Researcher:
Bozlak, Özlem Hilal Çağlayan

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Undergraduate Student

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Özlem Hilal Çağlayan

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Bozlak

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Bozlak, Özlem Hilal Çağlayan

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2016 - 20173

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Researcher Of Publications: search.filters.isAuthorOfPublication.26b76902-d5b6-45a9-8b61-ee41b6f02c82

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    Serum uric acid and risk for acute kidney injury following contrast: an evaluation of epidemiology, clinical trials, and potential mechanisms
    (Sage, 2017) Solak, Yalcin; Afsar, Baris; Nistor, Ionut; Aslan, Gamze; Donciu, Mihaela-Dora; Lanaspa, Miguel A.; Ejaz, Ahsan A.; Johnson, Richard J.; Covic, Adrian; N/A; Kanbay, Mehmet; Aykanat, Aslı; Bozlak, Özlem Hilal Çağlayan; Faculty Member; Undergraduate Student; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; 0000-0002-1297-0675; N/A; N/A
    Contrast-induced acute kidney injury (CI-AKI) is a common cause of hospital-acquired acute kidney injury (AKI). We evaluated the evidence that uric acid (UA) plays a pathogenic role in CI-AKI. Ten studies were eligible for inclusion for meta-analysis. Hyperuricemia predicted risk for cases with AKI in prospective cohort studies. Higher levels of serum UA (SUA), as defined by the authors, were associated with a 2-fold increased risk to develop AKI (pooled odds ratio 2.03; 95% confidence interval [CI] 1.48-2.78). Significant heterogeneity was found in cohort studies (P = .001, I-2 = 85.7%). In 2 clinical trials, lowering of SUA with saline hydration was significantly associated with reduced risk for AKI compared with saline hydration alone or saline hydration with N-acetyl cysteine. An analysis of 2 randomized controlled trials found that allopurinol with saline hydration had a significant protective effect on renal function (assessed by serum creatinine values) compared with hydration alone (mean difference: -0.52 mg/dL; 95% CI: -0.81 to -0.22). Hyperuricemia independently predicts CI-AKI. Two clinical trials suggest lowering SUA may prevent CI-AKI. The mechanism by which UA induces CI-AKI is likely related to acute uricosuria.
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    Transgene-free disease-specific iPSC generation from fibroblasts and peripheral blood mononuclear cells
    (Humana Press Inc, 2016) Ebrahimi, Ayyub; N/A; N/A; N/A; N/A; Fidan, Kerem; Bozlak, Özlem Hilal Çağlayan; Özçimen, Burcu; Önder, Tamer Tevfik; Master Student; Undergraduate Student; Phd Student; Faculty Member; Graduate School of Sciences and Engineering; School of Medicine; Graduate School of Sciences and Engineering; School of Medicine; N/A; 296433; 316273; 42946
    Induced pluripotent stem cells (iPSCs) offer great promise as tools for basic biomedical research, disease modeling, and drug screening. In this chapter, we describe the generation of patient-specific, transgene-free iPSCs from skin biopsies and peripheral blood mononuclear cells through electroporation of episomal vectors and growth under two different culture conditions. The resulting iPSC lines are characterized with respect to pluripotency marker expression through immunostaining, tested for transgene integration by PCR, and assayed for differentiation capacity via teratoma formation.
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    PublicationOpen Access
    The evaluation of tissue sufficiency regarding the transverse myocutaneous gracilis flap for breast reconstruction in thin individuals
    (Gazi Üniversitesi, 2017) Tuncer, Serhan; Güney, Kırdar; Fındıkcıoğlu, Kemal; Ayhan, Sühan; N/A; Sezgin, Billur; Bozlak, Özlem Hilal Çağlayan; Faculty Member; School of Medicine
    Objective: For autologous breast reconstruction, the flaps of choice are mainly centered around abdominal tissue as the primary donor site. Yet with the increase in newly diagnosed young, nulliparous breast cancer patients, the abdomen may sometimes not be a suitable option as donor tissue. The transverse myocutaneous gracilis (TMG) flap has become a popular alternative for breast reconstruction candidates in this patient group. The purpose of this study was to evaluate the tissue sufficiency of the medial thigh regarding breast reconstruction in thin individuals. Material and Methods: The study was conducted on 116 female volunteers with a slim body habitus. The age, height, weight, history of pregnancy and breast cup sizes were questioned for each patient and body mass indexes (BMI) were calculated. A skinfold caliper was used to objectively evaluate the tissue thickness of the proximal medial thigh and the lower abdomen. Participants were categorized into three groups according to their breast cup size and the relationship between breast size, BMI, and thigh pinch thickness were evaluated. Results: The mean age was 24.7 years and the mean BMI was 20.63. Statistical analysis revealed a significant relationship between the breast cup size and BMI values (p< 0.05). This correlation was also evident for the relationship between the breast cup size and the medial thigh pinch thickness. A similar relationship was not evident regarding the lower abdominal pinch values and breast cup size. Conclusion: The decision regarding the donor site and tissue sufficiency is undertaken by the surgeon in a mainly subjective manner. This study demonstrates that thin, nulliparous patients with abdominal areas that are unfit as donor sites can provide a higher thickness of tissue from the medial thigh region, especially for the reconstruction of small to medium sized breasts.