Researcher: Necef, Işıl
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Necef, Işıl
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Publication Metadata only Trauma, creativity, and trance: special ability in a case of dissociative identity disorder(Amer Psychiatric Publishing, Inc, 2018) N/A; N/A; N/A; N/A; Şar, Vedat; Mutluer, Tuba; Necef, Işıl; Fatih, Parmis; Faculty Member; Faculty Member; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 8542; 305311; N/A; N/AN/APublication Metadata only Neuropsychological profile differences between children with disruptive mood dysregulation disorder (DMDD) and attention-deficit/hyperactivity disorder (ADHD): a preliminary study(Elsevier Science Inc, 2017) Taşkıran, Ali Sarper; Mutluer, Tuba; Necef, Işıl; Other; Faculty Member; Doctor; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 195168; 305311; N/AObjectives: Disruptive mood dysregulation disorder (DMDD), characterized by severe irritability, and ADHD are highly comorbid. Clinical observation suggests that patients with DMDD have greater impairment in functioning at school. We compared the neuropsychological assessment scores across three groups of participants to test whether any cognitive differences exist among children with ADHD, DMDD and healthy control (HC) subjects. Methods: The study sample group consisted of 43 participants (14 DMDD, 14 ADHD and 15 age-matched HC, mean age = 9.51; SD = 2.10). All the subjects diagnosed with DMDD had comorbid ADHD. Subjects underwent extensive diagnostic measures including Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). We applied the following tests: trail making test (TMT), symbol cancellation task (SCT), single letter cancellation task (SLCT), digit span learning (DSL), benton judgment of line orientation (JLO), Rey-Osterrieth complex figure test (CFT), letter and symbol cancellation test (LCT, SCT), Stroop color word (TBAG), and Wisconsin card sorting test (WCST). Results: There were statistically significant differences between these three groups on the TMS, F (2,41) = 5.270, p = 0.009, structured SLCT, F (2,41) = 3.376, p = 0.044, unstructured SLCT, F (2,41) = 5.142, p = 0.010, unstructured SCT, F (2,41) = 5.282, p = 0.009, the ROCFT, F (2,40) = 6.622, p = 0.003, the ROCFT: delayed recall condition score, F (2,40) = 3.647, p = 0.035), the ROCFT: delayed condition time, F (2,40) = 9.195, p = 0.001), Stroop test: incongruent color words condition, F (2,40) = 4.522, p = 0.017), Stroop test: naming the color of random words condition, F (2,40) = 3.647, p = 0.035). Post hoc analyses revealed little difference between ADHD and ADHD and DMDD groups except for the TMT. Conclusions: Neuropsychological properties for children with DMDD are very similar to those of ADHD. Selective and sustained attentional impairment, working memory, and set shifting difficulties are prominent in both ADHD and DMDD. Although results did not yield a significant difference, we observed more impaired performance in all tests, likely due to greater impulsivity and poorer frustration tolerance. Larger sample size is required to confirm this notion.Publication Metadata only Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study(Wiley, 2020) Morey Özcan, Aslıhan; Ongur, Dost; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Taşkıran, Ali Sarper; Ertınmaz, Beliz; Mutluer, Tuba; Kılıç, Özge; Necef, Işıl; Yalçınay-İnan, Merve; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Doctor; Doctor; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; Koç University Hospital; 134359; 195168; N/A; 305311; 167890; N/A; N/A; N/AObjective Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD. Method We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted. Results Thirty-seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive-compulsive disorder (OCD) was 16.7%. Childhood-onset studies reported higher GAD and SAD comorbidity, while adolescent-onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders' comorbidity with PBD differently. Conclusion Anxiety disorders are highly comorbid with PBD. Early-onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.Publication Metadata only Psychopathology and dissociation among boarding school students in eastern Turkey(Springer Heidelberg, 2021) N/A; N/A; Mutluer, Tuba; Fatih, Parmis; Tayakısı, Emre; Shabsog, Mohammed Kamal Yahya; Çapacı, Merve; Yürük, Deniz; Necef, Işıl; Faculty Member; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 305311; N/A; N/A; N/A; N/A; N/A; N/AA subset of boarding schools for adolescents was established in 1993 in the rural sections of Eastern Turkey to provide equity in terms of availability of education. Even though these schools were beneficial in many respects, implementation of this institutional model gave rise to many challenges such as weaker relationships with parents and defiance of authority figures. Failure to develop a mature response to these challenges could lead to the development of psychopathologies such as depression, psychosis, and dissociation. The main objective of this study is to assess the incidence of psychopathology and dissociative experiences of the residential female students in the regional boarding schools compared to a control group. 187 female participants, 128 attending boarding school, and 59 attending day school, as the control group, were included in the study. Brief Symptom Inventory (BSI) and Adolescent Dissociative Experiences Scale (ADES) were used as measurement scales. T-test, Mann Whitney-U, Spearman correlation chi-square tests were used to evaluate the association between the variables. There was a significant difference in Interpersonal sensitivity and Psychoticism subscales of BSI. ADES score was found to be significantly higher in the Boarding school group. Boarding school students are at a higher risk of developing psychopathology as a common trauma on a group of people can result in shared dissociation, a collective defense mechanism to cope with the injury, which resembles shared delusional disorder within DSM-V (The Diagnostic and Statistical Manual of Mental Disorders). Screening measures should be implemented in boarding schools to evaluate adolescents for psychopathology and preventive measures should be taken to intervene in the early stages.Publication Metadata only Is there a unique symptom in lower urinary tract dysfunction in children?(Wiley, 2021) N/A; N/A; Özen, Mehmet Ali; Taşdemir, Mehmet; Aygün, Murat Serhat; Necef, Işıl; Aydın, Emrah; Bilge, İlmay; Eroğlu, Egemen; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 293404; 175867; 291692; N/A; 32059; 198907; 214688Objectives Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool. Methods Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained. Results There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other. Conclusions While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this.Publication Metadata only Face emotion recognition differences with respect to frustration in disruptive mood dysregulation disorder (DMDD) and attention-deficit/hyperactivity disorder (ADHD)(Elsevier Science Inc, 2017) N/A; N/A; N/A; N/A; N/A; Department of Psychology; Taşkıran, Ali Sarper; Türkakın, Esin; Mutluer, Tuba; Necef, Işıl; Balcı, Fuat; Other; Master Student; Researcher; Faculty Member; Doctor; Faculty Member; Department of Psychology; School of Medicine; Graduate School of Social Sciences and Humanities; N/A; School of Medicine; School of Medicine; College of Social Sciences and Humanities; Koç University Hospital; 195168; N/A; N/A; 305311; N/A; 51269Objectives: We examined the effect of frustration in emotion recognition across children with ADHD and disruptive mood dysregulation disorder (DMDD) and healthy control (HC) subjects. Methods: Sample group consisted of 43 participants (14 DMDD + ADHD, 14 ADHD, 15 HC subjects, mean = 9.51; SD = 2.10), who completed a novel emotion recognition task with a frustration component that we developed using happy, angry, and neutral faces from the FACES database of Max Planck Institute for Human Development. The task was a two-alternative forced choice paradigm in which participants were asked to identify if a face was happy versus neutral or if a face was angry versus neutral. Frustration, in some blocks, was elicited by providing conflicting feedback and holding back deserved points after some correct answers. Results: In the frustration blocks of the emotion recognition task, there were statistically significant main effects of emotion on accuracy [ F (1,39) = 18.886, P < 0.001, η 2 = 0.326] and the type of feedback in previous trial on the response time [ F (1,39) = 11.019, P < 0.002, η 2 = 0.220], as well as a between-subjects effect of diagnosis on accuracy [ F (2,39) = 6.384, P = 0.004, η 2 = 0.247]. Post hoc analyses revealed that participants were more accurate recognizing happy faces as opposed to angry faces ( P < 0.001), slower after frustrating trials ( P = 0.002), and that participants with DMDD were less accurate than control subjects ( P = 0.017) and participants with ADHD ( P = 0.007). Linear integrated speed-accuracy scores (LISAS), interpreted as reaction time adjusted by error rate, showed a main effect of emotion [ F (1,39) = 12.389, P = 0.001, η 2 = 0.241] and feedback type in previous trial [ F (1,39) = 6.350, P = 0.016, η 2 = 0.140], but there was no between-subjects effect of diagnosis group on LISAS. The post hoc analyses revealed that the reaction time adjusted for error rates when recognizing happy faces were found to be faster as opposed to angry faces ( P = 0.001) and slower in postfrustration trials ( P = 0.016). Conclusions: Children with DMDD are less accurate overall compared with healthy control subjects and children with ADHD in the novel task that involves emotion recognition. Their impairment becomes more pronounced after frustrating trials, which emerge as a distinctive feature between participants with pure ADHD and those with ADHD/DMDD comorbidity.Publication Metadata only A revised and expanded version of the Turkish childhood trauma questionnaire (CTQ-33): overprotection-overcontrol as additional factor(Routledge Journals, Taylor & Francis Ltd, 2021) Türk-Kurtça, Tuğba; N/A; N/A; N/A; N/A; Şar, Vedat; Necef, Işıl; Mutluer, Tuba; Fatih, Parmis; Faculty Member; Doctor; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 8542; N/A; 305311; N/AThis study was concerned with a culture-sensitive revision of the Turkish version of the Childhood Trauma Questionnaire (CTQ-28) and expansion of the instrument through integration of a dimension assessing overprotection - overcontrol (OP-OC). Participants (n = 783) were 37 dissociative and 78 non-dissociative and non-psychotic psychiatric outpatients, and 668 non-clinical people. They completed the revised and expanded version of the CTQ, Dissociative Experiences Scale, Beck Depression Scale, and Relationship Scales Questionnaire. A test-retest assessment was conducted on 25 non-clinical individuals. Among twenty-one alternative and the twenty-five original statements, the items of subsections were selected by correlations between item and item deleted total scores for each subset of original and alternative statements. The 33-item final version (CTQ-33) included five statements for each subsection including OP-OC and three denial items. The principal component analysis on items of the CTQ-33 with a varimax rotation yielded six factors including OP-OC. The inner consistency and the test-retest reliability were good. OP-OC correlated particularly with emotional abuse and neglect, and other types of trauma. There were significant correlations between CTQ-33 and depression, dissociation, and fearful attachment scores. The CTQ-33 differentiated psychiatric from non-clinical groups. The Turkish CTQ-33 is a reliable and valid instrument. OP-OC by caregivers may be as traumatic as other types of childhood adversities. Cross-cultural research would illuminate the significance of OP-OC beyond Turkish culture. The possibility of intergenerational transmission of trauma through OP-OC by fearful parents in and after times of cultural upheaval and political oppression should be considered for future research.Publication Metadata only A meta-analysis of anxiety disorder comorbidity in pediatric bipolar disorder(Elsevier Science Inc, 2016) Taşkıran, Ali Sarper; Eser, Hale Yapıcı; Mutluer, Tuba; Kılıç, Özge; Özcan, Aslıhan; Necef, Işıl; Yalçınay-İnan, Merve; Öngür, Dost; Other; Faculty Member; Faculty Member; Doctor; Other; Doctor; Doctor; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A College of Engineering; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; 195168; 134359; 305311; N/A; N/A; N/A; N/A; N/AObjectives: AD are among the most prevalent comorbid conditions in pediatric bipolar disorder (PBD). There are conflicting results in the literature regarding prevalence of AD subtypes, and significant discrepancy with PBD course of illness (episodic or chronic) or diagnostic criteria (narrow or broad). Our aim in conducting meta-analysis is to investigate the prevalence of subtypes of comorbid anxiety disorders and its relations with the onset (childhood or adolescent) and course (episodic or chronic) of PBD. Methods: We have conducted a systematic research of Pubmed by using “bipolar disorder, affective psychosis, generalized anxiety disorder, panic, social phobia, obsessive compulsive disorder and anxiety disorder” as keywords to search in title/abstract until September 2015. Among 3202 articles, a total of 430 abstracts were found to be related; 82 were conducted in pediatric population, which were read in full text by at least two authors and data was extracted for outcome measures. Articles that include the data from the same population sample were excluded. Data was analyzed with random effects model using R statistical program package. Results: Data from 33 studies were included in the final analysis. The prevalence of any AD in PBD was 44 percent (95% CI 0.38–0.50), prevalence of AD subtypes were GAD 25 percent (95% CI 0.18–0.36); Separation Anxiety Disorder (SAD) 22 percent (95% CI 0.14–0.33); OCD 17 percent (95% CI 0.11–0.23); Social Phobia (SP) 15 percent (95% CI 0.08–0.27); Panic Disorder (PD) 10 percent (95% CI 0.05–0.19). When only episodic PBD were concerned, prevalence rates differed, with any AD 38 percent (95% CI 0.28–0.48); GAD 19 percent (95% CI 0.08–0.41); SAD 21 percent (95% CI 0.10–0.40); OCD 11 percent (95% CI 0.03–0.29); SP 11 percent (95% CI 0.04–0.27); PD 9 percent (95% CI 0.03–0.23). Prevalence of any AD (34% (95% CI 0.23-0.48), GAD and SAD were found as lower and OCD, SP and PD were slightly higher in adolescent onset compared to childhood onset PBD. Conclusions: Youth with BD are at increased risk of AD; nearly one in two has an AD. GAD and SAD are among the most prevalent comorbidities. AD are seen less with episodic and adolescent onset PBD. AD should be carefully investigated alongside the mood symptoms in PBD, as comorbidity may change course, treatment and subtyping of the disorder.Publication Metadata only The relationship between dietary elimination and maternal psychopathology in breastfeeding mothers of infants with food allergy(Wiley, 2022) Can, Ceren; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Yılmaz, Özlem; Saçkesen, Cansın; Kaçar, Anıl Şafak; Göğebakan, Emre; Necef, Işıl; Mutluer, Tuba; Taşkıran, Ali Sarper; Kızılkan, Nuray Uslu; Doctor; Faculty Member; PhD Student; Undergraduate Student; Faculty Member; Faculty Member; Other; Faculty Member; N/A; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 140706; 182537; N/A; N/A; N/A; 305311; 195168; 221274Background: There has been no study evaluating the psychopathology in breastfeeding mothers of infants with food allergy (FA). Objective: The aim of the study was to investigate the relationship between dietary elimination and maternal psychopathology, specifically anxiety, depression, and mother-to-infant bonding, in breastfeeding mothers of infants with food allergy. Methods: Breastfeeding mothers following an elimination diet due to FA in their children aged 1-to-12 months were compared with the healthy controls. The physician-diagnosed FA group was divided into IgE-, non-IgE-mediated, and infants with some minor symptoms which were not enough to make the diagnosis of FA were classified as Indecisive symptoms for FA group. Mothers completed standardized questionnaires including Symptom Checklist 90R, Beck Depression/Anxiety Inventories (BDI/BAI), Postpartum Bonding Questionnaire (Bonding). Results: Of 179 mother and infants, 64 were healthy, 89 were FA, 16 were indecisive symptoms for FA. The mean age of the mothers and infants were 31.1 ± 4.7 years and 6.3 ± 3.6 months, respectively. The physician-diagnosed FA groups had higher scores for anxiety (p = .008), anger (p = .042), depression (p < .001), obsession (p = .002), phobia (p = .008), somatization (p = .002), general symptom index (GSI) (p = .001), BDI (p < .001), BAI (p = .008), and Bonding (attachment [p = .001], anger [p = .019], and total [p = .036]) than the healthy ones. The indecisive symptoms for FA group had a similar score pattern to physician-diagnosed FA, except interpersonal sensitivity, BDI, and attachment. Conclusion: Breastfeeding mothers of infants with FA were more anxious, with higher depression scores than controls, and had many psychopathologies which affected bonding. Interventions targeting negativity in caregivers' social relationships are urgently needed.Publication Metadata only Socio-legal consequences of tourette syndrome and its comorbidities: a case study and review of the literature(Elsevier Sci Ltd, 2020) Yorulmaz, Coşkun; Fatih, Parmis; Mutluer, Tuba; Çapacı, Merve; Necef, Işıl; Taşkıran, Ali Sarper; Researcher; Faculty Member; Undergraduate Student; Undergraduate Student; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 305311; N/A; N/A; N/A; 195168Tourette Syndrome is a neurodevelopmental disorder that is associated with the presence of multiple motor and one or more verbal tics. In this case report, we present a 16 years old Tourette syndrome patient who was diagnosed with comorbid Attention Deficit Hyperactivity Disorder. The patient was evaluated for legal responsibility after she made untrue allegations saying that a bus driver had sexually harassed her. We summarize the case and review the current literature to assess the socio-legal aspects of Tourette syndrome.