Researcher:
Ertan, Fatoş Sibel

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Fatoş Sibel

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Ertan

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Ertan, Fatoş Sibel

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2012 - 201922020 - 202320

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Researcher Of Publications: search.filters.isAuthorOfPublication.57d44987-5416-4a6a-a9d9-9755aaa0f2cf

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    Altered transcriptional profile of mitochondrial DNA-Encoded OXPHOS subunits, mitochondria quality control genes, and intracellular ATP levels in blood samples of patients with Parkinson's disease
    (Ios Press, 2020) Gezen-Ak, Duygu; Alaylioglu, Merve; Genc, Gencer; Sengul, Busra; Keskin, Ebru; Sordu, Pelin; Gulec, Zeynep Ece Kaya; Apaydin, Hulya; Bayram-Gurel, Cigdem; Ulutin, Turgut; Yilmazer, Selma; Dursun, Erdinc; N/A; Ertan, Fatoş Sibel; Faculty Member; School of Medicine; 112829
    Mitochondrial dysfunctions are significant contributors to neurodegeneration. One result or a cause of mitochondrial dysfunction might be the disruption of mtDNA transcription. Limited data indicated an altered expression of mtDNA encoded transcripts in Alzheimer's disease (AD) or Parkinson's disease (PD). The number of mitochondria is high in cells with a high energy demand, such as muscle or nerve cells. AD or PD involves increased risk of cardiomyopathy, suggesting that mitochondrial dysfunction might be systemic. If it is systemic, we should observe it in different cell types. Given that, we wanted to investigate any disruption in the regulation of mtDNA encoded gene expression in addition to PINK1, PARKIN, and ATP levels in peripheral blood samples of PD cases who are affected by a neurodegenerative disorder that is very well known by its mitochondrial aspects. Our results showed for the first time that: 1) age of onset > 50 PD sporadic (PDS) cases: mtDNA transcription and quality control genes were affected; 2) age of onset <50 PDS cases: only mtDNA transcription was affected; and 3) PD cases with familial background: only quality control genes were affected. mtDNA copy number was not a confounder. Intracellular ATP levels of PD case subgroups were significantly higher than those of healthy subjects. We suggest that a systemic dysregulation of transcription of mtDNA or mitochondrial quality control genes might result in the development of a sporadic form of the disease. Additionally, ATP elevation might be an independent compensatory and response mechanism. Hyperactive cells in AD and PD require further investigation.
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    Low levels of LRRK2 gene expression are associated with LRRK2 SNPs and contribute to Parkinson's disease progression
    (Humana Press Inc, 2021) Yilmazer, Selma; Candas, Esin; Genc, Gencer; Alaylioglu, Merve; Sengul, Busra; Gunduz, Aysegul; Apaydin, Hulya; Kiziltan, Gunes; Dursun, Erdinc; Gezen-Ak, Duygu; N/A; Ertan, Fatoş Sibel; Faculty Member; School of Medicine; 112829
    Parkinson's disease (PD) is a chronic neurodegenerative disease that has relatively slow progression with motor symptoms.Leucine-rich repeat kinase 2 (LRRK2)gene mutations and polymorphisms are suggested to be associated with PD. In this study, we aimed to investigate the association between single-nucleotide polymorphisms (SNPs) of theLRRK2gene, namely, rs11176013, rs10878371, rs11835105, and PD. Genotypes of 132 PD cases and 133 healthy individuals were determined by qRT-PCR. Haplotype analysis was performed. Additionally,LRRK2mRNA expression levels were determined in 83 PD cases and 55 healthy subjects. The relationship betweenLRRK2mRNA levels, the target SNPs, and clinical data was also investigated. Our results indicated that the "GG" genotype and "G" allele of rs11176013 and the "CC" genotype and "C" allele of rs10878371 were more frequent in cases. The "GCG" haplotype was significantly more frequent in cases.LRRK2mRNA expression levels in patients were significantly lower than those in healthy individuals. The patients with the "CC" genotype for rs10878371 and the "GG" genotype for rs11176013 had decreasedLRRK2mRNA levels. We found that the rs11176013 "GG" genotype and the rs10878371 "CC" genotype were less frequently seen in cases with akinetic rigid or combined akinetic rigid and tremor-dominant initial symptoms. Consequently, our results demonstrate that the rs11176013 and rs10878371 polymorphisms are associated with PD in a Turkish cohort, and moreover, these results suggest that these polymorphisms may affect the expression of theLRRK2gene and disease progression and thus play a role in the pathogenesis of PD.
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    Acute-onset hemiparkinsonism secondary to subacute-chronic subdural hematoma
    (Turkish Neurosurgical Soc, 2022) Özekmekçi, Sibel; Şenel, Gülçin Benbir; N/A; Ertan, Fatoş Sibel; Çakmak, Özgür Öztop; Peker, Selçuk; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 112829; 299358; 11480
    Subdural hematomas constitute rare causes of secondary Parkinsonism in elderly. Subacute or chronic subdural hematomas occur in the elderly following minor head trauma or even without a remarkable history of trauma. A 69-year-old woman admitted with a rapidly progressive acute-onset hemiparkinsonism on the left side of her body. She denied any precipitating event before the onset of her symptoms, and her medical history was unremarkable. The anti-Parkinsonian therapy showed no benefit, but gradually worsening of the symptoms was observed. Her brain magnetic resonance imaging revealed a large subacute-chronic subdural hematoma on the right side with a mass effect on the basal ganglia structures, contralateral to her symptomatology. On thorough questioning, she confessed to having fallen out of the bed at night almost four weeks ago, three-weeks before the onset of her symptomatology. She had no complications associated with this fall and merely remembered this event. She denied any history of rapid eye movements (REM) sleep behavior disorder. The anti-Parkinsonian treatment was discontinued; the subdural hematoma was evacuated via burr hole drainage surgery. Her symptoms disappeared instantly after the surgery, with a normal neurologic examination one week after the surgery.
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    Frequency of non-motor symptoms in Parkinson's disease patients carrying the E326K and T369M GBA risk variants
    (Elsevier Ltd, 2023) Usnich, Tatiana; Olmedillas, Maria; Schell, Nathalie; Paul, Jefri J.; Curado, Filipa; Skobalj, Snezana; Csoti, Ilona; Gruber, Doreen; Zittel, Simone; Sammler, Esther; Isaacson, Stuart H.; Kühn, Andrea A.; Pedrosa, David J.; Reetz, Kathrin; Kasten, Meike; Rolfs, Arndt; Bauer, Peter; Skrahina, Volha; Klein, Christine; Brüggemann, Norbert; Ertan, Fatoş Sibel; Faculty Member; School of Medicine; 112829
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    Anticorrosion efficiency of ultrasonically deposited silica coatings on titanium
    (Elsevier Science Bv, 2013) N/A; N/A; Department of Chemistry; N/A; Ertan, Fatoş Sibel; Kaş, Recep; Miko, Annamaria; Birer, Özgür; Master Student; Master Student; Teaching Faculty; Researcher; Department of Chemistry; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; N/A; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); N/A; N/A; 163509; N/A
    We utilized high intensity ultrasound to prepare coatings of silica and organically modified silica composed of multiple layers of densely packed nanoparticles. Ultrasound was used to collide nanoparticles onto an activated titanium surface with high speed. Large areas could be homogeneously coated by this method. These coatings were characterized by spectroscopy and microscopy methods and the anticorrosion efficiency in NaCl solution was evaluated by electrochemical measurements. The results indicated that the composite coatings provided good quality barrier layer on bare titanium and decreased the anodic corrosion rate. It was found that increase in the organic content of the coating shifted the passivation potential towards more positive direction. The comparison of the impedance results recorded at the corrosion potential pointed out that in each case a good quality barrier layer was formed on the titanium surface. The outstanding corrosion resistance of the composite coatings with only similar to 200 nm thickness shows that ultrasound assisted deposition can be a competitive method to obtain corrosion protective layers. (c) 2013 Elsevier B.V. All rights reserved.
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    Jumping stump
    (N/A, 2020) N/A; N/A; Çakmak, Özgür Öztop; Eren, İlker; Aygün, Murat Serhat; Özer, Fahriye Feriha; Ertan, Fatoş Sibel; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 299358; 168021; 291692; N/A; 112829
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    Cerebellar cognitive-affective syndrome preceding ataxia associated with complex extrapyramidal features in a Turkish SCA48 family
    (Springer, 2020) Kaya-Güleç, Zeynep Ece; Genç, Gencer; N/A; Palvadeau, Robin Jerome; Şimşir, Gülşah; Vural, Atay; Çakmak, Özgür Öztop; Aygün, Murat Serhat; Falay, Fikri Okan; Başak, Ayşe Nazlı; Ertan, Fatoş Sibel; Researcher; Master Student; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 182369; 299358; 291692; 246484; 1512; 112829
    SCA48 is a novel spinocerebellar ataxia (SCA) originally and recently characterized by prominent cerebellar cognitive-affective syndrome (CCAS) and late-onset ataxia caused by mutations on the STUB1 gene. Here, we report the first SCA48 case from Turkey with novel clinical features and diffusion tensor imaging (DTI) findings, used for the first time to evaluate a SCA48 patient. A 65-year-old female patient with slowly progressive cerebellar ataxia, cognitive impairment, behavioral changes, and a vertical family history was evaluated. Following the exclusion of repeat expansion ataxias, whole exome sequencing (WES) was performed. Brain magnetic resonance imaging (MRI), including DTI, and single-photon emission computed tomography (SPECT) were used to study the primarily affected tracts and regions. WES revealed the previously reported heterozygous truncating mutation in ubiquitin ligase domain of STUB1 (ENST00000219548:c.823_824delCT, ENSP00000219548:p.L275Dfs*16) leading to a frameshift. Patient's cognitive status was compatible with CCAS. Novel clinical features different from the original report include later onset chorea, dystonia, general slowness of movements, apraxia, and palilalia, some of which have been recently reported in two families with different STUB1 mutations. CCAS is a prominent and often early feature of SCA48 which may be followed years after the onset of the disease by other complex neurological signs and symptoms. DTI may be helpful for demonstrating the cerebello-frontal tracts, involved in CCAS-associated SCA48, the differential diagnosis of which may be challenging especially in its early years.
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    Comparison of two different methods for assessing inspiratory muscle strength in patients with multiple system atrophy: a pilot study
    (European Respiratory Soc, 2020) Oğuz, Semra; Ünlü, Begüm; Polat, Mine Gülden; Yurdalan, Saadet Ufuk; Apaydın, Hulya; Ertan, Fatoş Sibel; Faculty Member; School of Medicine; 112829
    Introduction: In people with neuromuscular disease, the influence of the orofacial muscles can cause air leakage from the mouth. As a result, low values for inspiratory muscle strength may be due to air escape which caused by weakness of the facial muscles, true respiratory muscle weakness or submaximal effort. Also, loss of facial muscle movements can be seen in multiple system atrophy (MSA) due to symptoms of parkinsonism.
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    Investigation of factors affecting the side of the disease onset in Parkinson's disease
    (Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2022) Selte, Ceren Muserref; N/A; Özkan, Esra; Çakmak, Özgür Öztop; Şekerdağ, Emine; Ertan, Fatoş Sibel; Researcher; Faculty Member; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; 299358; N/A; 112829
    Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disease that starts unilaterally in almost all cases and tends to emerge on the side of the dominant hand, but what we know about the cause of this lateralization is limited. Frequent use of the extremity and physical activity are argued to be protective from PD in preclinical and clinical studies. This study aimed to evaluate the effect of handedness and working in occupations that require continuous use of upper extremities on the disease onset-side.Methods: We retrospectively collected 84 PD patients who applied to Koc University Neurology outpatient clinic between July 2016-October 2018. We analyzed the parameters of the side and region of disease onset, age of onset, number of drugs used for PD, hand preference, and patients' occupations.Results: The median age of our study group was 61 (53-69). Thirty (36%) of the 84 patients were women. Seventy-nine patients (94%) were right-handed. Eighty-three (99%) had asymmetric onset. The disease started on the dominant hand side in 47 patients (57%) and on the non dominant hand side in 36 (43%) patients. In our group with a median disease duration of four (2-7) years, the side with more severe complaints measured with the Unified Parkinson's Disease Evaluation Scale was consistent with the onset-side of the disease (p<0.001). In addition, the number of drugs used for PD and the scale score were higher in patients with longer disease duration (p=0.039, p=0.005). The number of drugs used for PD was also higher in patients with lower extremity-onset or both upper and lower extremities affected simultaneously than the upper extremity-onset (p=0.005). While the probability of starting on the dominant side was 43% in patients working in occupations requiring continuous use of upper extremities, it was 65% in others (p=0.027).Conclusion: According to this study, the onset of PD tends to be on the dominant hand side. Continuous upper extremity use may reduce the possibility of starting on the dominant side.
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    Molecular complexity of spastic ataxias and hereditary spastic paraplegias in Turkey
    (Springernature, 2020) Apaydin, H.; N/A; Şimşir, Gülşah; Tekgül, Şeyma; Ertan, Fatoş Sibel; Çepni, Ece; Master Student; Master Student; Faculty Member; PhD Student; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; School of Medicine; Graduate School of Health Sciences; N/A; 63142; 112829; N/A
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