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Mutluer, Tuba

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    Trauma, creativity, and trance: special ability in a case of dissociative identity disorder
    (Amer Psychiatric Publishing, Inc, 2018) N/A; N/A; N/A; N/A; Şar, Vedat; Mutluer, Tuba; Necef, Işıl; Fatih, Parmis; Faculty Member; Faculty Member; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 8542; 305311; N/A; N/A
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    Neuropsychological profile differences between children with disruptive mood dysregulation disorder (DMDD) and attention-deficit/hyperactivity disorder (ADHD): a preliminary study
    (Elsevier Science Inc, 2017) Taşkıran, Ali Sarper; Mutluer, Tuba; Necef, Işıl; Other; Faculty Member; Doctor; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 195168; 305311; N/A
    Objectives: Disruptive mood dysregulation disorder (DMDD), characterized by severe irritability, and ADHD are highly comorbid. Clinical observation suggests that patients with DMDD have greater impairment in functioning at school. We compared the neuropsychological assessment scores across three groups of participants to test whether any cognitive differences exist among children with ADHD, DMDD and healthy control (HC) subjects. Methods: The study sample group consisted of 43 participants (14 DMDD, 14 ADHD and 15 age-matched HC, mean age = 9.51; SD = 2.10). All the subjects diagnosed with DMDD had comorbid ADHD. Subjects underwent extensive diagnostic measures including Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS). We applied the following tests: trail making test (TMT), symbol cancellation task (SCT), single letter cancellation task (SLCT), digit span learning (DSL), benton judgment of line orientation (JLO), Rey-Osterrieth complex figure test (CFT), letter and symbol cancellation test (LCT, SCT), Stroop color word (TBAG), and Wisconsin card sorting test (WCST). Results: There were statistically significant differences between these three groups on the TMS, F (2,41) = 5.270, p = 0.009, structured SLCT, F (2,41) = 3.376, p = 0.044, unstructured SLCT, F (2,41) = 5.142, p = 0.010, unstructured SCT, F (2,41) = 5.282, p = 0.009, the ROCFT, F (2,40) = 6.622, p = 0.003, the ROCFT: delayed recall condition score, F (2,40) = 3.647, p = 0.035), the ROCFT: delayed condition time, F (2,40) = 9.195, p = 0.001), Stroop test: incongruent color words condition, F (2,40) = 4.522, p = 0.017), Stroop test: naming the color of random words condition, F (2,40) = 3.647, p = 0.035). Post hoc analyses revealed little difference between ADHD and ADHD and DMDD groups except for the TMT. Conclusions: Neuropsychological properties for children with DMDD are very similar to those of ADHD. Selective and sustained attentional impairment, working memory, and set shifting difficulties are prominent in both ADHD and DMDD. Although results did not yield a significant difference, we observed more impaired performance in all tests, likely due to greater impulsivity and poorer frustration tolerance. Larger sample size is required to confirm this notion.
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    Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study
    (Wiley, 2020) Morey Özcan, Aslıhan; Ongur, Dost; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Taşkıran, Ali Sarper; Ertınmaz, Beliz; Mutluer, Tuba; Kılıç, Özge; Necef, Işıl; Yalçınay-İnan, Merve; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Doctor; Doctor; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; Koç University Hospital; 134359; 195168; N/A; 305311; 167890; N/A; N/A; N/A
    Objective Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD. Method We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted. Results Thirty-seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive-compulsive disorder (OCD) was 16.7%. Childhood-onset studies reported higher GAD and SAD comorbidity, while adolescent-onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders' comorbidity with PBD differently. Conclusion Anxiety disorders are highly comorbid with PBD. Early-onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.
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    Psychopathology and dissociation among boarding school students in eastern Turkey
    (Springer Heidelberg, 2021) N/A; N/A; Mutluer, Tuba; Fatih, Parmis; Tayakısı, Emre; Shabsog, Mohammed Kamal Yahya; Çapacı, Merve; Yürük, Deniz; Necef, Işıl; Faculty Member; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 305311; N/A; N/A; N/A; N/A; N/A; N/A
    A subset of boarding schools for adolescents was established in 1993 in the rural sections of Eastern Turkey to provide equity in terms of availability of education. Even though these schools were beneficial in many respects, implementation of this institutional model gave rise to many challenges such as weaker relationships with parents and defiance of authority figures. Failure to develop a mature response to these challenges could lead to the development of psychopathologies such as depression, psychosis, and dissociation. The main objective of this study is to assess the incidence of psychopathology and dissociative experiences of the residential female students in the regional boarding schools compared to a control group. 187 female participants, 128 attending boarding school, and 59 attending day school, as the control group, were included in the study. Brief Symptom Inventory (BSI) and Adolescent Dissociative Experiences Scale (ADES) were used as measurement scales. T-test, Mann Whitney-U, Spearman correlation chi-square tests were used to evaluate the association between the variables. There was a significant difference in Interpersonal sensitivity and Psychoticism subscales of BSI. ADES score was found to be significantly higher in the Boarding school group. Boarding school students are at a higher risk of developing psychopathology as a common trauma on a group of people can result in shared dissociation, a collective defense mechanism to cope with the injury, which resembles shared delusional disorder within DSM-V (The Diagnostic and Statistical Manual of Mental Disorders). Screening measures should be implemented in boarding schools to evaluate adolescents for psychopathology and preventive measures should be taken to intervene in the early stages.
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    Face emotion recognition differences with respect to frustration in disruptive mood dysregulation disorder (DMDD) and attention-deficit/hyperactivity disorder (ADHD)
    (Elsevier Science Inc, 2017) N/A; N/A; N/A; N/A; N/A; Department of Psychology; Taşkıran, Ali Sarper; Türkakın, Esin; Mutluer, Tuba; Necef, Işıl; Balcı, Fuat; Other; Master Student; Researcher; Faculty Member; Doctor; Faculty Member; Department of Psychology; School of Medicine; Graduate School of Social Sciences and Humanities; N/A; School of Medicine; School of Medicine; College of Social Sciences and Humanities; Koç University Hospital; 195168; N/A; N/A; 305311; N/A; 51269
    Objectives: We examined the effect of frustration in emotion recognition across children with ADHD and disruptive mood dysregulation disorder (DMDD) and healthy control (HC) subjects. Methods: Sample group consisted of 43 participants (14 DMDD + ADHD, 14 ADHD, 15 HC subjects, mean = 9.51; SD = 2.10), who completed a novel emotion recognition task with a frustration component that we developed using happy, angry, and neutral faces from the FACES database of Max Planck Institute for Human Development. The task was a two-alternative forced choice paradigm in which participants were asked to identify if a face was happy versus neutral or if a face was angry versus neutral. Frustration, in some blocks, was elicited by providing conflicting feedback and holding back deserved points after some correct answers. Results: In the frustration blocks of the emotion recognition task, there were statistically significant main effects of emotion on accuracy [ F (1,39) = 18.886, P < 0.001, η 2 = 0.326] and the type of feedback in previous trial on the response time [ F (1,39) = 11.019, P < 0.002, η 2 = 0.220], as well as a between-subjects effect of diagnosis on accuracy [ F (2,39) = 6.384, P = 0.004, η 2 = 0.247]. Post hoc analyses revealed that participants were more accurate recognizing happy faces as opposed to angry faces ( P < 0.001), slower after frustrating trials ( P = 0.002), and that participants with DMDD were less accurate than control subjects ( P = 0.017) and participants with ADHD ( P = 0.007). Linear integrated speed-accuracy scores (LISAS), interpreted as reaction time adjusted by error rate, showed a main effect of emotion [ F (1,39) = 12.389, P = 0.001, η 2 = 0.241] and feedback type in previous trial [ F (1,39) = 6.350, P = 0.016, η 2 = 0.140], but there was no between-subjects effect of diagnosis group on LISAS. The post hoc analyses revealed that the reaction time adjusted for error rates when recognizing happy faces were found to be faster as opposed to angry faces ( P = 0.001) and slower in postfrustration trials ( P = 0.016). Conclusions: Children with DMDD are less accurate overall compared with healthy control subjects and children with ADHD in the novel task that involves emotion recognition. Their impairment becomes more pronounced after frustrating trials, which emerge as a distinctive feature between participants with pure ADHD and those with ADHD/DMDD comorbidity.
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    Investigation of the relationship between physical problems and aberrant behavior categories in autism spectrum disorder
    (Galenos Yayınevi, 2020) N/A; N/A; N/A; Mutluer, Tuba; Doenyas, Ceymi; Faculty Member; PhD Student; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Social Sciences and Humanities; 305311; 277852
    Objectives: Autism spectrum disorder is a neurodevelopmental conditiona that manifests with impairments in social interactions and communication and repetitive behaviors and restricted interests. It is known that autism spectrum disorder is accompanied by medical comorbidities, and as the number of accompanying comorbidities increase, the intensity of aberrant behaviors also increases in individuals with autism spectrum disorder. Yet, how subgroups of aberrant behaviors relate to physical complaints with unknown primary etiology in autism spectrum disorder has not yet been investigated. Understanding and solving these physical problems can improve the quality of life of individuals with autism spectrum disorder, as interventions should not only address core autism spectrum disorder symptoms but also all physical complaints affecting an individual’s life. Additionally, an examination of such a relation may help better understand the underlying mechanisms of autism spectrum disorder. Materials and Methods: In this study, in 64 individuals with autism spectrum disorder (11 girls) aged between 6 and 18 years, the relationship between the physical complaints subcategory of Child Behavior Checklist and the severity of autism spectrum disorderaccording to Childhood Autism Rating Scale was examined. Additionally, the relationship between physical complaints and the subgroups of the Aberrant Behavior Checklist was evaluated. Results: A significant positive correlation was found between physical symptoms and autism spectrum disorder severity. Among the five factors of this checklist (irritability, agitation, crying; lethargy, social withdrawal; stereotypic behavior; hyperactivity, non-compliance; inappropriate speech), only hyperactivity/non-compliance and inappropriate speech correlated with physical complaints. This relationship was independent of sociodemographic factors such as child age, parental age, and parental education. Conclusion: These findings indicate that children with autism spectrum disorder who exhibit extreme mobility and disobedience are at risk of physical discomfort. In addition to psychiatric and psychologic examinations, a comprehensive and holistic approach should be adopted for individuals with autism spectrum disorder, especially for those individuals experiencing physical problems. / Amaç: Otizm spektrum bozukluğu sosyal beceri eksikliği ve yineleyen davranışlar ile kısıtlı ilgi alanlarını içeren nörogelişimsel bir durumdur. Bugüne kadar alanyazında fiziksel rahatsızlıklar ile otizm şiddeti arasındaki ilişki incelenmiş, ancak birincil nedeni bilinmeyen bedensel rahatsızlıkların otizme eşlik eden sorun davranış alt grupları ile ilişkisi araştırılmamıştır. Otizme eşlik eden fiziksel sorunların anlaşılması ve çözümlenmesi bu bireylerin hayat kalitelerinin iyileşmesini sağlayabilir. Ayrıca bu ilişkinin incelenmesi, otizmin altında yatan nedensel mekanizmaların daha iyi anlaşılmasına yardımcı olabilir. Gereç ve Yöntem: Çalışmada, 6-18 yaş arası 64 otizmli bireyde (11 kız), bedensel rahatsızlıkların otizm şiddeti ve otizmdeki sorunlu davranışlar ile ilişkisi araştırılmıştır. Bu amaç doğrultusunda, 4-18 Yaş Grubu Çocuk ve Gençler İçin Davranış Değerlendirme Ölçeği’nin alt ölçeklerinden biri olan bedensel rahatsızlık kategorisi ile Çocukluk Otizmi Derecelendirme Ölçeği aracılı ölçülen otizm şiddeti ve Otizm Sorun Davranış Listesi’nin alt başlıkları arasındaki olası ilişki incelenmiştir. Bulgular: Otizmin şiddeti ile bedensel şikayetler arasında anlamlı bir ilişki bulunmuştur. Ayrıca otizme eşlik eden sorun davranışlar olan huzursuzluk, atalet ve sosyal içe kapanıklık, yinelenen davranışlar, aşırı hareketlilik ve itaat etmeme ile uygun olmayan konuşma davranış alt grupları arasından sadece aşırı hareketlilik ve itaat etmeme ile bedensel şikayetler arasında anlamlı bir ilişki bulunmuştur. Bu ilişkinin çocuk yaşı, anne-baba yaşı ve anne-baba eğitimi gibi sosyodemografik etmenlerden bağımsız olduğu gösterilmiştir. Sonuç: Bu bulgular, otizmde aşırı hareketlilik ve itaatsizlik gösteren çocukların bedensel rahatsızlık yaşama riski taşıdığına işaret etmektedir. Psikiyatrik ve psikolojik incelemelerin yanı sıra bu davranışları gösteren otizmli bireylere kapsamlı bir yaklaşım ve bütüncül bir tedavi uygulanmasının önemi ortaya çıkmaktadır.
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    A revised and expanded version of the Turkish childhood trauma questionnaire (CTQ-33): overprotection-overcontrol as additional factor
    (Routledge Journals, Taylor & Francis Ltd, 2021) Türk-Kurtça, Tuğba; N/A; N/A; N/A; N/A; Şar, Vedat; Necef, Işıl; Mutluer, Tuba; Fatih, Parmis; Faculty Member; Doctor; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 8542; N/A; 305311; N/A
    This study was concerned with a culture-sensitive revision of the Turkish version of the Childhood Trauma Questionnaire (CTQ-28) and expansion of the instrument through integration of a dimension assessing overprotection - overcontrol (OP-OC). Participants (n = 783) were 37 dissociative and 78 non-dissociative and non-psychotic psychiatric outpatients, and 668 non-clinical people. They completed the revised and expanded version of the CTQ, Dissociative Experiences Scale, Beck Depression Scale, and Relationship Scales Questionnaire. A test-retest assessment was conducted on 25 non-clinical individuals. Among twenty-one alternative and the twenty-five original statements, the items of subsections were selected by correlations between item and item deleted total scores for each subset of original and alternative statements. The 33-item final version (CTQ-33) included five statements for each subsection including OP-OC and three denial items. The principal component analysis on items of the CTQ-33 with a varimax rotation yielded six factors including OP-OC. The inner consistency and the test-retest reliability were good. OP-OC correlated particularly with emotional abuse and neglect, and other types of trauma. There were significant correlations between CTQ-33 and depression, dissociation, and fearful attachment scores. The CTQ-33 differentiated psychiatric from non-clinical groups. The Turkish CTQ-33 is a reliable and valid instrument. OP-OC by caregivers may be as traumatic as other types of childhood adversities. Cross-cultural research would illuminate the significance of OP-OC beyond Turkish culture. The possibility of intergenerational transmission of trauma through OP-OC by fearful parents in and after times of cultural upheaval and political oppression should be considered for future research.
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    Sociodemographic and clinical characteristics of sexually abused children and adolescents cases living in Turkey's Eastern Anatolia Region
    (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2016) Gençoğlu, Salih; Hekimoğlu, Yavuz; Özdemir, Pınar Güzel; Gümüş, Orhan; Durmaz, Onur; Nasıroğlu, Serhat; Aşırdizer, Mahmut; N/A; Mutluer, Tuba; Faculty Member; School of Medicine; 305311
    Objective: The aim of this study was to investigate the sociodemographic features of sexually abused children and adolescents who were sent for forensic evaluation, besides that psychopathologies developing after the abuse. Materials and Methods: Ninety child and adolescents who were admitted to Van judicial branch of forensic medicine units for forensic evaluation due to sexual abuse have been enrolled to the study between 01.01.2010 and 30.06.2015 retrospectively. General physical examination was carried out by forensic experts. The clinical interviews were conducted by two expert psychiatrists. Results: Our study consists of 60 (66,7%) girls and 30 (33,3%) boys aged between 4 and 18 years (11,9±4,02) old. The most frequently reported sexual abuse type was vaginal penetration in girls (48,3%) and anal penetration in boys (90%). It was found that 12,2 % (n=11) of victims were exposed to sexual abuse longer than a year, 31,1% (n=28) of victims were exposed more than one sexual abuse and 5,6% (n=5) of victims were abused by more than one abuser. Concerning the abusers; 64,4% (n=58) were familiar and 21,1% (n=19) were among family members. 28,9% (n=26) of the child and adolescents were diagnosed with Posttraumatic Stress Disorder, 8,9% (n=8) Major Depressive Disorder and 5,6% (n=5) Acute Stress Disorder. Conclusion: It has been found that female gender and primary education level are high risk factors in children for exposure to sexual abuse and psychopathologies particularly Posttraumatic Stress Disorder increase in sexual abuse victims. It is observed that children generally suffer sexual abuse in the hands of people they closely know and trust. / Amaç: Çalışmamızda cinsel istismar mağduru çocuk ve ergenlerin sosyodemografik özellikleri, istismar sonrası gelişen ruhsal tanıları, istismar süresi, istismar sıklığı, cinsel istismar ve istismarcı ile ilişkili özellikleri incelemesi amaçlanmıştır. Gereç ve Yöntem: Van adliyesi adli tıp şubesinde 01.01.2010 ile 30.06.2015 tarihleri arasında bilirkişi adli heyet raporu düzenlenmesi amacıyla yönlendirilen adli olguların (n=90) bilgileri geriye dönük olarak incelenmiştir. Genel fizik muayenesi adli tıp uzmanları tarafından yapıldı. Hasta ve ebeveynleri ile psikiyatrik görüşme çocuk ve ergen ruh sağlığı ve hastalıkları uzmanı ve yetişkin psikiyatri uzmanı tarafından yapılmıştır. Bulgular: Çalışmamız 4 ile 18 yaş aralığında (11,9±4,02) değişen 60 (%66,7) kız ve 30 (%33,3) erkek olmak üzere toplam 90 çocuk ve ergen mağdurlardan oluşmaktadır. En sık bildirilen cinsel istismar tipi kızlarda %48,3 ile vajinal penetrasyon, erkeklerde %90 ile anal penetrasyon olduğu belirlendi. Olguların %31,1’i (n=28) birden fazla cinsel istismara maruz kaldığını, %5,6’si (n=5) birden fazla istismarcının olduğu ve 12,2’sinin (n=11) de bir yıldan daha uzun süre cinsel istismara maruz kaldığı bulunmuştur. Olguların %64,4’inde (n=58) istismarcının tanıdık biri ve %21,1’ünde (n=19) aileden biri olduğu tespit edilmiştir. Çocuk ve ergenlerin %28,9’ında (n=26) travma sonrası stres bozukluğu (TSSB), %5,6’sında (n=5) akut stres bozukluğu (ASB), %8,9’inde (n=8) major depresif bozukluk (MDB) tespit edilmiştir. Sonuç: Cinsel istismar mağdurlarında başta TSSB olmak üzere psikopatoloji gelişme riskinin artığını göstermektedir. Kız cinsiyet ve ilköğretim çağında olmanın cinsel istismara maruz kalma açısından yüksek risk taşıdığı bulunmuştur. Çocuklar genellikle yakından tanıdığı ve güvendiği kişiler tarafından cinsel istismara uğradığı görülmektedir.
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    A meta-analysis of anxiety disorder comorbidity in pediatric bipolar disorder
    (Elsevier Science Inc, 2016) Taşkıran, Ali Sarper; Eser, Hale Yapıcı; Mutluer, Tuba; Kılıç, Özge; Özcan, Aslıhan; Necef, Işıl; Yalçınay-İnan, Merve; Öngür, Dost; Other; Faculty Member; Faculty Member; Doctor; Other; Doctor; Doctor; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A College of Engineering; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; 195168; 134359; 305311; N/A; N/A; N/A; N/A; N/A
    Objectives: AD are among the most prevalent comorbid conditions in pediatric bipolar disorder (PBD). There are conflicting results in the literature regarding prevalence of AD subtypes, and significant discrepancy with PBD course of illness (episodic or chronic) or diagnostic criteria (narrow or broad). Our aim in conducting meta-analysis is to investigate the prevalence of subtypes of comorbid anxiety disorders and its relations with the onset (childhood or adolescent) and course (episodic or chronic) of PBD. Methods: We have conducted a systematic research of Pubmed by using “bipolar disorder, affective psychosis, generalized anxiety disorder, panic, social phobia, obsessive compulsive disorder and anxiety disorder” as keywords to search in title/abstract until September 2015. Among 3202 articles, a total of 430 abstracts were found to be related; 82 were conducted in pediatric population, which were read in full text by at least two authors and data was extracted for outcome measures. Articles that include the data from the same population sample were excluded. Data was analyzed with random effects model using R statistical program package. Results: Data from 33 studies were included in the final analysis. The prevalence of any AD in PBD was 44 percent (95% CI 0.38–0.50), prevalence of AD subtypes were GAD 25 percent (95% CI 0.18–0.36); Separation Anxiety Disorder (SAD) 22 percent (95% CI 0.14–0.33); OCD 17 percent (95% CI 0.11–0.23); Social Phobia (SP) 15 percent (95% CI 0.08–0.27); Panic Disorder (PD) 10 percent (95% CI 0.05–0.19). When only episodic PBD were concerned, prevalence rates differed, with any AD 38 percent (95% CI 0.28–0.48); GAD 19 percent (95% CI 0.08–0.41); SAD 21 percent (95% CI 0.10–0.40); OCD 11 percent (95% CI 0.03–0.29); SP 11 percent (95% CI 0.04–0.27); PD 9 percent (95% CI 0.03–0.23). Prevalence of any AD (34% (95% CI 0.23-0.48), GAD and SAD were found as lower and OCD, SP and PD were slightly higher in adolescent onset compared to childhood onset PBD. Conclusions: Youth with BD are at increased risk of AD; nearly one in two has an AD. GAD and SAD are among the most prevalent comorbidities. AD are seen less with episodic and adolescent onset PBD. AD should be carefully investigated alongside the mood symptoms in PBD, as comorbidity may change course, treatment and subtyping of the disorder.
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    The relationship between dietary elimination and maternal psychopathology in breastfeeding mothers of infants with food allergy
    (Wiley, 2022) Can, Ceren; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Yılmaz, Özlem; Saçkesen, Cansın; Kaçar, Anıl Şafak; Göğebakan, Emre; Necef, Işıl; Mutluer, Tuba; Taşkıran, Ali Sarper; Kızılkan, Nuray Uslu; Doctor; Faculty Member; PhD Student; Undergraduate Student; Faculty Member; Faculty Member; Other; Faculty Member; N/A; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 140706; 182537; N/A; N/A; N/A; 305311; 195168; 221274
    Background: There has been no study evaluating the psychopathology in breastfeeding mothers of infants with food allergy (FA). Objective: The aim of the study was to investigate the relationship between dietary elimination and maternal psychopathology, specifically anxiety, depression, and mother-to-infant bonding, in breastfeeding mothers of infants with food allergy. Methods: Breastfeeding mothers following an elimination diet due to FA in their children aged 1-to-12 months were compared with the healthy controls. The physician-diagnosed FA group was divided into IgE-, non-IgE-mediated, and infants with some minor symptoms which were not enough to make the diagnosis of FA were classified as Indecisive symptoms for FA group. Mothers completed standardized questionnaires including Symptom Checklist 90R, Beck Depression/Anxiety Inventories (BDI/BAI), Postpartum Bonding Questionnaire (Bonding). Results: Of 179 mother and infants, 64 were healthy, 89 were FA, 16 were indecisive symptoms for FA. The mean age of the mothers and infants were 31.1 ± 4.7 years and 6.3 ± 3.6 months, respectively. The physician-diagnosed FA groups had higher scores for anxiety (p = .008), anger (p = .042), depression (p < .001), obsession (p = .002), phobia (p = .008), somatization (p = .002), general symptom index (GSI) (p = .001), BDI (p < .001), BAI (p = .008), and Bonding (attachment [p = .001], anger [p = .019], and total [p = .036]) than the healthy ones. The indecisive symptoms for FA group had a similar score pattern to physician-diagnosed FA, except interpersonal sensitivity, BDI, and attachment. Conclusion: Breastfeeding mothers of infants with FA were more anxious, with higher depression scores than controls, and had many psychopathologies which affected bonding. Interventions targeting negativity in caregivers' social relationships are urgently needed.