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Taşkıran, Çağatay

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Çağatay

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Taşkıran

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Taşkıran, Çağatay

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2014 - 2019402020 - 202334

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    The clinical utility of a pulsed bipolar system and its electrosurgical device during total laparoscopic hysterectomy
    (Mary Ann Liebert, Inc., 2017) N/A; N/A; Mısırlıoğlu, Selim; Türkgeldi, Engin; Boza, Ayşen; Öktem, Özgür; Ata, Mustafa Barış; Urman, Cumhur Bülent; Taşkıran, Çağatay; Doctor; Faculty Member; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 329649; N/A; 102627; 232576; 12147; 134190
    Objective: The aim of this research was to evaluate the efficacy and safety of the PlasmaKinetic (PK) PKS OMNI (R) (Gyrus ACMI, Maple Grove, MN) sealing device in laparoscopic hysterectomy. Materials and Methods: For this retrospective observational study, 60 patients who underwent multiport total laparoscopic hysterectomy between January 2014 and January 2015 in a tertiary-care university-based teaching hospital and an academically affiliated hospital were included in this study. The PKS OMNI is a bipolar electrosurgical device that takes energy from a PK generator workstation G400. This pulsed wave system has two different modes; cutting (High Cut 1,2,3) and coagulation (Vaporization 1,2,3). Results: Records of 60 patients were analyzed. The median age was 50 (range: ages 40-84), median body mass index was 26kg/m(2) (range: 22-32kg/m(2)), and median parity was 2 (range: 1-8). The median total operation time was 100 minutes (range: 70-240 minutes), estimated blood loss was 80mL (range: 30-250mL), and uterine weight was 207g (range: 50-900g). Degree of Surgical Difficulty and postoperative pain scores at rest were evaluated with a visual analogue scale system, from 0 to 10, and the medians of these scores were 5 (range: 3-7) and 4 (range: 2-6), respectively. The median recovery time of bowel movement was 16 hours (range: 8-26 hours), median spontaneous urination time was 7 hours (range: 4-29 hours), and median postoperative mobilization time was 8 hours (range: 6-10 hours). Conversion to laparotomy was needed in 1 patient due to severe pelvic adhesions. The median duration of hospital stay was 2 days (range: 2-4 days). Vaginal cuff dehiscence was detected in 1 (1.7%) patient who engaged in sexual intercourse on the 122nd day after surgery. Cuff cellulitis in 1 (1.7%) patient and unexplained fever in 1 (1.7%) patient were the other recorded complications. The median follow-up time was 12 months (range: 6-17 months). Conclusions: The PKS OMNI is a novel, underused energy modality that promotes quick recovery and acceptable operation time with minimal blood loss.
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    Intraoperative endoscopic ultrasound guidance for laparoscopic excision of invisible symptomatic deep intramural myomas
    (Taylor & Francis Inc, 2018) Boza, Ayşen; Aksu, Sertan; Arslan, Tonguç; Urman, Cumhur Bülent; Ata, Mustafa Barış; Taşkıran, Çağatay; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 12147; 182910; 134190
    The aim of this study was to evaluate the feasibility of intraoperative endoscopic ultrasound guidance for excision of symptomatic deep intramural myomas that are not otherwise visible at laparoscopy. Seventeen patients with symptomatic deep intramural myomas who underwent laparoscopic myomectomy with intraoperative endoscopic ultrasound guidance were followed up and reported. All myomas were removed successfully. The endometrium was breached in one patient. All patients were relieved of their symptoms and three patients presenting with infertility conceived. There were no short- or long-term complications associated with the procedure. One patient who had multiple myomas necessitated intravenous iron treatment prior to discharge. Laparoscopic removal of small symptomatic deep intramural myomas is facilitated by the use of intraoperative endoscopic ultrasound that enables exact localisation and correct placement of the serosal incision. IMPACT STATEMENT What is already known on this subject: When the myoma is symptomatic, compressing the endometrium, does not show serosal protrusion and is not amenable to hysteroscopic resection, laparoscopic surgery may become challenging. What do the results of this study add: The use of intraoperative endoscopic ultrasound under these circumstances may facilitate the procedure by accurate identification of the myoma and correct placement of the serosal incision. What are the implications of these findings for clinical practice and/or further research: Intraoperative ultrasound should be more oftenly used to accurately locate deep intramural myomas to the end of making laparoscopy feasible and possibly decreasing recurrence by facilitating removal of otherwise unidentifiable disease.
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    Complications of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: an evaluation of 100 cases
    (Wiley, 2022) Akıllı, Huseyin; Günakan, Emre; Haberal, Ali; Altundağ, Özden; Kuşçu, Ülkü Esra; Ayhan, Ali; Taşkıran, Çağatay; Faculty Member; School of Medicine; 134190
    Objective: To evaluate the perioperative outcomes and complications of patients with peritoneal carcinomatosis who underwent cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (HIPEC). Methods: This retrospective study included 100 patients operated on between 2016 and 2020. Patients' characteristics, including age, comorbidities, chemotherapy history, treatment failures, cancer type, histology, platinum sensitivity, and perioperative complications, were documented. Perioperative complications were classified according to the Clavien-Dindo classification. Results: Median age was 58 years and median follow-up time was 16 months. Eighty-six (86%) patients had ovarian cancer; 11 (11%) experienced grade III-IV complications, and the only relevant factor was the presence of multiple metastasis (P = 0.031). Seven patients (7%) had surgical-site infection; in multivariant analyses, only ostomy formation was found as an independent risk factor for surgical-site infection (odds ratio [OR] 14.01; 95% confidence interval [CI] 1.36-143.52; P = 0.024). Fifteen (15%) patients experienced elevated serum creatinine after surgery and the median time to creatinine elevation was 5 days postoperatively (range 3-15 days). In multivariant analyses, only age of of 58 years or more was found as a significant factor for the elevation of serum creatinine (OR 6.96; 95% CI 1.42-32.81; P = 0.014). Conclusion: Our results showed that the presence of multiple metastases increased the risk of grade III-IV complications and age of 58 years or more was the leading risk factor for renal complications. However, we could not find a relation between postoperative complications and oncologic outcomes. HIPEC seems to be a safe approach in experienced hands.
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    Diagnostic accuracy of sentinel node biopsy in non-endometrioid, high-grade and/or deep myoinvasive endometrial cancer: a Turkish gynecologic oncology group study (TRSGO-SLN-006)
    (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022) Altın, Duygu; Taşkın, Salih; Ortaç, Firat; Tokgözoğlu, Nedim; Güler, Abdul Hamid; Güngör, Mete; Taşcı, Tolga; Bese, Tugan; Turan, Hasan; Kahramanogğu, İlker; Yalçın, İbrahim; Çelik, Çetin; Demirkıran, Fuat; Köse, Faruk; Arvas, Macit; Ayhan, Ali; Vatansever, Doğan; Taşkıran, Çağatay; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 193687; 134190
    Introduction: This study aimed to evaluate the diagnostic accuracy of the sentinel lymph node (SLN) mapping algorithm in high-risk endometrial cancer patients. Methods: Two hundred forty-four patients with non-endometrioid histology, grade 3 endometrioid tumors and/or tumors with deep myometrial invasion were enrolled in this retrospective, multicentric study. After removal of SLNs, all patients underwent pelvic +/- paraaortic lymphadenectomy. Operations were performed via laparotomy, laparoscopy or robotic surgery. Indocyanine green (ICG) and methylene blue (MB) were used as tracers. SLN detection rate, sensitivity, negative predictive value (NPV) and false-negative rate (FNR) were calculated. Results: Surgeries were performed via laparotomy in 132 (54.1%) patients and 152 (62.3%) underwent both bilateral pelvic and paraaortic lymphadenectomy. At least 1 SLN was detected in 222 (91%) patients. Fifty-five (225%) patients had lymphatic metastasis and 45 patients had at least 1 metastatic SLN. Lymphatic metastases were detected by side-specific lymphadenectomy in 8 patients and 2 patients had isolated paraaortic metastasis. Overall sensitivity, NPV and FNR of SLN biopsy were 81.8%, 95% and 182%, respectively. By applying SLN algorithm steps, sensitivity and NPV improved to 96.4% and 98.9%, respectively. For grade 3 tumors, sensitivity, NPV and FNR of the SLN algorithm were 97.1%, 98.9% and 2.9%. Conclusion: SLN algorithm had high diagnostic accuracy in high-risk endometrial cancer. All pelvic metastases were detected by the SLN algorithm and the isolated paraaortic metastasis rate was ignorable. But long-term survival studies are necessary before this approach becomes standard of care.
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    Laparoscopic removal of bladder from the uterine niche with retrograde dissection
    (Elsevier, 2015) N/A; N/A; Mısırlıoğlu, Selim; Türkgeldi, Engin; Taşkıran, Çağatay; Urman, Cumhur Bülent; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 329649; 134190; 12147
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    Molecular evidence against the preventive actions of GnRH agonists in chemotherapy induced damage in human ovary and granulosa cells
    (2015) Güzel, Y.; Urman, B; N/A; Bildik, Gamze; Akın, Nazlı; Taşkıran, Çağatay; Selek, Uğur; Öktem, Özgür; Teaching Faculty; Master Student; Faculty Member; Faculty Member; Faculty Member; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 134190; 27211; 102627
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    Laparoscopic myomectomy and myoma retrieval without power morcellation
    (Elsevier, 2015) Aksu, Sertan; Ayhan, Cem; N/A; Mısırlıoğlu, Selim; Ata, Mustafa Barış; Urman, Cumhur Bülent; Taşkıran, Çağatay; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 232576; 12147; 134190
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    In-vitro AMH production of ovarian tissue samples in culture correlates with their primordial follicle pool
    (Elsevier, 2020) N/A; N/A; N/A; N/A; N/A; N/A; Vatansever, Doğan; İncir, Said; Bildik, Gamze; Taşkıran, Çağatay; Öktem, Özgür; Faculty Member; Faculty Member; PHD Student; Faculty Member; Faculty Member; School of Medicine; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; 193687; 175430; N/A; 134190; 102627
    Objective: We aimed to investigate if there is a correlation between in-vitro AMH production and primordial follicle reserve of the ovarian cortical samples in culture. Methods: Seven patients undergoing laparoscopic excision of ovarian dermoid cysts were included in the study. 0.5 x 0.5 cm of ovarian cortical samples embedded within the cyst wall were removed and cultured for one day. Then, the cultured cortical pieces were fixed, paraffin-embedded and serially sectioned for histormorphometric analysis. AMH and estradiol (E-2) production of the samples after one-day culture period were measured in the spent culture media. Primordial follicle density was expressed as the number of primordial follicles per mm(2). Pearson correlation and linear regression analyses were applied. Results: The mean age of the patients was 29.2 +/- 6.8 (ranging from 18 to 36). There was a negative correlation between age and PF density (r=-0.92, %95CI: -0.99 to -0.76, p <0.001). In-vitro AMH level of the cortical samples was significantly associated with age (R-2 = 0.67, p = 0.023), primordial follicle density (R-2 = 0.71, p = 0.015). There was a borderline significance between in-vitro levels of AMH and E-2 level (R-2 = 0.55, p = 0.058). A similar comparison could not be made for secondary follicles (preantral and small antral follicles) because of their rarity in the histological sections analyzed. Conclusions: This histomorphometric study provides evidence that in-vitro AMH production of the ovarian cortical samples reflects primordial follicle pool of the samples. (C) 2020 Elsevier B.V. All rights reserved.
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    Deep cervical injection: a novel technique to increase bilateral sentinel lymph node detection rate in endometrial cancer patients with indocyanine green (TRSGO-SLN-008)
    (BMJ Publishing Group, 2022) Altin, Duygu; Taskin, Salih; Tokgozoglu, Nedim; Guler, Abdul Hamid; Tasci, Tolga; Bese, Tugan; Turan, Hasan; Kahramanoglu, Ilker; Yalcin, Ibrahim; Celik, Cetin; Demirkiran, Fuat; Gungor, Mete; Ortac, Firat; Kose, Faruk; Arvas, Macit; Ayhan, Ali; N/A; Taşkıran, Çağatay; Vatansever, Doğan; Giray, Burak; Dönmez, Emin Erhan; Faculty Member; Faculty Member; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 134190; 193687; 316087; 334646
    Objectives: Lymph node assessment provides information that may influence decisions regarding adjuvant treatment in endometrial cancer patients. However, systematic lymphadenectomy may cause significant morbidity. In recent years, the use of sentinel lymph node (SLN) mapping with indocyanine green (ICG) has been accepted to avoid the morbidity of lymphadenectomy. We aimed to assess the diagnostic accuracy of a novel injection technique in detection of sentinel lymph nodes in women with endometrial cancer. Methods: A total of 214 patients with endometrial cancer underwent sentinel lymph node mapping using ICG. ICG was injected into the uterine cervix at the 3 and 9 o’clock positions, submucosally and to the level of junction between uterine cervix and isthmus in group 1(n=107) and to the uterine cervix at the 3 and 9 o’clock positions according to conventional Memorial Sloan Kettering algorithm in group 2(n=107). All the patients in group 2 selected by propensity matching. None of the patients underwent a re-injection neither in group 1 nor group 2. Results: There was no significant difference between baseline characteristics of two groups. The groups were similar in terms of stage, type of tumor, BMI and lymphovascular space invasion. The bilateral detection rates were 94.4% and 76.6% in group 1 and group 2, respectively (p=0.003). No lymph node or lymphatic vessels were identified in only one patient with a history of chronic lymphocytic leukemia in group 1. Conclusions: Deep cervical injection technique significantly increases bilateral SLN detection rate in endometrial cancer patients.
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    Utility of pks omni(®) electrosurgical device in laparoscopic hysterectomy
    (Elsevier, 2015) N/A; Urman, Cumhur Bülent; Mısırlıoğlu, Selim; Bengisu, Hale; Türkgeldi, Engin; Ata, Mustafa Barış; Öktem, Özgür; Taşkıran, Çağatay; Faculty Member; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Doctor; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 12147; N/A; N/A; 329649; 182910; 102627; 134190; N/A
    Study Objective: The aim of this study is to evaluate the efficacy and safety of PKS Omni ® sealing device in laparoscopic hysterectomy. Design: Retrospective, non-randomized observational cohort. Setting: University hospital and academic affiliated private hospital. Patients: Patients with benign diseases undergoing multi-port laparoscopic hysterectomy between 2014 and 2015. Intervention: PKS Omni ® (Gyrus ACMI Inc..,USA) is bipolar electrosurgical device takes the energy from Plasmakinetic generator workstation G400, and this pulsed wave system involves two different modes; cutting (HC 1,2,3) and coagulation (VP1,2,3). We choosed VP3-power level 110 for coagulation and for cutting HC2-power level 50 according to tissue empedance. All the cases in this study were performed with a plasma kinetic energy system, and its electosurgical device PKS Omni ® The surgical operations were carried out by two surgeons who are experienced in gynecologic oncology and advance endoscopic surgery. Measurements and Main Results: Fifty-nine patients were evaluated, and all of the operations were completed by laparoscopy, but one is needed conversion to laparotomy because of severe adhesions between bowel and pelvic viscera. The median operating time was 100 minutes (60-185 min), and estimated blood loss was 20 ml (10-50 ml). Transfusion was not required. Recovery of gastrointestinal activity is occurred at post-operative 16 hour (12-24 houtr). Urinary catheter was not placed pre-or post operative, and spontaneous urinary activity started at 6 hour after operation (4-8 hour). Post-operative abdominal pain at rest was noted due to VAS (visual analog scale) score 0 to 10; 0 referring to no pain and 10 to unbearable pain. VAS score was 2 (0-6), and signified mild pain. Conclusion PKS Omni is a novel, underused energy modality that promotes quick recovery and acceptable operation time with minimal blood loss and excellent post-operative pain scores.