Researcher:
Aslan, Gamze

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Doctor

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Gamze

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Aslan

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Aslan, Gamze

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2016 - 2019172020 - 20224

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    A rare case of right sided pulmonary artery agenesis associated with congenital mitral valve prolapse
    (Turkish Assoc Tuberculosis & Thorax, 2016) N/A; N/A; İliaz, Sinem; Aslan, Gamze; Öztürk, Ayşe Bilge; Özyiğit, Sabiha Leyla Pur; Tabak, Levent; Doctor; Doctor; Faculty Member; Doctor; Faculty Member; N/A; N/A; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; 147629; 214687; N/A
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    The impact of exercise on physical function, cardiovascular outcomes and quality of life in chronic kidney disease patients: a systematic review
    (Springer, 2018) Afsar, Baris; Siriopol, Dimitrie; Kanbay, Asiye; Burlacu, Alexandru; Covic, Adrian; N/A; N/A; N/A; N/A; N/A; Aslan, Gamze; Eren, Özgür Can; Kılıç, Uğur; Dağel, Tuncay; Kanbay, Mehmet; Doctor; Researcher; Other; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 110580
    The prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) is increasing steadily. CKD does not only relate to morbidity and mortality but also has impact on quality of life, depression and malnutrition. Such patients often have significantly decreased physical activity. Recent evidence suggests that low physical activity is associated with morbidity, mortality, muscle atrophy, quality of life impairment, cardiovascular outcomes and depression. Based on this, it is now recommended to regularly improve the physical activity of these patients. Furthermore, studies have shown the beneficial effects of various exercise programs with respect to outcomes such as low physical activity muscle atrophy, quality of life, cardiovascular outcomes and depression. Despite these encouraging findings, the subject is still under debate, with various aspects still unknown. In this review, we tried to critically summarize the existing studies, to explore mechanisms and describe future perspectives regarding physical activity in CKD/ESRD patients.
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    Determinants of age-adjusted higher nt-pro-bnp values in adults with coronary artery disease and obstructive sleep apnea in the RICCADSA cohort
    (Elsevier, 2019) Glantz, H.; Thunstrom, E.; N/A; Peker, Yüksel; Aslan, Gamze; Çelik, Yeliz; Ural, Dilek; Faculty Member; Doctor; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; N/A; 234103; N/A; N/A; 1057
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    Iron in kidney and heart failure: from theory to practice
    (Springer, 2018) Afsar, Baris; Voroneanu, Luminita; Siriopol, Dimitire; Covic, Adrian; N/A; N/A; N/A; N/A; N/A; Yerlikaya, Aslıhan; Bülbül, Mustafa Cem; Dağel, Tuncay; Aslan, Gamze; Kanbay, Mehmet; Undergraduate Student; Researcher; Doctor; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; School of Medicine; N/A; N/A; 327626; N/A; N/A; 110580
    There is evidence that serum iron levels, regardless of the presence of anemia, directly impact outcomes in congestive heart failure (CHF) including quality of life, hospitalization rate and overall survival. Despite modern medical treatments, the prognosis of CHF remains grim. Ironically, simple iron replenishment may serve as a powerful tool in the armamentarium. This review will start from fundamental concepts of iron in oxygen delivery and analyze evidence-based outcomes in CHF iron-directed therapeutic trials. Imaging rationale that dovetails with this pathophysiology will also be detailed in a clinician-directed fashion.
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    Evaluation of serum sST2 and sCD40L values in patients with microvascular angina
    (Academic Press Inc Elsevier Science, 2019) Polat, Veli; Opan, Selçuk; Çetin, Nurcan; Aslan, Gamze; Polat, Evin Bozçalı; Ural, Dilek; Doctor; Doctor; Faculty Member; N/A; N/A; School of Medicine; Koç University Hospital; N/A; 239008; 1057
    Objectives: Coronary microvascular dysfunction plays a major role in the pathogenesis of microvascular angina (MVA). Along with endothelial dysfunction, microvascular atherosclerosis and inflammation seem to contribute to the development of coronary microvascular dysfunction. Serum soluble ST2 (sST2) and serum soluble CD40 ligand (sCD40L) are two biomarkers associated with inflammation and atherosclerosis. The aim of this study was to investigate the role of these biomarkers in the pathogenesis of MVA and determine their possible association with coronary microvascular dysfunction. Methods: A total of 152 patients were included in the study. Ninety-one patients with MVA {median age 56 years (40-79), of which 55 are women} and sixty-one controls {median age 52 (38-76), of which 29 are women} were included in the study. Serum concentration of sST2 and sCD40L were measured with a commercially available ELISA kit. Results: Serum sST2 (median 13.6 ng/ml; interquartile range (IQR), 3.5-63.8 ng/ml vs median 10.6 ng/ml; IQR, 2.9-34.2 ng/ml, p < 0.0005) and sCD40L (median 5.3 ng/ml; IQR, 0.5-20.6 ng/ml vs median 2.2 ng/ml; IQR, 0.7-10.8 ng/ml, p < 0.0005) were significantly higher in patients with MVA compared to controls. Analysis of the associations between these biomarkers and potential contributors of MVA revealed that serum sST2 showed a positive correlation with LDL-cholesterol (r = 0.19, p = 0.016) and serum sCD40L concentrations correlated positively with hs-CRP (r = 0.22, p = 0.005). In logistic regression analysis, sCD40L and hs-CRP but not sST2 were found to be significantly associated with MVA. Conclusion: Higher serum concentrations of sST2 and sCD40L in MVA patients may be associated with inflammatory activation and coronary microvascular dysfunction. Larger studies are required for understanding their role in the pathogenesis of inflammatory and possibly fibrotic process in MVA patients.
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    Acute effects of salt on blood pressure are mediated by serum osmolality
    (Wiley, 2018) Afsar, Baris; Siriopol, Dimitrie; Kuwabara, Masanari; Rodriguez-Iturbe, Bernardo; Lanaspa, Miguel A.; Covic, Adrian; Johnson, Richard J.; N/A; Kanbay, Mehmet; Aslan, Gamze; Dağel, Tuncay; Çamkıran, Volkan; İncir, Said; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; School of Medicine; N/A; N/A; N/A; School of Medicine; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; 110580; N/A; N/A; N/A; 175430
    It is classically thought that it is the amount of salt that is critical for driving acute blood pressure responses. However, recent studies suggest that blood pressure responses, at least acutely, may relate to changes in serum osmolality. Here, we test the hypothesis that acute blood pressure responses to salt can be altered by concomitant water loading. Ten healthy patients free of any disease and medication underwent 4 interventions each a week apart in which they took 300 mL of lentil soup with no salt (visit 1), lentil soup with 3 g salt (visit 2), or lentil soup with 3 g salt and 500 mL water (visit 3) or 750 mL water (visit 4). At each visit, hourly blood measurements and blood pressure measurements (baseline, 1st, 2nd, 3rd, and 4th hour) were performed and plasma osmolarity, sodium and copeptin levels were measured. Patients receiving the 3 g salt showed a 6 mOsm/L change in osmolality with a 2.5 mmol/L change in plasma sodium and 10 mm Hg rise in systolic blood pressure at 2 hours. When the same patients drank salty soup with water, the changes in plasma osmolarity, plasma sodium, and blood pressure were prevented. The ability to raise blood pressure acutely with salt appears dependent on changes in plasma osmolality rather than the amount of salt. Our findings suggest that concurrent intake of water must be considered when evaluating the role of salt in blood pressure.
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    Assessment of inflammatory markers in microvascular angina
    (Elsevier Ireland Ltd, 2019) Polat, V.; Şahin, M. H.; Aslan, Gamze; Polat, Evin Bozçalı; Ural, Dilek; Baysal, Kemal; Doctor; Doctor; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; 239008; 1057; 119184
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    Cardiovascular effects of continuous positive airway pressure treatment in patients with obstructive sleep apnea: a meta-analysis
    (Sage, 2018) Afsar, Baris; Siriopol, Dimitrie; Kanbay, Asiye; Covic, Adrian; N/A; Aslan, Gamze; Şal, Oğuzhan; Benli, Çağhan; Okçuoğlu, John; Kanbay, Mehmet; Doctor; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; 341966; N/A; N/A; 110580
    Continuous positive airway pressure (CPAP) is the first-line treatment of obstructive sleep apnea (OSA). Obstructive sleep apnea is a predictor of cardiovascular (CV) events. In this meta-analysis, we evaluated the effect of CPAP on left ventricular ejection fraction (LVEF), CV events, CV mortality, and all-cause mortality in patients with OSA. Nine articles (n = 9610 patients) were analyzed. Four different meta-analyses were performed: evaluation of LVEF, assessment of all-cause mortality, CV mortality, and CV events. Continuous positive airway pressure treatment was associated with a significant increase in LVEF (mean difference: 2.1%, 95% confidence interval [CI]: 0.8%-3.4%). There was a nonsignificant reduction in all-cause mortality (hazard ratio [HR]: 0.92, 95% CI: 0.73-1.15) but a significant reduction of 66% in the risk of CV mortality associated with the CPAP treatment (HR: 0.34, 95% CI: 0.17-0.68, P = .002). There was a nonsignificant reduction in the risk of CV events in the CPAP-treated patients (HR: 0.84, 95% CI: 0.60-1.18, P = .31). Our meta-analyses showed that CPAP treatment improves LVEF and could have a beneficial effect on CV mortality.
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    The quality of ECG data acquisition, and diagnostic performance of a novel adhesive patch for ambulatory cardiac rhythm monitoring in arrhythmia detection
    (Churchill Livingstone Inc Medical Publishers, 2019) Deliormanli, Bilgen Gulsen; Adiguzel, Omer; Li, Ko-Mai; Yılmaz, Elif Nur; N/A; N/A; N/A; Department of Industrial Engineering; Karaoğuz, Mustafa Remzi; Yurtseven, Ece; Aslan, Gamze; Gönen, Mehmet; Doctor; Teaching Faculty; Doctor; Faculty Member; Department of Industrial Engineering; N/A; School of Medicine; N/A; College of Engineering; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; 176021; N/A; 237468
    Background: Short and long ambulatory electrocardiographic monitoring with different systems is a widely used method to detect cardiac arrhythmias. In this study, we aimed to evaluate the effectiveness of a novel monitoring device on cardiac arrhythmia detection. Methods: We used two different protocols to evaluate device performance. For the first one, 36 healthy subjects were enrolled. The standard 12-lead, 24-h Holter monitoring and the novel single lead electrocardiogram (ECG) Patch Monitor (EPM) device (BeyondCare (R), Rooti Labs Ltd., Taipei, Taiwan) were simultaneously applied to all subjects for 24 h. The quality of ECG data acquisition of novel system was compared to that of standard Holter. The second phase included 73 patients that were referred from our outpatient arrhythmia clinic for evaluation of their symptoms relevant to the cardiac arrhythmias. Advanced algorithms, statistical methods (cross-correlation method, Pearson's correlation coefficient, Bland-Altman plots) were used to process and verify the acquired data. Results: The overall average beat per minute correlation between BeyondCare (R) and standard 12-lead Holter was found 98% in 33 healthy subjects. The mean percentage of invalid measurements in BeyondCare (R) was 1.6% while the Holter's was 1.7%. In the second protocol of the study, prospective data from 67 patients who were referred for evaluation of their symptoms relevant to cardiac arrhythmias, showed that the mean BeyondCare (R) wear time was 4.7 +/- 0.5 days out of five total days per protocol. The mean analyzable wear time was 93.6%. The water-resistant design enabled 73.5% of the participants to take a shower. 7.3% of participants had minor skin irritations related to the electrodes. Among the patients with detected arrhythmia (40.2% of all patients), 29.6% had their first arrhythmia after the initial two days period. A clinically significant pause was detected in one patient, ventricular tachycardia was detected in four patients, and supraventricular tachycardia was detected in 15 patients. Paroxysmal atrial fibrillation was identified in seven patients. Three of them had their first episodes after the second day of monitoring. Conclusion: BeyondCare (R) Patch was well-tolerated and allowed prolonged time periods for continuous ECG monitoring, may result in an improvement in clinical accuracy and detection of arrhythmias by cloud-based artificial intelligence operating system. (C) 2019 Elsevier Inc. .
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    Evaluation of pulmonary arterial stiffness and comparison with right ventricular functions in patients with cirrhosis preparing for liver transplantation
    (Wiley, 2022) Elçioğlu, Betül Cengiz; Baydar, Onur; Helvacı, Füsun; Karataş, Cihan; Aslan, Gamze; Kılıç, Alparslan; Tefik, Nihal; Demir, Barış; Gürsoy, Erol; Demirci, Yasemin; Ural, Dilek; Kanmaz, Turan; Aytekin, Vedat; Aytekin, Saide; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Doctor; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; NA; N/A; N/A; 1057; 275799; 140946; N/A
    Objective Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. The aim of this study is to investigate PAS and compare it with right ventricular (RV) functions in patients with cirrhosis who are scheduled for liver transplantation. Methods The study included 52 cirrhosis patients (mean age 51.01 +/- 12.18 years, male gender 76.9%) who were prepared for liver transplantation and 59 age and sex matched (mean age 51.28 +/- 13.63 years, male gender 62.7%) healthy individuals. Patients with left ventricular ejection fraction (LVEF) less than 55%, ischemic heart disease, more than mild valvular heart disease, chronic pulmonary disease, congenital heart disease, rheumatic disease, moderate to high echocardiographic PH probability, rhythm or conduction disorders on electrocardiography were excluded from the study. In addition to conventional echocardiographic parameters, PAS value, pulmonary vascular resistance (PVR) and RV ejection efficiency was calculated by the related formulas with transthoracic echocardiography (TTE). Results Demographic characteristics and cardiovascular risk factors of the groups were similar. PAS, PVR, and sPAP values were found to be significantly higher in the patient group (20.52 +/- 6.52 and 13.73 +/- 2.05; 1.43 +/- 0.15 and 1.27 +/- 0.14; 27.69 +/- 3.91 and 23.37 +/- 3.81 p < 0.001, respectively). RV FAC and RV Ee were significantly lower and RV MPI was significantly higher in the patient group (45.31 +/- 3.85 and 49.66 +/- 3.62, p < 0.001; 1.69 +/- 0.35 and 1.85 +/- 0.23, p = 0.005; 0.39 +/- 0.07 and 0.33 +/- 0.09, p = 0.001, respectively). PAS was significantly correlated with RV FAC and MPI (r = -0.423, p < 0.001; r = 0.301, p = 0.001, respectively). Conclusions Increased PAS in cirrhosis patients may be associated with early pulmonary vascular involvement. Evaluation of RV functions is important to determine the prognosis in these patients. FAC, MPI, and RV Ee measurements instead of TAPSE or RV S ' may be more useful in demonstrating subclinical dysfunction. The correlation of PAS with RV FAC and MPI may indicate that RV subclinical dysfunction is associated with early pulmonary vascular remodeling in patients with liver cirrhosis.