Researcher:
Mortazavi, Deniz

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PhD Student

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Deniz

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Mortazavi

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Mortazavi, Deniz

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2020 - 20224

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Researcher Of Publications: search.filters.isAuthorOfPublication.08b1cf60-c793-47cf-a9c0-b9fefcca6efb

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Now showing 1 - 4 of 4
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    The role of reactive nitrogen species as biomarkers of disease severity in COVID-19
    (European Respiratory Society (ERS), 2022) Akyil, F. Tokgoz; Altin, S.; N/A; N/A; N/A; N/A; Department of Molecular Biology and Genetics; N/A; N/A; Konyalılar, Nur; Kayalar, Özgecan; Mortazavi, Deniz; Rajabi, Hadi; Korkunç, Seval Kübra; Erkan, Selim; Gönenli, Mehmet Gökhan; Bayram, Hasan; PhD Student; Researcher; PhD Student; PhD Student; Master Student; Other; Other; Teaching Faculty; Faculty Member; Department of Molecular Biology and Genetics; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; N/A; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 350445; 4890
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    PublicationMetadata only
    Genetic variability and clinical spectrum of limb-girdle muscular dystrophy in a cohort of Turkish patients
    (Springernature, 2020) Avcı, Seymen; N/A; N/A; N/A; N/A; N/A; N/A; Mortazavi, Deniz; Vanlı-Yavuz, Ebru Nur; Börklü Yücel, Esra; Eraslan, Serpil; Oflazer, Piraye; Kayserili, Hülya; PhD Student; Doctor; Other; Researcher; Faculty Member; Faculty Member; School of Medicine / Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine / Koç University HospitGraduate School of Health Sciences; N/A; School of Medicine; School of Medicine; N/A; 251177; N/A; N/A; N/A; 7945
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    PublicationOpen Access
    Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
    (BioMed Central, 2022) Rahbarghazi, Reza; Rajabi, Hadi; Konyalılar, Nur; Erkan, Sinem; Mortazavi, Deniz; Korkunç, Seval Kübra; Kayalar, Özgecan; Bayram, Hasan; PhD Student; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 4890
    Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.
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    PublicationOpen Access
    Epi-miRNAs: regulators of the histone modification machinery in human cancer
    (Hindawi, 2022) Sohrabi, B.; Mosallaei, M.; Nariman Saleh Fam, Z.; Bastami, M.; Mansoori, Y.; Daraei, A.; Zununi Vahed, S.; Navid, S.; Saadatian, Z.; Jamialahmadi, T.; Teng, Y.; Sahebkar A.; Mortazavi, Deniz; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
    Cancer is a leading cause of death and disability worldwide. Epigenetic deregulation is one of the most critical mechanisms in carcinogenesis and can be classified into effects on DNA methylation and histone modification. MicroRNAs are small noncoding RNAs involved in fine-tuning their target genes after transcription. Various microRNAs control the expression of histone modifiers and are involved in a variety of cancers. Therefore, overexpression or downregulation of microRNAs can alter cell fate and cause malignancies. In this review, we discuss the role of microRNAs in regulating the histone modification machinery in various cancers, with a focus on the histone-modifying enzymes such as acetylases, deacetylases, methyltransferases, demethylases, kinases, phosphatases, desumoylases, ubiquitinases, and deubiquitinases. Understanding of microRNA-related aberrations underlying histone modifiers in pathogenesis of different cancers can help identify novel therapeutic targets or early detection approaches that allow better management of patients or monitoring of treatment response.