Researcher:
Meram, Ece

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Undergraduate Student

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Ece

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Meram

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Meram, Ece

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2013 - 20183

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Researcher Of Publications: search.filters.isAuthorOfPublication.30e574de-5397-4644-b155-a9cbb02c897c

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    A 70-year-old patient with seronegative lupus nephritis: rare case
    (Logos Tıp Yayıncılığı, 2018) N/A; N/A; N/A; N/A; N/A; N/A; Dağel, Tuncay; Meram, Ece; Önal, Emine Meltem; Erbil, Damla; Bülbül, Mustafa Cem; Uysal, Sanem Pınar; Doctor; Undergraduate Student; Undergraduate Student; Undergraduate Student; Researcher; Undergraduate Student; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 327626; N/A
    Systemic lupus erythematosus (SLE) is an autoimmune disease known to be associated with various kinds of autoantibodies such as Antinuclear antibodies (ANA). ANA is found to be positive in most of the SLE patients. In fact, ANA positivity in serum is one of the diagnostic criteria of SLE. However, a minority of SLE patients may present with ANA negativity. We report a 70-year-old female who presented with massive edema and 10-gram/day proteinuria. Her serum antibodies for SLE were all negative and the renal biopsy showed a class V lupus nephritis. This case was unusual type of SLE due to multiple reasons namely the patient was an elderly woman, with isolated lupus nephritis and negative serology including ANA negativity.
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    Crimean-Congo hemorrhagic fever infections reported by ProMED
    (Elsevier Sci Ltd, 2014) N/A; İnce, Hüseyin Yavuz; Yasa, Çağla; Metin, Mustafa Mert; Sönmez, Melda; Meram, Ece; Benkli, Barlas; Ergönül, Önder; Undergraduate Student; Undergraduate Student; Undergraduate Student; Master Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 110398
    Objective: There are limited sources describing the global burden of emerging diseases. We reviewed the Crimean-Congo hemorrhagic fever virus (CCHFV) infections reported by ProMED and assessed the reliability of the data retrieved compared to published reports. We evaluated the effectiveness of ProMED as a source of epidemiological data by focusing on CCHFV infections. Methods: Using the keywords "Crimean Congo hemorrhagic fever'' and "Crimean Congo'' in the ProMED search engine, we reviewed all the information about the news and harvested data using a structured form, including year, country, gender, occupation, the number of infected individuals, and the number of fatal cases. Results: We identified 383 entries reported between January 1998 and October 2013. A total 3426 infected cases were reported, with 451 fatal cases, giving an overall case fatality rate (CFR) of 13%. Out of 144 cases for which the gender was reported, 97 (67%) were male. Most of the cases were reported from Turkey, followed by Russia, Iran, Pakistan, and Afghanistan. Conclusions: Case reporting systems such as ProMED are useful to gather information and synthesize knowledge on the emerging infections. Although certain areas need to be improved, ProMED provided good information about Crimean-Congo hemorrhagic fever. (C) 2014 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license.
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    PublicationOpen Access
    Shear stress-induced improvement of red blood cell deformability
    (IOS Press, 2013) Meiselman, Herbert J.; Meram, Ece; Yılmaz, Bahar Dikmen; Baş, Ceren; Ataç, Nazlı; Yalçın, Özlem; Başkurt, Oğuz Kerim; Faculty Member; Researcher; School of Medicine; N/A; N/A; N/A; N/A; 218440; 2389
    Classically, it is known that red blood cell (RBC) deformability is determined by the geometric and material properties of these cells. Experimental evidence accumulated during the last decade has introduced the concept of active regulation of RBC deformability. This regulation is mainly related to altered associations between membrane skeletal proteins and integral proteins, with the latter serving to anchor the skeleton to the lipid matrix. It has been hypothesized that shear stress induces alterations of RBC deformability: the current study investigated the dynamics of the transient improvement in deformability induced by shear stress at physiologically-relevant levels. RBC were exposed to various levels of shear stress (SS) in a Couette type shearing system that is part of an ektacytometer, thus permitting the changes in RBC deformability during the application of SS to be monitored. Initial studies showed that there is an increase in deformability of the RBC subjected to SS in the range of 5–20 Pa, with kinetics characterized by time constants of a few seconds. Such improvement in deformability, expressed by an elongation index (EI), was faster with higher levels of SS and hence yielded shorter time constants: absolute values of EI increased by 3–8% of the starting level. Upon the removal of the shear stress, this response by RBC was reversible with a slower time course compared to the increase in EI during application of SS. Increased calcium concentration in the RBC suspending medium prevented the improvement of deformability. It is suggested that the improvement of RBC deformability by shear forces may have significant effects on blood flow dynamics, at least in tissues supplied by blood vessels with impaired vasomotor reserve, and may therefore serve as a compensating mechanism for the maintenance of adequate microcirculatory perfusion.