = 6.9 [95% CI: 1.4-33.4]) were the 2 risk factors finally identified. Conclusions: we have demonstrated that higher urine UACR is associated with the development of CIN in patients undergoing elective coronary angiography.