Researcher:
Andaçoğlu, Oya Münevver

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Doctor

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Oya Münevver

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Andaçoğlu

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Andaçoğlu, Oya Münevver

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20219

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Researcher Of Publications: search.filters.isAuthorOfPublication.227835c4-420d-4799-80c4-35c935e87585

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Now showing 1 - 9 of 9
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    Global perspective on kidney transplantation: Turkey
    (Amer Soc Nephrology, 2021) Aki, Fazil Tuncay; N/A; Andaçoğlu, Oya Münevver; Doctor; N/A; Koç University Hospital; N/A
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    Risk factors for surgical site occurrence or infection and recurrence after incisional hernia repair in abdominal transplant population
    (Elsevier Science Inc, 2021) Cheema, Fareed; Huang, Li-Ching; Phillips, Sharon E.; Malcher, Flavio; N/A; Andaçoğlu, Oya Münevver; Doctor; N/A; Koç University Hospital; N/A
    Purpose: To investigate risk factors for hernia recurrence, surgical site occurrence/infection (SSO/I) and those requiring procedural intervention (SSOPI) after incisional hernia repair (IHR) following abdominal transplantation. Methods: Patients undergoing IHR following abdominal transplant were retrospectively identified in the Americas Hernia Society Quality Collaborative database. Primary outcome measures were SSO/I, SSOPI and hernia recurrence. Results: There was a total of 166 patients. Seventeen patients (10%) had an SSO/I at 30 days. Overall complication rate was 26%, and there was 1 mortality (1%). Composite recurrence rate was 28% (21/75) over 2 years. In univariate analysis, history of diabetes (DM), body mass index (BMI) .05). Immunosuppression had a negative correlation with SSO/Is and SSOPIs. BMI 35 kg/m(2) was associated with 180-day recurrence, whereas history of hypertension remained significant for recurrence at 2 years (P < .05). Conclusion: History of an open abdomen, DM, and obesity are risk factors for SSO/I, and obesity and hypertension are associated with short-term and long-term recurrence after IHR following abdominal organ transplantation. Immunosuppression had negative correlation with SSO/I. However, long-term outcomes and those related to immunosuppression should be interpreted cautiously in view of the small sample size and low follow-up rates. Baseline comorbidities seem to be the main drive for hernia outcomes for transplant population, similar to the general population. Larger cohorts and longer follow-up are necessary to delineate preventable risk factors for SSO/Is and hernia recurrences after organ transplantation.
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    Multicentric donor survey 20 years after donor hepatectomy
    (Wiley, 2021) Sabisch, Eva; Malamutmann, Eugen; Yuzer, Yildiray; Tokat, Yaman; Oezcelik, Arzu; N/A; Andaçoğlu, Oya Münevver; Doctor; N/A; Koç University Hospital; N/A
    Background:We implementedamulticenter interviewwiththedonors to investigateQualityof Life (QoL)upto20yearsfollowingdonation. Methods:Data were collected retrospectively. Complications were graded by Dindo–Clavien classification. Results:Medianfollow-upwas16.1years.Outof485donors,272responded(56.1%).Themajority (>90%) reported theyare inexcellent/goodoverall healthandpositiveor no impact of donationon professional life. Lengthof stay (LOS)wasassociatedwith impactonprofessional lifeandreturn to baseline functionality (bothp=0.046).Major complicationwasnot associatedwithcurrentphysical conditionorreturntobaselinenormalcy(p=0.06).Seventy-five(27.5%)reportedunsureornotodonate again.Noneof theparameterswereassociatedwithdonationagainresponse.Fasterreturntobaseline functionality, andmorepositive impact onprofessional lifewere reported in the last decade, likely secondarytolesscomplicationrates(allp<0.001). Conclusion: Thisthelongest followupreportsafter livingliverdonationamongGermanandTurkish populations.Althoughsubject torecallbias,LOSwasassociatedwithnegativeimpactonprofessional lifeandreturntobaselinefunctionality.Regret feelingswerehigher thanliterature.Theselong-termeffectsshouldbeincorporatedintodonordiscussions.
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    Association of graft to recipient weight ratio and outcomes of living and split donor liver transplantation in pediatric less than 20 kg
    (Wiley, 2021) N/A; N/A; N/A; N/A; N/A; N/A; Andaçoğlu, Oya Münevver; Karataş, Cihan; Baygül, Arzu Eden; Mecit, Nesimi; Kanmaz, Turan; Kalayoğlu, Münci; Doctor; Doctor; Faculty Member; Doctor; Faculty Member; Doctor; Koç University Hospital; N/A; N/A; 272290; N/A; 275799; N/A
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    Comparison of 1-year morbidity following liver transplant for acute alcoholic hepatitis versus alcoholic cirrhosis
    (Baskent Univ, 2021) Ozbek, Umut; Liu, Jack; Figueredo, Carlos; Chacko, Kristina R.; Tow, Clara; Reinus, John F.; Kinkhabwala, Milan; N/A; Andaçoğlu, Oya Münevver; Doctor; N/A; Koç University Hospital; N/A
    Objectives: With limited data on the morbidity profile of liver transplant as therapy for alcoholic hepatitis, we compared 30- day and 1-year morbidity in liver transplant recipients with alcoholic hepatitis versus alcoholic cirrhosis. Materials and Methods: We retrospectively reviewed 38 perioperative variables in patients with alcoholic hepatitis (n = 15) and with alcoholic cirrhosis (n = 46). Multivariable analysis was performed to identify factors independently associated with outcomes. Results: Patients with alcoholic hepatitis were younger (43 vs 58 years; P =.001), with higher pretransplant Model for End-Stage Liver Disease scores (36 vs 29; P =.009) and worse Karnofsky scores (20 vs 50; P<.001). All patients with alcoholic hepatitis received standard criteria deceased donor grafts; however, in the alcoholic cirrhosis group, 64% received standard criteria deceased, 11% living, 11% after cardiac death, 9% extended criteria, and 2% split graft donor organ donations (P > .05). The alcoholic hepatitis group had higher degree of steatosis on explant (P < .005), and the alcoholic cirrhosis group had higher 30-day reoperation rate (P = .001); however, 1-year interventions, vascular and biliary complications, graft and patient survival, and all other variables were similar (P > .05). Rates of alcohol relapse, 1-year infection, and 1-year rejection were higher but not significant (P > .05) in the alcoholic hepatitis group. Thirty-day reoperation (odds ratio of 82.63; 95% CI, 8.02-3338.96; P = .002) and Karnofsky scores (odds ratio of 1.18; 95% CI, 1.08-1.36; P = .006) remained significant on multivariate analysis. Conclusions: Our results showed significant differences between our patient groups, including worse functional status in the alcoholic hepatitis group but significantly higher 30-day reoperation rates and more variable grafts in the alcoholic cirrhosis group, although both groups had similar overall 1-year complication and survival rates. Although not significant, patients with alcoholic hepatitis had higher alcohol relapse and 1-year infection and rejection rates. A larger cohort is necessary to confirm the strength of these findings.
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    Outcomes of donors with BMI >= 30 for living donor liver transplantation
    (Frontiers Media Sa, 2021) Yüzer, Yıldıray; Tokat, Yaman; Özçelik, Arzu; Andaçoğlu, Oya Münevver; Doctor; N/A; Koç University Hospital; N/A
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    PublicationOpen Access
    Invasive fungal infections after liver transplantation: a retrospective matched controlled risk analysis
    (International Scientific Information (ISI), 2021) Karadağ, Halil İbrahim; Papadakis, Marios; Paul, Andreas; Özçelik, Arzu; Malamutmann, Eugen; Andaçoğlu, Oya Münevver; School of Medicine
    Background: invasive fungal infections (IFI) are major risks for mortality after liver transplantation (LT). The aim of this study was to evaluate possible risk factors for the development of IFI after LT. Material and methods: all adult patients with IFI after LT between January 2012 and December 2016 at Essen University were identified. Pre-, intra-, and postoperative data were reviewed. These were compared to a 1-to-3 matched control group. Multinominal univariate and multivariate regression analyses were performed. Results: out of the 579 adults who underwent LT, 33 (5.6%) developed postoperative IFI. Fourteen had invasive aspergillosis with 7 (50%) mortality, and 19 had Candida sepsis with 7 (37%) mortality. The overall mortality due to invasive fungal infections was 42%. Perfusion fluid contamination with yeast was detected in 5 patients (15%). Multivariate regression analyses showed that preoperative dialysis (OR=1.163; CI: 1.038-1.302), Eurotransplant donor risk index (OR=0.04; CI=0.003-0.519), length of hospital stay (OR=25.074; CI: 23.99-26.208), and yeast contamination of the preservation fluid (OR=47.8; CI: 4.77-478, 96) were associated with IFI in the Candida group, whereas duration of surgery (OR=1.013; CI: 1.005-1.022), ventilation hours (OR=0.993; CI=0.986-0.999), and days of postoperative dialysis (OR=1.195; CI: 1.048-1,362) were associated with IFI in the aspergillosis group. Conclusions: post-LT IFI had 42% mortality in our cohort. Prophylactic antifungal therapy should be expanded to broader risk groups as defined above.
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    PublicationOpen Access
    A comparison of rates and severity of chronic kidney disease in deceased-donor and living-donor liver transplant recipients: times matter
    (TÜBİTAK, 2021) Yankol, Yücel; Bugeaud, Emily; Zens, Tiffany; Rizzari, Michael; Leverson, Glen E.; Foley, David; Mezrich, Joshua D.; D'Alessandro, Anthony M.; Acarlı, Koray S.; Fernandez, Luis A.; Mecit, Nesimi; Kanmaz, Turan; Andaçoğlu, Oya Münevver; Kalayoğlu, Münci; Faculty Member; School of Medicine; Koç University Hospital
    Background/aim: the progression of chronic kidney disease (CKD) in recipients of living-donor liver transplant (LDLT) compared to deceased-donor liver transplant (DDLT) has not been studied in the literature. We hypothesize that CKD stage progression in LDLT recipients is reduced compared to that of their DDLT counterparts. Materials and methods: a retrospective study was undertaken including 999 adult, single-organ, primary liver transplant recipients (218 LDLT and 781 DDLT) at 2 centers between January 2003 and December 2012, in which CKD progression and regression were evaluated within the first 3 years after transplantation. Results: waiting time from evaluation to transplantation was significantly lower in LDLT patients compared to recipients of DDLT. CKD stage progression from preoperative transplant evaluation to transplantation was significantly greater in DDLT. Deceased-donor liver transplant recipients continued to have higher rates of clinically significant renal disease progression (from stage I-II to stage III-V) across multiple time points over the first 3 years posttransplant. Furthermore, a greater degree of CKD regression was observed in recipients of LDLT. Conclusion: it can be concluded that LDLT provides excellent graft and patient survival, significantly reducing the overall incidence of clinically significant CKD stage progression when compared to DDLT. Moreover, there is a significantly higher incidence of CKD stage regression in LDLT compared to DDLT. These observations were maintained in both high and low model for end-stage liver disease(MELD)populations. This observation likely reflects earlier access to transplantation in LDLT as one of the contributing factors to preventing CKD progression.
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    PublicationOpen Access
    Predictors of mid-term glomerular filtration rate after deceased donor renal transplantation: kidney donor profile index as a predictor of mid-term GFR
    (Lidsen Publishing, 2021) Liu, J.; Brooks, A.L.; Blumfield, A.; Trivedi, M.; Lehman, S.; Parides, M.K.; Akalın, E.; Graham, J.A.; Rocca, J.P.; Greenstein, S.M.; Andaçoğlu, Oya Münevver; School of Medicine; Koç University Hospital
    Glomerular filtration rate (GFR) is an excellent indicator of renal function; however, it is rarely evaluated as an endpoint. We investigated donor and recipient factors for associations that might be predictive of mid-term GFR after renal transplantation. We performed a retrospective review of 828 deceased donor renal transplantations performed at Montefiore Medical Center between the years 2009-2015. Donor characteristics included KDPI, [low (<20%), medium (20-80%), high (>80%)], age, graft types [extended criteria (ECD), cardiac death (DCD), standard criteria (SCD)], CDC high risk, HCV status and cold ischemic time (CIT). Recipient factors included age at transplant, induction agent, BK status, CMV status, acute and chronic rejection, cPRA and DSA status. Primary outcome is 3-year GFR calculated via the MDRD equation. In univariate analysis, donor age, KDPI, ECD, and chronic rejection were significantly associated with changes in 3-year GFR (p<0.001). In the multivariable regression analysis, donor age, KDPI, and chronic rejection remained associated with changes in 3-year GFR (p<0.001). Acute rejection, DCD, HCV status, CIT, BK and CMV viremia, PRA, pretransplant or de novo DSA were not associated with changes in 3-year GFR (p>0.05). We conclude that donor age, KDPI, and chronic rejection are independently associated with 3-year GFR while acute rejection, DCD, HCV status, CIT, BK and CMV viremia, PRA, existing or de novo DSA were not. Based on these findings, current scoring systems may need refinement to address the prognosis of mid-term GFR.