Researcher:
Yıldız, Şule

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Şule

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Yıldız

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Yıldız, Şule
Oğuz, Şule Yıldız

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2016 - 2019202020 - 202332

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Researcher Of Publications: search.filters.isAuthorOfPublication.378eb7de-37a9-4394-9e79-ac6eafea9358

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Now showing 1 - 10 of 52
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    Utilization of the Bologna criteria: a promise unfulfilled? A review of published and unpublished/ongoing trials
    (Elsevier, 2018) Boza, Ayşen; N/A; Yıldız, Şule; Mısırlıoğlu, Selim; Yakın, Kayhan; Urman, Cumhur Bülent; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; 134205; N/A; 106822; 12147
    Objective: To study the use of the Bologna criteria (BC) for the definition of poor ovarian responders (POR) in clinical practice and research. Design: Systematic review of published and unpublished/ongoing trials between January 2012 and August 2017 on POR. Setting: Not applicable. Patient(s): Not applicable. Intervention(s): The databases were searched using the relevant medical subject headings including all subheadings. The search was limited to humans and English language. The references of the included studies were cross-searched for possibly missed articles. Only clinical trials providing an evidence level >= III were included. Case reports, review, letters, and hypothetical articles were excluded. Main Outcome Measure(s): Extracted studies were divided into two groups: studies in which the BC were used or not. Result(s): One hundred nine published clinical studies analyzing a total of 30,540 women and 112 unpublished/ongoing trials were identified. The BC were used to define POR in 56 (51%) of the published and 44 (39%) of the unpublished trials. The use of the BC gradually increased from 29% to 53% from 2012 to 2017. Asian researchers were more likely to use the BC compared with European and North American researchers (65%, 49%, and 23%, respectively). Neither the design of the study nor the impact factor of the publishing journal was correlated with the use of the BC. Conclusion(s): There is still reluctance to use the BC for the definition of POR, which makes it difficult to combine data from small studies and reach a meaningful conclusion. (C) 2017 by American Society for Reproductive Medicine.
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    Progestins vs gonadotropin releasing hormone analogues for pituitary suppression during ovarian stimulation for assisted reproductive technology, a systematic review and meta-analysis
    (Oxford Univ Press, 2020) Yıldız, Şule; Alexandru, Polexa; Çekiç, Sebile Güler; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; N/A; Doctor; Faculty Member; Faculty Member; Koç University Hospital; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; 134205; N/A; N/A; 329649; 182910
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    A novel flexible progestin primed ovarian stimulation protocol: comparison of pregnancy outcomes with the flexible GnRH antagonist protocol in an oocyte donation program
    (Elsevier, 2019) Eraslan, Alper; Angun, Berk; N/A; Yıldız, Şule; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; 134205; 329649; 232576
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    Ovarian endometriomas are heterogenous for the steroidogenic function and the expression of estrogen and progesterone receptors
    (Oxford Univ Press, 2021) N/A; N/A; N/A; N/A; Esmaeilian, Yashar; Yıldız, Şule; Yakın, Kayhan; Öktem, Özgür; Researcher; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; 134205; 106822; 102627
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    Endometriosis and adenomyosis: shared pathophysiology
    (Elsevier, 2023) Bulun, Serdar E.; Adli, Mazhar; Chakravarti, Debabrata; Parker, James Brandon; Milad, Magdy; Yang, Linda; Chaudhari, Angela; Tsai, Susan; Wei, Jian Jun; Yin, Ping; N/A; Yıldız, Şule; Faculty Member; School of Medicine; 134205
    Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are extremely similar. Both tissues originate from the eutopically located intracavitary endometrium. Oligoclones of endometrial glandular epithelial cells with somatic mutations and attached stromal cells may give rise to endometriosis if they travel to peritoneal surfaces or the ovary via retrograde menstruation and/or may be entrapped in the myometrium to give rise to adenomyosis. In both instances, the endometrial cell populations possess survival and growth capabilities conferred by somatic epithelial mutations and epigenetic abnormalities in stromal cells. Activating mutations of KRAS are the most commonly found genetic variant in endometriotic epithelial cells, whereas the adenomyotic epithelial cells almost exclusively bear KRAS mutations. Epigenetic abnormalities in the stromal cells of endometriosis and adenomyosis are very similar and involve an abnormal expression pattern of nuclear receptors, including the steroid receptors. These epigenetic defects give rise to excessive local estrogen biosynthesis by aromatase and abnormal estrogen action via estrogen receptor-β. Deficient progesterone receptor expression results in progesterone resistance in both endometriosis and adenomyosis.
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    How can optimal cytoreduction rates increased over ninety percent with a minimal usage of neoadjuvant chemotherapy ?
    (Lippincott Williams and Wilkins (LWW), 2016) Onan, Anıl; Karataş, Funda; Bostancı, Esra; Kerem, Mustafa; Arvas, Macit; Güner, Haldun; Taşkıran, Çağatay; Mısırlıoğlu, Selim; Yıldız, Şule; Balık, Emre; Alper, Aydın; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 134190; N/A; 134205; 18758; 119809
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    Pre-hCG serum progesterone elevation in consecutive 762 IVF cycles: there is a cycle to cycle variation in ovarian response and progesterone levels
    (Oxford University Press (OUP), 2017) Isiklar, A.; Balaban, B.; N/A; Yıldız, Şule; Yakın, Kayhan; Urman, Cumhur Bülent; Öktem, Özgür; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 134205; 106822; 12147; 102627
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    The role of protective ileostomy and the validity of bowel resection as a part of cytoreductive surgery for advanced stage epithelial ovarian cancer
    (Lippincott Williams and Wilkins (LWW), 2016) Onan, Anıl; Karataş, Funda; Güler, İsmail; Bostancı, Esra; Bedirli, Abdülkadir; Kerem, Mustafa; Arvas, Macit; Güner, Haldun; N/A; Mısırlıoğlu, Selim; Taşkıran, Çağatay; Yıldız, Şule; Balık, Emre; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 134190; 134205; 18758
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    Effectiveness of the flexible progestin primed ovarian stimulation protocol compared to the flexible gnrh antagonist protocol in women with decreased ovarian reserve
    (Taylor & Francis Ltd, 2022) Türkgeldi, Engin; Yıldız, Şule; Çekiç, Sebile Güler; Shakerian, Bahar; Keleş, İpek; Ata, Mustafa Barış; Faculty Member; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; N/A; School of Medicine; Koç University Hospital; 329649; 134205; N/A; N/A; N/A; 182910
    The aim of this retrospective cohort study was to compare the effectiveness of the new flexible progestin primed ovarian stimulation (fPPOS) protocol with the flexible gonadotropin-releasing-hormone antagonist (GnRH-ant) protocol in women with decreased ovarian reserve (DOR). Twenty-seven women who underwent fPPOS and 54 age-matched women who received GnRH-ant for pituitary suppression were included in the study. All women had DOR and underwent oocyte cryopreservation. Three-hundred IU/day FSH was started on cycle day 2-3 and 0.25 mg/day GnRH-ant or 10 mg/day medroxyprogesterone acetate was started when the leading follicle reached 14 mm or serum oestradiol level was >= 200 ng/mL. The median duration of stimulation, day of commencing pituitary suppression and duration of suppression were similar in both groups, with 8, 5, and 5 days, respectively. The median number of cumulus-oophorous complexes (4.0 vs 5.5), metaphase-two oocytes (3 vs 4), the total number of oocytes cryopreserved (3.0 vs 4.5), and oocyte maturation rates (0.67 vs 0.70) were similar between the fPPOS and GnRH-ant groups, respectively. There was one case of premature ovulation in the fPPOS group and none in the GnRH-ant group (p = 0.91). In conclusion, fPPOS may be used in women with DOR without compromising the number of oocytes retrieved and seems a viable alternative to the flexible GnRH-ant protocol.
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    Are live birth rate and obstetric outcomes different between immediate and delayed embryo transfers following a freeze-all cycle? a retrospective study combined with a meta-analysis
    (Oxford Univ Press, 2021) N/A; N/A; N/A; N/A; N/A; N/A; Yıldız, Şule; Türkgeldi, Engin; Kalafat, Erkan; Gökyer, Dilan; Keleş, İpek; Ata, Mustafa Barış; Faculty Member; Faculty Member; Faculty Member; Undergraduate Student; Doctor; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; 134205; 329649; 197389; N/A; N/A; 182910
    Study Question: Do livebirth rate (LBR), obstetric and perinatal outcomes vary between frozen embryo transfers (FET) in the first or subsequent menstrual cycles following a freeze-all approach? Summary Answer: Immediate FET has a higher LBR and similar perinatal outcomes than delayed FET. Quantitative synthesis of available literature shows an increased LBR with immediate transfer. What is Known Already: Whether FET should be done in the first menstrual cycle following oocyte collection (OC) is controversial and the duration of a possible detrimental effect of supraphysiological sex steroid levels on pregnancy outcome is unknown. A multinational survey centers showed that, 61% of clinicians prefer to wait for a washout period before proceeding to FET, even after a failed fresh embryo transfer. Limited number of studies compared FET in the first menstrual cycle with delayed FET in a subsequent cycle with varying results. There is limited data on obstetric outcomes of pregnancies resulting from FET in the first menstrual cycle. Study Design, Size, Duration: 198 women who underwent a freeze-all cycle followed by FET between July 2017 and June 2020 were included. 119 FET in the first menstrual cycle (<30 days from oocyte collection) and 79 FET in subsequent cycles (>30 days from oocyte collection) were retrospectively compared. MEDLINE was searched on 01 January 2021 using relevant keywords. Cohort studies comparing immediate versus delayed transfer following freeze all cycles were included and quantitative summary for LBR was obtained. Participants/Materials, Setting, Methods: Freeze-all was undertaken when (i) the woman is deemed to be at high risk for OHSS, (ii)serum progesterone level is > 1.5 ng/ml on the day of trigger, (iii)preimplantation genetic testing is planned, (iv)the woman will undergo surgery prior to ET, (v)couple preference. Main Results and the Role of Chance: Baseline characteristics were similar between the groups except for antral follicle count (22 vs 18, MD = 5, 95% CI = 0 to 8), and number of metaphase-two oocytes (13 vs 10, MD = 3, 95% CI = 1 to 6) all of which were significantly higher in the immediate transfer group. Clinical pregnancy rate (CPR) per ET was similar in two groups (50.4% vs 44.3%, RR = 1.14, 95% CI = 0.84 to 1.54). Miscarriage rate per pregnancy was significantly lower (12.3 vs 31.1, RR = 0.40, 95% CI = 0.19 to 0.84) and LBR per ET was significantly higher (42.9 vs 26.6, RR = 1.61, 95% CI = 1.06 to 2.46) in the immediate transfer group. Median gestational age at delivery was similar (267.5 (262.5–273) vs 268 (260–271.5) days, MD = 1.00, 95% CI= –4.00 to 5.00). Median birthweight was significantly higher in the delayed transfer group (3520 vs 3195 grams, MD= –300, 95% CI= –660 to –20 grams). Birthweight percentile, height at birth and head circumference were similar between groups. Literature search revealed 1712 studies from which nine were eligible for quantitative summary. Cumulative risk ratio showed a 10% increase in LBR with immediate transfer ompared to delayed transfer (RR = 1.10, 95% CI = 1.01 – 1.20, I2=67%, 17369 embryo transfers). Limitations, Reasons for Caution: Our study is limited by its retrospective design and relatively limited sample size for multivariate analyses. Yet, it is reassuring that the majority of our findings are consistent with previous publications. Wider Implications of the Findings: The hypotheses generated by our retrospective findings, i.e., FET in the immediate menstrual cycle resembling fresh ETs with strong trends towards lower birthweight and lower incidence of preeclampsia is noteworthy for the design of future studies, and these outcomes should be followed and reported.