Researcher:
Özata, İbrahim Halil

Loading...
Profile Picture
ORCID

Organizational Unit

Job Title

Teaching Faculty

First Name

İbrahim Halil

Last Name

Özata

Name

Name Variants

Özata, İbrahim Halil

Email Address

Birth Date

Search Results

Now showing 1 - 10 of 13
  • Placeholder
    Publication
    Impact of Indocyanine Green Angiography on postoperative parathyroid function: a propensity score matching study
    (MDPI, 2024) Karahan, Salih Nafiz; Toprak, Safa; Çelik, Burak; Özata, İbrahim Halil; Yığcı, Defne; Kalender, Mekselina; Tezelman, Tevfik Serdar; Ağcaoğlu, Orhan; School of Medicine; Koç University Hospital
    Background: Thyroidectomy constitutes an important portion of endocrine surgery procedures and is associated with various complications such as bleeding, recurrent laryngeal nerve injury, and postoperative hypoparathyroidsm. Effective parathyroid preservation during thyroid surgery is crucial for patient well-being, with current strategies heavily reliant on surgeon experience. Among various methods, Indocyanine Green Angiography (ICGA) offers a promising method for intraoperative assessment of parathyroid gland perfusion. Methods: In a retrospective study, patients undergoing bilateral thyroidectomy from January 2021 to January 2023 were analyzed, excluding those with previous thyroidectomy, parathyroid disease, or chronic kidney disease. The study compared a control group (n = 175) with an ICGA group (n = 120), using propensity score matching for statistical analysis. Matched cohorts included 120 patients in each group. The primary outcome of this study was identified as temporary postoperative hypoparathyroidism, with secondary outcomes including the rate of parathyroid reimplantation and the incidence of permanent postoperative hypoparathyroidism. Results: The ICGA group showed significantly more parathyroid autotransplantations (p < 0.01). While not statistically significant, the control group had a higher incidence of temporary postoperative hypoparathyroidism (p < 0.09). Rates of hypocalcemia on postoperative day 1 and permanent hypocalcemia were similar. Subgroup analysis indicated more postoperative day 1 hypoparathyroidism in the control group during central neck dissections (p < 0.049). Conclusions: Intraoperative ICGA use correlated with higher parathyroid autotransplantation and suggested reduced postoperative hypoparathyroidism. Changes in fluorescence intensity following a second ICG injection may provide an objective method to assess parathyroid perfusion. Further large-scale studies are needed to fully understand ICGA's impact on parathyroid preservation.
  • Placeholder
    Publication
    Multimodal assessment after total neoadjuvant therapy versus standard neoadjuvant chemoradiotherapy in locally advanced rectal cancer accurately predicts complete responders
    (Springer, 2023) Gürbüz, Bülent; Özoran, Emre; Özata, İbrahim Halil; Uymaz, Derya Salim; Omarov, Nail; Bozkurt, Emre; Tüfekçi, Tutku; Karahan, Salih Nafiz; Selçukbiricik, Fatih; Bölükbaşı, Yasemin; Taşkın, Orhun Çığ; Gürses, Bengi; Rencüzoğulları, Ahmet; Buğra, Dursun; Balık, Emre; School of Medicine; Koç University Hospital
    Purpose This study aimed to compare local regrowth rates after total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (SNCRT) in locally advanced rectal cancer (LARC) patients that were strictly selected and assessed with a multimodal approach. Secondary outcomes were 4-year disease-free (DFS) and overall survival (OS) rates.Methods Locally advanced rectal cancer patients without distant metastases treated at Koc Healthcare Group between January 2014 and January 2021 were included. Patients were assessed for complete response with a combination of digital rectal exam, endoscopy, and magnetic resonance imaging with a dedicated rectum protocol. The systemic evaluation was performed with an upper abdomen MRI using intravenous hepatobiliary contrast agent and a thorax CT.Results Of the 270 patients with LARC, 182 fulfilled the inclusion criteria. Ninety-seven (53.3%) underwent TNT, while 85 (46.7%) underwent SNCRT. A cumulative combination of pathological and sustained clinical complete response was significantly higher in the TNT group than in the SNCRT (45.4% vs. 20.0%, p < 0.0001). After a median follow-up of 48 months, seven patients in the W & W group had regrowth [TNT: 4 (10.8%) vs. SNCRT: 3 (23.1%), p = 0.357]. Based on pathological examination, complete/near complete mesorectum rates (p = 1.000) and circumferential resection margin positivity rates (p = 1.000) were similar between the groups. The 4-year DFS and OS rates were comparable. The patients with clinical or pathological complete response had significantly longer overall survival (p = 0.017) regardless of the type of neoadjuvant treatment.Conclusions Multimodal assessment after TNT effectively detects complete responders, resulting in low local recurrence and increased cumulative complete response rates. However, these outcomes did not translate into a survival advantage.
  • Placeholder
    Publication
    Reply
    (Lippincott Williams & Wilkins, 2023) Zenger, Serkan; Gürbüz, Bülent; Can, Uğur; Erginöz, Ergin; Kulle, Cemil Burak; Özata, İbrahim Halil; Balık, Emre; Buğra, Dursun; School of Medicine
  • Placeholder
    Publication
    Performance of CT in the locoregional staging of colon cancer: detailed radiology-pathology correlation with special emphasis on tumor deposits, extramural venous invasion and T staging
    (Springer, 2024) Karahacıoğlu, Duygu; Taşkın, Orhun Çığ; Esmer, Rohat; Armutlu, Ayşe; Saka, Burcu; Özata, İbrahim Halil; Rencüzoğulları, Ahmet; Buğra, Dursun; Balık, Emre; Adsay, Nazmi Volkan; Gürses, Bengi; School of Medicine; Koç University Hospital
    Purpose To investigate the performance of computed tomography (CT) in the local staging of colon cancer in different segments, with emphasis on parameters that have been found to be significant for rectal cancer, namely, extramural venous invasion (EMVI) and tumor deposits (TDs). Methods CT and pathology data from 137 patients were independently reviewed by radiology and pathology teams. The performance of CT in categorizing a given patient into good, versus poor prognostic groups was assessed for each segment, as well as the presence of lymph nodes (LNs), TDs and EMVIs. Discordant cases were re-evaluated to determine potential sources of error. Elastic stain was applied for EMVI discordance. Results The T staging accuracy was 80.2%. For T stage stratification, CT performed slightly better in the left colon, and the lowest accuracy was in the transverse colon. Under-staging was more common (in 12.4%), and most of the mis-staged cases were in sigmoid colon. According to the first comprehensive correlative analysis, the sensitivity, specificity, and accuracy of CT for detecting TDs were found to be 57.9%, 92.4%, 87.6%, respectively. These figures were 44.7%, 72.7%, and 63.5% for LN, and 58.5%, 82.1% and 73% for EMVI. The detection rate was better for multifocal EMVI. The detection rate was also comparable (although substantially underestimated) for LNs, with the half of the LNs missed by CT being < 5 mm. Four patients that were classified as TD by CT, disclosed to be LNs by pathology. Correlative analysis led to refinement of the pathology criteria, with subsequent modifications of the initial reports in 13 (9.5%) patients. Conclusion Overall, CT performed well in the evaluation of colon cancer, as did TD and EMVI. It is advisable to include these parameters in CT-based staging. Radiologists should be aware of the pitfalls that occur more commonly in different segments.
  • Placeholder
    Publication
    Right paraduodenal hernia accompanying superior mesenteric vein thrombosis: a rare case
    (Bmj Publishing Group, 2021) N/A; N/A; Omarov, Nail; Özata, İbrahim Halil; Balık, Emre; Doctor; Teaching Faculty; Faculty Member; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 177151; 18758
    A 59-year-old man with abdominal pain was admitted to the emergency department. Investigations had revealed a right-sided paraduodenal hernia and superior mesenteric vein (SMV) twisting around the superior mesenteric artery in rotation, the 'whirlpool sign'. Owing to the increasing severity of abdominal pain and the presence of SMV thrombosis complicated with strangulated paraduodenal herniation associated with high mortality rates, diagnostic laparoscopy was performed. Resection of the intestines was not needed and paraduodenal hernia was repaired. The patient was uneventfully discharged.
  • Placeholder
    Publication
    Author reply
    (Lippincott Williams and Wilkins (LWW), 2023) Zenger, Serkan; Gürbüz, Bülent; Can, Ugur; Erginoz, Ergin; Kulle, Cemil Burak; N/A; Özata, İbrahim Halil; Balık, Emre; Buğra, Dursun; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 177151; 18758; 1758
    N/A
  • Placeholder
    Publication
    Role of emotion regulation and fear of compassion on depression and anxiety in patients with colorectal cancer
    (Kartal Eğitim ve Araştırma Hastanesi, 2022) Kılıç, Özge; Dikmen, Yasemin; N/A; Özata, İbrahim Halil; Yalçınay-İnan, Merve; Tüfekçi, Tutku; Ağcaoğlu, Orhan; Kuşçu, Kemal; Balık, Emre; Teaching Faculty; Doctor; Researcher; Faculty Member; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; 177151; N/A; 327608; 175476; N/A; 18758
    INTRODUCTION: Maladaptive emotion regulation (ER) styles act as transdiagnostic mechanisms that underlie many psychiatric symptoms linked to cancer. ER and fear of compassion (FC) were studied in breast cancer, but their effects on psychiatric symptoms of colorectal cancer (CRC) patients are not studied. We aim to examine the role of ER and FC on depression and anxiety in Turkish CRC patients. METHODS: This observational, cross-sectional study recruited 38 patients with CRC who were being followed up by the general surgery department of a university hospital. Emotion Regulation Questionnaire, Fear of Compassion Scale, the Exercise of Self-care Agency Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Numeric Pain Intensity Scale, and Ostomy Adjustment Inventory were applied. Multiple regression analyses were performed to identify factors affecting depression and anxiety levels. RESULTS: Twenty-nine men and 9 women (median age=56.5, 28–69), most of whom were married and highly educated, were recruited. Expressive suppression (p=0.013) and pain (p=0.010) positively (Model, R2=0.42, p<0.001) and self-care agency (p=0.021) negatively influenced anxiety levels. Expressive suppression (p=0.017) and male gender (p=0.020) positively influenced depression levels (Model, R2=0.28, p=0.003). There was no association between cognitive reappraisal and levels of depression and anxiety. Among ostomates (n=17), 11 patients had low and 6 patients had medium adaptation to an active ostomy. No patient exhibited high adjustment to an ostomy. DISCUSSION AND CONCLUSION: Findings indicate that in CRC patients, expressive suppression affects levels of anxiety and depression while cognitive reappraisal does not. FC was not found to be related to anxiety and depression. Physicians should carefully observe the patients’ and the caregivers’ ER strategies and the dynamic and interactive psychological states to understand which patients need psychological and psychiatric interventions. We suggest future studies explore the interventions that target expressive suppression patterns to prevent anxiety and depression in CRC patients. / GİRİŞ ve AMAÇ: Uyumsal olmayan emosyon düzenleme biçimleri, kanserle ilişkili psikiyatrik belirtilerin altında yatan tanılar üstü mekanizmalar olarak rol oynar. Emosyon düzenleme ve şefkat korkusu meme kanseri hastalarında incelenmiştir ancak kolorektal kanser hastalarında psikiyatrik belirtiler üzerine etkileri araştırılmamıştır. Emosyon düzenleme ve şefkat korkusunun depresyon ve anksiyete üzerindeki rolünü Türk kolorektal kanser hastalarında incelemeyi amaçladık. YÖNTEM ve GEREÇLER: Bu gözlemsel, kesitsel çalışmaya, bir üniversite hastanesinin genel cerrahi bölümü tarafından takip edilen 38 kolorektal kanser hastası alındı. Emosyon Düzenleme Ölçeği, Şefkat Korkusu Ölçeği, Özbakım Gücü Ölçeği, Hastane Anksiyete ve Depresyon Ölçeği, Distres Termometresi, Sayısal Ağrı Derecelendirme Ölçeği, ve Stomaya Uyum Envanteri uygulandı. Depresyon ve anksiyeteyi etkileyen faktörleri belirlemek için çoklu regresyon analizleri yapıldı. BULGULAR: Çalışmaya çoğu evli ve yüksek eğitimli (medyan yaş= 56.5, 28–69) olan 29 erkek, 9 kadın alındı. Anksiyete düzeyleri üzerine dışavurumu bastırma (p=0.013) ve ağrının (p=0.010) etkisi pozitif, özbakım gücünün (p=0.02) etkisi negatifti (Model, R2=0.42, p<0.001). Depresyon düzeyleri üzerineyse dışavurumu bastırma (p=0.017) ve erkek cinsiyet (p=0.020) pozitif yönde etki etmekteydi. (Model, R2=0.28, p=0.003). Bilişsel yeniden değerlendirme ile depresyon ve ve anksiyete arasında ilişki saptanmadı. Stomaya uyum aktif stomalı hastaların (n=17) 11’inde düşük, altısında ortaydı. Stomaya yüksek uyum gözlenmedi. TARTIŞMA ve SONUÇ: Sonuçlar, kolorektal kanser hastalarında dışavurumu bastırmanın anksiyete ve depresyon düzeylerini etkilediğini, bilişsel yeniden değerlendirmenin ise bu düzeyleri etkilemediğini göstermiştir. Şefkat korkusu anksiyete ve depresyonla ilişkili bulunmamıştır. Hekimler, hangi hastaların psikolojik veya psikiyatrik müdahaleye ihtiyaç duyduğunu anlamak için hasta ve bakımverenin emosyon düzenleme biçimlerini ve dinamik ve etkileşimli psikolojik durumlarını dikkatle gözlemelidir. Gelecek çalışmaların kolorektal kanser hastalarında anksiyete ve depresyonu önlemek için dışavurumu bastırma paternini hedef alan müdahaleleri araştırmasını öneririz.
  • Placeholder
    Publication
    Is there no need to discuss adjuvant chemotherapy in stage II colon cancer patients with high tumor budding and lymphovascular invasion?
    (Springer Science and Business Media Deutschland GmbH, 2023) Zenger, Serkan; Gurbuz, Bulent; Can, Ugur; Erginoz, Ergin; Peker, Onder; Yilmaz, Serpil Postgil; N/A; Özata, İbrahim Halil; Balık, Emre; Buğra, Dursun; Taşkın, Orhun Çığ; Adsay, Nazmi Volkan; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 177151; 18758; 1758; 166686; 286248
    PURPOSE: The aim of this study is to evaluate the clinicopathologic associations of tumor budding (Bd) as well as other potential prognosticators including lymphovascular invasion (LVI) in T3/4aN0 colon cancer patients and to investigate their impact on the outcome. METHODS: The patients were enrolled in three groups according to the number of budding as Bd1 (0-4 buds), Bd2 (5-9 buds), and Bd3 (> 10 buds). These groups were retrospectively compared in terms of demographic features, other tumor characteristics, operative outcomes, recurrences, and survival. The mean follow-up time was 58 ± 22 months. RESULTS: A total of 194 patients were divided as follows: 97 in Bd1, 41 in Bd2, and 56 in Bd3 groups. The Bd3 group was associated with significantly higher LVI and larger tumor size. The rate of recurrence increased progressively from 5.2% in Bd1 to 9.8% in Bd2 and to 17.9% in Bd3 group (p = 0.03). More importantly, the 5-year overall survival (OS: Bd1 = 92.3% vs. Bd2 = 88% vs. Bd3 = 69.5%, p = 0.03) and disease-free survival (DFS: Bd1 = 87.9% vs. Bd2 = 75.3% vs. Bd3 = 66%, p = 0.02) were significantly worse in Bd3 group. In addition, in the subgroup of patients with the presence of Bd3 and LVI together, the 5-year OS (60% vs. 92%, p = 0.001) and DFS (56.1% vs. 85.4%, p = 0.001) were significantly worse. In multivariate analysis, Bd3+LVI was significantly associated with poor OS and DFS (p < 0.001). CONCLUSION: In patients with T3/4aN0 colon cancer, high tumor budding negatively affects long-term oncological outcomes. These findings strongly suggest that adjuvant chemotherapy be considered for the patients with Bd3 and LVI together.
  • Placeholder
    Publication
    The role of minimally invasive surgery in gastric cancer
    (Cureus Inc, 2021) N/A; N/A; Omarov, Nail; Uymaz, Derya Salim; Azamat, İbrahim Fethi; Özoran, Emre; Özata, İbrahim Halil; Selçukbiricik, Fatih; Taşkın, Orhun Çığ; Balık, Emre; Doctor; Teaching Faculty; Faculty Member; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 175554; 188598; 307296; 177151; 202015; 166686; 18758
    Objective: This study aims to investigate the efficacy and safety of minimally invasive surgery (MIS) in gastric cancer and to compare MIS versus open gastrectomy (OG) in terms of early mortality and morbidity, long-term oncological outcomes, and recurrence rates. Methods: A total of 75 patients who underwent MIS or OG for gastric cancer at Koc University School of Medicine between December 2014 and December 2019 were retrospectively analyzed. Postoperative complications and disease-specific survival were compared between surgical approaches. Results: Of the patients, 44 were treated with MIS and 31 with OG. In the MIS group, 33 patients underwent laparoscopic surgery, and 11 patients underwent robotic gastrectomy. Duration of operation was significantly longer in the MIS group than in the OG group (p<0.0001). The median amount of blood loss was 142.5 (range, 110 to 180) mL in the MIS group and 180.4 (range, 145 to 230) mL in the OG group (p<0.706). The median number of lymph node dissection was 38.9 (range, 15 to 66) and 38.7 (range, 12 to 70) in the MIS and OG groups, respectively (p<0.736). The median length of hospitalization, twelve days in the OG group and nine days in the MIS group. Median follow-up was 19.1 (range, 2 to 61) months in the MIS group and 22.1 (range, 2 to 58) months in the OG group. The median OS and DFS rates were 56.8 months and 39.6 months in the MIS group, respectively (log-rank; p=0.004) and 31.6 months and 23.1 months in the OG group, respectively (log-rank; p=0.003). Conclusion: Our study results suggest that, despite its technical challenges, MIS is an effective and safe method in treating gastric cancer with favorable early mortality and morbidity rates and long-term oncological outcomes, and acceptable recurrence rates.
  • Placeholder
    Publication
    Mid-transverse location in primary colon tumor: a poor prognostic factor?
    (Lippincott Williams and Wilkins (LWW), 2022) Zenger, Serkan; Gürbüz, Bülent; Can, Uğur; Erginöz, Ergin; N/A; Özata, İbrahim Halil; Kulle, Cemil Burak; Balık, Emre; Buğra, Dursun; Teaching Faculty; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; 177151; N/A; 18758; 1758
    BACKGROUND: The location of colonic tumors has been linked to different clinical and oncologic outcomes. Transverse colon cancers are generally included as right colon cancers. Furthermore, hepatic and splenic flexure tumors are usually included as components of the transverse colon. OBJECTIVE: This study was aimed at comparing the clinicopathologic characteristics and long-term outcomes between mid-transverse and right and left colon cancers and determining the prognostic impact of the primary tumor location in the mid-transverse colon. DESIGN: This was a retrospective study. SETTINGS: Two specialized colorectal centers were included. PATIENTS: Patients who underwent curative surgery for colon cancer were analyzed. Tumors located in the transverse colon, excluding the flexures, were defined as mid-transverse colon cancers. MAIN OUTCOME MEASURES: Demographic characteristics, operative outcomes, pathologic results, and long-term outcomes were the primary outcome measures. RESULTS: of the 487 patients, 41 (8.4%) had mid-transverse, 191 (39.2%) had right, and 255 (52.4%) had left colon cancers. For mid-transverse colon cancers, the mean length of hospital stay, mean length of the resected specimen, and the mean number of harvested lymph nodes were significantly higher. For patients with stage I to III cancer, the 5-year overall and disease-free survival rates were significantly worse in the mid-transverse colon cancers than in the right and left colon cancers (overall survival: 55.5% vs 82.8% vs 85.9%, p = 0.004, and disease-free survival; 47.7% vs 72.4% vs 79.5%, p = 0.003). After adjustment for other clinicopathologic factors, mid-transverse colon cancers were significantly associated with a poor prognosis (HR = 2.19 [95% CI, 1.25-3.83]; p = 0.006). LIMITATIONS: Molecular and genetic information were unavailable in this retrospective study. CONCLUSIONS: In our case series, colon cancers located in the mid-transverse colon showed poorer prognosis than cancers in other locations. The impact of tumor location in the mid-transverse colon on prognosis, including molecular and genetic markers, should be investigated further in prospective studies.