Researcher:
Önal, Emine Meltem

Profile Picture
ORCID

Job Title

Undergraduate Student

First Name

Emine Meltem

Last Name

Önal

Name

Name Variants

Önal, Emine Meltem

Email Address

Birth Date

Filters

2017 - 20207

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.397c8c7c-5cdc-4f80-adc4-618639bb1d0d

Search Results

Now showing 1 - 7 of 7
  • Placeholder
    PublicationMetadata only
    A 70-year-old patient with seronegative lupus nephritis: rare case
    (Logos Tıp Yayıncılığı, 2018) N/A; N/A; N/A; N/A; N/A; N/A; Dağel, Tuncay; Meram, Ece; Önal, Emine Meltem; Erbil, Damla; Bülbül, Mustafa Cem; Uysal, Sanem Pınar; Doctor; Undergraduate Student; Undergraduate Student; Undergraduate Student; Researcher; Undergraduate Student; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 327626; N/A
    Systemic lupus erythematosus (SLE) is an autoimmune disease known to be associated with various kinds of autoantibodies such as Antinuclear antibodies (ANA). ANA is found to be positive in most of the SLE patients. In fact, ANA positivity in serum is one of the diagnostic criteria of SLE. However, a minority of SLE patients may present with ANA negativity. We report a 70-year-old female who presented with massive edema and 10-gram/day proteinuria. Her serum antibodies for SLE were all negative and the renal biopsy showed a class V lupus nephritis. This case was unusual type of SLE due to multiple reasons namely the patient was an elderly woman, with isolated lupus nephritis and negative serology including ANA negativity.
  • Placeholder
    PublicationMetadata only
    The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus
    (Springer, 2018) Covic, Adrian; Vaziri, Nosratola D.; Afsar, Baris; N/A; Kanbay, Mehmet; Önal, Emine Meltem; Dağel, Tuncay; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; Doctor; Undergraduate Student; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; Koç University Hospital; N/A; 110580; N/A, N/A; N/A
    Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD. The gut microbiota closely interacts with the inflammatory, renal, cardiovascular, and endocrine systems via metabolic, humoral, and neural signaling pathways, events which can lead to chronic systemic inflammation, proteinuria, hypertension, diabetes, and kidney disease. Given the established role of the gut microbiota in the development and progression of CKD and its complications, favorable modification of the composition and function of the gut microbiome represents an appealing therapeutic target for prevention and treatment of CKD. This review provides an overview of the role of the gut microbial dysbiosis in the pathogenesis of the common causes of CKD including hypertension, diabetes, and proteinuria as well as progression of CKD.
  • Placeholder
    PublicationMetadata only
    The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures
    (Wiley, 2017) Sağ, Alan Alper; Şal, Oğuzhan; Kılıç, Yağmur; Önal, Emine Meltem; Kanbay, Mehmet; Faculty Member; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 341966; N/A; N/A; 110580
    This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.
  • Placeholder
    PublicationMetadata only
    Can incidental vascular calcifications at mammography be used as a screening biomarker for heart and kidney disease?
    (Sage, 2019) Covic, Adrian; A. Sag, Alan; Afsar, Barış; N/A; Erbil, Damla; Önal, Emine Meltem; Demirel, Çağrı; Dağel, Tuncay; Kanbay, Mehmet; Undergraduate Student; Undergraduate Student; Undergraduate Student; Doctor; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 110580
    Mammography is a screening test with extensive international application and financial infrastructure promoting accessibility and affordability. Designed specifically to detect microcalcifications, mammography is powered to detect calcifications in vessel walls. Breast arterial calcifications (BAC) are one of the most common incidental findings documented by mammography. This review considers the literature regarding BAC in relation to cardiovascular disease (CVD) and its risk factors. The aim is to assess the possibility of using BAC as an early surrogate imaging biomarker of CVD.
  • Placeholder
    PublicationMetadata only
    Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension
    (Taylor & Francis, 2017) Afsar, Baris; N/A; Kanbay, Mehmet; Önal, Emine Meltem; Sağ, Alan Alper; Şal, Oğuzhan; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; Faculty Member; Undergraduate Student; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 110580; N/A; N/A; 341966; N/A
    Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.
  • Placeholder
    PublicationMetadata only
    Diabetes mellitus in chronic kidney disease: biomarkers beyond HbA1c to estimate glycemic control and diabetes-dependent morbidity and mortality
    (Elsevier, 2020) Afsar, Baris; Ortiz, Alberto; van Raalte, Daniel H.; Cherney, David Z.; Rossing, Peter; N/A; Kanbay, Mehmet; Çöpür, Sidar; Önal, Emine Meltem; Faculty Member; Researcher; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; 110580; 368625; N/A
    Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). Optimal glycemic control contributes to improved outcomes in patients with DM, particularly for microvascular damage, but blood glucose levels are too variable to provide an accurate assessment and instead markers averaging long-term glycemic load are used. The most established glycemic biomarker of long-term glycemic control is HbA1c. Nevertheless, HbA1c has pitfalls that limit its accuracy to estimate glycemic control, including the presence of altered red blood cell survival, hemoglobin glycation and suboptimal performance of HbA1c assays. Alternative methods to evaluate glycemic control in patients with DM include glycated albumin, fructosamine, 1–5 anhydroglucitol, continuous glucose measurement, self-monitoring of blood glucose and random blood glucose concentration measurements. Accordingly, our aim was to review the advantages and pitfalls of these methods in the context of CKD.
  • Thumbnail Image
    PublicationOpen Access
    Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease
    (Nature Publishing Group (NPG), 2019) Afşar, Barış; Covic, Adrian; Vaziri, Nosratola D.; N/A; Önal, Emine Meltem; Kanbay, Mehmet; Faculty Member; School of Medicine; N/A; 110580
    The health and proper functioning of the cardiovascular and renal systems largely depend on crosstalk in the gut-kidney-heart/vessel triangle. Recent evidence suggests that the gut microbiota has an integral function in this crosstalk. Mounting evidence indicates that the development of chronic kidney and cardiovascular diseases follows chronic inflammatory processes that are affected by the gut microbiota via various immune, metabolic, endocrine, and neurologic pathways. Additionally, deterioration of the function of the cardiovascular and renal systems has been reported to disrupt the original gut microbiota composition, further contributing to the advancement of chronic cardiovascular and renal diseases. Considering the interaction between the gut microbiota and the renal and cardiovascular systems, we can infer that interventions for the gut microbiota through diet and possibly some medications can prevent/stop the vicious cycle between the gut microbiota and the cardiovascular/renal systems, leading to a decrease in chronic cardiovascular and renal diseases.