Researcher:
Dilege, Şükrü

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Şükrü

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Dilege

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Dilege, Şükrü
Dilege, Mustafa Şükrü

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Now showing 1 - 10 of 33
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    Publication
    The practice of antimicrobial stewardship in thoracic surgery and its effectiveness
    (Doc Design Informatics Co Ltd, 2024) Cesur, Ekin Ezgi; Pala, Selin; Madran, Bahar; Keske, Şiran; Tanju, Serhan; Dilege, Şükrü; Ergönül, Önder; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); Graduate School of Health Sciences; School of Medicine
    This study examines the effects of the bundle of antimicrobial stewardship measures for prophylactic antibiotics among thoracic surgery patients. A local protocol, based on current guidelines starting from December 2014, was developed by the Infection Control and Thoracic Surgery Teams. The effects of this protocol were assessed by monitoring a total of 1380 patients before and after its implementation from January 1, 2011, to December 31, 2022.
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    Extracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasiveness
    (Wiley, 2024) Arlov, Oystein; Cunningham, Katherine; Vunjak-Novakovic, Gordana; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Kızılel, Seda; Kuşoğlu, Alican; Örnek, Deniz; Dansık, Aslı; Özkan, Sena Nur; Sarıca, Sevgi; Yangın, Kardelen; Özdinç, Şevval; Solcan, Nuriye; Doğanalp, Efe Can; Karaoğlu, İsmail Can; Solaroğlu, İhsan; Bulutay, Pınar; Fırat, Pınar Arıkan; Erus, Suat; Tanju, Serhan; Dilege, Şükrü; Tunçbağ, Nurcan; Öztürk, Ece; Uzun, Ceren; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; School of Medicine
    Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kinase (RTK) activation via their sulfated glycosaminoglycan (sGAG) side chains. However, their role on tumor cell behavior is controversial. Here, it is demonstrated that PGs are heavily expressed in lung adenocarcinoma (LUAD) patients in correlation with invasive phenotype and poor prognosis. A bioengineered human lung tumor model that recapitulates the increase of sGAGs in tumors in an organotypic matrix with independent control of stiffness, viscoelasticity, ligand density, and porosity, is developed. This model reveals that increased sulfation stimulates extensive proliferation, epithelial-mesenchymal transition (EMT), and stemness in cancer cells. The focal adhesion kinase (FAK)-phosphatidylinositol 3-kinase (PI3K) signaling axis is identified as a mediator of sulfation-induced molecular changes in cells upon activation of a distinct set of RTKs within tumor-mimetic hydrogels. The study shows that the transcriptomic landscape of tumor cells in response to increased sulfation resembles native PG-rich patient tumors by employing integrative omics and network modeling approaches.
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    Publication
    Is alveolar spread may be predictive with PET CT scanning?
    (Elsevier Science inc, 2017) Zeren, Handan; Selçukbiricik, Fatih; Mandel, Nil Molinas; Tanju, Serhan; Falay, Fikri Okan; Bulutay, Pınar; Zeren, Emine Handan; Erus, Suat; Dilege, Şükrü; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; N/A; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; 202015; 194197; 214690; 246484; 133565; N/A; 175565; 22573
    Background: In this study we aim to investigate predictability of alveolar spread in primary lung cancer by using preoperatively scanning methods. Method: In order to re-evaluate alveolar spread, pathology preparations of 45 patients had operated for primary lung cancer diagnosis and scanned preoperatively with PET CT all in our hospital which interpreted by same nuclear medicine specialists implicated in this study. As using the patients pet CT findings, CTV (computerized tomography volume), MTV (metabolic tumor volume), TLG(total lesion glycolysis), SUDmax, SUDort values and their relation with alveolar spread analyzed. Result: Preoperatively PET-CT scanned all in our hospital 45 patients has included and cause of couldn't reach their pathological preparations, 6 of them exluded from the study. 21 of 39 patients were men (53.8%) , 18 of them were women (46.2%) and mean age was 66.67/+-7.88 (42-80). We didn't detect any relation between CTV, MTV, TLG, SUDmax, SUDort values and alveolar spread (p>0.05). However when the CTV/ MTV ratio analyzed, alveolar spread was statistically more common in the group of patients had ratio lower than 1. (62.9% versus 0%, p:0.01). Conclusion: High local recurrence risk in sublober rejected patients with alveolar spread has indicated in various studies. Regarding this matter, we recommend re-evaluation of the patients for sublober rejections whose CTV/MTV ratio is lower than 1.
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    Relation of visceral pleura invasion with hilar lymph node involvement and survival in primary lung cancer
    (Elsevier Science Inc, 2015) Bayrak, Yusuf; Tanju, Serhan; Erus, Suat; Mandel, Nil Molinas; Dilege, Şükrü; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 214690; 175565; 194197; 122573
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    The role of adjuvant chemotherapy in resected stage I non - small cell lung cancer: a Turkish Oncology Group Study
    (Imprimatur Publications, 2021) Ak, Naziye; Özkan, Berker; Yenigün, Mustafa B.; Yılmazbayhan, Dilek; Toker, Alper; Ferhatoğlu, Ferhat; Yaşar, Arzu; Sak, Serpil Dizbay; Kılıçkap, Sadettin; Önder, Sevgen; Dikmen, Erkan; Alan, Özkan; Yumuk, Perran F.; Bozkurtlar, Emine; Laçin, Tunç; Yıldızeli, Bedrettin; Özturk, Akın; Ürer, Nur; Oyan, Başak; Aydıner, Adnan; Demirkazık, Ahmet; Eralp, Yeşim; Kocatürk, Celalettin; Karapınar, Kemal; Tanju, Serhan; Dilege, Şükrü; Erus, Suat; Bulutay, Pınar; Fırat, Pınar Arıkan; Mandel, Nil Molinas; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 214690; 122573; 175565; 133565; 207545; 194197
    Purpose: The benefit of adjuvant chemotherapy for tumors smaller than 4 cm is not clear. We aimed to evaluate the prognostic impact of adjuvant platin-based chemotherapy in high-risk stage I patients with non-small cell lung cancer (NSCLC). Methods: This cooperative group study included 232 NSCLC patients who underwent curative surgery for stage I disease with tumor size 2-4 cm. Results: Median age at presentation was 63 years (range 18-90). The mean tumor size was 29.6 +/- 7.3 mm. The frequency of patients with specified risk factors were: visceral pleural effusion (VPI): n: 82 (36.6%); lymphovascular invasion (LVI): n: 86 (39.1%); Grade 3: n: 48 (32.7%); Solid micropapillary pattern (SMP): n: 70 (48.3%). Adjuvant platin-based chemotherapy was administered to 51 patients. During a median follow-up period of 50.5 months 68 patients (29.3%) developed recurrence, 54 (23.3%) died from any cause and 38 (16.4%) of them died of lung cancer. Patients who received chemotherapy compared with the non-chemotherapy group had a longer 5-years relapse-free survival (RFS) (84.5 vs. 61.1%). Also on multivariate analysis, adjuvant chemotherapy was a significant independent prognostic factor for RFS. Conclusion: Adjuvant platin-based chemotherapy should be considered for patients with small tumors with adverse risk factors.
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    Video-assisted thoracoscopic pleurectomy in spontaneous pneumothorax surgery
    (Aves, 2015) Dadaş, Erdoğan; Özkan, Berker; Sabuncu, Timuçin; Tanju, Serhan; Toker, Alper; N/A; Dilege, Şükrü; Faculty Member; School of Medicine; 122573
    OBJECTIVES: Published experiences with thoracoscopic apical or total pleurectomy for patients with a pneumothorax are limited. We aimed to evaluate the long-term results and effectiveness of pleurectomy in our patients, that vast majority of whom underwent thoracoscopic apical or total pleurectomy. MATERIAL and METHODS: Between January 2001 and December 2010, in the Istanbul University Medical School Department of Thoracic Surgery, 67 patients, consisting of 52 patients with a primary spontaneous pneumothorax and 15 with a secondary spontaneous pneumothorax who underwent 72 processes of thoracoscopic resection of blebs or bullae and pleural symphysis, consisting of 43% total pleurectomy, 42% apical pleurectomy plus pleural abrasion, and 15% non-pleurectomy pleurodesis procedures due to prolonged air leak or recurrent spontaneous pneumothorax, were analyzed retrospectively. The applied pleural procedures were: 1. total pleurectomy 2. apical pleurectomy and pleural abrasion for the remaining parts and 3. non-pleurectomy pleurodesis procedures. The long-term outcomes of patients undergoing the three different pleural procedures were compared. RESULTS: Total pleurectomy process, apical pleurectomy and abrasion process for remaining parietal pleura, and non-pleurectomy pleurodesis procedures were performed 31, 30, and 11 times, respectively. No recurrence was observed in the total pleurectomy group, 1 recurrence was observed for the apical pleurectomy plus pleural abrasion group, and 2 recurrences were observed for the non-pleurectomy group. CONCLUSION: Video-assisted thoracoscopic pleurectomy is a safe and effective method in spontaneous pneumothorax surgery. Especially, total pleurectomy has efficient results in the prevention of recurrences.
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    Surgical staging and advanced surgical techniques in early stage non-small cell lung cancers
    (Springer, 2016) Bayrak, Yusuf; N/A; N/A; N/A; Dilege, Şükrü; Tanju, Serhan; Erus, Suat; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 122573; 214690; 175565
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    Scrape cytology and radiological solid size correlation can be used in the intraoperative management of subsolid lung nodules
    (Wiley) N/A; N/A; N/A; N/A; N/A; N/A; Bulutay, Pınar; Atasoy, Kayhan Çetin; Erus, Suat; Tanju, Serhan; Dilege, Şükrü; Fırat, Pınar Arıkan; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 133565; 189220; 175565; 214690; 122573; 207545
    Background: The term radiologic subsolid lung nodule (SLN) represents a heterogeneous group of non-neoplastic and neoplastic lesions. Intraoperative evaluation (IO) is often required to differentiate and diagnose. The current study aims to investigate the feasibility and reliability of scrape cytology (SC) and radiologic solid size correlation for the IO diagnosis of SLNs.Methods: Sixty-eight patients with SLN signs were eligible to take part in the study due to intraoperatively prepared SC slides. We managed to complete the blind radio logic solid size measurement and cytologic evaluation retrospectively. Cases were grouped into three categories based on their cytological features: Group-0 (Benign), Group-1 (mild atypical features), and Group-2 (severe atypical features/unequivocally carcinoma). IO diagnoses were given by combining the radiologic solid size and cytological findings.Results: Cytological features of Group-1 were observed in 100%, 93%, 32.5%, and 17% of the AIS, MIA, IA, and benign lesions, respectively. Cytological features of Group-2 were observed in 67.5%, and 7% of the IA and MIA, respectively. By combining cytology with radiologic solid size, 100%, 85%, 71%, and 83% of the AIS, IA, MIA, and benign lesions respectively were diagnosed correctly. Fifteen (15%) percent of the IA cases were underdiagnosed as MIA since their radiological solid sizes were less than 0.5 cm with cytological features of Group-1. Conversely, 29% of the MIA cases were overdiagnosed as IA since their radiological solid sizes were greater than 0.5 cm. Conclusion: SLNs should be handled with caution in terms of IO management. SC and radiologic solid size correlation both provide a practical and tissue-protecting approach for the IO evaluation of SLNs, ensuring a high consistency between IO and definitive diagnosis.
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    Could fifty percent tumor viability be a good prognostic factor?
    (Elsevier Science Inc, 2022) Cesur, Ekin Ezgi; Özer, Kadir Burak; Mandel, Nil Molinas; N/A; Erus, Suat; Bulutay, Pınar; Selçukbiricik, Fatih; Tanju, Serhan; Fırat, Pınar Arıkan; Dilege, Şükrü; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 175565; 133565; 202015; 214690; 207545; 122573
    N/A
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    18F-FDG PET/CT imaging in a patient with a rare diagnosis of sarcomatoid malignant peritoneal mesothelioina
    (Lippincott Williams & Wilkins, 2013) Tokmak, Handan; Demirkol, Onur M.; Kaban, Kerim; N/A; Mandel, Nil Molinas; Dilege, Şükrü; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 194197; 122573
    Malignant peritoneal mesothelioma is an uncommon but deadly disease arising from serosal surfaces of the peritoneum. Asbestos exposure is the most recognized risk factor. We report a case of diffuse, sarcomatoid malignant peritoneal mesothelioma who presented to the hospital with abdominal pain. The patient had an abdominal MRI scan as initial scanning which demonstrated nonspecific findings suspected of peritoneal carcinomatosis. The patient was admitted to our department for the metabolic characterization of the lesions with F-18-FDG PET/CT imaging and the diagnosis of the primary malignancy. F-18-FDG PET/CT imaging revealed diffusely increased metabolic activity throughout the peritoneum and the histopathological features were compatible with sarcomatoid malignant peritoneal mesothelioma.