Researcher: Demirer, Gözde Sultan
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Demirer, Gözde Sultan
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Publication Metadata only Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (mionps)(Elsevier, 2014) N/A; N/A; Department of Chemical and Biological Engineering; N/A; Department of Chemistry; Department of Chemical and Biological Engineering; Department of Chemistry; Department of Chemical and Biological Engineering; Nazlı, Caner; Demirer, Gözde Sultan; Yar, Yasemin; Acar, Havva Funda Yağcı; Kızılel, Seda; PhD Student; Undergraduate Student; PhD Student; Faculty Member; Faculty Member; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Engineering; N/A; N/A; N/A; 178902; 28376Targeting tumors with nano-scale delivery systems shows promise to improve the therapeutic effects of chemotherapeutic drugs. However, the limited specificity of current nano-scale systems for cancer tissues prevents realization of their full clinical potential. Here, we demonstrate an effective approach to creating as targeted nanocarriers for drug delivery: MIONPs coated with integrin-targeted and matrix-metalloproteinase (MMP) sensitive PEG hydrogel scaffolds. The functional PEG hydrogel coating has been designed for active loading as well as triggered intra-cellular release of the cancer therapeutic agent doxorubicin (DOX). Our study demonstrated that coated nanocarriers could be taken into cancer cells 11 times more efficiently than uncoated ones. Furthermore, confocal laser scanning microscopy images revealed that these targeted nanocarriers could efficiently deliver and release DOX into the nuclei of HeLa cells within 2 h. Coating MIONPs with multifunctional PEG hydrogel could be a promising alternative to existing vehicles for targeted delivery of DOX into tumor tissue.Publication Metadata only Detection of interaction constants between biological clock proteins by Surface Plasmon Resonance(AIChE, 2012) Çakır, Bilal; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; N/A; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Kızılel, Seda; Kavaklı, İbrahim Halil; Gidon, Doğan; Asımgil, Hande; Kızılel, Rıza; Kepsütlü, Burcu; Demirer, Gözde Sultan; Faculty Member; Faculty Member; Undergraduated Student; PhD Student; Researcher; Master Student; Undergraduated Student; College of Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; 28376; 40319; N/A; N/A; 114475; N/A; N/AOrganisms adopt their behaviors and physiology to the appropriate time of the day to anticipate daily environmental changes and the circadian clock regulates their daily rhythms. In mammals, the clock is present in essentially every cell. A heterodimer of CLOCK and BMAL1 proteins binds to the E-box in Per and Cry promoters and activates their transcription. In this work, we have purified core clock proteins and characterized the affinity of previously identified clock-relevant transcription factors. We have investigated the mechanism of the clock complex and the interactions of clock proteins with and without DNA using Surface Plasmon Resonance (SPR). Kinetic parameters determined from real time data bring a solid insight into the interactions of the clock proteins with their cognate promoter.Publication Open Access Synthesis and design of biologically inspired biocompatible iron oxide nanoparticles for biomedical applications(Royal Society of Chemistry (RSC), 2015) Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Demirer, Gözde Sultan; Okur, Aysu Ceren; Kızılel, Seda; Faculty Member; College of Engineering; N/A; N/A; 28376During the last couple of decades considerable research efforts have been directed towards the synthesis and coating of iron oxide nanoparticles (IONPs) for biomedical applications. To address the current limitations, recent studies have focused on the design of new generation nanoparticle systems whose internalization and targeting capabilities have been improved through surface modifications. This review covers the most recent challenges and advances in the development of IONPs with enhanced quality, and biocompatibility for various applications in biotechnology and medicine.