Researcher: Mirzajani, Hadi
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Mirzajani, Hadi
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Publication Metadata only Femtosecond laser ablation assisted nfc antenna fabrication for smart contact lenses(Wiley, 2022) N/A; Department of Mechanical Engineering; Department of Mechanical Engineering; N/A; N/A; N/A; N/A; Department of Mechanical Engineering; Mirzajani, Hadi; İstif, Emin; Abbasiasl, Taher; Mirlou, Fariborz; Özkahraman, Ecem Ezgi; Hasanreisoğlu, Murat; Beker, Levent; Researcher; Other; PhD Student; PhD Student; N/A; Faculty Member; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); n2STAR-Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; N/A; School of Medicine; College of Engineering; N/A; N/A; N/A; N/A; N/A; 182001; 308798Smart contact lenses (SCLs) have drawn substantial interest for continuous health monitoring applications. Even though most of the reported works utilize near-field communication (NFC) or inductive coupling for wireless powering and data transmission, developing a scalable and rapid fabrication technique for annular ring antennas confined in a small contact lens area is still an unsolved challenge. Here, femtosecond laser ablation is employed for the first time as a simple, single-step, and highly precise fabrication technique for NFC antennas using conventional flexible printed circuit board materials. Antenna lines with depth and width of 9 and 35 mu m are achieved, respectively. The antenna with a footprint of 19.5 mm(2) is characterized in biological solution followed by aging, and bending tests, and a frequency deviation of less than %1 is recorded. A real-life application is demonstrated by fabricating an SCL embedded with the antenna, an NFC chip, and an electrochemical sensor for wireless monitoring of glucose in artificial tear solution by a smartphone. The device could successfully quantify biologically relevant glucose concentrations ranging from 0.2 to 1 mM with a limit-of-detection of 66 mu M. In addition, device response to interfering molecules is less than +/- 1 nA, and the spike-and-recovery test is successfully demonstrated.Publication Metadata only Photolithography-based microfabrication of biodegradable flexible and stretchable sensors(Wiley-V C H Verlag Gmbh, 2023) İstif, Emin; N/A; N/A; Department of Mechanical Engineering; N/A; N/A; Department of Mechanical Engineering; Bathaei, Mohammad Javad; Singh, Rahul; Mirzajani, Hadi; Akhtar, Muhammad Junaid; Abbasiasl, Taher; Beker, Levent; PhD Student; PhD Student; Researcher; Master Student; PhD Student; Faculty Member; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 308798Biodegradable sensors based on integrating conductive layers with polymeric materials in flexible and stretchable forms have been established. However, the lack of a generalized microfabrication method results in large-sized, low spatial density, and low device yield compared to the silicon-based devices manufactured via batch-compatible microfabrication processes. Here, a batch fabrication-compatible photolithography-based microfabrication approach for biodegradable and highly miniaturized essential sensor components is presented on flexible and stretchable substrates. Up to 1600 devices are fabricated within a 1 cm(2) footprint and then the functionality of various biodegradable passive electrical components, mechanical sensors, and chemical sensors is demonstrated on flexible and stretchable substrates. The results are highly repeatable and consistent, proving the proposed method's high device yield and high-density potential. This simple, innovative, and robust fabrication recipe allows complete freedom over the applicability of various biodegradable materials with different properties toward the unique application of interests. The process offers a route to utilize standard micro-fabrication procedures toward scalable fabrication of highly miniaturized flexible and stretchable transient sensors and electronics.Publication Metadata only An ultra-compact and wireless tag for battery-free sweat glucose monitoring(Elsevier Advanced Technology, 2022) N/A; Department of Mechanical Engineering; N/A; N/A; Department of Mechanical Engineering; N/A; N/A; N/A; N/A; Department of Mechanical Engineering; Mirzajani, Hadi; Abbasiasl, Taher; Mirlou, Fariborz; İstif, Emin; Bathaei, Mohammad Javad; Dağ, Çağdaş; Deyneli, Oğuzhan; Dereli, Dilek Yazıcı; Beker, Levent; Researcher; PhD Student; PhD Student; Other; PhD Student; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Department of Mechanical Engineering; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); n2STAR-Koç University Nanofabrication and Nanocharacterization Center for Scientifc and Technological Advanced Research; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; N/A; School of Medicine; School of Medicine; College of Engineering; N/A; N/A; N/A; N/A; N/A; N/A; 171914; 179659; 308798Glucose monitoring before, during, and after exercise is essential for people with diabetes as exercise increases the risk of activity-induced hyper- and hypo-glycemic events. The situation is even more challenging for athletes with diabetes as they have impaired metabolic control compared to sedentary individuals. In this regard, a compact and noninvasive wearable glucose monitoring device that can be easily worn is critical to enabling glucose monitoring. This report presents an ultra-compact glucose tag with a footprint and weight of 1.2 cm(2) and 0.13 g, respectively, for sweat analysis. The device comprises a near field communication (NFC) chip, antenna, electrochemical sensor, and microfluidic channels implemented in different material layers. The device has a flexible and conformal structure and can be easily attached to different body parts. The battery-less operation of the device was enabled by NFC-based wireless power transmission and the compact antenna. Femtosecond laser ablation was employed to fabricate a highly compact and flexible NFC antenna. The proposed device demonstrated excellent operating characteristics with a limit of detection (LOD), limit of quantification (LOQ), and sensitivity of 24 mu M, 74 mu M, and 1.27 mu A cm(-2) mM(-1), respectively. The response of the proposed sensor in sweat glucose detection and quantification was validated by nuclear magnetic resonance spectroscopy (NMR). Also, the device's capability in attachment to the body, sweat collection, and glucose measurement was demonstrated through in vitro and in vivo experiments, and satisfactory results were obtained.Publication Metadata only Powering smart contact lenses for continuous health monitoring: Recent advancements and future challenges(Elsevier Advanced Technology, 2022) N/A; Department of Mechanical Engineering; N/A; Department of Mechanical Engineering; N/A; Department of Mechanical Engineering; Mirzajani, Hadi; Mirlou, Fariborz; İstif, Emin; Singh, Rahul; Beker, Levent; Researcher; PhD Student; Other; PhD Student; Faculty Member; Department of Mechanical Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; N/A; N/A; 308798As the tear is noninvasively and continuously available, it has been turned into a convenient biological interface as a wearable medical device for out-of-hospital and self-monitoring applications. Recent progress in integrated circuits (ICs) and biosensors coupled with wireless data communication techniques have led to the implementation of smart contact lenses that can continuously sample tear fluid, analyze physiological conditions, and wirelessly transmit data to an electronic device such as smartphone, which can send data to relevant healthcare units. Continuous analyte monitoring is one of the significant characteristics of wearable biosensors. However, despite several advantages over other on-skin wearable medical devices, batteries cannot be incorporated on smart contact lenses for continuous electrical power supply due to the limited area. Herein, we review the progress of power delivery techniques of smart contact lenses for the first time. Different approaches, including wireless power transmission (WPT), biofuel cells, supercapacitors, flexible batteries, wired connections, and hybrid methods, are thoroughly discussed to understand the principles of self-sustainable contact lens biosensors comprehensively. Additionally, recent progress in contact lens biosensors is reviewed in detail, thereby providing the prospects for further developments of smart contact lenses as a common biosensing platform for various disease monitoring and diagnostic applications.Publication Metadata only Optimization of ACEK-enhanced, PCB-based biosensor for highly sensitive and rapid detection of bisphenol a in low resource settings(Elsevier, 2022) Cheng, Cheng; Vafaie, Reza Hadjiaghaie; Wu, Jayne; Chen, Jiangang; Eda, Shigotoshi; Aghdam, Esmaeil Najafi; Ghavifekr, Habib Badri; Department of Mechanical Engineering; Mirzajani, Hadi; Researcher; Department of Mechanical Engineering; College of Engineering; N/AIn this study, we developed a low-cost and easy-to-use capacitive biosensor employing printed-circuit-board (PCB)-based technique for electrode fabrication and a specific alternative current (AC) signal for AC Electrokinetics (ACEK) effect excitation. Fast, accurate, and highly sensitive detection and quantification of bisphenol A (BPA) was achieved. An easy characterization of the biofunctionalization process is introduced by measuring interfacial capacitance which is simple and superior to most of methods currently in use. The frequency and amplitude of the AC signal used for capacitive interrogation were optimized to achieve maximum interfacial capacitance and maximum sensitivity. To evaluate the performance of the developed biosensor, its operation was compared with in-house microfabricated and commercially available electrodes. The limit-of-detection (LOD) obtained using the PCB-based electrodes was found to be at least one order of magnitude lower than that obtained with the commercial and in-house microfabricated electrodes. The linear range for BPA detection was wide from 1 fM to 10 pM with an LOD of 109.5 aM and sample to result in 20s. The biosensor operation was validated by spike-and-recovery tests of BPA using commercial food samples. Thus, the platform has a potential as an on-site detection of bisphenol A in low-resource settings.