Researcher: Karaoğuz, Mustafa Remzi
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Karaoğuz, Mustafa Remzi
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Publication Metadata only The quality of ECG data acquisition, and diagnostic performance of a novel adhesive patch for ambulatory cardiac rhythm monitoring in arrhythmia detection(Churchill Livingstone Inc Medical Publishers, 2019) Deliormanli, Bilgen Gulsen; Adiguzel, Omer; Li, Ko-Mai; Yılmaz, Elif Nur; N/A; N/A; N/A; Department of Industrial Engineering; Karaoğuz, Mustafa Remzi; Yurtseven, Ece; Aslan, Gamze; Gönen, Mehmet; Doctor; Teaching Faculty; Doctor; Faculty Member; Department of Industrial Engineering; N/A; School of Medicine; N/A; College of Engineering; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; 176021; N/A; 237468Background: Short and long ambulatory electrocardiographic monitoring with different systems is a widely used method to detect cardiac arrhythmias. In this study, we aimed to evaluate the effectiveness of a novel monitoring device on cardiac arrhythmia detection. Methods: We used two different protocols to evaluate device performance. For the first one, 36 healthy subjects were enrolled. The standard 12-lead, 24-h Holter monitoring and the novel single lead electrocardiogram (ECG) Patch Monitor (EPM) device (BeyondCare (R), Rooti Labs Ltd., Taipei, Taiwan) were simultaneously applied to all subjects for 24 h. The quality of ECG data acquisition of novel system was compared to that of standard Holter. The second phase included 73 patients that were referred from our outpatient arrhythmia clinic for evaluation of their symptoms relevant to the cardiac arrhythmias. Advanced algorithms, statistical methods (cross-correlation method, Pearson's correlation coefficient, Bland-Altman plots) were used to process and verify the acquired data. Results: The overall average beat per minute correlation between BeyondCare (R) and standard 12-lead Holter was found 98% in 33 healthy subjects. The mean percentage of invalid measurements in BeyondCare (R) was 1.6% while the Holter's was 1.7%. In the second protocol of the study, prospective data from 67 patients who were referred for evaluation of their symptoms relevant to cardiac arrhythmias, showed that the mean BeyondCare (R) wear time was 4.7 +/- 0.5 days out of five total days per protocol. The mean analyzable wear time was 93.6%. The water-resistant design enabled 73.5% of the participants to take a shower. 7.3% of participants had minor skin irritations related to the electrodes. Among the patients with detected arrhythmia (40.2% of all patients), 29.6% had their first arrhythmia after the initial two days period. A clinically significant pause was detected in one patient, ventricular tachycardia was detected in four patients, and supraventricular tachycardia was detected in 15 patients. Paroxysmal atrial fibrillation was identified in seven patients. Three of them had their first episodes after the second day of monitoring. Conclusion: BeyondCare (R) Patch was well-tolerated and allowed prolonged time periods for continuous ECG monitoring, may result in an improvement in clinical accuracy and detection of arrhythmias by cloud-based artificial intelligence operating system. (C) 2019 Elsevier Inc. .Publication Metadata only Outcome of drug resistant severe atrial tachycardia during pregnancy treated with catheter ablation(Premchand Shantidevi Research Foundation, 2018) N/A; Aslan, Gamze; Yıldız, Ömer; Bengisu, Hale; Mutluer, Ferit Onur; Karaoğuz, Mustafa Remzi; Doctor; Doctor; Doctor; Doctor; Doctor; N/A; N/A N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/AA 24-year-old primigravid woman at 28 weeks of gestation was admitted to the hospital because of drug-refractory atrial tachycardia and heart failure. The arrhythmia did not respond to drug therapy and electrical cardioversion. Since tachycardia was intractable and had potentially life-threatening consequences for mother and fetus, it was decided to ablate the tachycardia after a multidisciplinary meeting. During the procedure, maternal hypotension occurred, consequently causing persistent fetal heart rate reduction. Radiofrequency ablation was immediately cancelled and emergency cesarean section was carried out. At 72 hours after the caesarean-section, successful RF ablation could be performed. Mother was discharged on the 7. postoperative day. The newborn was hospitalized until having reached 2500 g and he was discharged in good condition. Mother's left ventricle systolic function significantly improved and no atrial tachyarrhythmia was observed on the 6th month follow-up visit.