Researcher:
Karahüseyinoğlu, Serçin

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Serçin

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Karahüseyinoğlu

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Karahüseyinoğlu, Serçin

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2015 - 2019272020 - 202315

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Researcher Of Publications: search.filters.isAuthorOfPublication.562a2af5-92d1-4003-8986-f94c78396511

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Now showing 1 - 10 of 42
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    Global gene expression analysis of blastocyst implantation on 2D and 3D implantation models: towards a comprehensive and inclusive research
    (Oxford Univ Press, 2018) Sari, K.; Yucel, D.; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; School of Medicine; 110772
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    Wound healing effects of methanol extract of Laurocerasusofficinalis roem
    (Taylor & Francis, 2019) Ayla, S.; Okur, M. E.; Gunal, M. Y.; Ozdemir, E. M.; Polat, D. Cicek; Yoltas, A.; Biceroglu, O.; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; 110772
    Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using an excisional wound model model in mice. We used four groups of eight mice as follows: untreated (control), empty gel, extract +gel (L. officinalis +gel), and Madecassol (R) groups. All treatments were applied topically once daily. The scar area, percentage wound closure and epithelization time were measured. L. officinalis promoted wound healing and increased granulation tissue, epidermal regeneration and angiogenesis. L. officinalis extract, which is known for its antioxidant and antimicrobial activities, may be useful for promoting wound healing.
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    The rhythmicity of life: A review of the circadian clocks
    (Begell House Inc., 2021) Acikgoz, E.; Ayla, S.; Oktem, G.; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; 110772
    Physiology of the mammalian body has been adapted to diurnal cycles of around 24 h, an evolutionary situation that affects a wide spectrum of biological events including sleep-to-wake transitions, feeding/fasting, body temperature, and hormonal regulations. The patterns of the diurnal cycle occur due to rhythmic oscillations that arise from the suprachiasmatic nucleus of hypothalamus, which also can be defined as the pacemaker of the system. The clock can be defined as a molecular machinery driven by the core clock genes that encode clock proteins in a rhythmic oscillatory fashion maintained by the light/dark cycles of the environment. Although the well-established knowledge refers to the function of the circadian rhythm as maintenance of the normal physiology, growing evidence shows that disruptions in the system usually caused by genetic and/or epigenetic misregulations may have a direct effect to lead major pathological conditions, such as carcinogenesis. This review outlines the main molecular aspects of circadian physiology, and reveals the reasons for and results of the circadian disruptions at different levels. In spite of the fact that more proof is needed for a direct correlation between circadian disruptions and oncogenesis and other pathological events, data obtained from current research supports the role of circadian rhythms in malfunctioning of the normal cellular metabolism.
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    Investigation of the effects of tumor necrosis factor-alpha, H2o2, ethanol and butyrate on intestinal epithelial cell permeability
    (Wiley, 2019) Yazıcı, Duygu; Süer, Hande; Yılmaz, Özlem; Karahüseyinoğlu, Serçin; Saçkesen, Cansın; PhD Student; PhD Student; Master Student; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; N/A; N/A; N/A; 110772; 182537
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    Comparing glutamatergic neuron population in the mediodorsal thalamic nucleus of genetic absence epilepsy rats from strasbourg (GAERS) and normal control Wistar rats
    (Elsevier Science Bv, 2016) Kirazli, Özlem; Onat, Filiz; N/A; N/A; N/A; Çavdar, Safiye; Özgür, Merve; Karahüseyinoğlu, Serçin; Faculty Member; PhD Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; School of Medicine; Koç University Hospital; 1995; 197462; 110772
    An imbalance between GABAergic inhibition and glutamatergic excitation is suspected to play a role in the genesis of epileptic processes. In the present study we quantified the number of glutamate+ve neurons in the mediodorsal thalamic nucleus (MD) of genetic absence epilepsy rats from Strasbourg (GAERS) and compared these with values for normal Wistar rats. The MD thalamic nucleus was removed from each animal and the glutamatergic neurons were labelled using light-microscopy glutamate immunohistochemistry. The disector method was used to quantify the glutamate+ve neurons in the MD thalamic nucleus of GAERS and Wistar rats. The data were statistically analyzed. In the Wistar animals glutamate+ve neurons formed 89% and in GAERS 92.3% of the total neurons in 1000 mu m(3) of MD thalamic nucleus. In GAERS glutamate+ve neurons showed statistically significant increase in the MD thalamic nucleus compared to Wistar animals. In Wistar animals the glutamate-ve neurons formed 11% and in GAERS 7.7% of the total neurons in 1000 mu m(3) of MD thalamic. No significant difference was observed in glutamate ye neurons between the two strains. The average diameter of glutamate-ve neurons showed no significance, while glutamate-ve neurons were significant between the two strains. The results of the present study, on genetic absence epilepsy model, GAERS, confirms the role of MD thalamic nucleus in chemically induced absence epilepsy. (C) 2016 Elsevier B.V. All rights reserved.
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    Construction of gel based 3D endometrial co -culture systems: can human mesenchymal stem cells be an alternative?
    (Oxford Univ Press, 2017) Yücel, D.; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Şevgin, Kübra; Kocabay, Ahmet; Taşkın, Ali Cihan; Faculty Member; Master Student; PhD Student; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; 110772; N/A; N/A; N/A; 291296
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    Polymeric and collagen biomaterials enhance implantation of mouse blastocysts in three-dimensional culture models
    (Elsevier, 2021) Başoz, Deniz; Yücel, Deniz; N/A; N/A; N/A; N/A; N/A; Department of Industrial Engineering; N/A; Ergün, Yağmur; Şahin, Gizem Nur; Şevgin, Kübra; Kocabay, Ahmet; Taşkın, Ali Cihan; Gönen, Mehmet; Karahüseyinoğlu, Serçin; PhD Student; PhD Student; PhD Student; Other; Other; Faculty Member; Faculty Member; Department of Industrial Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; College of Engineering; School of Medicine; N/A; N/A; N/A; N/A; 291296; 237468; 110772
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    Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage
    (Elsevier, 2018) Ayla, Sule; Tunali, Gulden; Bilgic, Bulent E.; Sofuoglu, Kenan; Ozdemir, A. Arman; Tanriverdi, Gamze; Ozdemir, Semra; Soner, B. Cem; Ozturk, Bahar; Aslan, Esra Guler; Seckin, Ismail; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; 110772
    Purpose: Sperm processing (e.g., centrifugation) used in preparation for assisted reproduction can result in excessive generation of reactive oxygen species (ROS) and potential sperm damage. The use of antioxidants during sperm processing has been shown to prevent iatrogenic sperm damage, including DNA damage. In this study, we evaluated the effect of caffeic acid phenethyl ester (CAPE) on oxidative stress mediated sperm dysfunction and DNA damage. Methods: Semen samples were obtained to liquefy at room temperature. After centrifugation and washing protocols, spermatozoa were incubated in a single step supplemented medium with either of 10, 50 or 100 mu mol/L CAPE for 2 hours at 36 degrees C. After incubation period, MDA levels of seminal plasma were measured. The fragmentation in sperm DNA was detected by light microscopy via use of an aniline blue assay, while ultrastructural morphology was analyzed by transmission electron microscopy. Results: Significant increase has been observed in percent chromatin condensation (assessed by aniline blue staining) and Malondialdehyde (Mmol/L) in oligoasthenoteratozoospermia group before the centrifugation (0.57 +/- 0.15). Incubation of samples with 100 mu mol/L CAPE after centrifugation resulted in a significantly lower percent chromatin condensation compared to samples incubated without CAPE (0.42 +/- 0.12) (P < 0.0033). Incubation of all samples with CAPE (10 mu mol/L, 50 mu mol/L, 100 mu mol/L.) after centrifugation resulted in a significantly lower percentage of Malondialdehyde levels. Conclusions: The data suggests that preincubation of spermatozoa with the antioxidant CAPE offers protection against oxidative DNA damage in vitro.
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    Celcular and molecular dynamics of in-vitro 2D and 3D cultured blastocysts throughout the implantation process
    (Amer Soc Cell Biology, 2016) Yucel, D.; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Kocabay, Ahmet; Taşkın, Ali Cihan; Faculty Member; PhD Student; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 110772; N/A; N/A; 291296
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    The role of ovarian reserve markers in prediction of clinical pregnancy
    (Taylor & Francis Inc, 2017) Zebitay, Ali G.; Çetin, Orkun; Verit, Fatma F.; Keskin, Seda; Sakar, M. Nafi; İlhan, Gülşah; Şahmay, Sezai; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; 110772
    To evaluate the role of ovarian reserve markers in the prediction of clinical pregnancy and embryo transfer accomplishment among poor responder IVF applicants. 304 female poor responder IVF applicants were included in this prospective cohort study conducted at the IVF-unit. Antral follicle count, FSH, LH, E2, AMH and IVF outcomes were compared in pregnant and non-pregnant groups as well as in ET vs. non-ET groups. The number of retrieved oocytes was significantly correlated positively with AMH and AFC, and negatively with FSH and age. Quartiles of FSH and AFC were similar to the rate of pregnancy. Quartiles of AMH (<25%/25-75% and <25%/>75%) were statistically significant. Mean serum levels for AMH were significantly lower in the non-ET group. Our findings seem to indicate that day 3 AMH values can predict ET accomplishment with a sensitivity of 96% and a specificity of 35%. Quartiles of AMH <25% (<0.21ng/mL) can predict the IVF results among poor responder IVF applicants.Impact statementVarious cut-off values have been determined for day 3 serum AMH values. These values help to determine the groups that are expected to give normal, high or low response to stimulation and decide the treatment options.In contrast to other groups of patients, poor responders cannot reach the embryo transfer stage for several reasons. These are; absence of a mature oocyte after oocyte pick-up, fertilisation failure without male factor or poor embryo quality.In the present study; a cut-off value of 0.33ng/mL for the prediction of ET accomplishment in poor responder patients was determined with a sensitivity of 96%. Additionally, clinical pregnancy could not be achieved under the value of 0.21ng/mL day 3 AMH values.It is important to clarify the embryo transfer success of poor responder patients prior to expected treatment success. Pre-treatment counselling for these patients would lessen the disappointment that may develop after treatment. The cost-effectiveness of treatments below these AMH values can be determined by further studies.