Researcher:
Yavuz, Ömer

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Teaching Faculty

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Ömer

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Yavuz

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Yavuz, Ömer

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Now showing 1 - 7 of 7
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    Publication
    A rare presentation of a rare disease: endobronchial hamartoma with lobar bronchiectasis
    (Turkish Society of Thoracic Surgery, 2020) Kapdağlı, Murat; Yavuz, Ömer; Erus, Suat; Bulutay, Pınar; Tanju, Serhan; Teaching Faculty; Faculty Member; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 175565; 133565; 214690
    Benign lung tumors are very rare, endobronchial hamartomas -one of which- are even more rare. Endobronchial masses tend to represent themselves via obstruction related symptoms and endobronchial hamartomas are not an exception. It is important to diagnose endobronchial masses before they bring untreatable damage to the lung. It is also important to differentiate endobronchial hamartomas from endobronchial malignancies, such as carcinomas, for they also tend to act mildly symptomatic for a long period of time. In our case, the patient was admitted to our clinic with the symptoms of cough and mild hemoptysis. A computed chest tomography showed total bronchiectasis of right upper lobe along with an endobronchial mass in the right upper lobe bronchus. Bronchoscopic biopsy of the mass revealed no diagnosis. We performed a right upper lobectomy and the pathological examination resulted as endobronchial hamartoma. There are numerous cases about endobronchial hamartomas in the literature which represented with countless symptoms and diseases as persistent cough, recurrent pneumonia, local bronchiectasis and so forth. Our case of endobronchial hamartoma representing with total bronchiectasis of a whole lobe of the lung is the first and only case in the English literature to our knowledge.
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    Publication
    The role of pathology in the proposed subdivided n descriptors of the tnm staging system for lung cancer- a single center experience
    (Elsevier Science Inc, 2021) Zeren, Handan Emine; N/A; N/A; N/A; N/A; N/A; N/A; Bulutay, Pınar; Erus, Suat; Yavuz, Ömer; Çöpür, Sidar; Tanju, Serhan; Dilege, Şükrü; Fırat, Pınar Arıkan; Teaching Faculty; Faculty Member; Teaching Faculty; Researcher; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 133565; 175565; N/A; 368625; 214690; 122573; 207545
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    Publication
    Erector Spinae Plane Block for videothoracoscopic left pleurectomy decortication and hyperthermic intrathoracic chemotherapy
    (Elsevier Science Inc, 2021) N/A; N/A; N/A; N/A; N/A; N/A; Manici, Mete; Salgın, Belitsu; Gürkan, Yavuz; Yavuz, Ömer; Söğüt, Muhammet Selman; Faculty Member; Researcher; Faculty Member; Teaching Faculty; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 113502; 327625; 154129; N/A; N/A
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    Publication
    The prediction of spread through air spaces with preoperative 18F-FDG PET/CT in cases with primary lung adenocarcinoma, its effect on the decision for an adjuvant treatment and its prognostic role
    (Lippincott Williams and Wilkins (LWW), 2021) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Falay, Fikri Okan; Selçukbiricik, Fatih; Tanju, Serhan; Erus, Suat; Kapdağlı, Murat; Cesur, Ekin Ezgi; Yavuz, Ömer; Bulutay, Pınar; Fırat, Pınar Arıkan; Mandel, Nil Molinas; Dilege, Şükrü; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Other; Other; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; /N/A; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 246484; 202015; 214690; 75565; /N/A; N/A; /N/A; 133565; 207545; 194197; 122573
    Purpose In lung adenocarcinoma cases, 'spread through air spaces' (STAS) is a new indicator of invasion and directly related to disease survival. The aim of our study is to establish whether a preoperatively performed 18F-Fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging data can predict the presence of STAS in cases with lung adenocarcinoma and thus predict the decision for the type of surgery and adjuvant chemotherapy. Materials and methods Between 2000 and 2019, we retrospectively analyzed 63 patients with lung adenocarcinoma cases that had undergone lobectomy or pneumonectomy. Semiquantitative parameters were calculated and metabolic tumor volume (MTV)/CT volume (CTV) ratio was recorded from FDG PET/CT data. The pathological samples from these patients were evaluated for STAS. All these values were evaluated for their correlation with the alveolar spread. Results There was no statistically significant correlation to be found between CTV, MTV, total lesion glycolysis (TLG), standardized uptake value (SUV)(max), SUVmean and STAS (P > 0.05). However, MTV/CTV ratio above 1 had statistically more alveolar spread. In the group with an MTV ratio above 1, STAS positivity was 27 (75%), and 9 (25%) did not have STAS, whereas these were 6 (22.2%) patients who had STAS, and 21 (77.8%) did not have STAS in the group with below 1 (P < 0.001). Conclusions In the preoperative PET study inoperable lung adenocarcinoma cases, MTV/CTV ratio higher than 1 was found to predict STAS positivity. As a result, it was found that it provided significant clinical additional information regarding the need for a surgical approach (lobar resection instead of sublobar) and adjuvant chemotherapy.
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    PublicationOpen Access
    Immune profiling after minimally invasive lobectomy
    (Oxford University Press (OUP), 2020) Kapdağlı, Murat Hüseyin; Cesur, Ekin Ezgi; Erus, Suat; Öztürk, Ayşe Bilge; Albayrak, Özgür; İncir, Said; Yavuz, Ömer; Tanju, Serhan; Dilege, Şükrü; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 175565; 147629; N/A; N/A; N/A; 214690; N/A
    Objectives: Whether acute phase and immune responses are minimally affected following minimally invasive lung surgery needs further investigation. We performed a pilot study to evaluate the immune profile of patients who underwent video-assisted thoracoscopic surgery or robot-assisted thoracic surgery lobectomies for the treatment of suspicious or known stage I non-small-cell lung cancer. Methods: blood samples were taken preoperatively and 3 and 24 h postoperatively were analysed for C-reactive protein, glucose, cortisol, tumour necrosis factor alpha (TNF-α), interleukin 8 (IL-8) and interleukin 10 (IL-10) levels. TNF-α, IL-8 and IL-10 were also measured in lung tissues. T (CD4, CD8), B (CD19) and natural killer (CD56, CD16) cell counts and natural killer cell functions were analysed using a flow cytometry-based assay before and after surgery. Results: minimally invasive surgery (robot-assisted thoracic surgery + video-assisted thoracoscopic surgery) significantly decreased IL-10 (P = 0.016) levels after surgery. No significant differences were detected in TNF-α (P = 0.48) and IL-8 (P = 0.15) levels before and after surgery. C-reactive protein (P < 0.001), cortisol (P < 0.001) and glucose levels (P < 0.001) increased significantly after surgery. Lymphocyte, total T cell, CD3+CD4+ and CD3+CD8+ CD16+CD56+ cell counts were significantly lower on postoperative day 1. Conclusion: there seems to be a dynamic balance between pro- and anti-inflammatory cytokines and immune cells following minimally invasive lobectomy.
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    PublicationOpen Access
    Is elective cancer surgery feasible during the lock-down period of the COVID-19 pandemic? Analysis of a single institutional experience of 404 consecutive patients
    (Wiley, 2021) Cesur, Ezgi; Kırış, Talat; Giray, Burak; Kulle, Cemil Burak; Azamat, İbrahim Fethi; Ağcaoğlu, Orhan; Dilege, Ece; Erkan, Murat Mert; Balık, Emre; Bilge, Orhan; Buğra, Dursun; Vatansever, Doğan; Taşkıran, Çağatay; Erus, Suat; Yavuz, Ömer; Tanju, Serhan; Dilege, Şükrü; Tarım, Kayhan; Kiremit, Murat Can; Kılıç, Mert; Canda, Abdullah Erdem; Kordan, Yakup; Akyoldaş, Göktuğ; Solaroğlu, İhsan; Sasani, Mehdi; Gökler, Ozan; Ünsaler, Selin; Altuntaş, Muzaffer Ozan; Hafız, Ayşenur Meriç; Şimşek, Sezai Aykın; Deveci, Mehmet Ali; Korkmaz, Murat; Çakar, Nahit; Ergönül, Önder; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Researcher; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 175476; 218050; 214689; 18758; 176833; 1758; 193687; 134190; 175565; N/A; 214690; 122573; 327605; N/A; N/A; 116202; 157552; N/A; 102059; N/A; 311179; 167909; 169795; 53676; N/A; 206311; N/A; 198906; 110398
    Background: we aimed to assess the feasibility and short-term clinical outcomes of surgical procedures for cancer at an institution using a coronavirus disease 2019 (COVID-19)-free surgical pathway during the peak phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Materials and methods: this was a single-center study, including cancer patients from all surgical departments, who underwent elective surgical procedures during the first peak phase between March 10 and June 30, 2020. The primary outcomes were the rate of postoperative SARS-CoV-2 infection and 30-day pulmonary or non-pulmonary related morbidity and mortality associated with SARS-CoV-2 disease. Results: four hundred and four cancer patients fulfilling inclusion criteria were analyzed. The rate of patients who underwent open and minimally invasive procedures was 61.9% and 38.1%, respectively. Only one (0.2%) patient died during the study period due to postoperative SARS-CoV2 infection because of acute respiratory distress syndrome. The overall non-SARS-CoV2 related 30-day morbidity and mortality rates were 19.3% and 1.7%, respectively; whereas the overall SARS-CoV2 related 30-day morbidity and mortality rates were 0.2% and 0.2%, respectively. Conclusions: under strict institutional policies and measures to establish a COVID-19-free surgical pathway, elective and emergency cancer operations can be performed with acceptable perioperative and postoperative morbidity and mortality.
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    PublicationOpen Access
    KRAS signaling in malignant pleural mesothelioma
    (Wiley, 2022) Marazioti, Antonia; Krontira, Anthi C.; Behrend, Sabine J.; Giotopoulou, Georgia A.; Ntaliarda, Giannoula; Blanquart, Christophe; Iliopoulou, Marianthi; Vreka, Malamati; Trassl, Lilith; Pepe, Mario A. A.; Hackl, Caroline M.; Klotz, Laura, V; Weiss, Stefanie A., I; Koch, Ina; Lindner, Michael; Hatz, Rudolph A.; Behr, Juergen; Wagner, Darcy E.; Papadaki, Helen; Antimisiaris, Sophia G.; Jean, Didier; Deshayes, Sophie; Gregoire, Marc; Kayalar, Özgecan; Mortazavi, Deniz; Psallidas, Ioannis; Spella, Magda; Giopanou, Ioanna; Lilis, Ioannis; Lamort, Anne-Sophie; Stathopoulos, Georgios T.; Bayram, Hasan; Dilege, Şükrü; Tanju, Serhan; Erus, Suat; Yavuz, Ömer; Bulutay, Pınar; Fırat, Pınar Arıkan; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 4890; 122573; 214690; 175565; N/A; 133565; 207545
    Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we show that a proportion of human MPM harbor point mutations, copy number alterations, and overexpression of KRAS with or without TP53 changes. These are likely pathogenic, since ectopic expression of mutant KRAS(G12D) in the pleural mesothelium of conditional mice causes epithelioid MPM and cooperates with TP53 deletion to drive a more aggressive disease form with biphasic features and pleural effusions. Murine MPM cell lines derived from these tumors carry the initiating KRAS(G12D) lesions, secondary Bap1 alterations, and human MPM-like gene expression profiles. Moreover, they are transplantable and actionable by KRAS inhibition. Our results indicate that KRAS alterations alone or in accomplice with TP53 alterations likely play an important and underestimated role in a proportion of patients with MPM, which warrants further exploration.