Researcher:
Ergenç, Tuğba İpek

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Undergraduate Student

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Tuğba İpek

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Ergenç

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Ergenç, Tuğba İpek

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2011 - 20123

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Researcher Of Publications: search.filters.isAuthorOfPublication.273fdca9-1733-4da9-9346-3c1c93aa8818

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    Recent advances in the modeling of peg hydrogel membranes for biomedical applications
    (Intech Europe, 2011) Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Ergenç, Tuğba İpek; Kızılel, Seda; Undergraduate Student; Faculty Member; Department of Chemical and Biological Engineering; College of Engineering; College of Engineering; N/A; 28376
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    Encapsulation of magnetic nanoparticles within biofunctional poly (ethylene glycol) hydrogel formed via surface initiated photopolymerization
    (AICHE, 2011) Department of Chemistry; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; N/A; Acar, Havva Funda Yağcı; Kızılel, Seda; Ergenç, Tuğba İpek; Nazlı, Caner; Faculty Member; Faculty Member; Undergraduated Student; PhD Student; Department of Chemistry; Department of Chemical and Biological Engineering; College of Sciences; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; 178902; 28376; N/A; N/A
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    PublicationOpen Access
    RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells
    (Dove Medical Press, 2012) N/A; Department of Chemical and Biological Engineering; Department of Chemistry; Nazlı, Caner; Ergenç, Tuğba İpek; Yar, Yasemin; Acar, Havva Funda Yağcı; Kızılel, Seda; PhD Student; Undergraduate Student; Faculty Member; Department of Chemical and Biological Engineering; Department of Chemistry; Graduate School of Sciences and Engineering; College of Sciences; N/A; N/A; N/A; 178902; 28376
    The objective of this study was to develop thin, biocompatible, and biofunctional hydrogel-coated small-sized nanoparticles that exhibit favorable stability, viability, and specific cellular uptake. This article reports the coating of magnetic iron oxide nanoparticles (MIONPs) with covalently cross-linked biofunctional polyethylene glycol (PEG) hydrogel. Silanized MIONPs were derivatized with eosin Y, and the covalently cross-linked biofunctional PEG hydrogel coating was achieved via surface-initiated photopolymerization of PEG diacrylate in aqueous solution. The thickness of the PEG hydrogel coating, between 23 and 126 nm, was tuned with laser exposure time. PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles. RGDS-bound PEG hydrogel-coated MIONPs showed a 17-fold higher uptake by the human cervical cancer HeLa cell line than that of amine-coated MIONPs. This novel method allows for the coating of MIONPs with nano-thin biofunctional hydrogel layers that may prevent undesirable cell and protein adhesion and may allow for cellular uptake in target tissues in a specific manner. These findings indicate that the further biofunctional PEG hydrogel coating of MIONPs is a promising platform for enhanced specific cell targeting in biomedical imaging and cancer therapy.