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Çekiç, Sebile Güler

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Doctor

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Sebile Güler

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Çekiç

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Çekiç, Sebile Güler

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2019 - 201922020 - 202310

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    Progestins vs gonadotropin releasing hormone analogues for pituitary suppression during ovarian stimulation for assisted reproductive technology, a systematic review and meta-analysis
    (Oxford Univ Press, 2020) Yıldız, Şule; Alexandru, Polexa; Çekiç, Sebile Güler; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; N/A; Doctor; Faculty Member; Faculty Member; Koç University Hospital; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; 134205; N/A; N/A; 329649; 182910
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    Effectiveness of the flexible progestin primed ovarian stimulation protocol compared to the flexible gnrh antagonist protocol in women with decreased ovarian reserve
    (Taylor & Francis Ltd, 2022) Türkgeldi, Engin; Yıldız, Şule; Çekiç, Sebile Güler; Shakerian, Bahar; Keleş, İpek; Ata, Mustafa Barış; Faculty Member; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; N/A; School of Medicine; Koç University Hospital; 329649; 134205; N/A; N/A; N/A; 182910
    The aim of this retrospective cohort study was to compare the effectiveness of the new flexible progestin primed ovarian stimulation (fPPOS) protocol with the flexible gonadotropin-releasing-hormone antagonist (GnRH-ant) protocol in women with decreased ovarian reserve (DOR). Twenty-seven women who underwent fPPOS and 54 age-matched women who received GnRH-ant for pituitary suppression were included in the study. All women had DOR and underwent oocyte cryopreservation. Three-hundred IU/day FSH was started on cycle day 2-3 and 0.25 mg/day GnRH-ant or 10 mg/day medroxyprogesterone acetate was started when the leading follicle reached 14 mm or serum oestradiol level was >= 200 ng/mL. The median duration of stimulation, day of commencing pituitary suppression and duration of suppression were similar in both groups, with 8, 5, and 5 days, respectively. The median number of cumulus-oophorous complexes (4.0 vs 5.5), metaphase-two oocytes (3 vs 4), the total number of oocytes cryopreserved (3.0 vs 4.5), and oocyte maturation rates (0.67 vs 0.70) were similar between the fPPOS and GnRH-ant groups, respectively. There was one case of premature ovulation in the fPPOS group and none in the GnRH-ant group (p = 0.91). In conclusion, fPPOS may be used in women with DOR without compromising the number of oocytes retrieved and seems a viable alternative to the flexible GnRH-ant protocol.
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    Novel vaginal cerclage assisted laparoscopic hysteropexy technique: VCAHL
    (Springer London Ltd, 2022) N/A; Aydın, Sibel Zehra; Çekiç, Sebile Güler; PhD Student; Doctor; Graduate School of Health Sciences; N/A; N/A; Koç University Hospital; N/A; N/A
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    Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women
    (Taylor & Francis, 2019) Yüksel, Semra; Özyürek, Şefik Eser; Acar, Deniz Kanber; Özdemir, Çağdaş; Kıyak, Hüseyin; Gedikbaşı, Ali; N/A; Çekiç, Sebile Güler; Doctor; Koç University Hospital; N/A
    Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Conclusion: Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
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    Lefort partial colpocleisis technique in an ulcerated uterovaginal prolapse
    (Springer London Ltd, 2020) Aydın, S.; Ofli, T.; N/A; Çekiç, Sebile Güler; Other; N/A; Koç University Hospital; N/A
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    Alterations in vaginal microbiota among pregnant women with COVID-19
    (Wiley, 2023) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Department of Computer Engineering; Department of Chemical and Biological Engineering; N/A; Çelik, Ebru; Özcan, Gülin; Vatansever, Cansel; Paerhati, Erxiati; Kuşkucu, Mert Ahmet; Doğan, Özlem; Çekiç, Sebile Güler; Ergönül, Önder; Gürsoy, Attila; Keskin, Özlem; Can, Füsun; Faculty Member; PhD Student; PhD Student; PhD Student; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Department of Computer Engineering; Department of Chemical and Biological Engineering; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; N/A; School of Medicine; College of Engineering; College of Engineering; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; 116631; N/A; N/A; N/A; N/A; 170418; N/A; 110398; 8745; 26605; 103165
    The maintenance of vaginal microbiota is an important factor to achieve optimum pregnancy outcomes. The study aims to describe the alterations in the composition of vaginal microbiota in pregnant women with coronavirus disease 2019 (COVID-19). This was a prospective case-control study. Vaginal swabs were collected from uninfected pregnant women (n = 28) and pregnant women with COVID-19 (n = 19) during the active phase of infection and within a month after recovering from infection. The vaginal microbiota on the swabs was examined by 16S rRNA gene sequencing. Shannon index indicates that alpha diversity is significantly higher in women with COVID-19 (p = 0.012). There was a significant decrease in Firmicutes (p = 0.014) with an increase in Bacteroidota (p = 0.018) phyla and a decrease in Lactobacillus (p = 0.007) genus in women with COVID-19 than those of uninfected pregnant women. The relative abundance of L. crispatus, L. iners, L. gasseri, and L. jensenii were lower in the COVID-19 group than in uninfected pregnant women. In subgroup analysis, the amount of Ureaplasma spp. was higher in women with moderate/severe than those of asymptomatic/mild disease (p = 0.036). The study revealed that vaginal dysbiosis with low abundance of Lactobacillus species occurred in pregnant women infected with severe acute respiratory syndrome coronavirus-2. These findings may lead to new studies to elucidate the risk of pregnancy adverse outcomes related to COVID-19.
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    Progestins versus GnRH analogues for pituitary suppression during ovarian stimulation for assisted reproductive technology: a systematic review and meta-analysis
    (Elsevier Sci Ltd, 2020) N/A; N/A; N/A; N/A; N/A; Alexandru, Polexa; Çekiç, Sebile Güler; Yıldız, Şule; Türkgeldi, Engin; Ata, Mustafa Barış; N/A; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 134205; 329649; 182910
    This systematic review and meta-analysis of comparative studies investigated whether progestins are as effective as gonadotrophin releasing hormone (GnRH) analogues for pituitary suppression in assisted reproduction. The primary outcome was live birth rate per woman. Secondary outcomes were live birth or ongoing pregnancy per woman and per embryo transfer, ongoing pregnancy, clinical pregnancy, numbers of oocytes and metaphase-two oocytes, duration of stimulation and gonadotrophin consumption. Adverse events included miscarriage, ectopic pregnancy and multiple pregnancy rates. The GRADE system was used to assess the quality of evidence. Seven studies involving a total of 2047 women were included. Three studies compared a progestin with a GnRH antagonist and four studies compared a progestin with a GnRH agonist. Most studies are non-randomized and report outcomes per embryo transfer, rather than per woman. Although progestins were similar to GnRH antagonists in effectiveness and safety parameters, they were associated with significantly higher live birth or ongoing pregnancy per embryo transfer compared with the short GnRH agonist protocol (RR 1.49, 95% CI 1.16 to 1.91). Progestin primed stimulation lasted significantly longer (mean difference 0.61 days, 95% CI 0.33 to 0.89) and required significantly more gonadotrophins (mean difference 433.2 IU, 95% CI 311.11 to 555.19) than the short GnRH agonist protocol, but the differences were clinically negligible. Safety parameters were similar between progestins and GnRH agonists. In conclusion, progestins can effectively prevent premature ovulation in assisted reproductive technology cycles. If larger and well-designed studies confirm these findings, progestins may be an effective and low-cost alternative to GnRH analogues when a fresh embryo transfer is not planned owing to a medical indication.
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    Are blastulation and clinical pregnancy rates in women with endometriomas different than those without?
    (Oxford Univ Press, 2021) Kantarci, R.; N/A; Çekiç, Sebile Güler; Türkgeldi, Engin; Yıldız, Şule; Keleş, İpek; Ata, Mustafa Barış; Doctor; Faculty Member; Faculty Member; Other; Faculty Member; N/A; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; N/A; 329649; 134205; N/A; 182910
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    Comparison of different progestin regimens for pituitary suppression during ovarian stimulation for assisted reproductive technology, a systematic review
    (Oxford Univ Press, 2020) N/A; N/A; N/A; N/A; N/A; Ata, Mustafa Barış; Türkgeldi, Engin; Alexandru, Polexa; Çekiç, Sebile Güler; Yıldız, Şule; Faculty Member; Faculty Member; Other; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; 182910; 329649; N/A; N/A; 134205
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    PublicationOpen Access
    Placental deficiency during maternal SARS-CoV-2 infection
    (Elsevier, 2021) Duru, Banu; Ergönül, Önder; Can, Füsun; Çelik, Ebru; Vatansever, Cansel; Özcan, Gülin; Kapucuoğlu, Fatma Nilgün; Manici, Mete; Çekiç, Sebile Güler; Ata, Mustafa Barış; Gürsoy, Tuğba; Turğal, Mert; Doğan, Özlem; Faculty Member; Faculty Member; Faculty Member; Undergraduate Student; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); School of Medicine; Graduate School of Health Sciences; Koç University Hospital; 110398; 103165; 116631; N/A; N/A; 7421; N/A; N/A; 182910; 214691; 199792; 170418; N/A; N/A; N/A
    Introduction: maternal anti-SARS-CoV-2 Spike antibodies can cross the placenta during pregnancy, and neonates born to infected mothers have acquired antibodies at birth. Few studies reported data on the histopathological changes of the placenta during infection and placental infection. SARS-CoV-2 infection may cause impaired development of the placenta, thus predisposing maternal and fetal unfavorable outcomes. The prospective study aims to evaluate the risk of vertical transmission of SARS-CoV-2 and placental passage of anti-Spike antibodies as well as the impact of clinical severity on placental structures. Methods: this is a prospective cohort study on 30 pregnant women infected by SARS-CoV-2 with their neonates. The demographic features and pregnancy outcomes were collected. Gross and microscopic examinations of the placentas were done. Maternal and umbilical cord sera were obtained at the time of delivery. Nasopharyngeal swabs were collected from neonates immediately after birth. Results: the concentrations of total anti-SARS-CoV-2 Spike antibodies were higher in pregnant women with moderate to severe/critical disease. The maternal total anti-SARS-CoV-2 Spike levels were correlated with those of neonatal levels. The rate of placental abnormalities is high in the mothers with severe disease, and those with positive anti-SARS-CoV-2 IgM. All neonates had negative nasopharyngeal swabs for SARS- CoV-2 infections and all placentas were negative in immunohistochemical staining for Spike protein. Discussion: the maternally derived anti-SARS-CoV-2 Spike antibody can transmit to neonates born to infected mothers regardless of gestational age. Our results indicated that the disease severity is associated with ischemic placental pathology which may result in adverse pregnancy outcomes.