Researcher:
Ersöz, Mehmet Giray

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Doctor

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Mehmet Giray

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Ersöz

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Ersöz, Mehmet Giray

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2021 - 20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.1239aeaf-9ba3-4325-a1d8-3947d0a21410

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    Henle fiber layer mapping with directional optical coherence tomography
    (Lippincott Williams & Wilkins, 2022) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Department of Computer Engineering; N/A; Department of Computer Engineering; Kesim, Cem; Bektaş, Şevval Nur; Kulalı, Zeynep Umut; Yıldız, Erdost; Ersöz, Mehmet Giray; Şahin, Afsun; Demir, Çiğdem Gündüz; Hasanreisoğlu, Murat; Doctor; Undergraduate Student; Undergraduate Student; PhD Student; Doctor; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; College of Engineering; School of Medicine; Koç University Hospital; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; 387367; N/A; N/A; N/A; 324533; 171267; 43402; 182001
    Purpose: To perform a macular volumetric and topographic analysis of Henle fiber layer (HFL) from retinal scans acquired by directional optical coherence tomography. Methods: Thirty healthy eyes of 17 subjects were imaged using the Heidelberg spectral-domain optical coherence tomography (Spectralis, Heidelberg Engineering, Heidelberg, Germany) with varied horizontal and vertical pupil entry. Manual segmentation of HFL was performed from retinal sections of horizontally and vertically tilted optical coherence tomography images acquired within macular 20 x 20 degrees area. Total HFL volume, mean HFL thickness, and HFL coverage area within Early Treatment for Diabetic Retinopathy Study grid were calculated from mapped images. Results: Henle fiber layer of 30 eyes were imaged, segmented and mapped. The mean total HFL volume was 0.74 +/- 0.08 mm(3) with 0.16 +/- 0.02 mm(3), 0.18 +/- 0.03 mm(3), 0.17 +/- 0.02 mm(3), and 0.19 +/- 0.03 mm(3) for superior, temporal, inferior, and nasal quadrants, respectively. The mean HFL thickness was 26.5 +/- 2.9 mu m. Central 1-mm macular zone had the highest mean HFL thickness with 51.0 +/- 7.6 mu m. The HFL coverage that have thickness equal or above to the mean value had a mean 10.771 +/- 0.574 mm(2) of surface area. Conclusion: Henle fiber layer mapping is a promising tool for structural analysis of HFL. Identifying a normative data of HFL morphology will allow further studies to investigate HFL involvement in various ocular and systemic disorders.
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    Repeatability of choroidal vascularity index measurements using directional optical coherence tomography images
    (Lippincott Williams & Wilkins, 2021) N/A; N/A; Ersöz, Mehmet Giray; Kesim, Cem; Karslıoğlu, Melisa Zişan; Taş, Ayşe Yıldız; Hasanreisoğlu, Murat; Şahin, Afsun; Doctor; Teaching Faculty; Doctor; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; 324533; 387367; N/A; 200905; 182001; 171267
    Purpose: To investigate the repeatability of choroidal vascularity index (CVI) measurements in centered and decentered (regarding pupil entry position of the beam) directional subfoveal optical coherence tomography (OCT) scans with (CVI1) and without (CVI2) brightness adjustment. Methods: Thirty-two eyes of 32 healthy volunteers were included in this prospective study. First, the fovea was evaluated by a single horizontal enhanced depth imaging OCT scan in a centered direction. Then, the same subfoveal horizontal line was scanned in a decentered direction. The agreement between CVIs obtained from these centered and decentered directional OCT scans was investigated using Bland-Altman analysis and intraclass correlation coefficient. Results: Intraclass correlation coefficient between centered and decentered CVI1 was 0.71 (95% CI: 0.48-0.85, P value < 0.001). Intraclass correlation coefficient between centered and decentered CVI2 was 0.73 (95% CI: 0.5-0.86, P value < 0.001). The mean difference between centered and decentered directional measurements for CVI1 and CVI2 were 0.5 and 0.8, respectively. Conclusion: There is moderate agreement between CVIs obtained from centered and decentered directional single OCT scans of the same subfoveal area. Studies investigating choroidal vascularity should be standardized by using the same OCT beam direction in all scans.