Researcher:
Gökalp, Hilal

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Doctor

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Hilal

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Gökalp

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Gökalp, Hilal

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2016 - 201813

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    Cutaneous foreign body granulomas associated with lipolytic cocktail: who is the enemy, mesotherapy or drugs injected?
    (Taylor & Francis Inc, 2017) Kutlubay, Zekayi; İnce, Ümit; Engin, Burhan; N/A; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Mesotherapy is widely used for its lipolytic effect as an alternative procedure to surgical methods. Although many benefits of lipolytic mesotherapy have been observed, numerous side effects have also been reported. Here, we report a case of cutaneous foreign body granulomas that occurred after lipolytic rnesotherapy.
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    Long-term results of the treatment of pregnancy-induced striae distensae using a 1550-nm non-ablative fractional laser
    (Taylor & Francis Inc, 2017) Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Background: Striae distensae (SD) are a type of dermal scarring that is quite common and difficult to treat. Two forms are known: striae rubrae (SR) and striae albae (SA). Objective: We compared the long-term clinical effectiveness of a 1550-nm non-ablative fractional laser (NAFL) in treating SR and SA. Materials and methods: We included 16 female patients (8 with SR and 8 with SA) who had developed abdominal SD during pregnancy. All underwent five moderately high-energy sessions of 1550-nm NAFL treatment at 4-week intervals. The strial widths and lengths were measured before, and 1 month and 1 year after treatment. Results: The mean strial width decreased from 6.94 mm before treatment to 3.25 mm at the first follow-up visit (p = 3.95 x 10(-5)) and to 3.13 mm at the second follow-up visit (p = 2.44 x 10(-5)). Similarly, the mean strial length decreased from 6.06 to 2.88 cm at the first follow-up visit (p = 1.7 x 10(-4)) and to 2.75 cm at the second follow-up visit (p = 9.52 x 10(-5)). Conclusion: NAFL treatment was effective long term in both SR and SA patients.
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    Evaluation of nonablative fractional laser treatment in scar reduction
    (Springer London Ltd, 2017) N/A; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Fractional lasers have been used for the improvement of scar tissue in the recent years but there has not been extensive research on their impact. The purpose of this study was to evaluate the efficacy of nonablative fractional laser (NAFL) on acne, burn, and surgery/traumatic scar. The scars were also categorized as atrophic, hypertrophic, and keloid, and treatment efficacy was investigated accordingly. This is a retrospective, single-center study. Scar tissues were treated using a nonablative fractional 1550-nm Erbium glass laser in high-energy parameters at 4-week interval for 4-8 sessions. The scar regression score (SRS) was used to determine the decrease in scar appearance. Forty-six patients with acne (n:18), burn (n:13), or surgery/traumatic (n:15) scar were included. The number of sessions was higher for burn patients while SRS in burn patients was lower than in patients with acne or a surgical/traumatic scar. Evaluation according to scar types showed that atrophic scars had a significantly better response to NAFL treatment. This study indicates that NAFL treatment with the high-energy parameters has better outcomes in atrophic acne scars, while the success rate is considerably low in post-burn and keloid scars.
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    Epidemiological distribution of ticks analyzed at our laboratory between april 2008 and november 2015; a study of Borrelia burgdorferi in Ixodes
    (Kare Publ, 2017) Polat, Erdal; Sirekbasan, Serhat; Kutlubay, Zekayi; N/A; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Objectives: The aim of this study was to determine the distribution of ticks in the Marmara region and the ratio of Borrelia burgdorferi infection caused by ticks (Ixodes spp). Methods: Live ticks collected from the Marmara region were brought to the laboratory. Ticks on patients who came to our laboratory with tick bites were removed using forceps. These ticks were examined by stereo microscope and identified. The patients were informed about ticks and tick-borne diseases. People bitten by Hyalomma ticks were directed to the infectious diseases clinic and were kept under observation. The presence of B. burgdorferi in these ticks was determined using dark-field microscopy and B. burgdorferi was cultured in vitro using Barbour-Stoenner-Kelly (BSK)-H medium. Results: of the 462 ticks in our sample, 208 (45%) belonged to the genus Ixodes, 105 (22.7%) to Boophilus, 63 (13.6%) to Rhipicephalus, 61 (13.2%) to Hyalomma, 20 (4.3%) to Dermacentor, and 5 (1.1%) to Haemaphysal is. Ixodes was the most prevalent genus of ticks observed, and 194 of the 208 (93.3%) were I. ricinus. Patients diagnosed with Lyme disease were treated. Borrelia was observed in 4 (2.1%)/. ricinus ticks from İstanbul and Kastamonu using dark-field microscopy, and 6 ticks (3.1%) contained Borrelia that reproduced in the BSK-H medium. There was no clinical development of Crimean-Congo hemorrhagic fever among the individuals under observation. Conclusion: Tick-borne Lyme disease does not receive the public attention that CCHF has, but our results indicate that it is an important public health problem.
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    Evaluation of the effects of acne vulgaris on quality of life in Turkey by using TAQLI
    (Wiley, 2017) Bulur, Işıl; Erdoğan, Hilal Kaya; Karapınar, Tekden; Bilgin, Muzaffer; N/A; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Background Acne vulgaris (AV) is a chronic, inflammatory skin disease that may cause various psychiatric and/or psychological problems. Objective In this study, we aimed to determine the effect of AV on the quality of life in the Turkish population using the Turkish Acne Quality of Life Index (TAQLI). Methods A total of 960 patients with AV who attended the dermatology department were included in the study. Acne severity was determined using the global acne classification system. TAQLI was used to evaluate the effect of acne on quality of life. Results The 960 patients consisted of 673 (70.1%) females and 287 (29.9%) males. There were 536 (55.8%) patients under the age of 20, 386 (40.2%) aged 20-30, and 38 (4.0%) over 30. Acne duration varied between 1 and 20 years, and the mean duration was 2.95 +/- 2.53 years. The mean TAQLI value of all patients was 20.8 +/- 9.5. The mean TAQLI value was statistically significantly higher in female patients, in patients with an acne duration of more than 2 years, and in those with very severe acne. However, no statistically significant difference was found between the age groups. Conclusion We observed that the quality of life in patients with AV was affected, and this effect was more significant in female patients, patients with severe acne and longer acne duration. We believe that the psychiatric/psychological effects should be followed up closely in this group of patients.
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    Vulvar inflammatory linear verrucous epidermal nevus: remission with nonsteroidal antiinflammatory cream: case report
    (Türkiye Klinikleri, 2017) N/A; N/A; Gökalp, Hilal; Armutlu, Ayşe; Doctor; Teaching Faculty; Koç University Hospital; School of Medicine; N/A; 133567
    Inflammatory linear verrucous epidermal nevus (ILVEN) is usually accompanied by persistent and severe pruritus. It is mostly located in the lower left limb as hyperpigmented or erythematous hyperkeratotic linear papules and/or plaques. Genital/perigenital involvement is extremely rare. It varies in size from very small lesions to the involvement of the whole extremity. The differential diagnosis is broad, including but not limited to lineer psoriasis, lichen striatus, verrucous epidermal nevus, lichen simplex chronicus, linear lichen planus and linear Darier disease and, prognosis is poor. In this report, we present a case of vulvar ILVEN that responded to topical nonsteroidal anti-inflammatory cream.
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    Development of acute sacroiliitis due to the use of oral isotretinoin in patients with acne vulgaris: four case presentations
    (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2017) Köse, Özlem Karadağ; Hız, Özcan; Üstüner, Pelin; Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Sacroiliitis, an inflammation of the sacroiliac joint, is a characteristic finding of ankylosing spondylitis. Acute sacroiliitis has been described relatively uncommonly, and typically featuring the underlying infectious, rheumatic, neoplastic, or drug-related causality. Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Oral isotretinoin is a synthetic vitamin A derivative that has been used to treat severe nodulocystic acne and resistant acne to systemic antibiotic therapy. Few cases have been reported about acute sacroiliitis occurrence due to oral isotretionin treatment in patients with acne vulgaris. The mechanism of sacroiliitis owing to the use of oral isotretionin is not clear. The cessation of drug after early diagnosis, nonsteroidal antiinflammatory treatment, physical rehabilitation and exercise programs limit the progression of disease and the patients can reach their normal functions within 6 months. In this study, we present 4 cases of acne vulgaris with acute sacroiliitis caused by oral isotretionin. / Öz: Sakroiliit, sakroiliak eklemin inflamasyonu olup en sık ankilozan spondilit hastalarında görülür. Akut sakroiliit ise altta yatan enfeksiyöz, romatolojik, neoplastik veya ilaç-ilişkili nedenlere bağlı olarak daha nadir izlenir. Akne vulgaris, pilosebase üniteyi etkileyen kronik inflamatuar bir hastalıktır. Oral izotretinoin şiddetli nodülokistik ve sistemik antibiyotik tedavilerine dirençli aknede verilen sentetik A vitamini türevidir. Akne vulgarisi olan hastalarda oral izotretinoin kullanımına bağlı az sayıda akut sakroiliit olgusu rapor edilmiştir. Izotretinoin kullanımına bağlı sakroiliit gelişiminin mekanizması tam olarak bilinmemektedir. Erken tanı sonrasında ilacın kesilmesi, nonsteroid antiinflamatuar tedavi, fizik tedavi ve egzersiz programı ile hastalık sınırlanmakta ve 6 ay içinde hastalar normal fonksiyonlarına kavuşmaktadır. Biz bu çalışmamızda, oral izotretinoin kullanımına bağlı gelişen akne vulgarisli 4 akut sakroiliit olgusu sunduk.
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    Sweet's syndrome induced by granulocyte colony-stimulating factor: case report
    (Türkiye Klinikleri, 2017) N/A; N/A; Gökalp, Hilal; Bulutay, Pınar; Doctor; Teaching Faculty; Koç University Hospital; School of Medicine; N/A; 133565
    Sweet's syndrome (SS) is a neutrophilic dermatosis presenting with sudden onset of tender erythematous papules and plaques. It is a febrile disease, more commonly seen in females, 30-50 years of age. Neutrophilic leukocytosis and extensive dermal neutrophilic infiltration are prominent. Although pathogenesis is not clear, hypersensitivity reaction associated with infections, pregnancy, autoimmune/inflammatory diseases, malignancies and drugs thought to have a role. Various antibiotics, antiepileptics, retinoids, antihypertensive agents, oral contraceptives, azathiopurine and granulocyte colony stimulating factor (G-CSF) have been implicated as the causes of drug-related SS. We present a case with SS that occurred after the treatment of G-CSF in a patient with splenic marginal zone lymphoma.
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    Efficacy of monopolar radiofrequency in middle and lower face laxity
    (İnönü Üniversitesi Tıp Fakültesi, 2017) Gökalp, Hilal; Doctor; N/A; Koç University Hospital; N/A
    Aim: In recent years, radiofrequency (RF) systems have become one of the most commonly used rejuvenation methods, especially in the skin of the mid-lower face. In this study, the efficacy of monopolar RF energy in mid-lower face skin sagging was evaluated.Material and Methods: A total of 42 patients between the ages of 34 and 67 were included in this study. All patients underwent monopolar RF and were followed for 6 months. The monopolar RF energy level was determined based on the maximum level that each patient could tolerate. Patients were photographed with a digital camera before and 6 months after the procedure. The sagging grade of the mid-lower face before and after treatment was determined using the Merz skin laxity scale (MSLS). According to the MSLS, the level of laxity was divided into 5 groups: none, mild, moderate, severe, and very severe. The patient satisfaction levels were grouped into the following categories: not satisfied, minimally, well, and perfectly satisfied. Patients were monitored for side effects.Results: After the RF treatment, the mean MSLS score decreased from 2.60±0.80 to 1.86±0.87. The decrease in skin laxity after treatment was statistically significant (p=0.0001173). Patient satisfaction was correlated with treatment response (p=3.7x10-7). Erythema and edema were observed in all 42 patients; two patients complained of fat tissue reduction.Conclusion: Monopolar RF is an effective method for treating mid-lower face skin laxity. However, RF energy applied at high energy parameters may lead to thinning in the subcutaneous fat layer.
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    Long-term results in low-fluence 1064-nm Q-Switched Nd:YAG laser for melasma: is it effective?
    (Wiley, 2016) Oram, Yasemin; N/A; N/A; Gökalp, Hilal; Akkaya, Ayşe Deniz; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; 274199
    Objective This study assessed the safety and clinical efficacy of a low-fluence 1064-nm Q-switched neodymium-doped: yttrium aluminum garnet (QS-Nd:YAG) laser in the treatment of patients with melasma. Methods The study evaluated 34 melasma patients treated at a single institution using a 1064-nm QS-Nd: YAG laser. The laser parameters were 6 mm spot size and 2.5 J/cm(2) fluence with multiple passes for 6-10 (median 8) sessions at 2-week intervals. Outcomes were evaluated using photography, the modified Melasma Area and Severity Index (mMASI) score, and patient satisfaction interviews after the last treatment and 1 year after the last treatment. Results After the low-fluence 1064-nm QS-Nd:YAG laser treatments, the mean mMASI score decreased from 6.7 +/- 3.3 to 3.2 +/- 1.6 (P < 0.01). After treatment completion, 20 of 34 patients (58.8%) rated themselves as having at least a 50% reduction in melasma severity. One year after the last treatment, recurrence was observed in 20 patients (58.8%) and the mean mMASI score increased from 3.2 +/- 1.6 to 5.8 +/- 1.9 in all patients. Conclusion The recurrence of low-fluence 1064-nm QS-Nd:YAG laser rates in melasma was high when the long-term results were considered. This result may be attributed to certain patient and treatment-related factors.