Researcher: Ekinci, Can
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Ekinci, Can
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Publication Metadata only Effects of volume overload and current techniques for the assessment of fluid status in patients with renal disease(Karger Publishers, 2018) Siriopol, Dimitrie; Covic, Adrian; Ekinci, Can; Karabörk, Merve; Dinçer, Neris; Kanbay, Mehmet; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 323478; 358512; 349025; 110580Volume overload is an important, may be the foremost, independent prognostic factor determining the outcome of hemodialysis patients. Therefore, it is crucial to measure fluid status of these patients and avoid volume overload. This review aims to evaluate volume overload, its effects on patients with renal diseases and current methodologies measuring volume status in the body. These techniques will be first classified as clinical evaluation and non-clinical and/or instrumental techniques, which includes biomarkers, ultrasonography, relative blood volume monitoring, bioimpedance, echocardiography, pulmonary artery catheterization, esophageal and/or suprasternal Doppler, and blood viscosity. Advantages and limitations of these different techniques will be reviewed extensively by comparing each other. At last, insights gained from this review can highlight the future prospects in this active area of research. (C) 2018 S. Karger AG, Basel.Publication Metadata only Sox2: regulation of expression and contribution to brain tumors(Future Medicine, 2016) Mansouri, Sheila; Nejad, Romina; Aldape, Kenneth D.; Zadeh, Gelareh; N/A; Karabörk, Merve; Ekinci, Can; Solaroğlu, İhsan; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; 323478; 102059Tumors of the CNS are composed of a complex mixture of neoplastic cells, in addition to vascular, inflammatory and stromal components. Similar to most other tumors, brain tumors contain a heterogeneous population of cells that are found at different stages of differentiation. The cancer stem cell hypothesis suggests that all tumors are composed of subpopulation of cells with stem-like properties, which are capable of self-renewal, display resistance to therapy and lead to tumor recurrence. One of the most important transcription factors that regulate cancer stem cell properties is SOX2. In this review, we focus on SOX2 and the complex network of signaling molecules and transcription factors that regulate its expression and function in brain tumor initiating cells. We also highlight important findings in the literature about the role of SOX2 in glioblastoma and medulloblastoma, where it has been more extensively studied.