Researcher: Ödemiş, Ender
Name Variants
Ödemiş, Ender
Email Address
Birth Date
12 results
Search Results
Now showing 1 - 10 of 12
Publication Metadata only Evaluation of the total hydrodynamic energy loss using 4D flow MRI in a case with Fontan failure(Elsevier, 2024) Aka, İbrahim Başar; Department of Mechanical Engineering; Department of Mechanical Engineering; Ödemiş, Ender; Gümüş, Terman; Özkök, Serçin; Pekkan, Kerem; School of Medicine; Graduate School of Sciences and Engineering; College of Engineering; Koç University HospitalFontan Failure (FF) is a common problem for single-ventricle patients as they reach adulthood. Although several mechanisms may cause FF, an optimized blood flow stream through the surgical conduits is essential to avoid excessive energy loss (EL). Recent clinical studies showed EL is related to the quality of life, exercise capacity, and hepatic function since the single-ventricle feeds pulmonary and systemic circulation serially. 4D flow MRI effectively estimates EL in Fontan circulation and allows clinicians to compare the effectiveness of the treatment strategy concerning pre-intervention. Here, we present 26-year-old women with FF who had normal cardiac catheterization findings and were treated according to high EL definitions that are measured through 4D flow MRI. © 2024Publication Metadata only Optimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment(Frontiers Media Sa, 2024) Aka, İbrahim Başar; Ali, Mhd Homam Alhaj; Department of Mechanical Engineering; Department of Mechanical Engineering; Ödemiş, Ender; Gümüş, Terman; Pekkan, Kerem; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; College of Engineering; Koç University HospitalBackground: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). However, the success of PPVI depends on precise patient-specific valve sizing, the avoidance of oversizing complications, and optimal valve performance. In recent years, innovative adaptations of commercially available cardiovascular mock loops have been used to test conduits in the pulmonary position. These models are instrumental in facilitating accurate pulmonic valve sizing, mitigating the risk of oversizing, and providing insight into the valve performance before implantation. This study explored the utilization of custom-modified mock loops to implant patient-specific 3D-printed pulmonary artery geometries, thereby advancing PPVI planning and execution.Material and Methods: Patient-specific 3D-printed pulmonary artery geometries of five patients who underwent PPVI using Pulsta transcatheter heart valve (THV) (R) were tested in a modified ViVitro pulse duplicator system (R). Various valve sizes were subjected to 10 cycles of testing at different cardiac output levels. The transpulmonary systolic and regurgitation fractions of the valves were also recorded and compared.Results: A total of 39 experiments were conducted using five different patient geometries and several different valve sizes (26, 28, 30, and 32 mm) at 3, 4, and 5 L/min cardiac output at heart rates of 70 beats per minute (bpm) and 60/40 systolic/diastolic ratios. The pressure gradients and regurgitation fractions of the tested valve sizes in the models were found to be similar to the pressure gradients and regurgitation fractions of valves used in real procedures. However, in two patients, different valve sizes showed better hemodynamic values than the actual implanted valves.Discussion: The use of 3D printing technology, electromagnetic flow meters, and the custom-modified ViVitro pulse duplicator system (R) in conjunction with patient-specific pulmonary artery models has enabled a comprehensive assessment of percutaneous pulmonic valve implantation performance. This approach allows for accurate valve sizing, minimization of oversizing risks, and valuable insights into hemodynamic behavior before implantation. The data obtained from this experimental setup will contribute to advancing PPVI procedures and offer potential benefits in improving patient outcomes and safety.Publication Open Access Approach to red blood cell transfusions in post-operative congenital heart disease surgery patients: when to stop?(Cambridge Univ Press, 2023) Tanyıldız, Murat; Güngörmüş, Asiye; Erden, Selin Ece; Özden, Ömer; Biçer, Mehmet; Akçevin, Atıf; Ödemiş, Ender; School of Medicine; Koç University HospitalBackground: The best transfusion approach for CHD surgery is controversial. Studies suggest two strategies: liberal (haemoglobin <= 9.5 g/dL) and restrictive (waiting for transfusion until haemoglobin <= 7.0 g/dL if the patient is stable). Here we compare liberal and restrictive transfusion in post-operative CHD patients in a cardiac intensive care unit.Methods: Retrospective analysis was conducted on CHD patients who received liberal transfusion (2019-2021, n=53) and restrictive transfusion (2021-2022, n=43).Results: The two groups were similar in terms of age, gender, Paediatric Risk of Mortality-3 score, Paediatric Logistic Organ Dysfunction-2 score, Risk Adjustment for Congenital Heart Surgery-1 score, cardiopulmonary bypass time, vasoactive inotropic score, total fluid balance, mechanical ventilation duration, length of cardiac intensive care unit stay, and mortality. The liberal transfusion group had a higher pre-operative haemoglobin level than the restrictive group (p < 0.05), with no differences in pre-operative anaemia. Regarding the minimum and maximum post-operative haemoglobin levels during a cardiac intensive care unit stay, the liberal group had higher haemoglobin levels in both cases (p<0.01 and p=0.019, respectively). The number of red blood cell transfusions received by the liberal group was higher than that of the restrictive group (p < 0.001). There were no differences between the two groups regarding lactate levels at the time of and after red blood cell transfusion. The incidence of bleeding, re-operation, acute kidney injury, dialysis, sepsis, and systemic inflammatory response syndrome was similar.Conclusions: Restrictive transfusion may be preferable over liberal transfusion. Achieving similar outcomes with restrictive transfusions may provide promising evidence for future studies.Publication Metadata only Does a prenatal diagnosis affect mortality and morbidity for neonatal arterial switch operation(Cambridge Univ Press, 2022) Guvenc, Osman; Beken, Serdar; Inamlik, Aysegul; Albayrak, Eda; Temur, Bahar; Basgoze, Serdar; Aydin, Selim; Saygi, Murat; Erek, Ersin; Toygar, Ayse Korkmaz; N/A; Ödemiş, Ender; Faculty Member; School of Medicine; 194545Background: The effect of prenatal diagnosis on prognosis in patients with transposition of the great arteries is not clear. In this study, we compared the outcomes after arterial switch operation. Methods: Outcome of 112 patients who had arterial switch operation in the neonatal period were analysed. The patients were divided into two groups: those who had prenatal diagnosis (Group 1; n = 34) and those who did not (Group 2; n = 78). The patients were also classified based on their diagnosis: simple transposition, transposition with ventricular septal defect and/or aortic arch hypoplasia, and Taussig-Bing anomaly. Results: In Group 1, the C-section delivery rate was higher (82% vs. 44%; p = 0.004), and it was observed that patients in Group 1 were more often intubated upon admission to the neonatal ICU (38% vs. 9%; p = 0.005). No differences were found between the two groups in terms of operation time, cardiopulmonary bypass time, post-operative invasive respiratory support duration, or extracorporeal membrane oxygenation support. It was observed that those who had Taussig-Bing anomaly had a higher mortality. Conclusions: Timely treatment have a positive effect on neonatal mortality and morbidity. That's why all families with prenatal diagnosis of critical CHD should be recommended to have the delivery in a tertiary care hospital. Although it could not be demonstrated in this study, prenatal diagnosis has a potential to improve surgical results especially in countries or cities, which does not have enough resources for transfer and surgical units. Further efforts are needed to improve prenatal screening programmes.Publication Open Access A rare complication after an interventional procedure using the common carotid: carotid pseudoaneurysm in an infant(Cambridge University Press (CUP), 2023) N/A; Biçer, Mehmet; Kızılkaya, Mete Han; Ödemiş, Ender; Gündoğmuş, Cemal Aydin; Faculty Member; Doctor; Faculty Member; Doctor; School of Medicine; N/A; School of Medicine; N/A; Koç University Hospital; 310599; N/A; 194545; N/AThe carotid artery is a valuable vascular access that can be used in patients who have undergone repetitive interventional and surgical procedures and premature babies. In the past, cut-down was used but nowadays, mostly the procedure is performed under ultrasonographic guidance. Complications such as bleeding, haematoma, and pseudoaneurysm may occur when the carotid artery is used as a vascular access for the procedures such as aortic balloon valvuloplasty, coarctation balloon angioplasty, or after interventional or surgical treatments to the carotid artery. Although pseudoaneurysm is very rare, prompt diagnosis and accurate treatment planning are life-saving. In this article, the diagnosis and treatment of pseudoaneurysm in the left common carotid after transcatheter coarctation balloon angioplasty in a 6-month-old infant will be presented.Publication Metadata only Early postnatal metabolic profile in neonates with critical CHDs(Cambridge University Press (CUP)) Guvenc, Osman; Beken, Serdar; Abali, Saygin; Saral, Neslihan Yildirim; Yalçın, Gizem; Albayrak, Eda; Bulum, Burcu; Demirelce, Ozlem; Basgoze, Serdar; Erek, Ersin; Serteser, Mustafa; Toygar, Ayse Korkmaz; N/A; Ödemiş, Ender; Faculty Member; School of Medicine; Koç University Hospital; 194545Background: Cyanotic CHD is a life-threatening condition that presents with low oxygen saturation in the newborn period. Hypoxemia might cause alterations in the metabolic pathways. In the present study, we aimed to evaluate the early postnatal amino acid and carnitine/acylcarnitine profiles of newborn infants with cyanotic CHD. Methods: A single centre case-control study was conducted. Twenty-seven patients with cyanotic CHD and 54 healthy newborn controls were enrolled. As part of the neonatal screening programme, results of amino acid and carnitine/acylcarnitine were recorded and compared between groups. Results: Twenty-seven neonates with cyanotic CHD and 54 healthy newborns as controls were enrolled in the study. Cyanotic CHD neonates had higher levels of alanine, phenylalanine, leucine/isoleucine, citrulline, ornithine, C5, C5-OH; but lower levels of C3, C10, C12, C14, C14:1, C16, C16.1, C18, C5-DC, C6-DC, C16-OH, C16:1-OH when compared with the healthy controls. Conclusion: This study showed that there are differences between patients with cyanotic CHD and healthy controls in terms of postnatal amino acid and carnitine/acylcarnitine profiles.Publication Metadata only Early and mid-term outcomes of transcatheter closure of perimembranous ventricular septal defects using the lifetech (tm) konar-mf occluder device (mfo)(Cambridge Univ Press) N/A; N/A; Ödemiş, Ender; Kızılkaya, Mete Han; Faculty Member; Doctor; School of Medicine; N/A; N/A; Koç University Hospital; 194545; N/ABackground: Transcatheter closure of perimembranous ventricular septal defects is challenging. Double disk-designed devices have high adverse event rates; therefore, research into new devices persists. One such devise is the LifetechTM Konar-MF Occluder device (MFO), which is increasingly used. The purpose of this study is to present mid-term results of MFO for transcatheter closure of patients with perimembraneous ventricular septal defect. Patients and methods: Records of the 52 patients with perimembraneous ventricular septal defect who had undergone transcatheter closure with MFO were reviewed. Demographic, echocardiographic, and procedure details were investigated. Three years follow-up results were recorded. Results: We closed the perimembraneous ventricular septal defect in 51 of 52 patients (98%). The femoral venous approach was used in 27 patients (53 %) whilst no arteriovenous loop was established in the remaining patients. No significant procedure-related complication occurred. On day 1 echocardiography, the residual ventricular septal defect rate was 31%. Mean +/- SD (range) follow-up duration was 36 +/- 7,9 (18-54) months. At 6th month follow-up, only four patients had haemodynamically significant residual defects. No severe dysrhythmia was detected including complete heart block. A right bundle branch block pattern was seen in one patient. Conclusion: This study showed that MFO is a safe and effective device in the transcatheter treatment of perimembraneous ventricular septal defect's with mid-term follow-up.Publication Metadata only Early results of pulsta (R) transcatheter heart valve in patients with enlarged right ventricular outflow tract and severe pulmonary regurgitation due to transannular patch(Cambridge Univ Press, 2022) N/A; N/A; Ödemiş, Ender; Yenidoğan, İrem; Kızılkaya, Mete Han; Faculty Member; Researcher; Doctor; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; 194545; 327591; N/AObjective: the purpose of this study is to assess the feasibility, effectivity, and safety of a novel self-expandable valve system, Pulsta (R) transcatheter heart valve in patients with tetralogy of fallot and severe pulmonary regurgitation after transannular patch repair. Background: Severe pulmonary regurgitation after tetralogy of fallot repair is a life-threatening problem and should be treated by pulmonary valve implantation. although percutaneous pulmonary valve implantation has been ever increasingly used for this purpose, Available balloon-expandable valves have limitations and cannot be used by most patients. Pulsta (R) transcatheter heart valve is a new self-expandable valve system and offers a new solution to be used in patients with different types of native right ventricular outflow tract geometry. Patients and Methods: Ten patients with severe regurgitation after tetralogy of fallot repair with a transannular patch have been enrolled in the study according to echocardiographic examination. MRI was used in asymptomatic patients to delineate the indication and the right ventricular outflow tract geometry. Pulsta (R) transcatheter heart valve implantation was performed in ten patients, and preprocedural, procedure, and 6 months follow-up findings of the patients were evaluated. Results: Pulsta (R) pulmonary valve implantation was performed in ten patients successfully without any severe complications. Valve functions were perfect in six of ten patients, while the others had insignificant regurgitation by echocardiographic examination at the end of 6 months follow-up. Conclusions: This study showed that Pulsta (R) transcatheter heart valve is a feasible, effective, and safe method in the treatment of severe pulmonary regurgitation due to transannular patch repair in patients with tetralogy of fallot.Publication Metadata only Treatment of 12-year-old girl with midaortic syndrome by using Cook Formula stent(Cambridge Univ Press, 2022) N/A; N/A; Ödemiş, Ender; Çelikyurt, Aydın; Faculty Member; Researcher; School of Medicine; School of Medicine; 194545; 327610Middle aortic syndrome is a severe form of aortic coarctation and mostly involves the thoracic and abdominal part of the aorta. Traditional surgical approach has some potential risks and repetitive operations. Percutaneous stent implantation is a feasible and safe method for the palliation of middle aortic syndrome in childhood. Herein, a child with middle aortic syndrome was presented who has been treated by transcatheter stent implantation.Publication Metadata only First experiences with myval transcatheter heart valve system in the treatment of severe pulmonary regurgitation in native right ventricular outflow tract and conduit dysfunction(Cambridge Univ Press, 2022) N/A; N/A; Ödemiş, Ender; Yenidoğan, İrem; Faculty Member; Researcher; School of Medicine; School of Medicine; 194545; 327591The rate of morbidity and mortality related to pulmonary regurgitation and pulmonary stenosis are big concerns after the surgery for CHD. Percutaneous pulmonary valve implantation has been established as a less invasive technique compared to surgery with promising results according to long-term follow-up of the patients. There are only two approved valve options for percutaneous pulmonary valve implantation until now, which are Melody (Medtronic, Minneapolis, Minn, USA) and Sapien (Edwards Lifesciences, Irvine, Ca, USA). Both valves have limitations and do not cover entire patient population. Therefore, the cardiologists need more options to improve outcomes with fewer complications in a such promising area. Herein, we present a case series applying for pulmonary position in conduits and native right ventricular outflow tract of a new transcatheter valve system Myval (R) which is designed for transcatheter aortic valve implantation procedures. This is the first patient series in which the use of Myvalv in dysfunctional right ventricular outflow tracts is described, after surgical repair of CHD.