Researcher: Özışık, Seçil
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Özışık, Seçil
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Publication Metadata only Clinical features of generalized lipodystrophy in Turkey: a cohort analysis(Wiley, 2023) Yıldırım Şimşir, Ilgın; Tüysüz, Beyhan; Özbek, Mehmet Nuri; Tanrıkulu, Seher; Çelik Güler, Merve; Karhan, Asuman Nur; Denkboy Öngen, Yasemin; Güneş, Nilay; Soyaltın, Utku Erdem; Altay, Canan; Nur, Banu; Özalkak, Servan; Akgün Doğan, Özlem; Dursun, Fatma; Pekkolay, Zafer; Eren, Mehmet Ali; Usta, Yusuf; Özgen Saydam, Basak; Adıyaman, Süleyman Cem; Ünal, Mehmet Çağrı; Güngör Semiz, Gökçen; Turan, İhsan; Eren, Erdal; Jeru, Isabelle; Vigouroux, Corinne; Atik, Tahir; Onay, Huseyin; Özen, Samim; Arioğlu Oral, Elif; Akıncı, Barış; N/A; Özışık, Seçil; Kayserili, Hülya; Doctor; Faculty Member; N/A; School of Medicine; Koç University Hospital; N/A; N/A; 7945Aim: to describe the Turkish generalized lipodystrophy (GL) cohort with the frequency of each complication and the death rate during the period of the follow-up. Methods: this study reports on 72 patients with GL (47 families) registered at different centres in Turkey that cover all regions of the country. The mean ± SD follow-up was 86 ± 78 months. Results: the Kaplan–Meier estimate of the median time to diagnosis of diabetes and/or prediabetes was 16 years. Hyperglycaemia was not controlled in 37 of 45 patients (82.2%) with diabetes. Hypertriglyceridaemia developed in 65 patients (90.3%). The Kaplan–Meier estimate of the median time to diagnosis of hypertriglyceridaemia was 14 years. Hypertriglyceridaemia was severe (≥ 500 mg/dl) in 38 patients (52.8%). Seven (9.7%) patients suffered from pancreatitis. The Kaplan–Meier estimate of the median time to diagnosis of hepatic steatosis was 15 years. Liver disease progressed to cirrhosis in nine patients (12.5%). Liver disease was more severe in congenital lipodystrophy type 2 (CGL2). Proteinuric chronic kidney disease (CKD) developed in 32 patients (44.4%) and cardiac disease in 23 patients (31.9%). Kaplan–Meier estimates of the median time to diagnosis of CKD and cardiac disease were 25 and 45 years, respectively. Females appeared to have a more severe metabolic disease, with an earlier onset of metabolic abnormalities. Ten patients died during the follow-up period. Causes of death were end-stage renal disease, sepsis (because of recurrent intestinal perforations, coronavirus disease, diabetic foot infection and following coronary artery bypass graft surgery), myocardial infarction, heart failure because of dilated cardiomyopathy, stroke, liver complications and angiosarcoma. Conclusions: standard treatment approaches have only a limited impact and do not prevent the development of severe metabolic abnormalities and early onset of organ complications in GL.Publication Open Access An intrathyroidal nodule consisting of papillary thyroid cancer and ectopic hyperechoic parathyroid adenoma: a case report(Iuliu Hatieganu Medical Publishing House, 2021) Altınmakas, Emre; Güneyli, Serkan; Kabaalioğlu, Adnan; Çil, Barbaros Erhan; Samadli, Vugar; Doğan, Hakan; Taşkın, Orhun Çığ; Özışık, Seçil; Ağcaoğlu, Orhan; Faculty Member; Researcher; Faculty Member; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 169993; N/A; 327614; 166686; N/A; 175476A 53-year-old woman with fatigue lasting for 6 weeks and increased parathormone level underwent a neck ultrasound. It revealed a large, lobulated, solid intrathyroidal nodule consisting of hypoechoic component with microcalcifications and hy-perechoic component with vascularity on Doppler mode. There were also subcentimetric intrathyroidal hypo- and hyperechoic nodules. Upon the diagnosis of papillary thyroid cancer on fine-needle aspiration biopsy, a total thyroidectomy procedure was performed. In the histopathologic evaluation, the hypoechoic component was diagnosed as papillary thyroid cancer, while the hyperechoic component was diagnosed as ectopic parathyroid adenoma. Subcentimetric nodules were demonstrated as multi-foci of papillary thyroid cancer.Publication Open Access Status of weight change, lifestyle behaviors, depression, anxiety, and diabetes mellitus in a cohort with obesity during the COVID-19 lockdown: Turk-Com Study Group(Karger Publishers, 2022) Fersahoglu, Mehmet Mahir; Fersahoglu, Tuba; Bulut, Nuriye Esen; Cigiltepe, Hueseyin; Celer, Ozgen; Sancak, Seda; Sulu, Cem; Durcan, Emre; Sahin, Serdar; Polat Korkmaz, Oezge; Bozdogan Polat, Sila Hidayet; Taskin, Eren; Iseri, Ceren; Guersoy, Evren; Kucuk Yetgin, Meral; Kaya, Tugba; oezdemir, Feyza; Mestanoglu Istanbullu, Naime; Kiyici, Sinem; oeztuerk, Serkan; Guengoer, Kagan; Can, Buelent; Sargin, Mehmet; Tabak, Zeynep; Averi, Sevda; Nazli, Aysun; Polat, Yeliz; Akbas, Feray; Tekin, Sakin; Topaloglu, Omercan; Boz Uzaldi, Ebru; catalcam, Safiye; Bayraktaroglu, Taner; Calikoglu, Bedia Fulya; Nasifova, Vefa; Soyluk Selcukbiricik, Oezlem; Karsidag, Kubilay; Dincer, Ceyda; Gogas Yavuz, Dilek; Ilkova, Hasan; Yumuk, Volkan Demirhan; Dereli, Dilek Yazıcı; Sezer, Havva; Özışık, Seçil; Bulut, Hande; Bekdemir, Bahar; Deyneli, Oğuzhan; Faculty Member; Teaching Faculty; Doctor; Faculty Member; School of Medicine; Koç University Hospital; 179659; N/A; N/A; N/A; N/A; 171914Introduction: the coronavirus disease 2019 (COVID-19) pandemic led to a lockdown period. Confinement periods have been related to unhealthy lifestyle behaviors. Our study aimed to determine weight change, changes in eating and exercise habits, the presence of depression and anxiety, and diabetes mellitus (DM) status in a cohort of patients with obesity. Methods: the study was undertaken in nine centers of Collaborative Obesity Management (COM) of the European Association for the Study of Obesity (EASO) in Turkey. An e-survey about weight change, eating habits, physical activity status, DM status, depression, and anxiety was completed by patients. The International Physical Activity Questionnaire (IPAQ) score was used to determine physical activity in terms of metabolic equivalents (METs). A healthy nutrition coefficient was calculated from the different categories of food consumption. The Patient Health Questionnaire (PHQ-9) and General Anxiety Disorder (GAD-7) Questionnaire were used for determining depression and anxiety, respectively. Results: four hundred twenty-two patients (age 45 +/- 12.7 years, W/M = 350/72) were included. The healthy nutrition coefficient before the pandemic was 38.9 +/- 6.2 and decreased to 38.1 +/- 6.4 during the pandemic (p < 0.001). Two hundred twenty-nine (54.8%) patients gained weight, 54 (12.9%) were weight neutral, and 135 (32.3%) lost weight. Patients in the weight loss group had higher MET scores and higher healthy nutrition coefficients compared with the weight gain and weight-neutral groups (p < 0.001). The PHQ and GAD scores were not different between the groups. Percent weight loss was related to healthy nutrition coefficient (CI: 0.884 [0.821-0.951], p = 0.001) and MET categories (CI: 0.408 [0.222-0.748], p = 0.004). One hundred seventy patients had DM. Considering glycemic control, only 12 (8.4%) had fasting blood glucose <100 mg/dL and 36 (25.2%) had postprandial BG <160 mg/dL. When patients with and without DM were compared in terms of dietary compliance, MET category, weight loss status, PHQ-9 scores, and GAD-7 scores, only MET categories were different; 29 (11.7%) of patients in the nondiabetic group were in the highly active group compared with 5 (2.9%) in the diabetic group. Conclusion: the COVID-19 lockdown resulted in weight gain in about half of our patients, which was related to changes in physical activity and eating habits. Patients with DM who had moderate glycemic control were similar to the general population in terms of weight loss but were less active.