Researcher:
Kuvvet, Yasemin

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PhD Student

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Yasemin

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Kuvvet

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Kuvvet, Yasemin

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2018 - 201942020 - 20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.59afd56b-152b-4a5a-8b76-86328319f65b

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Now showing 1 - 6 of 6
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    The cerebello-hypothalamic and hypothalamo-cerebellar pathways via superior and middle cerebellar peduncle in the rat
    (Springer, 2018) Bay, Hüsniye Hacıoğlu; Çavdar, Safiye; Özgür, Merve; Kuvvet, Yasemin; Faculty Member; PhD Student; PhD Student; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; 1995; N/A; N/A
    The connections between the cerebellum and the hypothalamus have been well documented. However, the specific cerebellar peduncle through which the hypothalamo-cerebellar and cerebello-hypothalamic connections pass has not been demonstrated. The present study aims to define the specific cerebellar peduncle through which connects the cerebellum to specific hypothalamic nuclei. Seventeen male albino rats received 20-50-nl pressure injections of either Fluoro-Gold (FG) or biotinylated dextran amine (BDA) tracer into the superior (SCP), middle (MCP), and inferior (ICP) cerebellar peduncle. Following 7-10days of survival period, the animals were processed according to the appropriate protocol for the two tracers used. Labeled cells and axons were documented using light or fluorescence microscopy. The present study showed connections between the hypothalamus and the cerebellum via both the SCP and the MCP but not the ICP. The hypothalamo-cerebellar connections via the SCP were from the lateral, dorsomedial, paraventricular, and posterior hypothalamic nuclei, and cerebello-hypothalamic connections were to the preoptic and lateral hypothalamic nuclei. The hypothalamo-cerebellar connections via the MCP were from the lateral, dorsomedial, ventromedial, and mammillary hypothalamic nuclei; and cerebello-hypothalamic connections were to the posterior, arcuate, and ventromedial hypothalamic nuclei. The hypothlamo-cerebellar connections were denser compared to the cerebello-hypothlamic connections via both the SCP and the MCP. The connection between the cerebellum and the hypothalamus was more prominent via the SCP than MCP. Both the hypothlamo-cerebellar and cerebello-hypothalamic connections were bilateral, with ipsilateral prepÖnderance. Reciprocal connections were with the lateral hypothalamic nucleus via the SCP and the ventromedial nucleus via the MCP were observed. Cerebellum takes part in the higher order brain functions via its extensive connections. The knowledge of hypothalamo-cerebellar and cerebello-hypothalamic connections conveyed within the SCP and MCP can be important for the lesions involving the MCP and SCP. These connections can also change the conceptual architecture of the cerebellar circuitry and deepen current understanding.
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    FKBP5 methylation, psychiatric disorders and stress: a systematic review and synthesis
    (Elsevier Science Inc, 2022) Çiçek, Yusuf; N/A; İzgi, Büşra; Kuvvet, Yasemin; Musaoğlu, Miraç Nur; Öztosun, Çınar; Eser, Hale Yapıcı; PhD Student; Master Student; PhD Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 134359
    Background FKBP5 methylation levels are among the most studied epigenetic modifications related to psychiatric disorder vulnerability, however there are contradictory findings. We aimed to investigate the role of FKBP5 methylation in psychiatric disorders, in addition to its association with stress exposure (either life adversities, traumatic events or acute stress). Methods In accordance with PRISMA guidelines, ‘FKBP5’ and ‘methylation’ were searched in PubMed and Web of Science in March 2021. 330 studies were identified. Studies on non-psychiatric disorders, animal or cell lines were excluded. Type of study, sample size, sociodemographic properties of the participants, type of stress exposure, type of psychiatric disorder, CPG loci at FKBP5, and other related methods and covariates were extracted from 53 studies found to be eligible based on the inclusion criteria. Results Preliminary analysis showed that 19 studies investigated FKBP5 methylation in psychiatric disorders, 32 studies investigated the effects of stress types on FKBP5 methylation. Among the 197 CpG sites investigated, CpG at chr6:35,590,711 (intron 7), chr6:35,689,425 (promoter region), and chr6:35,590,736 (intron 7/GRE) sites were investigated by 26, 24, and 22 studies, respectively. CpG sites at chr6:35,590,736 and chr6:35,590,711 were reported to be linked to psychiatric disorder; CpG site at chr6:35,590,711, were reported to be linked to types of stress by more than half of the studies that investigated this region. Conclusions The studies on FKBP5 methylation and psychiatric disorder vulnerability are highly heterogeneous and most significant associations are found in intron 7. However, a great percentage of literature report insignificant associations of FKBP5 methylation sites with psychiatric disorder vulnerability.
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    The role of chronic stress on mitochondria related neurodegeneration in parkinson's disease
    (Elsevier, 2021) N/A; N/A; N/A; Kuvvet, Yasemin; Atak, Dila; Eser, Hale Yapıcı; Master Student; Master Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; N/A; 134359
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    Afferent projections of the subthalamic nucleus in the rat: mphasis on bilateral and interhemispheric connections
    (Nencki Inst Experimental Biology, 2018) Çavdar, Safiye; Özgür, Merve; Çakmak, Yusuf Özgür; Kuvvet, Yasemin; Kunt, Kezban Sıla; Sağlam, Gökay; Faculty Member; PhD Student; Faculty Member; PhD Student; Undergraduate Student; Undergraduate Student; School of Medicine; Graduate School of Health Sciences; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; Koç University Hospital; 1995; 197462; N/A; N/A; N/A; N/A
    The subthalamic nucleus (STN) is important for normal movement as well as in movement disorders. The STN is a target nuclei in patients with advanced Parkinson's disease (PD). Deep brain stimulation (DBS) is a standard surgical treatment for PD. Although DBS results in a significant reduction in motor disability, several negative side effects have been reported. Thus, to understand the side effects of DBS the connection of the STN should be well known. Therefore, the present study aims to re-examine the STN with an emphasis on poorly- or un-documented connections. Furthermore, the bilateral and interhemispheric connections of the STN are evaluated. Fifteen male albino rats received injections of Fluoro-Gold retrograde and biotinylated dextran amine anterograde tracers into the STN. Following a 7-10 day survival period, the animals were processed according to the relevant protocol for each tracer. The present study demonstrates ipsilateral connections of the STN with cortical regions (i.e., infralimbic, cingulate, frontal, piriform, primary motor, primary sensory, insular and retrosplenial cortices), the endopiriform nucleus, basal ganglia related structures (i.e., caudate putamen, globus pallidus, ventral pallidum, nucleus accumbens, claustrum and substantia innominata) and the deep cerebellar nuclei (i.e., lateral, anterior interposed). Bilateral connections of the STN were observed with limbic (amygdala, bed nucleus of stria terminalis), hypothalamic (ventromedial, posterior, anterior, lateral and mammillary) thalamic (thalamic reticular nucleus), epithalamic (habenular nucleus), and brainstem structures (superior colliculus, substantia nigra, spinal nucleus of the trigeminal nerve, red nucleus, dorsal raphe nucleus, pedunculopontine tegmental nuclei). Interhemispheric connections between left and right STN were also observed. The present study fills important gaps in connectivity of the STN. In particular, we report STN connectivity with cortical areas (i.e., piriform, endopiriform and insular), claustrum, hypothalamic, thalamic reticular, cerebellar, habenular, trigeminal, red, cuneate and gracile nuclei and substantia innominate. These connections, which have not been previously described or poorly described, provide new routes that can alter the conceptual architecture of the basal ganglia circuitry and may modify our view of the functional identity of the STN.
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    Relationships between astrocytes and absence epilepsy in rat: an experimental study
    (Elsevier Ireland Ltd, 2019) Onat, Filiz; N/A; N/A; N/A; N/A; Çavdar, Safiye; Kuvvet, Yasemin; Sur, İlknur Erdem; Özgür, Merve; Faculty Member; PhD Student; Faculty Member; PhD Student; School of Medicine; Graduate School of Health Sciences; School of Medicine; Graduate School of Health Sciences; 1995; N/A; N/A; 197462
    Astrocytes take part in the modulation of neuronal activity through the uptake and release of both GABA and glutamate. In the present study we aimed to quantify the number of astrocytes expressing the astrocyte marker glial fibrillary acidic protein (GFAP) in the somatosensory cortex (SSCx), ventrobasal (VB), centromedial (CM), reticular (TRN) and dorsal lateral geniculate (dLGN) nuclei of thalamus in Genetic Absence Epilepsy Rats from Strasbourg (GAERS), Wistar Albino Glaxo Rats from Rijswijk (WAG/Rij) and control Wistar animals. Further, we aimed to compare the GFAP protein expression levels between the three animal strains. The GFAP-immunohistochemistry was applied to sections from the SSCx, VB, CM, TRN and dLGN and GFAP-positive astrocytes were quantified for the three animal strains. Further, GFAP Western Blot was applied to the tissue samples from the same regions of the three strain. The data obtained from Wistar animals were compared with GAERS and WAG/Rij animals. The number of GFAP-positive astrocytes per unit area in all brain regions studied showed high significance between Wistar-GAERS and Wistar-WAG/Rij except the dLGN. The GAERS had significant higher endogenous GFAP expression in all brain regions studied compared to Wistar and WAG/Rij animals. These findings demonstrate a discrete difference in both GFAP-positive astrocyte populations and GFAP protein expression levels between Wistar and genetically epileptic strains (GAERS and WAG/Rij). Absence seizures are thought to result from a possible imbalance in glutamatergic and GABAergic neurotransmission. Astrocytes regulate the concentration of glutamate and GABA in the extracellular space in the brain, the difference in the astrocyte population and GFAP protein expression in the epileptic strains clearly shows the involvement of astrocytes in the mechanism of absence epilepsy
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    Cortical, subcortical and brain stem connections of the cerebellum via the superior and middle cerebellar peduncle in the rat
    (World Scientific Publishing, 2018) Bay, Hüsniye; Aydoğmuş, Evren; N/A; Çavdar, Safiye; Özgür, Merve; Kuvvet, Yasemin; Faculty Member; PhD Student; School of Medicine; 1995; N/A; N/A
    The role of cerebellum in coordination of somatic motor activity has been studied in detailed in various species. However, experimental and clinical studies have shown the involvement of the cerebellum with various visceral and cognitive functions via its vast connections with the central nervous system. The present study aims to define the cortical and subcortical and brain stem connections of the cerebellum via the superior (SCP) and middle (MCP) cerebellar peduncle using biotinylated dextran amine (BDA) and Fluoro-Gold (FG) tracer in Wistar albino rats. 14 male albino rats received 20-50-n1 pressure injections of either FG or BDA tracer into the SCP and MCP. Following 7-10 days of survival period, the animals were processed according to the related protocol for two tracers. Labelled cells and axons were documented using light and fluorescence microscope. The SCP connects cerebellum to the insular and infralimbic cortices whereas, MCP addition to the insular cortex, it also connects cerebellum to the rhinal, primary sensory, piriform and auditory cortices. Both SCP and MCP connected the cerebellum to the ventral, lateral, posterior and central, thalamic nuclei. Additionally, SCP also connects parafasicular thalamic nucleus to the cerebellum. The SCP connects cerebellum to basal ganglia (ventral pallidum and clastrum) and limbic structures (amygdaloidal nuclei and bed nucleus of stria terminalis), however, the MCP have no connections with basal ganglia or limbic structures. Both the SCP and MCP densely connects cerebellum to various brainstem structures. Attaining the knowledge of the connections of the SCP and MCP is important for the diagnosis of lesions in the MCP and SCP and would deepen current understanding of the neuronal circuit of various diseases or lesions involving the SCP and MCP.