Researcher:
Uymaz, Derya Salim

Profile Picture
ORCID

Job Title

Teaching Faculty

First Name

Derya Salim

Last Name

Uymaz

Name

Name Variants

Uymaz, Derya Salim

Email Address

Birth Date

Filters

2018 - 201912020 - 20238

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.572568e4-a7b0-47a9-b685-e7fcac62e0b4

Search Results

Now showing 1 - 9 of 9
  • Placeholder
    PublicationMetadata only
    A complicated case of monkeypox and viral shedding characteristics
    (Elsevier, 2023) N/A; N/A; Kapmaz, Mahir; Uymaz, Derya Salim; Özcan, Gülin; Barlas, Tayfun; Esken, Gülen Güney; Manici, Mete; Keske, Şiran; Kuşkucu, Mert Ahmet; Can, Füsun; Ergönül, Önder; Doctor; Teaching Faculty; Researcher; Researcher; Researcher; Faculty Member; Faculty Member; Researcher; Faculty Member; Faculty Member; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); N/A; School of Medicine; Graduate School of Health Sciences; N/A; N/A; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 175554; N/A; N/A; N/A; 113502; 125555; N/A; 103165; 110398
    N/A
  • Placeholder
    PublicationMetadata only
    The ChoCO-W prospective observational global study: does COVID-19 increase gangrenous cholecystitis?
    (BioMed Central, 2022) De Simone, Belinda; Abu-Zidan, Fikri M.; Chouillard, Elie; Di Saverio, Salomone; Sartelli, Massimo; Podda, Mauro; Gomes, Carlos Augusto; Moore, Ernest E.; Moug, Susan J.; Ansaloni, Luca; Kluger, Yoram; Coccolini, Federico; Landaluce-Olavarria, Aitor; Estraviz-Mateos, Begona; Uriguen-Etxeberria, Ana; Giordano, Alessio; Luna, Alfonso Palmieri; Amin, Luz Adriana Hernandez; Hernandez, Adriana Maria Palmieri; Shabana, Amanda; Dzulkarnaen, Zakaria Andee; Othman, Muhammad Asyraf; Sani, Mohamad Ikhwan; Balla, Andrea; Scaramuzzo, Rosa; Lepiane, Pasquale; Bottari, Andrea; Staderini, Fabio; Cianchi, Fabio; Cavallaro, Andrea; Zanghi, Antonio; Cappellani, Alessandro; Campagnacci, Roberto; Maurizi, Angela; Martinotti, Mario; Ruggieri, Annamaria; Jusoh, Asri Che; Rahman, Karim Abdul; Zulkifli, Anis Suraya M.; Petronio, Barbara; Matias-Garcia, Belen; Quiroga-Valcarcel, Ana; Mendoza-Moreno, Fernando; Atanasov, Boyko; Campanile, Fabio Cesare; Vecchioni, Ilaria; Cardinali, Luca; Travaglini, Grazia; Sebastiani, Elisa; Chooklin, Serge; Chuklin, Serhii; Cianci, Pasquale; Restini, Enrico; Capuzzolo, Sabino; Curro, Giuseppe; Filippo, Rosalinda; Rispoli, Michele; Aparicio-Sanchez, Daniel; Munoz-Cruzado, Virginia Duran; Barbeito, Sandra Dios; Delibegovic, Samir; Kesetovic, Amar; Sasia, Diego; Borghi, Felice; Giraudo, Giorgio; Visconti, Diego; Doria, Emanuele; Santarelli, Mauro; Luppi, Davide; Bonilauri, Stefano; Grossi, Ugo; Zanus, Giacomo; Sartori, Alberto; Piatto, Giacomo; De Luca, Maurizio; Vita, Domenico; Conti, Luigi; Capelli, Patrizio; Cattaneo, Gaetano Maria; Marinis, Athanasios; Vederaki, Styliani-Aikaterini; Bayrak, Mehmet; Altintas, Yasemin; Uzunoglu, Mustafa Yener; Demirbas, Iskender Eren; Altinel, Yuksel; Meric, Serhat; Aktimur, Yunus Emre; Lostoridis, Eftychios; Nagorni, Eleni-Aikaterini; Pujante, Antonio; Anania, Gabriele; Bombardini, Cristina; Bagolini, Francesco; Gonullu, Emre; Mantoglu, Baris; Capoglu, Recayi; Cappato, Stefano; Muzio, Elena; Colak, Elif; Polat, Suleyman; Koylu, Zehra Alan; Altintoprak, Fatih; Bayhan, Zulfu; Akin, Emrah; Andolfi, Enrico; Rezart, Sulce; Il Kim, Jae; Jung, Sung Won; Shin, Yong Chan; Enciu, Octavian; Toma, Elena Adelina; Medas, Fabio; Canu, Gian Luigi; Cappellacci, Federico; d'Acapito, Fabrizio; Ercolani, Giorgio; Solaini, Leonardo; Roscio, Francesco; Clerici, Federico; Gelmini, Roberta; Serra, Francesco; Rossi, Elena Giulia; Fleres, Francesco; Clarizia, Guglielmo; Spolini, Alessandro; Ferrara, Francesco; Nita, Gabriela; Sarnari, Jlenia; Gachabayov, Mahir; Abdullaev, Abakar; Poillucci, Gaetano; Palini, Gian Marco; Veneroni, Simone; Garulli, Gianluca; Piccoli, Micaela; Pattacini, Gianmaria Casoni; Pecchini, Francesca; Argenio, Giulio; Armellino, Mariano Fortunato; Brisinda, Giuseppe; Tedesco, Silvia; Fransvea, Pietro; Ietto, Giuseppe; Franchi, Caterina; Carcano, Giulio; Martines, Gennaro; Trigiante, Giuseppe; Negro, Giulia; Vega, Gustavo Machain; Gonzalez, Agustin Rodriguez; Ojeda, Leonardo; Piccolo, Gaetano; Bondurri, Andrea; Maffioli, Anna; Guerci, Claudio; Sin, Boo Han; Zuhdi, Zamri; Azman, Azlanudin; Mousa, Hussam; Al Bahri, Shadi; Augustin, Goran; Romic, Ivan; Moric, Trpimir; Nikolopoulos, Ioannis; Andreuccetti, Jacopo; Pignata, Giusto; D'Alessio, Rossella; Kenig, Jakub; Skorus, Urszula; Fraga, Gustavo Pereira; Hirano, Elcio Shiyoiti; Bertuol, Jackson Vinicius de Lima; Isik, Arda; Kurnaz, Eray; Asghar, Mohammad Sohail; Afzal, Ameer; Akbar, Ali; Nikolouzakis, Taxiarchis Konstantinos; Lasithiotakis, Konstantinos; Chrysos, Emmanuel; Das, Koray; Ozer, Nazmi; Seker, Ahmet; Ibrahim, Mohamed; Hamid, Hytham K. S.; Babiker, Ahmed; Bouliaris, Konstantinos; Koukoulis, George; Kolla, Chrysoula-Christina; Lucchi, Andrea; Agostinelli, Laura; Taddei, Antonio; Fortuna, Laura; Agostini, Carlotta; Licari, Leo; Viola, Simona; Callari, Cosimo; Laface, Letizia; Abate, Emmanuele; Casati, Massimiliano; Anastasi, Alessandro; Canonico, Giuseppe; Gabellini, Linda; Tosi, Lorenzo; Guariniello, Anna; Zanzi, Federico; Bains, Lovenish; Sydorchuk, Larysa; Iftoda, Oksana; Sydorchuk, Andrii; Malerba, Michele; Costanzo, Federico; Galleano, Raffaele; Monteleone, Michela; Costanzi, Andrea; Riva, Carlo; Waledziak, Maciej; Kwiatkowski, Andrzej; Czyzykowski, Lukasz; Major, Piotr; Strzalka, Marcin; Matyja, Maciej; Natkaniec, Michal; Valenti, Maria Rosaria; Di Vita, Maria Domenica Pia; Sotiropoulou, Maria; Kapiris, Stylianos; Massalou, Damien; Veroux, Massimiliano; Volpicelli, Alessio; Gioco, Rossella; Uccelli, Matteo; Bonaldi, Marta; Olmi, Stefano; Nardi, Matteo; Livadoti, Giada; Mesina, Cristian; Dumitrescu, Theodor Viorel; Ciorbagiu, Mihai Calin; Ammendola, Michele; Ammerata, Giorgio; Romano, Roberto; Slavchev, Mihail; Misiakos, Evangelos P.; Pikoulis, Emmanouil; Papaconstantinou, Dimitrios; Elbahnasawy, Mohamed; Abdel-Elsalam, Sherief; Felsenreich, Daniel M.; Jedamzik, Julia; Michalopoulos, Nikolaos, V; Sidiropoulos, Theodoros A.; Papadoliopoulou, Maria; Cillara, Nicola; Deserra, Antonello; Cannavera, Alessandro; Negoi, Ionut; Schizas, Dimitrios; Syllaios, Athanasios; Vagios, Ilias; Gourgiotis, Stavros; Dai, Nick; Gurung, Rekha; Norrey, Marcus; Pesce, Antonio; Feo, Carlo Vittorio; Fabbri, Nicolo; Machairas, Nikolaos; Dorovinis, Panagiotis; Keramida, Myrto D.; Mulita, Francesk; Verras, Georgios Ioannis; Vailas, Michail; Yalkin, Omer; Iflazoglu, Nidal; Yigit, Direnc; Baraket, Oussama; Ayed, Karim; Ghalloussi, Mohamed Hedi; Patias, Parmenion; Ntokos, Georgios; Rahim, Razrim; Bala, Miklosh; Kedar, Asaf; Sawyer, Robert G.; Trinh, Anna; Miller, Kelsey; Sydorchuk, Ruslan; Knut, Ruslan; Plehutsa, Oleksandr; Liman, Rumeysa Kevser; Ozkan, Zeynep; Kader, Saleh Abdel; Gupta, Sanjay; Gureh, Monika; Saeidi, Sara; Aliakbarian, Mohsen; Dalili, Amin; Shoko, Tomohisa; Kojima, Mitsuaki; Nakamoto, Raira; Atici, Semra Demirli; Tuncer, Gizem Kilinc; Kaya, Tayfun; Delis, Spiros G.; Rossi, Stefano; Picardi, Biagio; Del Monte, Simone Rossi; Triantafyllou, Tania; Theodorou, Dimitrios; Pintar, Tadeja; Salobir, Jure; Manatakis, Dimitrios K.; Tasis, Nikolaos; Acheimastos, Vasileios; Ioannidis, Orestis; Loutzidou, Lydia; Symeonidis, Savvas; de Sa, Tiago Correia; Rocha, Monica; Guagni, Tommaso; Pantalone, Desire; Maltinti, Gherardo; Khokha, Vladimir; Abdel-Elsalam, Wafaa; Ghoneim, Basma; Lopez-Ruiz, Jose Antonio; Kara, Yasin; Zainudin, Syaza; Hayati, Firdaus; Azizan, Nornazirah; Khei, Victoria Tan Phooi; Yi, Rebecca Choy Xin; Sellappan, Harivinthan; Demetrashvili, Zaza; Lekiashvili, Nika; Tvaladze, Ana; Froiio, Caterina; Bernardi, Daniele; Bonavina, Luigi; Gil-Olarte, Angeles; Grassia, Sebastiano; Romero-Vargas, Estela; Bianco, Francesco; Gumbs, Andrew A.; Dogjani, Agron; Agresta, Ferdinando; Litvin, Andrey; Balogh, Zsolt J.; Gendrikson, George; Martino, Costanza; Damaskos, Dimitrios; Pararas, Nikolaos; Kirkpatrick, Andrew; Kurtenkov, Mikhail; Gomes, Felipe Couto; Pisanu, Adolfo; Nardello, Oreste; Gambarini, Fabrizio; Aref, Hager; de'Angelis, Nicola; Agnoletti, Vanni; Biondi, Antonio; Vacante, Marco; Griggio, Giulia; Tutino, Roberta; Massani, Marco; Bisetto, Giovanni; Occhionorelli, Savino; Andreotti, Dario; Lacavalla, Domenico; Biffl, Walter L.; Catena, Fausto; Uymaz, Derya Salim; Azamat, İbrahim Fethi; Omarov, Nail; Teaching Faculty; Faculty Member; Doctor; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; 175554; 188598; N/A
    Background: The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods: Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results: A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions: The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands.
  • Placeholder
    PublicationMetadata only
    No change in reward responsiveness, but decreased functional connectivity with right nucleus accumbens and left lateral occipital- precuneus cortex 3 months after sleeve gastrectomy
    (Elsevier Science Inc, 2020) Eren, Candan Yasemin; Uymaz, Derya Salim; Yavuz, Yunus; Kılıç, Özge; Eser, Hale Yapıcı; PhD Student; Teaching Faculty; Other; Doctor; Faculty Member; Graduate School of Health Sciences; N/A; School of Medicine; N/A; School of Medicine; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; 175554; N/A; 167890; 134359
    Background: Obesity is known to be linked to nucleus accumbens activity and altered reward responsiveness. Sleeve gastrectomy (SG) is often used for treatment of morbid obesity and activity in the NAcc was shown to positively affect weight-loss at 12 months post-surgery. The aim of this study is to measure the change in reward responses and nucleus accumbens (NAcc) functional connectivity 3 months after SG. Methods: 25 patients with a diagnosis of obesity were evaluated pre-surgery and 3 months post-surgery with Snaith-Hamilton Pleasure Scale (SHAPS), Beck Depression Inventory (BDI) and body weight. As a laboratory-based measure of reward learning, they performed probabilistic reward task (PRT). Resting-state fMRI images were obtained from 7 participants pre and post surgery. Results: Both SHAPS, BDI and response bias and discriminability scores in PRT were not significantly different post-surgery. Mean percentage body weight loss of individuals were 20.07 %. Right NAcc functional connectivity with left lateral occipital- precuneus cortex decreased significantly post-surgery (105 voxels, voxel wise threshold p<0.05, FWE corrected), however no change in left NAcc connectivity was observed. Change in right NAcc functional connectivity was not correlated with weight loss. Conclusions: Previous literature on gambling and alcoholism showed increased NAcc-precuneus connectivity. Functional connectivity decrease between NAcc and precuneus in the resting state can be associated with reduced impulsivity and sensation-seeking observed after BS which correlates positively with successful weight loss.
  • Placeholder
    PublicationMetadata only
    Can we benefit from the preoperative psychometric test with symptom checklist-90-revised (SCL-90-R) to predict weight loss after sleeve gastrectomy?
    (Springer, 2022) Sobutay, Erman; Bilgiç, Çağrı; Şahin, Banu; Mercan, Sibel; Kabaoğlu, Burçak; Yavuz, Yunus; Uymaz, Derya Salim; Eser, Hale Yapıcı; Yavuz, Yunus; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; 175554; 134359; N/A
    Background: The psychological assessment is crucial before bariatric surgery. Derogatis’ Symptom Checklist-90-Revised (SCL-90-R) is one of the most widely used measures of psychological symptoms and distress in both clinical and research settings. We aimed to investigate the predictive value of SCL-90-R subscale scores on postoperative excess weight loss percentage (EWLP) after laparoscopic sleeve gastrectomy (LSG). Methods: Patients who underwent primary LSG for morbid obesity and fully completed preoperative SCL-90-R between January 2016 and July 2019 were retrospectively examined. A multiple linear regression analysis was performed to investigate the relationship between descriptive and psychological variables associated with EWLP percentage at the 12th-month. Results: One hundred six patients who met the inclusion criteria were analyzed. The adequate weight loss (EWLP ˃ 50%) was achieved in 90% of patients after 12 months. The multiple linear regression analysis indicated that younger patients (β =  − 0.695; 95% CI − 1.056, − 0.333; p < 0.001), and patients with preoperative lower BMI (β =  − 1.524; 95% CI − 1.974, − 1.075; p < 0.001) achieved higher EWLP at 12th-month. High somatization score (β = 11.975; 95% CI 3.653, 20.296; p = 0.005) and a low Global Severity Index (GSI) score (β =  − 24.276; 95% CI − 41.457, − 7.095; p = 0.006) had a positive effect on EWLP at 12th-month. Conclusions: Preoperative psychological testing can help predict surgical outcomes in the bariatric population. More intense lifestyle and behavioral support can be applied by targeting patients who are expected to lose less weight after surgery, and patients’ weight loss potential can be increased.
  • Placeholder
    PublicationMetadata only
    coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit
    (Elsevier B.V., 2022) Podda M.; Pacella D.; Pellino G.; Coccolini F.; Giordano A.; Di Saverio S.; Pata F.; Ielpo B.; Virdis F.; Damaskos D.; De Simone B.; Agresta F.; Sartelli M.; Leppaniemi A.; Riboni C.; Agnoletti V.; Mole D.; Kluger Y.; Catena F.; Pisanu A.; Gerardi C.; Damaskos D.; Gourgiotis S.; Poillucci G.; Jayant K.; Ferrario L.; Calvo M.P.; Wilson M.; Soggiu F.; Hamdan A.; Gomes C.A.; Fraga G.; Ioannidis A.; Demetrashvili Z.; Sahani S.; Bains L.; Khamees A.; Ababneh H.; Aljaiuossi O.; Pimentel S.; Mohamad I.S.; Yusoff A.R.; Zarnescu N.O.; Calu V.; Litvin A.; Lesko D.; Elmehrath A.; Elshami M.; de Santibañes M.; Gundara J.; Alawadhi K.; Lui R.; Julianov A.; Ralon S.; Garzali I.-U.; Machain G.M.; Quispe-Cruz D.A.; Orantia A.C.C.; Walędziak M.; Correia de Sá T.; Ali S.M.; Kovacevic B.; Noel C.; Abdalah H.M.; Kchaou A.; Isik A.; Ansaloni L.; Biffl W.; Guerrieri M.; Sartori A.; Abradelo M.; Nigri G.; Di Lorenzo N.; Mingoli A.; Chiarugi M.; Di Menno Stavron J.; Mazza O.; Valenzuela J.I.; Pantoja Pachajoa D.A.; Alvarez F.A.; Liaño J.E.; Tefay J.; Alshaikh A.; Hasan L.; Augusto Gomes C.; Gomes F.C.; Fraga G.P.; Calderan T.R.A.; Hirano E.S.; Dardanov D.; Saroglu A.; Atanasov B.; Belev N.; Kovachev N.; Chan S.M.; Lok H.-T.; Salcedo D.; Robayo D.; Triviño M.A.; Manak J.; de Araujo J.; Sethi A.; Awad A.; Elbadawy M.; Farid A.; Hanafy A.; Nafea A.; Sherief-Ghozy, Salah – Abbas A.; Abdelsalam W.; Emile S.; Elfallal A.; Elfeki H.; Elghadban H.; Shoma A.; Shetiwy M.; Elbahnasawy M.; Mohamed S.; Hamed E.F.; Khalil U.A.; Chouillard E.; Gumbs A.; Police A.; Mabilia A.; Khutsishvili K.; Tvaladze A.; Ioannidis O.; Anestiadou E.; Loutzidou L.; Konstantinidis K.; Konstantinidou S.; Manatakis D.; Acheimastos V.; Tasis N.; Michalopoulos N.; Kokoropoulos P.; Papadoliopoulou M.; Sotiropoulou M.; Kapiris S.; Metaxas P.; Tsouknidas I.; Kefili D.; Petrakis G.; Dakis K.; Alexandridou E.; Synekidou E.; Dakis K.; Papadopoulos A.; Chouliaras C.; Mouzakis O.; Mulita F.; Maroulis I.; Vailas M.; Triantafyllou T.; Theodorou D.; Lostoridis E.; Nagorni E.-A.; Tourountzi P.; Baili E.; Charalabopoulos A.; Liakakos T.; Schizas D.; Kozadinos A.; Syllaios A.; Machairas N.; Kykalos S.; Stamopoulos P.; Delis S.; Farazi-Chongouki C.; Kalaitzakis E.; Giannarakis M.; Lasithiotakis K.; Petra G.; Gupta A.; Medappil N.; Muthukrishnan V.; Kamar J.; Lal P.; Agarwal R.; Magnoli M.; Aonzo P.; Serventi A.; Giuliani A.; Di Lascio P.; Pinto M.; Bergamini C.; Bottari A.; Fortuna L.; Martellucci J.; Cicako A.; Miglietta C.; Morino M.; Delogu D.; Picchetto A.; Assenza M.; D'Ambrosio G.; Argenio G.; Armellino M.F.; Ioia G.; Occhionorelli S.; Andreotti D.; Domenico L.; Luppi D.; Casadei M.; Di Donato L.; Manoochehri F.; Lucia Marchese T.R.; Sergi W.; Manca R.; Murgia R.; Piras E.; Conti L.; Gianazza S.; Rizzi A.; Segalini E.; Monti M.; Iiritano E.; Mariani N.M.; De Nicola E.; Scifo G.; Pignata G.; Andreuccetti J.; Fleres F.; Clarizia G.; Spolini A.; Biloslavo A.; Germani P.; Mastronardi M.; Bogoni S.; Palmisano S.; De Manzini N.; Marino M.V.; Martines G.; Trigiante G.; Lagouvardou E.; Anania G.; Bombardini C.; Oppici D.; Pilia T.; Murzi V.; Gessa E.; Bracale U.; Di Nuzzo M.M.; Peltrini R.; Salvetti F.; Viganò J.; Sganga G.; Bianchi V.; Fransvea P.; Fontana T.; Sarro G.; Dinuzzi V.P.; Scaravilli L.; Papa M.V.; Jovine E.; Ciabatti G.; Mastrangelo L.; Rottoli M.; Ricci C.; Russo I.S.; Aiolfi A.; Bona D.; Lombardo F.; Cianci P.; Bini R.; Chiara O.; Cioffi S.; Cantafio S.; Coretti G.; Licitra E.; Savino G.; Grimaldi S.; Porfidia R.; Moggia E.; Garino M.; Marafante C.; Pesce A.; Fabbri N.; Feo C.V.; Marra E.; Troian M.; Drigo D.; Nagliati C.; Andrea M.; Danna R.; Murgese A.; Crespi M.; Guerci C.; Frontali A.; Ferrari L.; Favi F.; Picariello E.; Rampini A.; D'Acapito F.; Ercolani G.; Solaini L.; Palmieri F.; Calì M.; Ferrara F.; Muttillo I.A.; Muttillo E.M.; Picardi B.; Galleano R.; Badran A.; Ghazouani O.; Cervellera M.; Campanella G.; Papa G.; Di Bella A.; Perrone G.; Petracca G.L.; Prioriello C.; Giuffrida M.; Cozzani F.; Rossini M.; Inama M.; Butturini G.; Moretto G.; Morelli L.; Di Candio G.; Guadagni S.; Cicuttin E.; Cremonini C.; Tartaglia D.; Genovese V.; Cillara N.; Cannavera A.; Deserra A.; Picciariello A.; Papagni V.; Vincenti L.; Bagaglini G.; Sica G.; Lapolla P.; Brachini G.; Bono D.; Nicotera A.; Zago M.; Sammartano F.; Benuzzi L.; Stella M.; Rossi S.; Cerioli A.; Puccioni C.; Olmi S.; Rubicondo C.; Uccelli M.; Balla A.; Guida A.; Lepiane P.; Sasia D.; Giraudo G.; Salomone S.; Belloni E.; Cossa A.; Lancellotti F.; Caronna R.; Chirletti P.; Saullo P.; Troiano R.; Mucilli F.; Barone M.; Ippoliti M.; Grande M.; Sensi B.; Siragusa L.; Ortenzi M.; Santini A.; Di Carlo I.; Veroux M.; Gioco R.; Veroux G.; Currò G.; Ammendola M.; Komaei I.; Navarra G.; Tonini V.; Sartarelli L.; Vaccari S.; Ceresoli M.; Perrone S.; Roccamatisi L.; Millo P.; Contul R.B.; Ponte E.; Zuin M.; Portale G.; Tonello A.S.; Fratini G.; Bianchini M.; Perotti B.; Doria E.; Lunghi E.G.; Visconti D.; Al-Shami K.; Awadi S.; Khalil Buwaitel M.M.; Naief Naffa' M.F.; Samhouri A.; Sawalha H.; Ramzi Yusoff A.; Che Ani M.F.; Ahmed Fathil I.N.; Huei J.; Zakaria A.D.; Ya'acob M.Z.; Beristain-Hernandez J.-L.; Garcia-Meza A.; Sepulveda-Rdriguez R.; Lozada Hernández E.E.; Acuña Pinzón C.L.; Condoy J.N.; Becerra García F.C.; Sadik M.; Jalpa, kadir B.; Devi J.; Seerani N.; Zainab, Asghar M.S.; Afzal A.; Akbar A.; Lohse H.S.; Lohse H.S.; Artidoro Quispe-Cruz D.; Leon Cabrera Z.S.; Yamamoto Seto G.S.; Chiuyari J.R.; Ordemar J.; Rodríguez M.; Orantia-Carlos A.C.C.; Quitoy M.A.; Kwiatkowski A.; Mawlichanów M.; Rocha M.; Soares C.; Muhammad Ali S.; Stoian A.R.; Diana Draghici A.; Draghici A.D.; Grigorean V.T.; Radulescu R.B.; Costea R.V.; Zarnescu E.C.; Kurtenkov M.; Gendrikson G.; Alla-Angelina V.; Arina T.; Kaldarov A.; Gachabayov M.; Abdullaev A.; Milentijevic M.; Karamarkovic M.; Panyko A.; Radonak J.; Soltes M.; Álvarez Morán L.; García H.C.; Vega P.S.; Estevez S.; Ausania F.; Farguell J.; González-Abós C.; Sánchez-Cabús S.; Martín B.; Molina V.; Oms L.; Ilzarbe L.; Feijóo E.P.; Perra E.S.; Rojas-Bonet N.; Penalba-Palmí R.; Pérez-Bru S.; Tur-Martínez J.; Álvarez-Torrado A.; Domingo-Gonzalez M.; Tejedor-Tejada J.; Di Martino M.; García del Alamo Y.; Mendoza-Moreno F.; García-Moreno-Nisa F.; Matías-García B.; Durán M.; Calleja-Lozano R.; Perez de Villar J.M.; Sánchez-Guillén L.; Caravaca I.; Triguero-Cánovas D.; Maya Aparicio A.C.; Meléndez B.D.; Palacios A.M.; Landaluce-olavarria A.; De Francisco M.; Estraviz-Mateos B.; Alconchel F.; Nicolás-López T.; Ramírez P.; Muñoz-Cruzado V.D.; Ciuró F.P.; Perea del Pozo E.; Pizarro S.O.; Cabrera V.H.; Bayo J.M.; Hamid H.K.S.; Roesel R.; Cristaudi A.; Abbas K.; Ali I.; Tlili A.; Bayhan H.; Türkoğlu M.A.; Uzunoglu M.Y.; Azamat I.F.; Omarov N.; Uymaz D.S.; Altintoprak F.; Akin E.; First N.; Das K.; Ozer N.; Seker A.; Kara Y.; Bozkurt M.A.; Kocataş A.; Atici S.D.; Akalin M.; Calik B.; Colak E.; Altinel Y.; Meric S.; Aktimur Y.E.; Hudson V.; Duval J.-L.; Khan M.; Saad A.; Kaur M.; Bradley A.; Fox K.; Tomasi I.; Beasley D.; Prasanti A.K.; Kotecha P.; Ebied H.; Paul M.; Sheth H.; Gerogiannis I.; Gaber M.; Sheikh Z.; Seth S.; Kunitsyna M.; Leo C.A.; Bellato V.; Zafar N.; Elserafy A.; Bond-smith G.; Tebala G.; Mathur P.; Abid I.; Chidumije N.; Sandhar P.; Zohaib Ullah S.O.; Lezama T.; Anwaar M.H.; Magee C.; Ahmed S.; Davies B.; Apollos J.; McCormack K.; Choudhary H.; Doulias T.; Morrison T.; Palepa A.; Cal F.B.; Sánchez L.; Domínguez F.; Al-Raimi I.; Alshargabi H.; Meead A.; the MANCTRA-1 Collaborative Group, Principal Investigator, Steering Committee, MANCTRA-1 Coordinating Group, Local Collaborators, Argentina, Australia, Bahrain, Brazil, Bulgaria, China, Colombia, Czech Republic, Egypt, France, Georgia, Greece, Guatemala, India, Italy, Jordan, Malaysia, Mexico, Nigeria, Pakistan, Paraguay, Peru, Philippines, Poland, Portugal, Qatar, Romania, Russia, Serbia, Slovak Republic, South Africa, Spain, Sudan, Switzerland, Syria, Tunisia, Turkey, United Kingdom, Uruguay, Yemen; Azamat, İbrahim Fethi; Uymaz, Derya Salim; Faculty Member; Teaching Faculty; School of Medicine; School of Medicine; 188598; 175554
    Background/objectives: Reports about the implementation of recommendations from acute pancreatitis guidelines are scant. This study aimed to evaluate, on a patient-data basis, the contemporary practice patterns of management of biliary acute pancreatitis and to compare these practices with the recommendations by the most updated guidelines. Methods: All consecutive patients admitted to any of the 150 participating general surgery (GS), hepatopancreatobiliary surgery (HPB), internal medicine (IM) and gastroenterology (GA) departments with a diagnosis of biliary acute pancreatitis between 01/01/2019 and 31/12/2020 were included in the study. Categorical data were reported as percentages representing the proportion of all study patients or different and well-defined cohorts for each variable. Continuous data were expressed as mean and standard deviation. Differences between the compliance obtained in the four different subgroups were compared using the Mann-Whitney U, Student's t, ANOVA or Kruskal-Wallis tests for continuous data, and the Chi-square test or the Fisher's exact test for categorical data. Results: Complete data were available for 5275 patients. The most commonly discordant gaps between daily clinical practice and recommendations included the optimal timing for the index CT scan (6.1%, χ2 6.71, P = 0.081), use of prophylactic antibiotics (44.2%, χ2 221.05, P < 0.00001), early enteral feeding (33.2%, χ2 11.51, P = 0.009), and the implementation of early cholecystectomy strategies (29%, χ2 354.64, P < 0.00001), with wide variability based on the admitting speciality. Conclusions: The results of this study showed an overall poor compliance with evidence-based guidelines in the management of ABP, with wide variability based on the admitting speciality. Study protocol registered in ClinicalTrials.Gov (ID Number NCT04747990). © 2022 IAP and EPC
  • Placeholder
    PublicationMetadata only
    The role of FDG Positron emission tomography/contrast-enhanced computed tomography in preoperative staging and postoperative follow-up in rectal cancer surgery
    (Index Copernicus International, 2022) Külle, Cemil Burak; Özkan, Zeynep Gözde; Azamat, Sena; Keskin, Metin; Bulut, Mehmet Türker; Uymaz, Derya Salim; Omarov, Nail; Teaching Faculty; Doctor; School of Medicine; Koç University Hospital; 175554; N/A
    Introduction: F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) is a valuable functional imaging modality for the clinical diagnosis which provides physiological information based on the altered tissue metabolism. Aim: This study aims to investigate the effectiveness of F-18 fluorodeoxyglucose (F18-FDG) positron emission tomography-computed tomography (PET/CT) in preoperative staging and postoperative local recurrence and distant metastases in patients with rectal cancer. Material and Methods: The imaging of 726 patients with rectal cancer who were operated on at Istanbul University, Istanbul School of Medicine and had F18-FDG PET/CT, CT, and magnetic resonance imaging (MRI) scans between September 2005 and October 2016 were retrospectively analyzed. Of these patients, 170 who had pre- and postoperative PET/CT scans, had their CT scans included in the study. The sensitivity and specificity of PET/CT in preoperative staging and detection of postoperative local recurrence and distant metastases were analyzed. Results: Of the patients, 101 were males and 69 were females with a median age of 62.27 (range, 31 to 89) years. The sensitivity and specificity of preoperative PET/CT in detecting liver metastases were 100% (confidence interval [CI]: 66.37–100%) and 94.2% (CI: 89.72–100%), respectively (Cohen’s kappa [κ]: 1.00; P < 0.001). The sensitivity and specificity of postoperative PET/ CT in diagnosing liver metastases were 100% (CI: 88.06–100%) and 98% (CI: 9–100%), respectively (Cohen’s κ: 1.00; P < 0.001). The sensitivity and specificity of preoperative PET/CT in detecting lung metastases were 100% (CI: 66.37–100%) and 91.8% (CI: 89.72–100%), respectively (Cohen’s κ: 1.00; P < 0.001). The sensitivity and specificity of postoperative PET/CT in detecting lung metastases were 100% (CI: 91.4–100%) and 96% (CI: 95.8–100%), respectively (Cohen’s κ: 1.00; P < 0.001). The sensitivity and specificity of PET/CT in preoperative staging of pathological pelvic lymph nodes were 100% (CI: 63.06–100%) and 94.29% (CI: 80.84–99.3%), respectively (Cohen’s κ: 0.860; P < 0.001). The sensitivity and specificity of postoperative PET/CT in detecting local recurrences were 100% (CI: 78.2–100%) and 76.74% (CI: 61.37–88.24%), respectively (Cohen’s κ: 0.219; P < 0.08). Results: Given the fact that PET/CT can detect all primary rectal cancer in preoperative staging, it can be effectively used in selected cases, particularly in those suspected of local and advanced disease and with metastases (T3N0, T3N1, and/or T4N1). Due to a relatively low specificity in detecting local recurrences postoperatively, PET/CT can be combined with further modalities.
  • Placeholder
    PublicationMetadata only
    Different uses of the breast implant to prevent empty pelvic complications following pelvic exenteration
    (Bmj Publishing Group, 2022) N/A; N/A; Omarov, Nail; Uymaz, Derya Salim; Buğra, Dursun; Doctor; Teaching Faculty; Faculty Member; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 175554; 1758
    Pelvic exenteration surgery is used as a standard procedure in recurrent pelvic cancers. Total pelvic exenteration (TPE) includes resection of the uterus, prostate, ureters, bladder and rectosigmoid colon from pelvic space. Empty pelvis syndrome is a complication of the TPE procedure. Following TPE, complications such as haematoma, abscess leading to permanent pus discharge and chronic infections can occur. Herein, we present the case of a man in his 50s who was referred for pelvic pain, foul-smelling discharge and non-functioning colostomy, and operated for distal rectal cancer 1.5 years ago and underwent low anterior resection. In this case, we performed TPE for the recurrent tumour. To prevent TPE complications, we used a breast implant for filling the pelvic cavity. The early and late postoperative course was uneventful.
  • Placeholder
    PublicationMetadata only
    The value of preoperative volumetric analysis by computerised tomography of retrosternal goiter to predict the need for an extra-cervical approach
    (Trakya Üniversitesi Tıp Fakültesi, 2018) Sormaz, İsmail Cem; İşcan, Ahmet Y.; Özgür, İlker; Salmaslıoğlu, Artur; Tunca, Fatih; Şenyürek, Yasemin G.; Terzioğlu, Tarık; Uymaz, Derya Salim; Teaching Faculty; School of Medicine; 175554
    Background: A thyroidectomy can be performed via a cervical incision in most patients with retrosternal goiter. Aims: To investigate the correlation between the volume of the mediastinal portion of the thyroid gland and the need for an extra-cervical approach for retrosternal goiter. Study Design: Diagnostic accuracy study. Methods: The measurement of craniocaudal length and the volume of the mediastinal component of the thyroid gland on computerised tomography images was performed in 47 patients with retrosternal goiter. of these 47 patients, 8 (17%) required an extra-cervical approach and were classified as group 1, and 39 (83%) patients that required a cervical incision were classified as group 2. Receiver operating characteristic analysis was performed to determine the cut-off value for the craniocaudal length and the volume of the mediastinal thyroid mass, which significantly correlated with an extra-cervical approach for retrosternal goiter. Results: Reoperative surgery was significantly more frequent in group 1 than in group 2 (50% vs 13%; p=0.03). The craniocaudal length of the mediastinal thyroid gland was significantly longer in group 1 than in group 2 (77±11 mm vs 31±21 mm, respectively; p=0.0001). The volume of the mediastinal component was significantly larger in group 1 compared to group 2 (264±106 cm3 vs 40±41 cm3, respectively; p=0.0001). The receiver operating characteristic curve of craniocaudal length and the volume of the mediastinal component identified ≥66 mm and ≥162 cm3 as the cut-off values with the maximum accuracy, respectively. The craniocaudal length of the thyroid mass below the thoracic inlet ≥66 mm or a volume of the mediastinal portion ≥162 cm3 were significantly associated with an extra-cervical approach (p=0.0001). For predicting an extra-cervical approach, the sensitivity, positive predictive value and negative predictive value of the cut-off value for craniocaudal length was 87.5%, 64% and 97%, respectively. For predicting an extra-cervical approach, the sensitivity, positive predictive value and negative predictive value of the cut-off values for the mediastinal volume were 100%, 89% and 100%, respectively Conclusion: A thyroid volume of ≥162 cm3 extending below the thoracic inlet was a significant determining factor for an extra-cervical approach, with a negative predictive value for the extra-cervical approach of 100% for retrosternal goiter with smaller volumes. Further studies with an increased number of patients are needed to determine the value of volumetric analysis of retrosternal goiter to predict the need for an extracervical approach in retrosternal goiter.
  • Placeholder
    PublicationMetadata only
    The role of minimally invasive surgery in gastric cancer
    (Cureus Inc, 2021) N/A; N/A; Omarov, Nail; Uymaz, Derya Salim; Azamat, İbrahim Fethi; Özoran, Emre; Özata, İbrahim Halil; Selçukbiricik, Fatih; Taşkın, Orhun Çığ; Balık, Emre; Doctor; Teaching Faculty; Faculty Member; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 175554; 188598; 307296; 177151; 202015; 166686; 18758
    Objective: This study aims to investigate the efficacy and safety of minimally invasive surgery (MIS) in gastric cancer and to compare MIS versus open gastrectomy (OG) in terms of early mortality and morbidity, long-term oncological outcomes, and recurrence rates. Methods: A total of 75 patients who underwent MIS or OG for gastric cancer at Koc University School of Medicine between December 2014 and December 2019 were retrospectively analyzed. Postoperative complications and disease-specific survival were compared between surgical approaches. Results: Of the patients, 44 were treated with MIS and 31 with OG. In the MIS group, 33 patients underwent laparoscopic surgery, and 11 patients underwent robotic gastrectomy. Duration of operation was significantly longer in the MIS group than in the OG group (p<0.0001). The median amount of blood loss was 142.5 (range, 110 to 180) mL in the MIS group and 180.4 (range, 145 to 230) mL in the OG group (p<0.706). The median number of lymph node dissection was 38.9 (range, 15 to 66) and 38.7 (range, 12 to 70) in the MIS and OG groups, respectively (p<0.736). The median length of hospitalization, twelve days in the OG group and nine days in the MIS group. Median follow-up was 19.1 (range, 2 to 61) months in the MIS group and 22.1 (range, 2 to 58) months in the OG group. The median OS and DFS rates were 56.8 months and 39.6 months in the MIS group, respectively (log-rank; p=0.004) and 31.6 months and 23.1 months in the OG group, respectively (log-rank; p=0.003). Conclusion: Our study results suggest that, despite its technical challenges, MIS is an effective and safe method in treating gastric cancer with favorable early mortality and morbidity rates and long-term oncological outcomes, and acceptable recurrence rates.