Researcher:
Kızılkan, Nuray Uslu

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Nuray Uslu

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Kızılkan

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Kızılkan, Nuray Uslu

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2016 - 201992020 - 20225

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    Clinical evaluation of dental enamel defects and oral findings in coeliac children
    (Istanbul Univ Press, Istanbul Univ Rectorate, 2018) Bicak, Damla Aksit; Urganci, Nafiye; Akyuz, Serap; Usta, Merve; Alev, Burcin; Yarat, Aysen; N/A; Kızılkan, Nuray Uslu; Faculty Member; School of Medicine; 221274
    Purpose To examine dental hard and soft tissue changes of coeliac children in order to increase the awareness of the pediatric dentists in prediagnosis of especially undiagnosed coeliac disease. Materials and methods Sixty children, 28 (46.7%) boys and 32 (53.3%) girls whose ages were between 6 to 16 years were included in the present study. Thirty children who had undergone endoscopy and diagnosed with the coeliac disease in the Sisli Hamidiye Etfal Hospital, Istanbul, Turkey, formed the study group. Also, thirty children clinically suspected of having the coeliac disease with the same gastrointestinal complaints had undergone endoscopy and proven not coeliac were chosen as the control group. Oral examination involved assessment of dentition and specific and unspecific dental enamel defects. Also, soft tissue lesions, clinical delay of the dental eruption, salivary flow rate, pH, and buffering capacity were examined. Results Twenty coeliac patients had enamel defects, however none in the control subjects. In the coeliac group, all enamel defects were diagnosed in permanent teeth and as specific in all children. Grade I dental enamel defects found mainly in the incisors. The clinical delayed eruption was observed in 10 (33.3%) of 30 coeliac children and none of the children in the control group. While the level of DMFT/S numbers and stimulated salivary flow rate were found significantly lower in the coeliac group, pH was found significantly higher. Conclusion Oral cavity may be involved in coeliac disease and pediatric dentists can play an important role in the early diagnosis of the coeliac disease.
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    A rare cause of chronic hyponatremia in an infant: aldosterone synthase type-2 deficiency
    (Springer, 2018) Güran, Tülay; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Börklü Yücel, Esra; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; N/A; 221274; N/A; 153504; 7945; 198907
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    The relationship between dietary elimination and maternal psychopathology in breastfeeding mothers of infants with food allergy
    (Wiley, 2022) Can, Ceren; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Yılmaz, Özlem; Saçkesen, Cansın; Kaçar, Anıl Şafak; Göğebakan, Emre; Necef, Işıl; Mutluer, Tuba; Taşkıran, Ali Sarper; Kızılkan, Nuray Uslu; Doctor; Faculty Member; PhD Student; Undergraduate Student; Faculty Member; Faculty Member; Other; Faculty Member; N/A; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 140706; 182537; N/A; N/A; N/A; 305311; 195168; 221274
    Background: There has been no study evaluating the psychopathology in breastfeeding mothers of infants with food allergy (FA). Objective: The aim of the study was to investigate the relationship between dietary elimination and maternal psychopathology, specifically anxiety, depression, and mother-to-infant bonding, in breastfeeding mothers of infants with food allergy. Methods: Breastfeeding mothers following an elimination diet due to FA in their children aged 1-to-12 months were compared with the healthy controls. The physician-diagnosed FA group was divided into IgE-, non-IgE-mediated, and infants with some minor symptoms which were not enough to make the diagnosis of FA were classified as Indecisive symptoms for FA group. Mothers completed standardized questionnaires including Symptom Checklist 90R, Beck Depression/Anxiety Inventories (BDI/BAI), Postpartum Bonding Questionnaire (Bonding). Results: Of 179 mother and infants, 64 were healthy, 89 were FA, 16 were indecisive symptoms for FA. The mean age of the mothers and infants were 31.1 ± 4.7 years and 6.3 ± 3.6 months, respectively. The physician-diagnosed FA groups had higher scores for anxiety (p = .008), anger (p = .042), depression (p < .001), obsession (p = .002), phobia (p = .008), somatization (p = .002), general symptom index (GSI) (p = .001), BDI (p < .001), BAI (p = .008), and Bonding (attachment [p = .001], anger [p = .019], and total [p = .036]) than the healthy ones. The indecisive symptoms for FA group had a similar score pattern to physician-diagnosed FA, except interpersonal sensitivity, BDI, and attachment. Conclusion: Breastfeeding mothers of infants with FA were more anxious, with higher depression scores than controls, and had many psychopathologies which affected bonding. Interventions targeting negativity in caregivers' social relationships are urgently needed.
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    Are synbiotics added to the standard therapy to eradicate helicobacter pylori in children beneficial? a randomized controlled study
    (Jaypee Brothers Medical Publishers, 2017) Şirvan, Banu N; Usta, Merve K; Urgancı, Nafiye; N/A; Kızılkan, Nuray Uslu; Faculty Member; School of Medicine; 221274
    Aim: we aimed to evaluate the role of the addition of Bifidobacterium lactis-containing synbiotic to the triple therapy in the case of Helicobacter pylori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics. Materials and methods: a total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. pylori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups. In the first group, 50 patients were administered amoxicillin + clarithromycin + lansoprazole for 14 days and B. lactis-containing synbiotic. In the second group, 50 patients were treated with the standard triple therapy. All patients were given information after completion of therapy. Results: H. pylori eradication was achieved in 88% in group I who received standard therapy with additional synbiotic and 72% in group II (p = 0.046). The number of patients in the second group who suffered from abdominal pain between the 3rd and 14th day of the treatment was higher (p < 0.05). The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively). Conclusion: the addition of synbiotic to the triple therapy is effective for eradicating H. py/ori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting. This study suggest that improved tolerance to the eradication treatment also reduces the treatment failure by adding probiotics and encourages the future study using probiotic supplementation in H. pylori treatment.
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    Influence of the gut microbiome on IgE and non-IgE-mediated food allergies
    (Wiley, 2018) Aktas, O. N.; Turturice, B. A.; Metwally, A.; Kaya, A.; Yilmaz, Arik E.; Nacaroglu, T.; Perkins, D. L.; Finn, P. W.; N/A; Dereli, Dilek Yazıcı; Öztürk, Ayşe Bilge; Kızılkan, Nuray Uslu; Saçkesen, Cansın; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 179659; 147629; 221274; 182537
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    Excessive food elimination by pediatricians in food allergic infants and their mothers
    (Wiley, 2017) Buyuktiryaki, B.; Nacaroglu, T.; Dut, R.; Soyer, O. U.; Sahiner, U. M.; Erkocoglu, M.; Yilmaz, Arik E.; N/A; Melek, Hacer Efnan; Akkaya, Ayşe Deniz; Kızılkan, Nuray Uslu; Saçkesen, Cansın; Doctor; Doctor; Undergraduate Student; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; N/A; 178110; 274199; N/A; 221274; 182537
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    A rare cause of chronic hyponatremia in an infant: questions
    (Springer, 2020) Guran, Tulay; N/A; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; 175867; 221274; 153504; 7945; 198907
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    A rare cause of chronic hyponatremia in an infant: answers
    (Springer, 2020) Güran, T.; N/A; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; 175867; 221274; 153504; 7945; 198907
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    Effect of dietary elimination on psychosocial functioning status in breastfeeding mothers of infants with food allergy
    (Wiley, 2017) N/A; N/A; Kaçar, Anıl Şafak; Mutluer, Tuba; Kızılkan, Nuray Uslu; Taşkıran, Ali Sarper; Saçkesen, Cansın; PhD Student; Faculty Member; Faculty Member; Other; Faculty Member; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 305311; 221274; N/A; 182537
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    Negative psychosocial effect of dietary elimination on breastfeeding mothers having infants with and without food allergy
    (Wiley-Blackwell, 2019) Can, Ceren; N/A; Kaçar, Anıl Şafak; Yılmaz, Özlem; Göğebakan, Emre; Necef, Işıl; Mutluer, Tuba; Kızılkan, Nuray Uslu; Taşkıran, Ali Sarper; Saçkesen, Cansın; PhD Student; Doctor; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Other; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 305311; 221274; 195168; 182537
    Background: There has been no trial evaluating the psychopathology in breastfeeding mothers of infants with food allergy (FA). Objective: To investigate the effect of dietary elimination on maternal psychopathology, specifically stress/anxiety and mother-to-infant bonding and explore the importance of sociodemographic features on these variables. Methods: Breastfeeding mothers following an elimination diet due to FA in their children aged 1-to-12 months were compared with the healthy controls. Physician-diagnosed FA group were divided into IgE-, non-IgE-mediated and infants with some minor symptoms which were not enough to make the diagnosis of FA were classified as Indecisive symptoms for FA group. Mothers completed standardized questionnaires including Symptom Checklist 90R, Beck Depression/Anxiety Inventories (BDI/BAI), Postpartum Bonding Questionnaire (Bonding). Results: Of 179 mother-infants, 64 were healthy, 89 were FA, 16 were indecisive symptoms for FA. The mean age of the mothers and infants were 31.1±4.7 years and 6.3±3.6 months. The physician diagnosed FA groups had higher scores for anxiety (p=0.008), anger (p=0.042), depression (p