Researcher:
Şişman, Uluman

Profile Picture
ORCID

Job Title

Undergraduate Student

First Name

Uluman

Last Name

Şişman

Name

Name Variants

Şişman, Uluman

Email Address

Birth Date

Filters

2021 - 20223

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.12b3a551-9396-41a1-a152-9796766b63bc

Search Results

Now showing 1 - 3 of 3
  • Placeholder
    PublicationMetadata only
    Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors
    (Springer, 2021) Samancı, Mustafa Yavuz; Şişman, Uluman; Altıntaş, Alara; Sarıoğlu, Sebile; Sharifi, Samira; Atasoy, Ali İhsan; Bölükbaşı, Yasemin; Peker, Selçuk; Faculty Member; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Other; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 275252; N/A; N/A; N/A; N/A; N/A; 216814; 11480
    Hypofractionated stereotactic radiosurgery has become an alternative for metastatic brain tumors (METs). We aimed to analyze the efficacy and safety of frameless hypofractionated Gamma Knife radiosurgery (hfGKRS) in the management of unresected, large METs. All patients who were managed with hfGKRS for unresected, large METs (> 4 cm(3)) between June 2017 and June 2020 at a single center were reviewed in this retrospective study. Local control (LC), progression-free survival (PFS), overall survival (OS), and toxicities were investigated. A total of 58 patients and 76 METs with regular follow-up were analyzed. LC rate was 98.5% at six months, 96.0% at one year, and 90.6% at 2 years during a median follow-up of 12 months (range, 2-37). The log-rank test indicated no difference in the distribution of LC for any clinical or treatment variable. PFS was 86.7% at 6 months, 66.6% at 1 year, and 58.5% at 2 years. OS was 81% at 6 months, 63.6% at one year, and 50.7% at 2 years. On the log-rank test, clinical parameters such as control status of primary cancer, presence of extracranial metastases, RTOG-RPA class, GPA group, and ds-GPA group were significantly associated with PFS and OS. Patients presented with grade 1 (19.0%), grade 2 (3.5%) and grade 3 (5.2%) side effects. Radiation necrosis was not observed in any patients. Our current results suggest that frameless hfGKRS for unresected, large METs is a rational alternative in selected patients with promising results.
  • Placeholder
    PublicationMetadata only
    Antibacdus-pan: antibacterial utilization among adult patients at Koc University Hospital before and during COVID-19 pandemic within 12-months period: a hospital pharmacoepidemiology study
    (Wiley, 2022) Gülmez, Sinem Ezgi; Güldan, Mustafa; Uçar, Ege Anıl; Karakuş, Mehmet Batuhan; Şahin, Selin Merve; Şişman, Uluman; Baygül, Arzu Eden; Faculty Member; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 281312; N/A; N/A; N/A; N/A; N/A; 272290
    N/A
  • Thumbnail Image
    PublicationOpen Access
    Antipacdus-pan: antibacterial utilization among adult patients before and during COVID-19 Pandemic within 12-months period: a tertiary hospital pharmacoepidemiology study
    (Design Oriented Community (DOC), 2022) Uçar, Ege Anıl; Karakuş, Mehmet Batuhan; Güldan, Mustafa; Şahin, Selin Merve; Şişman, Uluman; Baygül, Arzu Eden; Gülmez, Sinem Ezgi; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; N/A; N/A; N/A; N/A; 272290; 281312
    Objective: irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH). Materials and methods: this cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ? 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method. Results: finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%. Conclusion: there is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance.