Researcher: Ergün, Yağmur
Loading...
Name Variants
Ergün, Yağmur
Email Address
Birth Date
5 results
Search Results
Now showing 1 - 5 of 5
Publication Metadata only Polymeric and collagen biomaterials enhance implantation of mouse blastocysts in three-dimensional culture models(Elsevier, 2021) Başoz, Deniz; Yücel, Deniz; N/A; N/A; N/A; N/A; N/A; Department of Industrial Engineering; N/A; Ergün, Yağmur; Şahin, Gizem Nur; Şevgin, Kübra; Kocabay, Ahmet; Taşkın, Ali Cihan; Gönen, Mehmet; Karahüseyinoğlu, Serçin; PhD Student; PhD Student; PhD Student; Other; Other; Faculty Member; Faculty Member; Department of Industrial Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; College of Engineering; School of Medicine; N/A; N/A; N/A; N/A; 291296; 237468; 110772Publication Metadata only In vitro blastocyst implantation model by the use of synthetic polymer foam scaffolds(Mary Ann Liebert, Inc, 2022) Başöz, Deniz; Yücel, Deniz; N/A; Ergün, Yağmur; Kocabay, Ahmet; Taşkın, Ali Cihan; Karahüseyinoğlu, Serçin; Master Student; Other; Other; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; N/A; School of Medicine; N/A; N/A; 291296; 110772N/APublication Metadata only Microrna analysis of human decidua mesenchymal stromal cells from preeclampsia patients(W B Saunders Co Ltd, 2021) Kamali Simsek, Nilüfer; Benian, Ali; Çelik, Hale Göksever; Günel, Tuba; N/A; N/A; N/A; Şevgin, Kübra; Ergün, Yağmur; Karahüseyinoğlu, Serçin; N/A; Master Student; Faculty Member; N/A; Graduate School of Health Sciences; School of Medicine; N/A; N/A; 110772Introduction: In preeclampsia (PE), human decidua mesenchymal stromal cells (hDMSCs) are exposed to abnormally high levels of oxidative stress and inflammatory factors circulating in the maternal blood. MicroRNAs (miRNAs) have been shown to have a significant impact on the differentiation, maturation and function of mesenchymal stromal cells (MSCs). Our aim in the present study is firstly to investigate differentially expressed miRNA levels to be used as a biomarker in the early detection of PE and secondly to investigate whether those differentially expressed miRNAs in hDMSCs have an effect on the pathogenesis of PE. Methods: This study covers miRNA expression analysis of hDMSCs from 7 PE patient and 7 healthy pregnant women and is a preliminary study to investigate putative biomarkers. After cell culture and cell sorting, total RNA including miRNAs were isolated from hDMSCs. Let 7b 3p, let 7f 1 3p, miR-191-3p, miR-550a-5p, miR-33b-3p and miR-425-3p were used for miRNA analysis and U6 snRNA was used for normalization of the samples. MiRNA analysis was performed by droplet digital polymerase chain reaction (ddPCR) method and obtained results were evaluated statistically. Results: As a result of the analysis, it was observed that the levels of hsa-miR-33b-3p significantly (AUC: 0.93, p = 0.04, fold change: 4.5) increased in hDMSC of PE patients compared to healthy controls. However, let-7b-3p, let7f-1-3p, miR-191-3p, miR-550a-5p, and miR-425-3p were not considered as significant because they did not meet the p < 0,05 requirement. Discussion: Within the scope of the study, it is predicted that miR-33b-3p (p = 0.004, AUC = 0.93) can be used as a biomarker in detecting PE.Publication Metadata only The effects of oral mucosa-derived heterotopic fibroblasts on cutaneous wound healing(Elsevier Sci Ltd, 2021) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Tatar, Sedat; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Ergün, Yağmur; Meriç, Gizem; Ersoy, Kaan; Faculty Member; Faculty Member; Faculty Member; PhD Student; Master Student; Undergraduate Student; Undergraduate Student; School of Medicine; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 133762; N/A; 110772; N/A; N/A; N/A; N/AAn intriguing observation that has recently found support through clinical and experimental studies is that wounds of the oral mucosa tend to display faster healing and result in less scarring than in the skin. We aimed to investigate the potential of heterotopic oral mucosal fibroblasts in cutaneous wounds while determining the main differences between wounds conditioned with either the oral mucosa or dermis-derived human fibroblasts. A total of 48 nude mice were divided into four groups: control, sham, dermal fibroblast (DF), and oral fibroblast (OF). Fibroblasts were isolated, cultured, and seeded onto fibrin scaffolds for transfer to full-thickness dorsal wounds. Cell viability, wound area, healing rate, vascularization, cellular proliferation, dermal thickness, collagen architecture, and subtypes were evaluated. Both cell groups had a viability of 95% in fibrin gel prior to transfer. None of the wounds fully epithelialized on day 10, while all were epithelialized by day 21, which resulted in scars of different sizes and quality. Healing rate and scars were similar between the control and sham groups, whereas fastest healing and least scarring were noted in the OF group. Dermal thickness was highest in the DF group, which was also supported by highest levels of collagen types I and III. Proliferative cells and vascular density were highest in the OF group. DF result in healing through a thick dermal component, while oral fibroblasts result in faster healing and less scarring through potentially privileged angiogenic and regenerative gene expression.Publication Metadata only Effect of oral mucosa-derived heterotopic fibroblasts on cutaneous wound healing(Elsevier Science inc, 2020) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Tatar, Sedat; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Ergün, Yağmur; Meriç, Gizem; Ersoy, Kaan; Faculty Member; Faculty Member; Faculty Member; PhD Student; Master Student; Undergraduate Student; Undergraduate Student; School of Medicine; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 133762; N/A; 110772; N/A; N/A; N/A; N/AAn intriguing observation that has recently found support through clinical and experimental studies is that wounds of the oral mucosa tend to display faster healing and result in less scarring than in the skin. We aimed to investigate the potential of heterotopic oral mucosal fibroblasts in cutaneous wounds while determining the main differences between wounds conditioned with either the oral mucosa or dermis-derived human fibroblasts. A total of 48 nude mice were divided into four groups: control, sham, dermal fibroblast (DF), and oral fibroblast (OF). Fibroblasts were isolated, cultured, and seeded onto fibrin scaffolds for transfer to full-thickness dorsal wounds. Cell viability, wound area, healing rate, vascularization, cellular proliferation, dermal thickness, collagen architecture, and subtypes were evaluated. Both cell groups had a viability of 95% in fibrin gel prior to transfer. None of the wounds fully epithelialized on day 10, while all were epithelialized by day 21, which resulted in scars of different sizes and quality. Healing rate and scars were similar between the control and sham groups, whereas fastest healing and least scarring were noted in the OF group. Dermal thickness was highest in the DF group, which was also supported by highest levels of collagen types I and III. Proliferative cells and vascular density were highest in the OF group. DF result in healing through a thick dermal component, while oral fibroblasts result in faster healing and less scarring through potentially privileged angiogenic and regenerative gene expression.