Researcher: Canbaz, Hande Bulut
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Canbaz, Hande Bulut
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Publication Metadata only Early post-operative stimulated serum thyroglobulin: role in preventing unnecessary radioactive iodine treatment in low to intermediate risk papillary thyroid cancer(Sage Publications Inc, 2023) TerzioĞlu, Tarık; Tezelman, Serdar; Yerlikaya, Aslıhan; Çolakoğlu, Bülent; Sezer, Havva; Dereli, Dilek Yazıcı; Canbaz, Hande Bulut; Demirkol, Mehmet Onur; Kapran, Yersu; Çilingiroğlu, Eda Nur; Alagöl, Faruk; School of Medicine; Graduate School of Health Sciences; Koç University HospitalAim The aims of the study are to evaluate the predictive value of early post-operative stimulated thyroglobulin (sTg) analysis on the recurrence risk, and to define a cut-off value that is related to recurrence risk in low to intermediate risk papillary thyroid cancer (PTC). Methods This retrospective cohort study included individuals who were diagnosed with PTC aged 18 years or older and had been operated by experienced surgeons of a tertiary university hospital between the years 2011 and 2021. The American Thyroid Association thyroid cancer guidelines version 2015 was used as the risk stratification system. Early sTg measurement obtained at 3-4 weeks after surgery when TSH >30 mu IU/mL. Data was collected from the hospital database. A total of 328 patients who had post-operative early sTg values with negative anti-Tg antibodies were included. Results The median age was 44 years. Of the 328 patients, 223 (68%) were women. The median tumor diameter was 11 mm. One hundred ninety-one patients (58.2%) had low risk and 137 (41.8%) had intermediate risk for recurrent disease. Of the 328 patients, 4.0% had recurrent disease. In multivariate Cox regression, post-operative early sTg value [OR: 1.070 (1.038-1.116), P = .000], and the pre-operative malign cytology [OR: 1.483 (1.080-2.245), P = .042] were independent risk factors for recurrence. On the ROC curve analysis, the cut-off value of early sTg was 4.1 ng/mL for those with recurrent disease. Conclusion This study demonstrated that early sTg could predict recurrent disease in patients with low to intermediate risk PTC. A cut-off of 4.1 ng/mL was identified with a high negative predictive value.Publication Metadata only The frequency of acceptance of oral glucose tolerance test in Turkish pregnant women: a single tertiary center results(Kare Publ, 2022) Yerlikaya, Aslıhan; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezer, Havva; Dereli, Dilek Yazıcı; Canbaz, Hande Bulut; Gönenli, Mehmet Gökhan; Ata, Mustafa Barış; Bekdemir, Bahar; Nalbantoğlu, Emine Ayça; Teaching Faculty; Faculty Member; Master Student; Teaching Faculty; Faculty Member; Nurse; Faculty Member; School of Medicine; School of Medicine; School of Nursing; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital Nurse; 154807; 179659; N/A; 350445; 182910; N/A; 327621Objective: It is thought that there is not enough data about the frequency of acceptance of oral glucose tolerance test (OGTT) in Turkish pregnant women. The aim of this study was to investigate the frequency of acceptance of OGTT among participants in our single tertiary center. Methods: The data of non-diabetic 344 pregnant women seen at the Obstetrics Clinic of our hospital between September 2016 and September 2017 were obtained from the hospital records. Women who did not have regular follow-up during pregnancy were excluded. One of the two or one-step approaches was used in the diagnosis of gestational diabetes mellitus (GDM) depending on the choice of the physician following the patient. Results: There were 223 subjects eligible for the study. One hundred seventy-seven pregnant women (79.4%) accepted to do OGTT. We determined that 46 women (20.6%) did not complete at least one OGTT, of whom 74% (n=34) never completed the recommended screening test in this cohort. The overall frequency of GDM was approximately 15.2% (n=34). OGTT acceptability was higher among pregnant women with university graduates (p=0.02). Adverse pregnancy outcomes were similar between the accepted and rejected groups. Among the reasons for OGTT rejection, the media had a significant influence (n=35). Conclusion: Our results show that a significant percentage of patients refused to do OGTT. Therefore the actual frequency of pregnant women with GDM could not be determined. One way to increase compliance may be recommending only the one-step test for pregnant women in countries with a high rejection rate of OGTT.Publication Open Access Is obesity paradox valid for critically-ill COVID-19 patients with respiratory failure?(Aves, 2022) Canbaz, Hande Bulut; Sezer, Havva; Yurdakul, Fatma; Özserezli, Boğaç; Dereli, Dilek Yazıcı; Teaching Faculty; Faculty Member; School of Medicine; School of Nursing; Koç University Hospital; N/A; N/A; N/A; N/A; 179659Objective: we aimed to analyze the association between body mass index and mortality in patients with coronavirus disease 2019 induced acute respiratory distress syndrome. Materials and methods: in this retrospective cohort study, we analyzed 108 consecutive patients admitted in the intensive care unit for coronavirus disease 2019-induced lung disease in a single center between March 2020 and February 2021. Coronavirus disease 2019 infection was confirmed by real-time reverse transcription-polymerase chain reaction assay of nasal swabs or lower respiratory tract samples. Acute respiratory distress syndrome was defined using Berlin criteria. Acute respiratory distress syndrome severity was assessed with partial pressure of arterial oxygen/fraction of inspired oxygen ratio. We categorized patients according to the body mass index as underweight, <18.5 kg/m2; normal weight, from 18.5 kg/m2 to <25 kg/m2; overweight, from 25 kg/m2 to <30 kg/m2; obese, ?30 kg/m2. Clinical characteristics and mortality were compared among groups. Demographic and clinical data were collected from electronic medical records of the hospital system. Results: the mean age was 67.3 ± 13.3 years. Study participants were predominantly males (66.7%). The mean BMI was 28.2 ± 5.6 kg/m2. There were 2 patients (2%), 28 (26%), 42 (39%), and 36 patients (33%) in the underweight, normal-weight, overweight, and obese groups, respectively. The hospital mortality was 40.7%. There was no association between body mass index and mortality (P =.09). In multivariate analysis, mortality was associated with the presence of cancer [odds ratio = 7.338 (1.636-32.914), P =.009], and time between diagnosis and intubation [odds ratio = 1.318 (1.150-1.509), P ?.001]. Conclusion: neither acute respiratory distress syndrome severity nor mortality was higher in patients with higher body mass index compared to the ones with normal body mass index.