Researcher:
Polat, Evin Bozçalı

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Doctor

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Evin Bozçalı

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Polat

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Polat, Evin Bozçalı

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2014 - 202010

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    Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation
    (Aves, 2016) Polat, Veli; Kutlu, Gönül; Opan, Selçuk; Paker, Nurcan; Uygun, Turgut; Ökçün, Barış; Karakaya, Osman; Polat, Evin Bozçalı; Doctor; Koç University Hospital; 239008
    Objective: Inflammation is thought to play a role in the patho- genesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory mol- ecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also tested, regarding potential to distinguish patients with lone atrial fibril- lation from healthy individuals. Methods: Presently included were 35 patients with lone per- sistent atrial fibrillation and a control group of 30 healthy indi- viduals. Serum levels of CD40L and high-sensitive C-reactive protein (hs-CRP) were measured, and transthoracic echocar- diography was performed. Results: Mean serum CD40L, hs-CRP, left ventricular end- diastolic diameter, and left atrial diameter values were signifi- cantly higher in the group with lone persistent atrial fibrillation than in the control group (7.4±3.5 ng/mL vs 4.3±1.2 ng/mL, p<0.0001; 3.7±1.6 mg/L vs 1.7±0.8 mg/L, p<0.0001; 53.0±4.2 mm vs 46.0±3.8, p<0.0001; 43.5±3.5 mm vs 33.7±3.5, p<0.0001, respectively). Serum CD40L levels were positively correlated with left atrial diameter (r=0.81, p<0.0001) and hs-CRP (r=0.72, p<0.0001). Receiver operating characteris- tic curve analysis revealed that serum CD40L at the optimal cut-off level of >4.5 ng/mL successfully discriminated patients with lone atrial fibrillation from controls (area under the curve: 0.847; 95% confidence interval: 0.759-0.934; p<0.0001). Conclusion: The present findings suggest that CD40L levels play a crucial role in the development of lone atrial fibrillation. In addition, results support that regular clinical follow-up of these patients is necessary, due to increased cardiovascular disease risk, determined by elevated CD40L levels. / Amaç: Enflamasyonun atriyum fibrilasyonu (AF) patogenezinde rol oynadığı düşünülmektedir. Protrombotik ve proenflamatuvar bir molekül olan CD40 ligand (CD40L) ile tek başına AF arasında ilişki daha önce araştırılmamıştır. Çalışmamızda bu ilişki yanında serum CD40L düzeyinin sağlıklı bireylerle tek ba- şına AF'li hastaları ayırt etmedeki rolü de incelenmiştir. Yöntemler: Çalışmaya tek başına ısrarcı AF'si olan 35 hasta ve kontrol grubu olarak 30 sağlıklı birey alındı. Çalışmaya alınan bütün olgularda serum CD40L ve yüksek duyarlıklı C-reaktif protein (hs-CRP) seviyeleri ölçüldü. Tüm katılımcılara transtorasik ekokardiyografi yapıldı. Bulgular: Tek başına ısrarcı AF grubunda ortalama serum CD40L, hs-CRP, sol ventrikül diyastol sonu çap ve sol atriyum çap değerleri kontrol grubuna göre istatistiksel olarak anlamlı yüksek bulundu (sırasıyla, 7.4±3.5 ng/mL ve 4.3±1.2 ng/mL, p<0.0001; 3.7±1.6 mg/L ve 1.7±0.8 mg/L, p<0.0001; 53.0±4.2 mm ve 46.0±3.8, p<0.0001; 43.5±3.5 mm ve 33.7±3.5, p<0.0001). Spearman korelasyon analizi serum CD40L düzeyleri ile sol atriyum çapı (r=0.81, p<0.0001) ve hs-CRP düzeyleri (r=0.72, p<0.0001) arasında pozitif korelasyon olduğunu gösterdi. ROC (receiver operating curve) analizinde tek başına AF grubu ile sağlıklı kontrol grubunun ayrımında serum CD40L düzeyinin anlamlı etkinliği saptanarak uygun eşik değer >4.5 ng/mL olarak bulundu (eğri altında kalan alan: 0.847, %95 gü- ven aralığında: 0.759-0.934; p<0.0001). Sonuç: Çalışmamızın bulguları serum CD40 ligand seviyesinin tek başına AF gelişiminde önemli rol oynadığına işaret etmektedir. Tek başına AF'li hastalarda CD40L seviyelerinin yüksek tespit edilmesi bu hastaların kardiyovasküler hastalıklar açısından yakından takip edilmesi gerekliliğini düşündürmektedir.
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    Diagnostic significance of serum galectin-3 levels in heart failure with preserved ejection fraction
    (Taylor & Francis Inc, 2016) Polat, Veli; Uygun, Turgut; Opan, Selçuk; Karakaya, Osman; Polat, Evin Bozçalı; Doctor; N/A; Koç University Hospital; 239008
    Objective: Galectin-3, reflecting cardiac fibrosis, is a promising biomarker in early detection of heart failure with preserved ejection fraction (HFpEF). We aimed to clarify the clinical utility of galectin-3 levels in the diagnosis of HFpEF and to compare galectin-3 with N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels. Methods and results: The study included 44 HFpEF patients (mean age 60 +/- 6.78 years, 24 men) and 38 control subjects (mean age 57 +/- 8.98 years, 20 men). Galectin-3 and NT-proBNP levels were assessed by the ELISA kits. The receiver operating characteristics (ROC) curve was used to examine the diagnostic performance of galectin-3 and NT-proBNP in HFpEF. Galectin-3 and NT-proBNP levels were significantly increased in patients with HFpEF compared to controls [5.35 ng/ml (0.86 - 14.90) vs 0.51 ng/ml (0.15 - 1.71) P < 0.0001, 617.75 +/- 271.30 pg/ml vs 66.35 +/- 54.01 pg/ml P < 0.0001, respectively]. Galectin-3 correlated with NT-proBNP, left atrial volume index, left ventricular mass index, and E/E' (r=0.90, P<0.0001; r=0.75, P=0.0001; r=0.86, P=0.0001; r=0.80, P=0.0001; respectively). The area under the ROC curve was 0.98 for galectin-3 and 1.0 for NT-proBNP. Conclusions: Our results support that, in addition to NT-proBNP, galectin-3 is also a valuable biomarker for the diagnosis of patients with HFpEF.
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    Evaluation of serum sST2 and sCD40L values in patients with microvascular angina
    (Academic Press Inc Elsevier Science, 2019) Polat, Veli; Opan, Selçuk; Çetin, Nurcan; Aslan, Gamze; Polat, Evin Bozçalı; Ural, Dilek; Doctor; Doctor; Faculty Member; N/A; N/A; School of Medicine; Koç University Hospital; N/A; 239008; 1057
    Objectives: Coronary microvascular dysfunction plays a major role in the pathogenesis of microvascular angina (MVA). Along with endothelial dysfunction, microvascular atherosclerosis and inflammation seem to contribute to the development of coronary microvascular dysfunction. Serum soluble ST2 (sST2) and serum soluble CD40 ligand (sCD40L) are two biomarkers associated with inflammation and atherosclerosis. The aim of this study was to investigate the role of these biomarkers in the pathogenesis of MVA and determine their possible association with coronary microvascular dysfunction. Methods: A total of 152 patients were included in the study. Ninety-one patients with MVA {median age 56 years (40-79), of which 55 are women} and sixty-one controls {median age 52 (38-76), of which 29 are women} were included in the study. Serum concentration of sST2 and sCD40L were measured with a commercially available ELISA kit. Results: Serum sST2 (median 13.6 ng/ml; interquartile range (IQR), 3.5-63.8 ng/ml vs median 10.6 ng/ml; IQR, 2.9-34.2 ng/ml, p < 0.0005) and sCD40L (median 5.3 ng/ml; IQR, 0.5-20.6 ng/ml vs median 2.2 ng/ml; IQR, 0.7-10.8 ng/ml, p < 0.0005) were significantly higher in patients with MVA compared to controls. Analysis of the associations between these biomarkers and potential contributors of MVA revealed that serum sST2 showed a positive correlation with LDL-cholesterol (r = 0.19, p = 0.016) and serum sCD40L concentrations correlated positively with hs-CRP (r = 0.22, p = 0.005). In logistic regression analysis, sCD40L and hs-CRP but not sST2 were found to be significantly associated with MVA. Conclusion: Higher serum concentrations of sST2 and sCD40L in MVA patients may be associated with inflammatory activation and coronary microvascular dysfunction. Larger studies are required for understanding their role in the pathogenesis of inflammatory and possibly fibrotic process in MVA patients.
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    Assessment of inflammatory markers in microvascular angina
    (Elsevier Ireland Ltd, 2019) Polat, V.; Şahin, M. H.; Aslan, Gamze; Polat, Evin Bozçalı; Ural, Dilek; Baysal, Kemal; Doctor; Doctor; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; 239008; 1057; 119184
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    Serum concentrations of sst2 and cd40l in patients with cardiac syndrome X
    (Elsevier Ireland Ltd, 2018) N/A; Aslan, Gamze; Polat, Evin Bozçalı; Polat, Vural; Opan, Selçuk; Ural, Dilek; Doctor; Doctor; N/A; N/A; Faculty Member; N/A; N/A N/A; N/A; School of Medicine; Koç University Hospital; N/A; 239008; 108870; N/A; 1057
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    A retrospective study of congenital cardiac abnormality associated with scoliosis
    (Korean Soc Spine Surgery, 2016) Üçcpunar, Hanifi; Sevencan, Ahmet; Balioğlu, Mehmet Bülent; Albayrak, Akif; Polat, Veli; N/A; Polat, Evin Bozçalı; Doctor; N/A; Koç University Hospital; 239008
    Study Design: Retrospective study. Purpose: To identify the incidence of congenital cardiac abnormalities in patients who had scoliosis and underwent surgical treatment for scoliosis. Overview of Literature: Congenital and idiopathic scoliosis (IS) are associated with cardiac abnormalities. We sought to establish and compare the incidence of congenital cardiac abnormalities in patients with idiopathic and congenital scoliosis (CS) who underwent surgical treatment for scoliosis. Methods: Ninety consecutive scoliosis patients, who underwent surgical correction of scoliosis, were classified as CS (55 patients, 28 female [51%]) and IS (35 patients, 21 female [60%]). The complete data of the patients, including medical records, plain radiograph and transthoracic echocardiography were retrospectively assessed. Results: We found that mitral valve prolapse was the most common cardiac abnormality in both patients with IS (nine patients, 26%) and CS (13 patients, 24%). Other congenital cardiac abnormalities were atrial septal aneurysm (23% of IS patients, 18% of CS patients), pulmonary insufficiency (20% of IS patients, 4% of CS patients), aortic insufficiency (17% of IS patients), atrial septal defect (11% of IS patients, 13% of CS patients), patent foramen ovale (15% of CS patients), dextrocardia (4% of CS patients), bicuspid aortic valve (3% of IS patients), aortic stenosis (2% of CS patients), ventricular septal defect (2% of CS patients), and cardiomyopathy (2% of CS patients). Conclusions: We determined the increased incidence of congenital cardiac abnormalities among patients with congenital and IS. Mitral valve prolapse appeared to be the most prevalent congenital cardiac abnormality in both groups.
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    Approach to cardiovascular disease in women
    (Turkish Society of Cardiology, 2018) Acar, Rezzan Deniz; Aktoz, Meryem; Atamaner, Oya; Çelik, Hülya Gamze; Çelik, Ömer; Dinçer, İrem; Gazi, Emine; Gülmez, Öykü; N/A; N/A; N/A; Aytekin, Saide; Polat, Evin Bozçalı; Elçioğlu, Betül Cengiz; Doctor; Doctor; Doctor; N/A; N/A; N/A; Koç University Hospita; N/A; 239008; N/A
    Cardiovascular disease (CVD) in women is still not completely understood by either patients or physicians. It is perceived as a health problem that becomes manifest only after menopause; however, it is the most frequent cause of mortality in women and is often seen at an earlier age in the presence of risk factors. Moreover, the symptoms, course, and prognosis are quite different from those seen in men, and both physicians and patients remain inadequately aware of the character of the disease. In the approach to female patients, some risk factors inherent to women should be considered in addition to the classic factors. In this review article, aspects of CVD that are different in women, etiological factors, risk factors specific to women, and particular points to be taken into consideration in the treatment and diagnosis are illustrated in the form of questions and responses from experts.
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    Serum concentrations of galectin-3 in patients with cardiac syndrome X
    (Elsevier, 2014) Polat, Veli; Açıksarı, Gönül; Opan, Selçuk; Bayrak, İbrahim Halil; Paker, Nurcan; Karakaya, Osman; Polat, Evin Bozçalı; Doctor; Koç University Hospital; 239008
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    PublicationOpen Access
    Low vitamin D status associated with dilated cardiomyopathy
    (e-Century Publishing Corporation, 2015) Polat, Veli; Uygun, Turgut; Opan, Selçuk; Karakaya, Osman; N/A; Polat, Evin Bozçalı; Doctor; School of Medicine
    In recent years, a growing body of evidence supports that vitamin D plays a crucial role in various cardiovascular diseases. Cardiac muscle cells have vitamin D receptors as well as calcitriol-dependent Ca2+ binding protein. Therefore, the vitamin D may have an effect on cardiac function. In this research, we investigated the association between vitamin D status and dilated cardiomyopathy (DCMP). We compared serum 25-hydroxy-vitamin D3 (25OHD3) concentrations in 39 patients (mean age 50.4 +/- 11.7 years, 15 women) with DCMP and in 35 healthy controls (mean age 54.6 +/- 13.2 years, 17 women). Parathyroid hormone (PTH), calcium (Ca++), phosphorus, lipid profile, albumin and echocardiographic parameters (left-ventricular (LV) ejection fraction, LV fractional shortening, LV-end-diastolic and end-systolic dimensions) were measured in all study participants. The mean serum 25OHD3 concentrations in patients with the DCMP were significantly lower in compared to healthy controls (24.1 +/- 10.4 ng/mL versus 41.4 +/- 20.9 ng/mL, P < 0.0001). PTH concentrations were significantly higher in patients with DCMP in comparison with healthy controls (90.6 +/- 29.8 pg/mL versus 49.1 +/- 18 pg/mL, P < 0.0001). Additionally, we observed a significant negative correlation between 25OHD3 concentrations and PTH concentrations, LV end-diastolic dimensions, LV end-systolic dimensions (r = -0.66; P < 0.0001, r = -0.49; P < 0.0001, r = -0.50; P < 0.0001, respectively). Moreover, 25OHD3 was positively correlated with LV ejection fraction, LV fractional shortening, stroke volume, cardiac output, cardiac index (r = 0.46; P < 0.001, r = 0.44; P < 0.001, r = 0.25; P = 0.03, r = 0.37; P < 0.001, r = 0.25; P = 0.03; respectively). Our findings support that vitamin D has a potential role both in the development of DCMP and LV remodeling.
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    PublicationOpen Access
    Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina
    (Aves, 2020) Polat, Veli; Şahin, Mustafa Hakan; Çetin, Nurcan; Aslan, Gamze; Polat, Evin Bozçalı; Ural, Dilek; Doctor; Faculty Member; School of Medicine; Koç University Hospital
    Objective: microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA. Platelet-derived growth factor receptor β (PDGFR-β) and brain-derived neurotrophic factor (BDNF) are 2 biomarkers associated with microcirculation, particularly pericytes function. The aim of this study was to investigate the role of PDGFR-β and BDNF in MVA. Methods: ninety-one patients (median age, 56 y; age range, 40–79 y; 36 men) with MVA and 61 control group subjects (median age, 52 y; age range, 38–76 y; 29 men) were included in the study. Serum concentrations of PDGFR-β and BDNF were measured with commercially available enzyme-linked immunosorbent assay kits. Results: PDGFR-β [2.82 ng/ml; interquartile range (IQR), 0.57–7.79 ng/ml vs. 2.27 ng/ml; IQR, 0.41–7.16 ng/ml; p<0.0005] and BDNF (2.41 ng/ml; IQR, 0.97–7.97 ng/ml vs. 1.92 ng/ml; IQR, 1.07–6.67 ng/ml; p=0.023) concentrations were significantly higher in patients with MVA compared with the controls. PDGFR-β correlated positively with age (r=0.26, p=0.001), low-density lipoprotein (r=0.18; p=0.02), and BDNF (r=0.47; p<0.001), and BDNF showed a significant positive correlation with age (r=0.20; p=0.01). In binary logistic regression analysis, high-sensitivity C-reactive protein, uric acid, and PDGFR-β values were found to be independent predictors of MVA. Conclusion: MVA is associated with higher PDGFR-β and BDNF levels. This association may indicate an abnormality in microvascular function. Future studies are required to determine the role of these biomarkers in the pathogenesis of MVA.