Researcher:
Akcan, Uğur

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PhD Student

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Uğur

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Akcan

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Akcan, Uğur

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2017 - 201962020 - 20226

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Researcher Of Publications: search.filters.isAuthorOfPublication.1446cba3-d645-49fb-963c-6674cdb2e652

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Now showing 1 - 10 of 12
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    The effects of histamine receptor antagonists and RhoA inhibitor on histamine-induced blood-brain barrier disruption
    (Wiley, 2022) Polat, Fidan Şeker; Yılmaz, Canan Uğur; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Department of Chemistry; Akcan, Uğur; Temizyürek, Arzu; Özen, Deniz; Demirci, Gözde; Akbulak, İrem; Üzbe, Ayşe Selin; Üzbe, Pakize Pelin; Acar, Havva Funda Yağcı; Kaya, Mehmet; Ahıshalı, Bülent; PhD Student; Other; Other; Master Student; Master Student; Other; Other; Faculty Member; Faculty Member; Faculty Member; Department of Chemistry; Graduate School of Health Sciences; School of Medicine; N/A; Graduate School of Sciences and Engineering; N/A; N/A; N/A; College of Sciences; School of Medicine; School of Medicine; Koç University Hospital; N/A; 357912; N/A; N/A; N/A; N/A; N/A; 178902; 10486; 9509
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    Blood-brain barrier dynamics of nanotechnological drug carriers in animal model of temporal lobe epilepsy
    (2017) Yılmaz, Canan Uğur; Orhan, Nurcan; Temizyürek, Arzu; Arıcan, Nadir; Küçük, Mutlu; Gürses, Candan; Ahıshalı, Bülent; Emik, Serkan; N/A; N/A; Department of Chemistry; N/A; Atış, Müge; Akcan, Uğur; Khodadust, Rouhollah; Kaya, Mehmet; PhD Student; PhD Student; Other; Faculty Member; Department of Chemistry; Graduate School of Health Sciences; Graduate School of Health Sciences; College of Sciences; School of Medicine; Koç University Hospital; 346431; N/A; N/A; 10486
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    The strategies of drug targeting into the brain through the blood-brain barrier in drug-resistant epilepsy
    (Wiley, 2019) Yılmaz, Canan Uğur; Emik, Serkan; Orhan, Nurcan; Arican, Nadir; Temizyürek, Arzu; Ahıshalı, Bülent; Akcan, Uğur; Atış, Müge; Gürses, Rabia Candan; Kaya, Mehmet; Other; Faculty Member; PhD Student; PhD Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; 357912; 9509; N/A; 346431; 110149; 10486
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    Targeting the blood–brain barrier disruption in hypertension by ALK5/TGF-В type I receptor inhibitor SB-431542 and dynamin inhibitor dynasore
    (Elsevier, 2022) Ayvaz, Ecem; Yılmaz, Canan Uğur; Girouard, Helene; Atış, Müge; Akcan, Uğur; Altunsu, Deniz; Sarıkaya, Deniz; Temizyürek, Arzu; Ahıshalı, Bülent; Kaya, Mehmet; PHD Student; PHD Student; PHD Student; Undergraduate Student; Other; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 9509; 10486
    Introduction: In this study, we aimed to target two molecules, transforming growth factor-beta (TGF-beta) and dynamin to explore their roles in blood-brain barrier (BBB) disruption in hypertension. Methods: For this purpose, angiotensin (ANG) II-induced hypertensive mice were treated with SB-431542, an inhibitor of the ALK5/TGF-beta type I receptor, and dynasore, an inhibitor of dynamin. Albumin-Alexa fluor 594 was used to assess BBB permeability. The alterations in the expression of claudin-5, caveolin (Cav)-1, glucose transporter (Glut)-1, and SMAD4 in the cerebral cortex and the hippocampus were evaluated by quantification of immunofluorescence staining intensity.Results: ANG II infusion increased BBB permeability to albumin-Alexa fluor 594 which was reduced by SB431542 (P < 0.01), but not by dynasore. In hypertensive animals treated with dynasore, claudin-5 immunofluorescence intensity increased in the cerebral cortex and hippocampus while it decreased in the cerebral cortex of SB-431542 treated hypertensive mice (P < 0.01). Both dynasore and SB-431542 prevented the increased Cav-1 immunofluorescence intensity in the cerebral cortex and hippocampus of hypertensive animals (P < 0.01). SB431542 and dynasore decreased Glut-1 immunofluorescence intensity in the cerebral cortex and hippocampus of mice receiving ANG II (P < 0.01). SB-431542 increased SMAD4 immunofluorescence intensity in the cerebral cortex of hypertensive animals, while in the hippocampus a significant decrease was noted by both SB-431542 and dynasore (P < 0.01).Conclusion: Our data suggest that inhibition of the TGF beta type I receptor prevents BBB disruption under hypertensive conditions. These results emphasize the therapeutic potential of targeting TGF beta signaling as a novel treatment modality to protect the brain of hypertensive patients.
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    The effects of the methyl-beta-cyclodextrin and myriocin on blood-brain barrier integrity in septic rats
    (Wiley, 2019) Yılmaz, Canan Uğur; Orhan, Nurcan; Kotil, Tuğba; Arıcan, Nadir; N/A; Akcan, Uğur; Atış, Müge; Sarıkaya, Deniz; Ahıshalı, Bülent; Kaya, Mehmet; PhD Student; PhD Student; Undergraduate Student; Faculty Member; Faculty Member; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; 346431; N/A; 9509; 10486
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    Blood brain barrier dynamics and antiepileptogenic effects of antiepileptic drug-bound nanoparticle in WAG/Rij rats as a genetic absence epilepsy model
    (Wiley, 2019) Yılmaz, Canan Uğur; Orhan, Nurcan; Arican, Nadir; Temizyürek, Arzu; Akcan, Uğur; Atış, Müge; Ahıshalı, Bülent; Kaya, Mehmet; Other; PhD Student; PhD Student; Faculty Member; Faculty Member; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; 357912; N/A; 346431; 9509; 10486
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    Blood-brain barrier dynamics of nanotechnological drug carriers in animal model of temporal lobe epilepsy
    (Wiley, 2018) Yilmaz, C. U.; Orhan, N.; Temizyurek, A.; Arican, N.; Kucuk, M.; Gurses, C.; Ahishali, B.; Emik, S.; N/A; N/A; N/A; Department of Chemistry; Atış, Müge; Akcan, Uğur; Kaya, Mehmet; Khodadust, Rouhollah; PhD Student; PhD Student; Faculty Member; Other; Department of Chemistry; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; College of Sciences; 346431; N/A; 10486; N/A
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    Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats
    (Elsevier, 2020) Yılmaz, Canan Uğur; Emik, Serkan; Orhan, Nurcan; Arican, Nadir; Küçük, Mutlu; N/A; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; Temizyürek, Arzu; Atış, Müge; Akcan, Uğur; Khodadust, Rouhollah; Gürses, Rabia Candan; Ahıshalı, Bülent; Kaya, Mehmet; Other; PhD Student; PhD Student; Other; Faculty Member; Faculty Member; Faculty Member; Department of Chemistry;  Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; College of Sciences; School of Medicine; School of Medicine; School of Medicine; 357912; 346431; N/A; N/A; 110149; 9509; 10486
    Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and currently available drugs may fail to provide a thorough treatment of the patients. The present study demonstrates the utility of glucose-coated gold nanoparticles (GNPs) as selective carriers of an antiepileptic drug, lacosamide (LCM), in developing a strategy to cross the blood-brain barrier to overcome drug resistance. Intravenous administration of LCM-loaded GNPs to epileptic animals yielded significantly higher nanoparticle levels in the hippocampus compared to the nanoparticle administration to intact animals. The amplitude and frequency of EEG-waves in both ictal and interictal stages decreased significantly after LCM-GNP administration to animals with TLE, while a decrease in the number of seizures was also observed though statistically insignificant. In these animals, malondialdehyde was unaffected, and glutathione levels were lower in the hippocampus compared to sham. Ultrastructurally, LCM-GNPs were observed in the brain parenchyma after intravenous injection to animals with TLE. We conclude that glucose-coated GNPs can be efficient in transferring effective doses of LCM into the brain enabling elimination of the need to administer high doses of the drug, and hence, may represent a new approach in the treatment of drug-resistant TLE.
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    Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in acute hypertension induced by angiotensin-II
    (Wiley, 2017) Yılmaz, Canan Uğur; Orhan, Nurcan; Arican, Nadir; Ahishali, Bülent; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Atış, Müge; Akcan, Uğur; Düzgün, Poyraz; Ceylan, Umut Deniz; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Kaya, Mehmet; PhD Student; PhD Student; Undergraduate Student; Undergraduate Student; Faculty Member; PhD Student; Faculty Member; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; Graduate School of Health Sciences; School of Medicine; 346431; N/A; N/A; N/A; 110772; N/A; 10486
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    IgG-Conjugated gold nanoparticles restore blood-brain barrier damage in both in vitro and in vivo models of sepsis
    (Wiley, 2022) Esen, Figen; Orhun, Gunseli; Ozcan, Perihan Ergin; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; N/A; N/A; N/A; Akcan, Uğur; Çavuşlar, Özge; Acar, Havva Funda Yağcı; Temizyürek, Arzu; Bakbak, Haşim; Altunsu, Deniz; Ayvaz, Ecem; Ahıshalı, Bülent; Kaya, Mehmet; PhD Student; PhD Student; Faculty Member; Other; Doctor; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Chemistry; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; College of Sciences; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; 178902; 357912; N/A; N/A; N/A; 9509; 10486
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