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Yılmaz, Sezen Güçlü

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Sezen Güçlü

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Yılmaz

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Yılmaz, Sezen Güçlü

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2019 - 201962020 - 20225

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    Validity and reliability of the Turkish version of Snaith-Hamilton pleasure scale
    (Association for Cognitive and Behavioral Psychotherapies, 2020) Aydemir, Ömer; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Anhedonia is a core feature of many psychiatric disorders and its reliable evaluation is needed for the dimensional understanding of psychiatric disorders. Snaith-Hamilton Pleasure Scale (SHAPS) is one of the most widely used scales to assess anhedonia. Here, we aimed to search the validity and reliability of the Turkish version of SHAPS. Translation of the original scale was completed in a two-step procedure. 188 healthy controls, 56 patients with a depressive disorder (F32-F34, excluding F34.0 cyclothymic disorder, according to ICD-10), and 52 patients with anxiety, stress-related or somatoform disorder diagnoses (F40-49 diagnosis according to ICD-10) were recruited, and evaluated with the Turkish version of SHAPS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Symptom Checklist-90-R (SCL-90-R). For the Turkish version of SHAPS, Cronbach’s alpha coefficient was found 0.87. The item-total item correlation indices ranged from 0.39 to 0.64. Principal components analysis extracted two factors and explained 46.57 % of total variance. The most significant correlation of SHAPS was found with BDI and depression subscale of SCL-90-R scores. SHAPS also weakly but significantly correlated with obsessive compulsive and anxiety subscales of SCL-90-R, and weakly but non-significantly with BAI and somatization, interpersonal sensitivity, hostility and psychoticism subscales of SCL-90-R. Depressive group had significantly higher SHAPS scores compared to controls and anxious group. Anxious group and control group were not significantly different for SHAPS scores. The current study shows that the Turkish version of the SHAPS has good psychometric properties. SHAPS scores may correlate with depression, somatization, and interpersonal sensitivity scores, and it may help to differentiate depressive patients from anxious patients and controls. /Öz: Anhedoni, birçok psikiyatrik bozukluğun temel bir özelliğidir ve psikiyatrik bozuklukların boyutsal olarak anlaşılması için güvenilir bir şekilde değerlendirilmesi gerekir. Snaith-Hamilton Keyif Alma Ölçeği (SHKÖ), anhedoniyi değerlendirmek için en yaygın kullanılan ölçeklerden biridir. Burada, SHKÖ’nün Türkçe versiyonunun geçerliliği ve güvenilirliğinin araştırılması amaçlanmıştır. Orijinal ölçeğin çevirisi iki aşamalı bir prosedürle tamamlanmıştır. 188 sağlıklı kontrol, 56 depresif bozukluk (ICD-10’a göre F34.0 (siklotimi) dışında F32-F34 tanıları almış kişiler) ve 52 anksiyete, stres ilişkili veya somatoform bozukluk tanısı almış olan anksiyöz hasta (ICD-10’a göre F40-49 tanıları almış kişiler) çalışmaya alınmıştır. Katılımcılar SHKÖ’nün Türkçe versiyonu, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Belirti Kontrol Listesi-90-Gözden Geçirilmiş Form (SCL-90-R) ile değerlendirilmiştir. SHKÖ’nün Türkçe versiyonu için Cronbach alfa katsayısı 0,87 olarak bulunmuştur. Madde-toplam madde korelasyon endeksleri 0,39 ile 0,64 arasında değişmiştir. Temel bileşenler analizi iki faktörü ortaya çıkarmış ve toplam varyansın % 46,57‘ sini açıklamıştır. En yüksek SHKÖ korelasyonu BDE ve SCL-90-R‘nin depresyon alt ölçeği skorları ile bulunmuştur. SHKÖ ayrıca SCL-90-R‘nin obsesif kompulsif ve anksiyete alt ölçekleri ile zayıf fakat istatiksel olarak anlamlı bir korelasyon gösterirken, SCL-90- R‘nin somatizasyon, kişilerarası duyarlılık, hostilite ve psikotisizm alt ölçekleri ile zayıf fakat istatistiksel olarak anlamlı olmayan bir ilişki göstermiştir. Depresif hasta grubunda kontrol grubuna ve anksiyöz hasta grubuna göre anlamlı derecede yüksek SHKÖ skorları saptanmıştır. Anksiyöz hasta grubu ve kontrol grubu, SHKÖ skorları için farklı bulunmamıştır. Bu çalışma, SHKÖ’nün Türkçe versiyonunun iyi psikometrik özellikleri olduğunu göstermektedir. SHKÖ puanları depresyon, somatizasyon ve kişilerarası duyarlılık puanları ile ilişkili olabilir ve depresif hastaları anksiyöz hastalardan ve kontrollerden ayırmada yardımcı olabilir.
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    The effect of thyroid eye disease on corneal biomechanical properties
    (Kare Yayıncılık, 2022) N/A; Cömert, Melis Cansu; Yılmaz, Sezen Güçlü; Taş, Ayşe Yıldız; Şahin, Afsun; Undergraduate Student; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 200905; 171267
    Objectives: the aim of this study was to identify corneal biomechanical parameters measured by ORA in patients with TED compared to the healthy group. The NOSPECS classification of patients is used to assess the relation between biomechanical changes and disease severity. Methods: we included 22 TED patients, diagnosed with TED for more than five years, and 43 healthy participants. The NOSPECS classification was assessed as mild (grade 1-3) and severe (grade 4-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by ORA. Results: the mean age was 38.8±11.6 years for the TED patients and 42.9±15.58 years for the control group. For TED patients and healthy volunteers, the mean levels of CRF, CH, and CCT were measured as follows: 10.43±2.04 vs 10.28±1.91mmHg, p=0.67; 10.18±1.81 vs 10.21±1.68 mmHg, p=0.90; 550.31±35.73 vs 545.23±37.91 µm, p=0.47, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8.04-9.92) mmHg, p=0.002, CH; 10.43 (IQR: 9.48-11.25) vs 8.58 (IQR: 7.90-9.95) mmHg, p=0.003 and CCT; 554.25 (IQR: 536.05-579.52) vs 527.40 (IQR: 492.25-545.90) μm, p=0.014]. CRF values were negatively correlated with NOSPECS score (r=-0.317, p=0.036) and significantly higher CRF was observed in mild patients compared to severe disease (11.43 (IQR: 10.14-12.87) vs 9.46 (IQR: 8.75-10.28) mmHg, p=0.008). Conclusion: we found a significant gender effect on corneal biomechanical parameters of TED patients. CRF, CH and CCT values were significantly higher in females compared to males with TED. The clinical severity score of TED showed negative correlation with CRF. CRF value might be a useful parameter in follow-up of TED patients in clinical practice.
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    Development, validity and reliability of the 4-point likert Turkish version of cognitive failures questionnaire
    (İnönü Üniversitesi Tıp Fakültesi, 2020) Aydemir, Ömer; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Aim: Cognitive failures are suggested to be a transdiagnostic endophenotype that increases the vulnerability for psychiatric disorders. Broadbent’s Cognitive Failures Questionnaire (CFQ), is among the most widely used scales to assess cognitive function observed in an ecological manner. Despite its wide use in research and correlation with biological markers, CFQ is criticized for its unstable factorial structure among studies and 5-Likert structure that may lead to bias for neutral answers. Here we aimed to develop a 4-Likert Turkish version of CFQ, search its validity, reliability and factorial structure. Material and Methods: CFQ has been translated to Turkish in two steps. CFQ, Perceived Deficit Questionnaire-D (PDQ-D), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 272 participants (187 healthy controls, 55 patients diagnosed with depression, 30 patients diagnosed with anxiety disorder). Results: The Cronbach’s alpha coefficient of 4-Likert Turkish version of CFQ was found as 0.91. Principal component analysis extracted five factors and explained 53.7 % of total variance. CFQ scores were significantly different among groups. Both depressive and anxious groups reported higher CFQ scores compared to controls. CFQ significantly and strongly correlated with PDQ-D and showed a moderate correlation with BDI and BAI. Conclusion: 4-Likert Turkish version of CFQ is a valid and reliable tool to assess cognitive failures in non-demented groups. Our analysis revealed a five factorial structure for CFQ, however previous literature with the 5-Likert version shows different factor structures and does not indicate a dimensional stability.
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    Antidiuretic hormone and serum osmolarity physiology and related outcomes: what is old, what Is new, and what is unknown?
    (ENDOCRINE SOC, 2019) Ortiz, Alberto; Sag, Alan A.; Covic, Adrian; Sanchez-Lozada, Laura G.; Lanaspa, Miguel A.; Cherney, David Z. I.; Johnson, Richard J.; Afsar, Baris; N/A; Kanbay, Mehmet; Yılmaz, Sezen Güçlü; Dinçer, Neris; Faculty Member; Undergraduate Student; Undergraduate Student; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; 110580; N/A; N/A
    Context: Although the physiology of sodium, water, and arginine vasopressin (AVP), also known as antidiuretic hormone, has long been known, accumulating data suggest that this system operates as a more complex network than previously thought. Evidence Acquisition: English-language basic science and clinical studies of AVP and osmolarity on the development of kidney and cardiovascular disease and overall outcomes. Evidence Synthesis: Apart from osmoreceptors and hypovolemia, AVP secretion is modified by novel factors such as tongue acid-sensing taste receptor cells and brain median preoptic nucleus neurons. Moreover, pharyngeal, esophageal, and/or gastric sensors and gut microbiota modulate AVP secretion. Evidence is accumulating that increased osmolarity, AVP, copeptin, and dehydration are all associated with worse outcomes in chronic disease states such as chronic kidney disease (CKD), diabetes, and heart failure. on the basis of these pathophysiological relationships, an AVP receptor 2 blocker is now licensed for CKD related to polycystic kidney disease. Conclusion: From a therapeutic perspective, fluid intake may be associated with increased AVP secretion if it is driven by loss of urine concentration capacity or with suppressed AVP if it is driven by voluntary fluid intake. In the current review, we summarize the literature on the relationship between elevated osmolarity, AVP, copeptin, and dehydration with renal and cardiovascular outcomes and underlying classical and novel pathophysiologic pathways. We also review recent unexpected and contrasting findings regarding AVP physiology in an attempt to explain and understand some of these relationships.
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    A rare cause of AA amyloidosis and end-stage kidney failure: questions and answers
    (Springer, 2019) Baba, Zeliha Füsun; Taşdemir, Mehmet; Yılmaz, Sezen Güçlü; Bilge, İlmay; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 175867; N/A; 198907
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    A rare cause of AA amyloidosis and end-stage kidney failure: answers
    (Springer, 2019) Baba, Zeliha Füsun; Taşdemir, Mehmet; Yılmaz, Sezen Güçlü; Bilge, İlmay; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 175867; N/A; 198907
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    Comments on the letter of galland et al. On "a rare cause of AA amyloidosis and end-stage kidney failure"
    (Springer, 2019) Taşdemir, Mehmet; Yılmaz, Sezen Güçlü; Baba, Zeliha Füsun; Bilge, İlmay; Faculty Member; Undergraduate Student; Other; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; 175867; N/A; 140584; 198907
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    Subjective cognitive assessments and n-back are not correlated, and they are differentially affected by anxiety and depression
    Kılıç, Özge; Aydemir, Ömer; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; Koç University Hospital; 134359; N/A; N/A; N/A; 349025; N/A
    Cognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF’s objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization’s Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck’s Anxiety Inventory (BAI), and N-back. Both groups’ data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.
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    A novel investigation method for axonal damage in neuromyelitis optica spectrum disorder: in vivo corneal confocal microscopy
    (Sage, 2021) Zimmermann, Hanna; Brandt, Alexander U.; Paul, Friedemann; Altıntaş, Ayşe; Taş, Ayşe Yıldız; Yılmaz, Sezen Güçlü; Bayraktutar, Betül; Cömert, Melis Cansu; Şahin, Afsun; Faculty Member; Faculty Member; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 11611; N/A; N/A; N/A; N/A; 171267
    Background: neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disorder that damages optic nerves, brainstem, and spinal cord. In vivo corneal confocal microscopy (IVCM) is a noninvasive technique that provides corneal images with dendritic cells (DCs) and corneal subbasal nerve plexus (SBP), which arises from the trigeminal nerve. Objective: we investigated corneal SBP changes in NMOSD and proposed IVCM as a potential new disease severity biomarker for NMOSD. Methods: seventeen age-sex matched NMOSD patients and 19 healthy participants underwent complete neurologic and ophthalmologic examinations. The duration of disease, first symptom, presence of optic neuritis attack, antibody status, Expanded Disability Status Scale(EDSS) score and disease severity score(DSS) were recorded. Retinal nerve fibre layer (RNFL) thickness was measured with optical coherence tomography, and corneal SBP images were taken with IVCM. Results: NMOSD patients had significantly reduced corneal nerve fibre lenght-density and corneal nerve branch lenght-density compared with controls, while DC density was increased. NMOSD patients also showed significantly reduced RNFL thickness compared with controls. EDSS,DSS levels were inversely correlated with IVCM parameters. Conclusion: we observed significant corneal nerve fibre loss in NMOSD patients in relation to disease severity. IVCM can be a candidate noninvasive imaging method for axonal damage assessment in NMOSD that warrants further investigation.
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    PublicationOpen Access
    Classification of reflux patterns in patients with great saphenous vein insufficiency and correlation with clinical severity
    (Aves, 2021) Çakır Peköz, Burçak; Yılmaz, Sezen Güçlü; Dinçer, Neris; Deniz, Sinan; Oğuzkurt, Levent; Undergraduate Student; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 13559
    Purpose: this study aims to establish a clinically applicable classification of reflux patterns in patients with great saphenous vein insufficiency and to evaluate the relationship between this classification, the demographics, and severity of clinical findings. Methods: this is a retrospective study from prospectively collected data of 503 patients who had the complaint of varicose vein. All patients had complete physical examination and their medical history was recorded. Lower limbs of all patients were examined with Doppler ultrasonography. A total of 787 limbs with great saphenous vein insufficiency were included in the analysis. The reflux patterns of great saphenous vein insufficiency were classified into 4 types as: type 1, great saphenous vein reflux without involvement of malleolar region and saphenofemoral junction (SFJ); type 2, reflux involving malleolar region with competent SFJ; type 3, reflux involving SFJ with competent malleolar region; and type 4, reflux involving both the SFJ and the malleolar region. We evaluated the association between the classification of great saphenous vein insufficiency and age, sex, body mass index (BMI), disease duration, clinical, etiological, anatomical and pathophysiological elements (CEAP) classification and venous clinical severity score (VCSS). Results: the mean age of the patients was 45.3±11.7 years, with a male-to-female ratio of 2:3. The most common reflux pattern in patients with great saphenous vein insufficiency was type 3 (48.9%), while 14.8% of patients had type 1, 10.4% had type 2, and 25.7% had type 4. Patients with type I reflux pattern were younger in age (p = 0.002), had lower BMI (p = 0.002), fewer number of children (p = 0.008), as well as milder clinical severity score (p = 0.002) compared to other reflux types. Duration of disease symptoms was not significantly correlated with the reflux patterns, but VCSS increased with the involvement of malleolar region as in type 2 compared to type 1 (2.82±1.67 vs. 2.74±2.31), and further increased with the involvement of SFJ as in type 3 (4.13±2.92 vs. 2.82±1.67). Patients with diffuse reflux pattern (type 4) had the most severe clinical presentation (4.59±2.9). Conclusion: we developed a clinically applicable classification of reflux patterns in patients with great saphenous vein insufficiency based on the involvement of malleolar region and/or SFJ. We showed an association between weight, BMI, VCSS, CEAP classification and the extent of insufficiency.