Researcher:
Rajabi, Hadi

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PhD Student

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Hadi

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Rajabi

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Rajabi, Hadi

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2020 - 20227

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Researcher Of Publications: search.filters.isAuthorOfPublication.3356a900-bb30-481f-9cc2-ff5a14bcfe22

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Now showing 1 - 7 of 7
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    The role of reactive nitrogen species as biomarkers of disease severity in COVID-19
    (European Respiratory Society (ERS), 2022) Akyil, F. Tokgoz; Altin, S.; N/A; N/A; N/A; N/A; Department of Molecular Biology and Genetics; N/A; N/A; Konyalılar, Nur; Kayalar, Özgecan; Mortazavi, Deniz; Rajabi, Hadi; Korkunç, Seval Kübra; Erkan, Selim; Gönenli, Mehmet Gökhan; Bayram, Hasan; PhD Student; Researcher; PhD Student; PhD Student; Master Student; Other; Other; Teaching Faculty; Faculty Member; Department of Molecular Biology and Genetics; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; N/A; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 350445; 4890
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    Melatonin as a promising modulator of aging related neurodegenerative disorders: role of micrornas
    (2021) Alamdari, Arezoo Fathalizadeh; Rahnemayan, Sama; Vahed, Nafiseh; Kashani, Hamid Reza Khayat; Rezabakhsh, Aysa; Sanaie, Sarvin; N/A; Rajabi, Hadi; PhD Student; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A
    One of the host risk factors involved in aging-related diseases is coupled with the reduction of endogenous melatonin (MLT) synthesis in the pineal gland. MLT is considered a well-known pleiotropic regulatory hormone to modulate a multitude of biological processes such as the regulation of circadian rhythm attended by potent anti-oxidant, anti-inflammatory, and anti-cancer properties. It has also been established that the microRNAs family, as non-coding mRNAs regulating post-transcriptional processes, also serve a crucial role to promote MLT-related advantageous effects in both experimental and clinical settings. Moreover, the anti-aging impact of MLT and miRNAs participation jointly are of particular interest, recently. In this review, we aimed to scrutinize recent advances concerning the therapeutic implications of MLT, particularly in the brain tissue in the face of aging. We also assessed the possible interplay between microRNAs and MLT, which could be considered a therapeutic strategy to slow down the aging process in the nervous system.
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    PublicationOpen Access
    Putative therapeutic impacts of cardiac CTRP9 in ischaemia/reperfusion injury
    (Wiley, 2022) Sadat Ebrahimi, S.R.; Amini, H.; Rahbarghazi, R.; Habibollahi, P.; Ghaderi, S.; Rezabakhsh, A.; Rajabi, Hadi; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences
    Recently, cytokines belonging to C1q/tumour necrosis factor-related proteins (CTRPs) superfamily have attracted increasing attention due to multiple metabolic functions and desirable anti-inflammatory effects. These various molecular effectors exhibit key roles upon the onset of cardiovascular diseases, making them novel adipo/cardiokines. This review article aimed to highlight recent findings correlated with therapeutic effects and additional mechanisms specific to the CTRP9, particularly in cardiac ischaemia/reperfusion injury (IRI). Besides, the network of the CTPR9 signalling pathway and its possible relationship with IRI were discussed. Together, the discovery of all involved underlying mechanisms could shed light to alleviate the pathological sequelae after the occurrence of IRI.
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    PublicationOpen Access
    Emerging role of exosomes in the pathology of chronic obstructive pulmonary diseases; destructive and therapeutic properties
    (BioMed Central, 2022) Rahbarghazi, Reza; Rajabi, Hadi; Konyalılar, Nur; Erkan, Sinem; Mortazavi, Deniz; Korkunç, Seval Kübra; Kayalar, Özgecan; Bayram, Hasan; PhD Student; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 4890
    Chronic obstructive pulmonary disease (COPD) is known as the third leading cause of human death globally. Enhanced chronic inflammation and pathological remodeling are the main consequences of COPD, leading to decreased life span. Histological and molecular investigations revealed that prominent immune cell infiltration and release of several cytokines contribute to progressive chronic remodeling. Recent investigations have revealed that exosomes belonging to extracellular vesicles are involved in the pathogenesis of COPD. It has been elucidated that exosomes secreted from immune cells are eligible to carry numerous pro-inflammatory factors exacerbating the pathological conditions. Here, in this review article, we have summarized various and reliable information about the negative role of immune cell-derived exosomes in the remodeling of pulmonary tissue and airways destruction in COPD patients.
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    PublicationOpen Access
    Unraveling the therapeutic effects of mesenchymal stem cells in asthma
    (BioMed Central, 2020) Mirershadi, Fatemeh; Ahmadi, Mahdi; Rezabakhsh, Aysa; Rahbarghazi, Reza; Keyhanmanesh, Rana; Rajabi, Hadi; Faculty Member; Graduate School of Health Sciences
    Asthma is a chronic inflammatory disease associated with airway hyper-responsiveness, chronic inflammatory response, and excessive structural remodeling. The current therapeutic strategies in asthmatic patients are based on controlling the activity of type 2 T helper lymphocytes in the pulmonary tissue. However, most of the available therapies are symptomatic and expensive and with diverse side outcomes in which the interruption of these modalities contributes to the relapse of asthmatic symptoms. Up to date, different reports highlighted the advantages and beneficial outcomes regarding the transplantation of different stem cell sources, and relevant products from for the diseases' alleviation and restoration of injured sites. However, efforts to better understand by which these cells elicit therapeutic effects are already underway. The precise understanding of these mechanisms will help us to translate stem cells into the clinical setting. In this review article, we described current knowledge and future perspectives related to the therapeutic application of stem cell-based therapy in animal models of asthma, with emphasis on the underlying therapeutic mechanisms.
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    PublicationOpen Access
    Forthcoming complications in recovered COVID-19 patients with COPD and asthma; possible therapeutic opportunities
    (BioMed Central, 2022) Rahbarghazi, Reza; Rajabi, Hadi; Konyalılar, Nur; Aksoy, Gizem Tuşe; Erkan, Sinem; Korkunç, Seval Kübra; Kayalar, Özgecan; Bayram, Hasan; PhD Student; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; N/A; N/A; N/A; N/A; N/A; N/A; 4890
    Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients with background chronic pulmonary inflammations such as asthma or chronic obstructive pulmonary diseases (COPD) are likely to be infected with this virus. Of note, there is an argument that COVID-19 can remain with serious complications like fibrosis or other pathological changes in the pulmonary tissue of patients with chronic diseases. Along with conventional medications, regenerative medicine, and cell-based therapy could be alternative approaches to compensate for organ loss or restore injured sites using different stem cell types. Owing to unique differentiation capacity and paracrine activity, these cells can accelerate the healing procedure. In this review article, we have tried to scrutinize different reports related to the harmful effects of SARS-CoV-2 on patients with asthma and COPD, as well as the possible therapeutic effects of stem cells in the alleviation of post-COVID-19 complications.
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    PublicationOpen Access
    Exendin-4 as a versatile therapeutic agent for the amelioration of diabetic changes
    (Tabriz University of Medical Sciences, 2022) Ahmadi, Mahdi; Aslani, Somayeh; Saberianpour, Shirin; Rahbarghazi, Reza; Rajabi, Hadi; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences
    Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivides such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways.