(Wiley, 2016) N/A; N/A; N/A; Department of Chemical and Biological Engineering; Department of Molecular Biology and Genetics; Department of Chemical and Biological Engineering; Department of Molecular Biology and Genetics; Ünsal, Esra; Harmanda, Büşra; Erman, Burak; Master Student; N/A; PhD Student; Faculty Member; Faculty Member; Graduate School of Sciences and Engineering; N/A; Graduate School of Sciences and Engineering; College of Engineering; College of Sciences; N/A; N/A; N/A; 179997; 105301
Aurora B is a serine/threonine kinase that has a central role in the regulation of mitosis. The observation of Aurora B overexpression in cancer makes it a promising target to develop antitumoral inhibitors. We describe a new potential inhibitor that exclusively targets the interaction site of Aurora B and its activator INCENP. We performed a structure-based virtual screening and determined five potential candidates of 200000 compounds, which selectively bind to the Aurora B
