Researcher:
Cömert, Melis Cansu

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Undergraduate Student

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Melis Cansu

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Cömert

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Cömert, Melis Cansu

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2019 - 201922020 - 20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.10aea879-238c-4271-8e14-f500d8eab270

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    PublicationMetadata only
    The effect of thyroid eye disease on corneal biomechanical properties
    (Kare Yayıncılık, 2022) N/A; Cömert, Melis Cansu; Yılmaz, Sezen Güçlü; Taş, Ayşe Yıldız; Şahin, Afsun; Undergraduate Student; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 200905; 171267
    Objectives: the aim of this study was to identify corneal biomechanical parameters measured by ORA in patients with TED compared to the healthy group. The NOSPECS classification of patients is used to assess the relation between biomechanical changes and disease severity. Methods: we included 22 TED patients, diagnosed with TED for more than five years, and 43 healthy participants. The NOSPECS classification was assessed as mild (grade 1-3) and severe (grade 4-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by ORA. Results: the mean age was 38.8±11.6 years for the TED patients and 42.9±15.58 years for the control group. For TED patients and healthy volunteers, the mean levels of CRF, CH, and CCT were measured as follows: 10.43±2.04 vs 10.28±1.91mmHg, p=0.67; 10.18±1.81 vs 10.21±1.68 mmHg, p=0.90; 550.31±35.73 vs 545.23±37.91 µm, p=0.47, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8.04-9.92) mmHg, p=0.002, CH; 10.43 (IQR: 9.48-11.25) vs 8.58 (IQR: 7.90-9.95) mmHg, p=0.003 and CCT; 554.25 (IQR: 536.05-579.52) vs 527.40 (IQR: 492.25-545.90) μm, p=0.014]. CRF values were negatively correlated with NOSPECS score (r=-0.317, p=0.036) and significantly higher CRF was observed in mild patients compared to severe disease (11.43 (IQR: 10.14-12.87) vs 9.46 (IQR: 8.75-10.28) mmHg, p=0.008). Conclusion: we found a significant gender effect on corneal biomechanical parameters of TED patients. CRF, CH and CCT values were significantly higher in females compared to males with TED. The clinical severity score of TED showed negative correlation with CRF. CRF value might be a useful parameter in follow-up of TED patients in clinical practice.
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    PublicationMetadata only
    DNA methylation pattern of TM6SF2 influences NAFLD progression in genotype-dependent manner
    (Elsevier, 2019) Adalı, Gupse; Dayangaç, Murat; N/A; N/A; N/A; N/A; N/A; N/A; Ulukan, Bürge; Yiğit Alpdoğan, Buket; Yılmaz, Onur; Cömert, Melis Cansu; Erkan, Murat Mert; Zeybel, Müjdat; PhD Student; Researcher; Undergraduate Student; Undergraduate Student; Faculty Member; Faculty Member; Graduate School of Health Sciences; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 214689; 214694
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    PublicationOpen Access
    A novel investigation method for axonal damage in neuromyelitis optica spectrum disorder: in vivo corneal confocal microscopy
    (Sage, 2021) Zimmermann, Hanna; Brandt, Alexander U.; Paul, Friedemann; Altıntaş, Ayşe; Taş, Ayşe Yıldız; Yılmaz, Sezen Güçlü; Bayraktutar, Betül; Cömert, Melis Cansu; Şahin, Afsun; Faculty Member; Faculty Member; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 11611; N/A; N/A; N/A; N/A; 171267
    Background: neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disorder that damages optic nerves, brainstem, and spinal cord. In vivo corneal confocal microscopy (IVCM) is a noninvasive technique that provides corneal images with dendritic cells (DCs) and corneal subbasal nerve plexus (SBP), which arises from the trigeminal nerve. Objective: we investigated corneal SBP changes in NMOSD and proposed IVCM as a potential new disease severity biomarker for NMOSD. Methods: seventeen age-sex matched NMOSD patients and 19 healthy participants underwent complete neurologic and ophthalmologic examinations. The duration of disease, first symptom, presence of optic neuritis attack, antibody status, Expanded Disability Status Scale(EDSS) score and disease severity score(DSS) were recorded. Retinal nerve fibre layer (RNFL) thickness was measured with optical coherence tomography, and corneal SBP images were taken with IVCM. Results: NMOSD patients had significantly reduced corneal nerve fibre lenght-density and corneal nerve branch lenght-density compared with controls, while DC density was increased. NMOSD patients also showed significantly reduced RNFL thickness compared with controls. EDSS,DSS levels were inversely correlated with IVCM parameters. Conclusion: we observed significant corneal nerve fibre loss in NMOSD patients in relation to disease severity. IVCM can be a candidate noninvasive imaging method for axonal damage assessment in NMOSD that warrants further investigation.
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    PublicationOpen Access
    Reliability study of manual and automated trabecular-iris angle measurements and 360 degrees angle map
    (Association for Research in Vision and Ophthalmology (ARVO), 2019) Sevgi, Duriye Damla; Wu, Hao; Helms, Richard; Örge, Faruk H.; N/A; Taş, Ayşe Yıldız; Ayas, Görkem; Cömert, Melis Cansu; Yılmaz, Sezen Güçlü; Torun, Şafak; Esengür, Ömer Tarık; Demirlenk, Yusuf Mert; Undergraduate Student; Undergraduate Student; School of Medicine