Researcher:
İzgi, Büşra

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PhD Student

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Büşra

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İzgi

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İzgi, Büşra

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2018 - 201912020 - 20223

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    FKBP5 methylation, psychiatric disorders and stress: a systematic review and synthesis
    (Elsevier Science Inc, 2022) Çiçek, Yusuf; N/A; İzgi, Büşra; Kuvvet, Yasemin; Musaoğlu, Miraç Nur; Öztosun, Çınar; Eser, Hale Yapıcı; PhD Student; Master Student; PhD Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 134359
    Background FKBP5 methylation levels are among the most studied epigenetic modifications related to psychiatric disorder vulnerability, however there are contradictory findings. We aimed to investigate the role of FKBP5 methylation in psychiatric disorders, in addition to its association with stress exposure (either life adversities, traumatic events or acute stress). Methods In accordance with PRISMA guidelines, ‘FKBP5’ and ‘methylation’ were searched in PubMed and Web of Science in March 2021. 330 studies were identified. Studies on non-psychiatric disorders, animal or cell lines were excluded. Type of study, sample size, sociodemographic properties of the participants, type of stress exposure, type of psychiatric disorder, CPG loci at FKBP5, and other related methods and covariates were extracted from 53 studies found to be eligible based on the inclusion criteria. Results Preliminary analysis showed that 19 studies investigated FKBP5 methylation in psychiatric disorders, 32 studies investigated the effects of stress types on FKBP5 methylation. Among the 197 CpG sites investigated, CpG at chr6:35,590,711 (intron 7), chr6:35,689,425 (promoter region), and chr6:35,590,736 (intron 7/GRE) sites were investigated by 26, 24, and 22 studies, respectively. CpG sites at chr6:35,590,736 and chr6:35,590,711 were reported to be linked to psychiatric disorder; CpG site at chr6:35,590,711, were reported to be linked to types of stress by more than half of the studies that investigated this region. Conclusions The studies on FKBP5 methylation and psychiatric disorder vulnerability are highly heterogeneous and most significant associations are found in intron 7. However, a great percentage of literature report insignificant associations of FKBP5 methylation sites with psychiatric disorder vulnerability.
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    Pupillary window to assess emotion-somatization connection: alexithymia, somatization and pupillary responses to affective stimuli
    (Elsevier, 2018) Burley, Daniel; Snowden, Robert J.; N/A; N/A; Department of Psychology; N/A; Kaçar, Anıl Şafak; İzgi, Büşra; Gülgöz, Sami; Eser, Hale Yapıcı; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Psychology; Graduate School of Health Sciences; Graduate School of Health Sciences; College of Social Sciences and Humanities; School of Medicine; N/A; N/A; 49200; 134359
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    Chronic stress has direct effect on difficulty in identifying emotions but the effect is indirect through depression
    (Elsevier, 2021) N/A; N/A; N/A; N/A; N/A; N/A; İzgi, Büşra; Berberoğlu, İpek; Muhcu, Sevde Enfal; Aydın, Nuri Efe; Kaçar, Anıl Şafak; Eser, Hale Yapıcı; PhD Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; PhD Student; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; N/A; N/A; N/A; 134359
    Introduction: Emotional recognition is the identification of basic facial emotions like anger, disgust, fear, and sadness; it is an innate ability that involves perceptual analytical function and emotional processing for both parties in an interaction. Mood disorders like major depression disorder (MDD) and schizophrenia are found to interfere with this process in various levels for various emotions. Knowing that negative experiences and adverse life events are significant precursors for such disorders, we aimed to test the possible relationship between one's own emotional processing and recognition of others' emotions and the level of stress in their life. Method: 125 college students without any known psychiatric disorder participated to our study (66% female, Mage=20.48∓ 1.84, 18-29). To measure the stress typology, Childhood Trauma Questionnaire (CTQ), Perceived Stress Scale (PSS) and Chronic Stress Scale (CSS) were used. Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) were also used as independent measures of stress. To measure emotional processing, Emotion Recognition (ER-40) task of PennCNB, which questioned the recognition of anger, fear, sadness, happiness, and neutral emotional expressions was used and Toronto Alexithymia Inventory (TAI) was also used as a self-report scale to measure awareness of one's own emotions. Results: There is no correlation between emotion recognition (ER-40 task) scores and stress scales. All stress measurements correlated positively with TAI scores (BAI: pc:0.40, p<0.001, BDI: pc:0.39, p<0.001, PSS: pc:0.29, p=0.001, CSS: pc:0.27, p=0.003). This significance emerged for CSS, PSS, BAI, and BDI (PC scores>0.34, p<0.001) from identifying emotions subdimensions (TAI_identify) and for PSS, BAI, and BDI (PC scores ≥0.28, p≤0.02) from discriminating emotions subdimensions. In linear regression analysis to predict scores in difficulties in identifying emotions sub dimension (TAI_identify), it was found that it is predicted by scores in CSS (p=0.003), when corrected for CTQ, age and gender. As depression can cause deficits in identifying emotions and it is correlated with chronic stress, the role of beck depression level as a mediator of CSS and TAI_identify was investigated by mediation analysis and the output model for the mediation effect of Beck depression level was built. Chronic stress influences TAI_identify scores indirectly through its effect on Beck Depression Inventory score (ab= 0.093, 95% bootstrap CI= 0.036 to 0.179). Chronic stress causes more depression, with greater depression level associated with difficulties identifying emotions (b=0.233, p=0.0001). There was no definitive evidence that chronic stress directly influenced difficulties in identifying emotions independent of BDI (c' =0.069, p=0.122, 95% bootstrap CI=-0.019 to 0.156). Conclusion: While chronic stress can affect one's identification of one's own emotions, it does not affect the recognition of others' emotions. Previous studies support the role of insula in interoceptive awareness and depression. The mediator role of stress on insula and Major depression disorder-Interoceptive awareness association may be studied in future studies.
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    Test-retest reliability of the Turkish translation of the Penn Computerized Neurocognitive Battery
    (Routledge Journals, Taylor & Francis Ltd, 2022) Moore, Tyler M.; Gur, Ruben C.; N/A; İzgi, Büşra; Yalçınay-İnan, Merve; Port, Allison M.; Kuşçu, Kemal; Eser, Hale Yapıcı; PhD Student; Doctor; Other; Other; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM; Graduate School of Health Sciences; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 134359
    Psychiatric disorders are associated with cognitive dysfunction (CD), and reliable screening and follow-up of CD is essential both for research and clinical practice globally; yet, most assessments are in Western languages. We aimed to evaluate the test-retest reliability of the Turkish version of the Penn Computerized Neurocognitive Battery (PennCNB) to guide confident interpretation of results. Fifty-eight healthy individuals completed the PennCNB Turkish version in two sessions. After quality control, reliability analysis was conducted using Intraclass Correlation Coefficients (ICC), corrected for practice effects. Most measures were not significantly different between the sessions and had acceptable ICC values, with several exceptions. Scores were improved considerably for some memory measures, including immediate Facial Memory and Spatial Memory, and for incorrect responses in abstraction and mental flexibility, with correspondingly acceptable ICCs. Test-retest assessment of the Turkish version of the PennCNB shows that it can be used as a reliable real-time measurement of cognitive function in snapshot cross-sectional or longitudinal determinations. Preliminary validity assessment in this normative sample showed expected positive correlations with education level and negative correlations with age. Thus, the Turkish version of the PennCNB can be considered a reliable neuropsychological testing tool in research and clinical practice. Practice effects should be considered, especially when applied in short intervals. Significantly better performances in the retest, beyond practice effect, likely reflect nonlinear improvements in some participants who "learned how to learn" the memory tests or had insight on solving the abstraction and mental flexibility test.