Researcher:
Sönmez, Melda

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Master Student

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Melda

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Sönmez

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Sönmez, Melda

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2013 - 20194

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Researcher Of Publications: search.filters.isAuthorOfPublication.094d95ea-0156-42ae-b532-0568d0ec9677

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    Pulmonary infarction due to pulmonary embolism
    (Cleveland Clinic, 2018) Aboussouan, Loutfi S.; Farver, Carol; Murthy, Sudish C.; Kaw, Roop; N/A; Sönmez, Melda; Undergraduate Student; School of Medicine; N/A
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    Crimean-Congo hemorrhagic fever infections reported by ProMED
    (Elsevier Sci Ltd, 2014) N/A; İnce, Hüseyin Yavuz; Yasa, Çağla; Metin, Mustafa Mert; Sönmez, Melda; Meram, Ece; Benkli, Barlas; Ergönül, Önder; Undergraduate Student; Undergraduate Student; Undergraduate Student; Master Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 110398
    Objective: There are limited sources describing the global burden of emerging diseases. We reviewed the Crimean-Congo hemorrhagic fever virus (CCHFV) infections reported by ProMED and assessed the reliability of the data retrieved compared to published reports. We evaluated the effectiveness of ProMED as a source of epidemiological data by focusing on CCHFV infections. Methods: Using the keywords "Crimean Congo hemorrhagic fever'' and "Crimean Congo'' in the ProMED search engine, we reviewed all the information about the news and harvested data using a structured form, including year, country, gender, occupation, the number of infected individuals, and the number of fatal cases. Results: We identified 383 entries reported between January 1998 and October 2013. A total 3426 infected cases were reported, with 451 fatal cases, giving an overall case fatality rate (CFR) of 13%. Out of 144 cases for which the gender was reported, 97 (67%) were male. Most of the cases were reported from Turkey, followed by Russia, Iran, Pakistan, and Afghanistan. Conclusions: Case reporting systems such as ProMED are useful to gather information and synthesize knowledge on the emerging infections. Although certain areas need to be improved, ProMED provided good information about Crimean-Congo hemorrhagic fever. (C) 2014 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.
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    A subset of patients with acquired partial lipodystrophy developing severe metabolic abnormalities
    (Taylor & Francis, 2019) Saydam, Başak Özgen; Şimşir, Ilgın Yıldırım; Ertürk, Mehmet Sercan; Kulaksızoğlu, Mustafa; Arkan, Tuğba; Hekimsoy, Zeliha; Çavdar, Ümit; Akıncı, Gülçin; Demir, Tevfik; Altay, Canan Tuncer; Mihci, Ercan; Seçil, Mustafa; Akıncı, Barış; N/A; Sönmez, Melda; Master Student; Graduate School of Health Sciences; N/A
    Purpose/Aim of the Study: Acquired partial lipodystrophy (APL) is a rare disease characterized by selective loss of adipose tissue. In this study, we aimed to present a subset of patients with APL, who developed severe metabolic abnormalities, from our national lipodystrophy registry. Materials and Methods: Severe metabolic abnormalities were defined as: poorly controlled diabetes (HbA1c above 7% despite treatment with insulin more than 1 unit/kg/day combined with oral antidiabetics), severe hypertriglyceridemia (triglycerides above 500 mg/dL despite treatment with lipid-lowering drugs), episodes of acute pancreatitis, or severe hepatic involvement (biopsy-proven non-alcoholic steatohepatitis (NASH)). Results: Among 140 patients with all forms of lipodystrophy (28 with APL), we identified 6 APL patients with severe metabolic abnormalities. The geometric mean for age was 37 years (range: 27-50 years; 4 females and 2 males). Five patients had poorly controlled diabetes despite treatment with high-dose insulin combined with oral antidiabetics. Severe hypertriglyceridemia developed in five patients, of those three experienced episodes of acute pancreatitis. Although all six patients had hepatic steatosis at various levels on imaging studies, NASH was proven in two patients on liver biopsy. Our data suggested that APL patients with severe metabolic abnormalities had a more advanced fat loss and longer disease duration. Conclusions: We suggest that these patients represent a potential subgroup of APL who may benefit from metreleptin or investigational therapies as standard treatment strategies fail to achieve a good metabolic control.
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    PublicationOpen Access
    The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size
    (Public Library of Science, 2013) Ajdzanovic, Vladimir; Spasojevic, Ivan; Meiselman, Herbert J.; Sönmez, Melda; İnce, Hüseyin Yavuz; Yalçın, Özlem; Başkurt, Oğuz Kerim; Faculty Member; School of Medicine; N/A; N/A; 218440; 2389
    The role of membrane fluidity in determining red blood cell (RBC) deformability has been suggested by a number of studies. The present investigation evaluated alterations of RBC membrane fluidity, deformability and stability in the presence of four linear alcohols (methanol, ethanol, propanol and butanol) using ektacytometry and electron paramagnetic resonance (EPR) spectroscopy. All alcohols had a biphasic effect on deformability such that it increased then decreased with increasing concentration; the critical concentration for reversal was an inverse function of molecular size. EPR results showed biphasic changes of near-surface fluidity (i.e., increase then decrease) and a decreased fluidity of the lipid core; rank order of effectiveness was butanol > propanol > ethanol > methanol, with a significant correlation between near-surface fluidity and deformability (r = 0.697; p<0.01). The presence of alcohol enhanced the impairment of RBC deformability caused by subjecting cells to 100 Pa shear stress for 300 s, with significant differences from control being observed at higher concentrations of all four alcohols. The level of hemolysis was dependent on molecular size and concentration, whereas echinocytic shape transformation (i.e., biconcave disc to crenated morphology) was observed only for ethanol and propanol. These results are in accordance with available data obtained on model membranes. They document the presence of mechanical links between RBC deformability and near-surface membrane fluidity, chain length-dependence of the ability of alcohols to alter RBC mechanical behavior, and the biphasic response of RBC deformability and near-surface membrane fluidity to increasing alcohol concentrations.